Article
Biochemistry & Molecular Biology
Deiweson Souza-Monteiro, Marcia Cristina dos Santos Guerra, Leonardo Oliveira Bittencourt, Walessa Alana Braganca Aragao, Aline Dionizio, Felipe Martins Silveira, Marilia Afonso Rebelo Buzalaf, Manoela Domingues Martins, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Summary: This study investigated the effects of low-dose aluminum exposure on the oxidative biochemistry, proteomic profile, and morphology of the major salivary glands. The results showed that aluminum caused oxidative imbalance, dysregulation of protein expression, and histological alterations in the salivary glands. Prolonged exposure to low doses of aluminum may pose a risk to oral health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yeo-Jun Yoon, Donghyun Kim, Kwon Yong Tak, Seungyeon Hwang, Jisun Kim, Nam Suk Sim, Jae-Min Cho, Dojin Choi, Yongmi Ji, Junho K. Hur, Hyunki Kim, Jong-Eun Park, Jae-Yol Lim
Summary: In this study, the authors establish a protocol for long-term maintenance of murine and human salivary gland organoids exhibiting gland-specific gene expression, gland functions, and cellular diversity confirmed by scRNA-seq.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
N. B. Pushpa, Kumar Satish Ravi, Prashant Durgapal
Summary: Despite the COVID-19 pandemic in 2020, the discovery of a new salivary gland became a hot topic in the medical community. The significance of this finding lies in its clinical relevance in radiotherapy of oropharyngeal carcinoma, but there are differing views due to the lack of substantial evidence. Efforts have been made to shed light on Tubarial glands with potential evidence.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
L. Meme, M. Di Girolamo, A. Alushi, P. Rasicci, D. Marcattili, M. Capogreco, E. E. Carli
Summary: The article aims to analyze different approaches to solve the symptoms of chronic gland inflammation, specifically focusing on the high risk of relapse. Minor salivary glands, present in most oral cavities, play a vital role in moistening and lubricating oral tissues, as well as protecting against bacterial activity.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Environmental Sciences
Gessica de Oliveira Lopes, Walessa Alana Braganca Aragao, Priscila Cunha Nascimento, Leonardo Oliveira Bittencourt, Ana Carolina Alves Oliveira, Luana Ketlen Reis Leao, Sergio Melo Alves-Junior, Joao de Jesus Viana Pinheiro, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Summary: The study showed that chronic lead exposure induces oxidative stress in the blood and glands, causing cellular, morphological, and biochemical damage in both parotid and submandibular glands. This was evidenced by increased MT I/II expression, decreased CK-19 expression, and decreased α-SMA immunostaining in both glands.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Lili Zhang, Qiumei Zhou, Jiafu Zhang, Kefeng Cao, Chang Fan, Sen Chen, Hui Jiang, Furong Wu
Summary: Through the analysis of transcriptomic and proteomic data, this study provides a detailed understanding of the molecular changes in CCl4-induced LF and identifies genes and pathways associated with LF. This lays a theoretical foundation for further research on the mechanisms of LF and the development of targeted therapy.
Article
Multidisciplinary Sciences
Jingjing Sun, Sirui Liu, Kun Fu, Ning Gao, Rui Li, Wei He, Zhenjie Gao
Summary: This retrospective study examined the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients, revealing that SCSGs are typically indolent with a low locoregional recurrence rate and excellent survival.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Stephan Ihrler, David Stiefel, Philipp Jurmeister, Ann Sandison, Nicola Chaston, Jan Laco, Nina Zidar, Luka Brcic, Robert Stoehr, Abbas Agaimy
Summary: The formal pathogenesis of salivary carcinosarcoma (SCS) is clarified in this study, showing that it almost always develops from pleomorphic adenoma (PA) and follows a multistep adenoma-carcinoma-sarcoma sequence. This finding suggests that SCS is a rare and unique variant of carcinoma ex PA with secondary sarcomatous overgrowth.
Article
Multidisciplinary Sciences
Priscila Cunha Nascimento, Walessa Alana Braganca Aragao, Leonardo Oliveira Bittencourt, Aline Dionizio, Marilia A. R. Buzalaf, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Summary: The study found that maternal exposure to methylmercury significantly alters the proteomic profiles of developing rat salivary glands, affecting proteins related to cytoskeleton components, tissue morphogenesis, and response to stimulus and stress.
Review
Cell Biology
Jennifer M. Boland
Summary: While lung cancer is common, benign pulmonary neoplasms are rare. Pathologists need to be familiar with the typical diagnostic features of benign lung tumors to avoid confusion with malignant mimics. This review covers the most common benign lung tumors, including pulmonary adenomas, bronchial papillomas, and benign mesenchymal tumors, and discusses their classification, differential diagnosis, and genetic drivers.
Article
Cell Biology
Stephan Ihrler, Abbas Agaimy, Orlando Guntinas-Lichius, Christian J. Haas, Martin Mollenhauer, Ann Sandison, Lukas Greber
Summary: The study identified and statistically verified reasons behind the perceived greater difficulty in diagnosing minor salivary gland (MinSG) tumors, including high frequencies of initial incisional biopsies and low-grade categories in malignant tumors. Other factors contributing to diagnostic difficulties include rare entities, unusual locations, shortcomings in clinicopathological communication, and peculiarities of the special anatomical location of the hard palate. Recommendations were provided to aid in assessment and reduce misdiagnosis rates.
Article
Astronomy & Astrophysics
Y. P. Chen, S. Zhang, S. N. Zhang, L. Ji, L. D. Kong, P. J. Wang, L. Tao, M. Y. Ge, C. Z. Liu, F. J. Lu, J. L. Qu, T. P. Li, Y. P. Xu, X. L. Cao, Y. Chen, Q. C. Bu, C. Cai, Z. Chang, L. Chen, T. X. Chen, Y. B. Chen, W. W. Cui, Y. Y. Du, G. H. Gao, H. Gao, Y. D. Gu, J. Guan, C. C. Guo, D. W. Han, Y. Huang, J. Huo, S. M. Jia, W. C. Jiang, J. Jin, B. Li, C. K. Li, G. Li, W. Li, X. Li, X. B. Li, X. F. Li, Z. W. Li, X. H. Liang, J. Y. Liao, B. S. Liu, H. W. Liu, H. X. Liu, X. J. Liu, X. F. Lu, Q. Luo, T. Luo, R. C. Ma, X. Ma, B. Meng, Y. Nang, J. Y. Nie, G. Ou, X. Q. Ren, N. Sai, L. M. Song, X. Y. Song, L. Sun, Y. Tan, Y. L. Tuo, C. Wang, L. J. Wang, W. S. Wang, Y. S. Wang, X. Y. Wen, B. B. Wu, B. Y. Wu, M. Wu, G. C. Xiao, S. Xiao, S. L. Xiong, R. J. Yang, S. Yang, Y. J. Yang, Y. J. Yang, Q. B. Yi, Q. Q. Yin, Y. You, F. Zhang, H. M. Zhang, J. Zhang, P. Zhang, W. C. Zhang, W. Zhang, Y. F. Zhang, Y. H. Zhang, H. S. Zhao, X. F. Zhao, S. J. Zheng, Y. G. Zheng, D. K. Zhou
Summary: The study reveals that in the type-II X-ray bursts of MXB 1730-335, hard X-rays lag behind soft X-rays by 3 seconds, providing a new perspective for research. The energy spectrum of all bursts is nonthermal, indicating the possible presence of a coronal source.
ASTROPHYSICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Martha Ines Velez-Mercado, Alicia Guadalupe Talavera-Caro, Karla Maria Escobedo-Uribe, Salvador Sanchez-Munoz, Miriam Paulina Luevanos-Escareno, Fernando Hernandez-Teran, Alejandra Alvarado, Nagamani Balagurusamy
Summary: The production of biofuels and other value-added products from lignocellulose breakdown requires the coordinated metabolic activity of varied microorganisms. Optimization strategies are encouraged by increasing global demand for biofuels, which necessitates a thorough understanding of microbial mechanisms and metabolic pathways behind the formation of each product. The accessibility of biomass to microorganisms is crucial for the release of sugars that are transformed into desired products. The role of proteins and their activity under anaerobic conditions remains largely unexplored in the context of biofuel production processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Matthijs H. Valstar, Bernadette S. de Bakker, Roel J. H. M. Steenbakkers, Kees H. de Jong, Laura A. Smit, Thomas J. W. Klein Nulent, Robert J. J. van Es, Ingrid Hofland, Bart de Keizer, Bas Jasperse, Alfons J. M. Balm, Arjen van der Schaaf, Johannes A. Langendijk, Ludi E. Smeele, Wouter V. Vogel
Summary: This study identified previously unnoticed macroscopic salivary gland locations in the human nasopharynx, named tubarial glands. Results showed a significant association between the average radiotherapy dose to these glands and the severity of posttreatment xerostomia and dysphagia, indicating the importance of sparing these glands to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Gopa Kumar Gopinadhan Nair, Dimitrios Pollalis, Jonathan D. Wren, Constantin Georgescu, Virginie Sjoelund, Sun Young Lee
Summary: This study characterized vitreous humor (VH) exosomes and explored their role in the development of proliferative vitreoretinopathy (PVR) using mass spectrometry-based proteome profiling. The results suggest that exosomes may play a key role in mediating tissue remodeling along with a complex set of pathways involved in PVR development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Otorhinolaryngology
Iacopo Dallan, Miriana Picariello, Giacomo Fiacchini
Summary: Recent literature suggests that conservative management may help preserve orbital content in certain patients with sinonasal cancers. MRI is the recommended imaging tool for evaluating orbital invasion. Limited invasion of periorbital and extraconal fat should not be considered as an indication for orbital cleaning. Neoadjuvant chemotherapy guided by histology can be attempted and may provide prognostic information.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2022)
Article
Endocrinology & Metabolism
G. Rotondo Dottore, L. Torregrossa, G. Lanzolla, S. Mariotti, F. Menconi, P. Piaggi, L. Cristofani Mencacci, C. Posarelli, M. N. Maglionico, I. Dallan, M. Figus, M. Nardi, C. Marcocci, F. Basolo, M. Marino
Summary: The majority of GO patients have mononuclear cell infiltrates in the orbit, with a small percentage exclusively represented by plasmacells. CD4 cells play a major role in GO activity. These findings may contribute to a better understanding of the pathogenesis of GO.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Otorhinolaryngology
Iacopo Dallan, Lodovica Cristofani-Mencacci, Giacomo Fiacchini, Giacomo Benettini, Miriana Picariello, Giulia Lanzolla, Francesco Lazzerini, Roberto Rocchi, Mario Turri-Zanoni, Francesca Menconi, Stefano Sellari-Franceschini, Michele Marino
Summary: In this study, three different surgical protocols for the management of dysthyroid optic neuropathy (DON) were evaluated and the functional outcomes were assessed. The results showed that the extended endonasal approach and the three walls decompression were effective in the treatment of DON.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Allergy
Ilaria Puxeddu, Fiorella Petrelli, Lodovica Cristofani-Mencacci, Mariella Scarano, Manuela Latorre, Antonio De Rosa, Iacopo Dallan, Maria Laura Manca, Stefano Berrettini, Paola Migliorini, Veronica Seccia
Summary: This study aimed to identify atopic patients in the context of chronic rhinosinusitis with nasal polyps (CRSwNP) and characterize their allergen sensitization profile. The research found that patients with CRSwNP who were sensitized to grass pollens and/or house dust mites had a prevalence of sensitization to species-specific allergens rather than cross-reactive ones.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Microbiology
Giacomo Fiacchini, Agnese Proietti, Anello Marcello Poma, Miriana Picariello, Iacopo Dallan, Fabio Guarracino, Francesco Forfori, Gabriella Fontanini, Luca Bruschini
Summary: This study evaluates the possibility that the tracheal mucosa could be a high replication site of the SARS-CoV-2 virus, leading to weakened epithelium and increasing laryngotracheal complications in COVID-19 patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Clinical Neurology
Francesco Corrivetti, Matteo de Notaris, Alberto Di Somma, Iacopo Dallan, Joaquim Ensenat, Thomas Topczewski, Domenico Solari, Luigi Maria Cavallo, Paolo Cappabianca, Alberto Prats-Galino
Summary: This study conducted an anatomical study on the sagittal crest in the superior eyelid endoscopic transorbital approach (SETOA), and found it to be a common anatomical landmark composed of the residual part of the greater sphenoid wing. Complete resection of the sagittal crest is necessary to provide adequate working space during surgery and to guide subsequent interdural opening.
OPERATIVE NEUROSURGERY
(2022)
Article
Cell Biology
Laura Giusti, Marta Tesi, Federica Ciregia, Lorella Marselli, Lorenzo Zallocco, Mara Suleiman, Carmela De Luca, Silvia Del Guerra, Mariachiara Zuccarini, Marco Trerotola, Decio L. Eizirik, Miriam Cnop, Maria R. Mazzoni, Piero Marchetti, Antonio Lucacchini, Maurizio Ronci
Summary: Metformin was found to alleviate human beta-cell stress induced by pro-inflammatory cytokines, leading to proteome modifications in human islets.
Article
Endocrinology & Metabolism
Giovanna Rotondo Dottore, Giulia Lanzolla, Simone Comi, Francesca Menconi, Lodovica Cristofani Mencacci, Iacopo Dallan, Claudio Marcocci, Michele Marino
Summary: This study found that DNA methylation in orbital fibroblasts is associated with Graves orbitopathy (GO), leading to differential gene expression and functional alterations, ultimately contributing to the development of the GO phenotype.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo Zallocco, Roberto Silvestri, Federica Ciregia, Alessandra Bonotti, Riccardo Marino, Rudy Foddis, Antonio Lucacchini, Laura Giusti, Maria Rosa Mazzoni
Summary: This study found that the levels of prosaposin and SULF-1 in pleural effusion may be promising biomarkers for differentiating between mesothelioma and non-malignant pleural disease. However, more patients need to be enrolled to confirm the usefulness of these soluble proteins in differentiating mesothelioma pleural effusions from those linked to lung cancer.
Article
Biochemistry & Molecular Biology
Claudio Alimenti, Mariacaterina Lianza, Fabiana Antognoni, Laura Giusti, Onelia Bistoni, Luigi Liotta, Cristina Angeloni, Giulio Lupidi, Daniela Beghelli
Summary: Olive pomace (OP), a by-product of olive oil production, contains health-promoting bioactive compounds. Different OP batches showed variations in phenolic compounds and antioxidant activities. The aqueous extract of OP exhibited potential anti-inflammatory properties different from the metabolome of OP fractions.
Article
Otorhinolaryngology
Aria Jafari, Nithin D. Adappa, Vincent J. Anagnos, Raewyn G. Campbell, Paolo Castelnuovo, Ara Chalian, Christopher B. Chambers, Chandala Chitguppi, Iacopo Dallan, Edward El Rassi, Suzanne K. Freitag, Juan C. Fernandez Miranda, Manuel Ferreira, Paul A. Gardner, David A. Gudis, Richard J. Harvey, Qian Huang, Ian M. Humphreys, David W. Kennedy, John Y. K. Lee, Ashton E. Lehmann, Davide Locatelli, Kibwei A. McKinney, Annie Moreau, Gurston Nyquist, James N. Palmer, Narayanan Prepageran, Edmund A. Pribitkin, Mindy R. Rabinowitz, Marc R. Rosen, Raymond Sacks, Dhruv Sharma, Carl H. Snyderman, S. Tonya Stefko, Janalee K. Stokken, Eric W. Wang, Alan D. Workman, Arthur W. Wu, Jen Y. Yu, Matthew M. Zhang, Bing Zhou, Benjamin S. Bleier
Summary: Based on data from 11 international centers, a study found that the Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system can predict surgical outcomes of primary benign orbital tumors (PBOTs). In summary, the study concluded that endoscopic surgery is an effective approach for treating PBOTs and the proposed staging system is valuable for outcomes reporting.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Biology
Daniela Beghelli, Lorenzo Zallocco, Cristina Angeloni, Onelia Bistoni, Maurizio Ronci, Clarita Cavallucci, Maria Rosa Mazzoni, Anna Nuccitelli, Chiara Catalano, Silvana Hrelia, Antonio Lucacchini, Laura Giusti
Summary: A placebo-controlled study was conducted on 16 show jumping horses to evaluate the effects of a dietary supplement containing Verbascum thapsus, Curcuma longa, and Boswellia serrata extracts. The supplementation led to modulation of proteins and downregulation of proinflammatory cytokines in the horses. The study suggests that this phytotherapy can strengthen the innate immune responses and alleviate inflammation in sport horses.
Review
Otorhinolaryngology
Mario Turri-Zanoni, Gianluca Dalfino, Matt Lechner, Iacopo Dallan, Paolo Battaglia, Carla Facco, Francesca Franzi, Giacomo Gravante, Marco Ferrari, Dimitrios Terzakis, Amrita Jay, Martin D. Forster, Andrea Luigi Ambrosoli, Maurizio Bignami, Christos Georgalas, Philippe Herman, Piero Nicolai, Valerie J. Lund, Paolo Castelnuovo
Summary: Biphenotypic sinonasal sarcoma is a rare low-grade cancer with encouraging survival outcomes if treated with surgical resection and adjuvant radiotherapy.
ACTA OTORHINOLARYNGOLOGICA ITALICA
(2022)