Article
Oncology
Tongtong Wei, Jinjing Song, Kai Liang, Li Li, Xiaoxiang Mo, Zhiguang Huang, Gang Chen, Naiquan Mao, Jie Yang
Summary: In this study, NRK was found to be significantly elevated in LUAD-associated CAFs and may serve as a promising therapeutic target for cancer combination treatment. Modulation of ECM and glycolysis/gluconeogenesis pathways could be an efficient approach to alter CAFs functionality in LUAD.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Charalampos Fotsitzoudis, Asimina Koulouridi, Ippokratis Messaritakis, Theocharis Konstantinidis, Nikolaos Gouvas, John Tsiaoussis, John Souglakos
Summary: Tumor microenvironment, including cancer-associated fibroblasts (CAFs), plays a significant role in tumor growth, metastasis, and therapy resistance. Detecting CAFs is crucial for prognosis assessment and potential treatment targets, but further research is needed.
Article
Oncology
Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo
Summary: Cancer-associated fibroblasts (CAFs) promote tumor growth in human breast cancers. RUNX3 expression is higher in CAFs from cancerous regions compared to non-cancerous regions in breast cancer patients. Knockdown of RUNX3 in CAFs attenuates tumor growth and reduces cancer cell proliferation and microvessel formation.
Review
Medicine, Research & Experimental
Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam, Inigo Martinez-Zubiaurre
Summary: Radiotherapy not only kills malignant cells through ionizing radiation, but also activates anti-tumor immune responses. Cancer-associated fibroblasts (CAFs) are important components of the tumor microenvironment, playing central roles in cancer development and immune evasion. Despite the known immunoregulatory functions of CAFs, the interaction between CAFs and immune cells after radiation remains poorly understood.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Fengying Gong, Yuchao Yang, Liangtao Wen, Congrong Wang, Jingjun Li, Jingxing Dai
Summary: This review examines the role of mechanical forces in the development of lung cancer, focusing on how lung tissue is influenced by mechanical stimulation. It emphasizes the impact of mechanical stretching on lung cancer cells and CAFs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Shih-Hsuan Cheng, Hsin-Ying Clair Chiou, Jiunn-Wei Wang, Ming-Hong Lin
Summary: Gastrointestinal (GI) cancers are a major cause of cancer-related deaths worldwide. Despite advancements in current treatments, high recurrence rates still pose a challenge for patients with GI cancers. The tumor microenvironment (TME) plays a crucial role in tumor progression, metastasis, and chemotherapy resistance, particularly through the interaction of cytokines/chemokines produced by cancer-associated fibroblasts (CAFs). Understanding this crosstalk between CAFs and the TME can open new avenues for reducing therapeutic recurrence in GI cancers.
Article
Biotechnology & Applied Microbiology
Chen Ai, Xiao Sun, Shan Xiao, Lu Guo, Mengmeng Shang, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Jie Li
Summary: Despite advances in metabolic therapies, their efficacy in melanoma is limited due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells. This study developed a CAFs-targeted nanodroplet system for the delivery of ASCT2 inhibitor and GLUL siRNA. Ultrasound-targeted microbubble disruption was used to facilitate drug release and block the interaction between CAFs and cancer cells. The nanodroplets also served as contrast agents for tumor imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenge Dong, Yangyang Xie, Hai Huang
Summary: This study investigated the specific functions of cancer-associated fibroblast (CAF)-related genes in hepatocellular carcinoma (HCC) and found their prognostic significance. Cluster analysis and risk score model were used to identify different risk groups with significant differences in overall survival and chemosensitivity. Furthermore, the study explored the correlation between immune infiltration characteristics and different risk levels. These findings provide possibilities for personalized treatment in HCC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Hao Song, Chao Lou, Jie Ma, Qiyu Gong, Zhuowei Tian, Yuanhe You, Guoxin Ren, Wei Guo, Yanan Wang, Kunyan He, Meng Xiao
Summary: The study investigated the tumor microenvironment and tumor cell evolution in oral squamous cell carcinoma after chemotherapy using single-cell transcriptome analysis. The results identified different types of cancer-associated fibroblasts and tumor-associated macrophages in the tumor microenvironment, and enriched molecular pathways associated with epithelial-mesenchymal transition. Additionally, the study found the expression of CD74-MIF/COPA/APP interactions in the tumor microenvironment after chemotherapy. These findings provide new insights for further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Qiwei Wang, Yinan Zhao, Fang Wang, Guolin Tan
Summary: This study identified the infiltration of cancer-associated fibroblasts (CAFs) as a hallmark signature of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC). By analyzing CAFs gene expression patterns and using machine learning algorithms, a stable and accurate risk model was developed to classify HNSCC patients.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Kuan-Jung Chiu, Hsin-Ying Clair Chiou, Chi-Han Huang, Pin-Chun Lu, Hui-Ru Kuo, Jiunn-Wei Wang, Ming-Hong Lin
Summary: This review summarizes the research on natural compounds mediating the interaction between digestive system cancers and CAFs, discusses the roles and multifunctionality of CAFs in cancer progression, and provides a theoretical basis for CAF-related antitumor therapies.
Article
Oncology
Ilaria Giusti, Marianna Di Francesco, Giuseppina Poppa, Letizia Esposito, Sandra D'Ascenzo, Vincenza Dolo
Summary: Fibroblasts in the tumor microenvironment can be activated by cancer cells to become cancer-associated fibroblasts (CAFs), which promote tumor progression by remodeling the tumor stroma. Extracellular vesicles (EVs), including exosomes (EXOs) and microvesicles (MVs), play a crucial role in the communication between cancer cells and fibroblasts. Different subpopulations of EVs have different effects on fibroblasts, and the secretome of activated fibroblasts can modulate the response of bystander cells, indicating the important role of EVs in the mutual cross-talk between tumor cells and CAFs.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Ana Maia, Anna Schoellhorn, Juliane Schuhmacher, Cecile Gouttefangeas
Summary: Tumour cells interact with the surrounding microenvironment, including immune cells and cancer-associated fibroblasts (CAFs), which play a crucial role in tumour progression and therapy response. Understanding the complexity of CAFs and their interaction with immune cells is essential for improving treatment outcomes and developing predictive biomarkers.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Oncology
Julio Cesar Villegas-Pineda, Adrian Ramirez-de-Arellano, Lesly Jazmin Bueno-Urquiza, Melida del Rosario Lizarazo-Taborda, Ana Laura Pereira-Suarez
Summary: Molecular and cellular components of the tumor microenvironment, including cancer cells and non-cancer cell populations, play essential roles in cancer progression. Cancer-associated fibroblasts (CAFs), as mesenchymal cells, promote carcinogenesis and progression through the secretion of different molecules. Recent findings have increased our understanding of the leading role of CAFs in gynecological cancers, suggesting their potential as therapeutic targets and their possible tumor suppressor effects.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Julian Goetze, Christine Nitschke, Faik G. Uzunoglu, Klaus Pantel, Marianne Sinn, Harriet Wikman
Summary: PDAC patients have a poor prognosis, with the tumor microenvironment's CAFs playing a crucial role, including myCAFs, iCAFs, and apCAFs. Research on CAFs helps in developing anti-stromal therapies, and cCAFs may serve as new liquid biopsy biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)