Article
Immunology
Marta Machado-Pereira, Claudia Saraiva, Liliana Bernardino, Ana C. Cristovao, Raquel Ferreira
Summary: The study reveals the significance of Ago2 in the inflammatory responses of brain endothelial cells and glial cells, suggesting its potential as a therapeutic agent for inflammatory conditions affecting the neurovascular unit.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Multidisciplinary
Qian Zhang, Qingxiang Song, Xiao Gu, Mengna Zheng, Antian Wang, Gan Jiang, Meng Huang, Huan Chen, Yu Qiu, Bin Bo, Shanbao Tong, Rong Shao, Binyin Li, Gang Wang, Hao Wang, Yongbo Hu, Hongzhuan Chen, Xiaoling Gao
Summary: The multifunctional nanostructure RAP-RL developed in this study accelerates Aβ clearance and restores cerebral vasculature function, resulting in improved learning and memory abilities in AD mice.
Article
Pharmacology & Pharmacy
David Arenas-Mosquera, Alipio Pinto, Natacha Cerny, Clara Berdasco, Adriana Cangelosi, Patricia Andrea Geoghegan, Emilio Luis Malchiodi, Mauricio De Marzi, Jorge Goldstein
Summary: This study aims to investigate the pathogenesis of encephalopathy associated with hemolytic uremic syndrome. The findings suggest that toxins released by enterohemorrhagic E. coli infection can trigger neuroinflammatory response and alterations in the neurovascular unit, which are associated with neurological compromise and abnormal motor behavior.
Article
Cell Biology
Yohei Kume, Hayato Go, Ryo Maeda, Kazuhide Suyama, Tsutomu Mori, Yukihiko Kawasaki, Koichi Hashimoto, Mitsuaki Hosoya
Summary: In this study, a mouse model of hemolytic uremic syndrome (HUS) induced by LPS/Stx2 was used. The results showed that LPS/Stx2 administration led to decreased urinary osmolality and urinary potassium, suggesting distal nephron disorders. Microarray analysis identified differentially expressed genes at 6 h and 72 h after LPS/Stx2 administration, with activation of TNFR1/2, iNOS, and IL-6 signaling observed at both time points. Additionally, pathways associated with lipid metabolism were inhibited at 72 h only. The downregulated genes were mainly expressed in the distal nephrons.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Galina T. Shishkina, Tatyana S. Kalinina, Dmitriy A. Lanshakov, Veta V. Bulygina, Natalya P. Komysheva, Anita V. Bannova, Ulyana S. Drozd, Nikolay N. Dygalo, Xian (Phoebe) Zhou
Summary: This study investigated the molecular mechanisms involved in inflammatory-related cognitive dysfunction and its prevention. The researchers found that the expression of immunity/inflammatory-linked genes increased after lipopolysaccharide (LPS) treatment, which resulted in memory loss. However, pretreatment with dexamethasone (DEX) did not significantly affect the inflammatory response but influenced genes associated with ion channels, glutamatergic signaling, and nervous system development. These findings suggest that DEX pretreatment may play a role in the recovery of memory impairment induced by LPS.
Article
Endocrinology & Metabolism
Haci Omer Osmanlioglu, Mustafa Naziroglu
Summary: The protective role of dexamethasone (DEX) in lipopolysaccharide (LPS)-induced inflammation, apoptosis, and oxidative cytotoxicity in BV-2 cells was investigated by attenuating TRPM2 signaling. The results showed that DEX treatment reduced cell death, apoptosis, oxidants, and cytokine production induced by LPS. Therefore, DEX may be a potential therapeutic approach for neurodegenerative diseases caused by LPS-induced microglia oxidative injury.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Biniam Moges, Degisew Yinur, Aliyi Hassen, Tesfaye Sisay Tessema
Summary: A rapid, effective, sensitive, and specific immunodiagnostic assay for STEC strain detection was developed in this study. The assay showed high sensitivity, specificity, and accuracy in detecting STEC strains, including those in human feces. However, further studies are needed to improve the sensitivity, specificity, and reproducibility.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Alice E. White, Conner Jackson, Hannah Kisselburgh, Caroline Ledbetter, Elaine Scallan Walter
Summary: Hypothesis generation is a critical step in enteric disease outbreak investigation, and historical outbreak data can provide valuable information for this process. We developed a model to predict the vehicles for Shiga toxin-producing Escherichia coli and Salmonella outbreaks based on demographic and outbreak characteristics. The model performed well for outbreaks transmitted by animal contact and foodborne outbreaks associated with eggs, meat, or vegetables.
FOODBORNE PATHOGENS AND DISEASE
(2022)
Article
Public, Environmental & Occupational Health
C. Sawyer, B. Vishram, C. Jenkins, F. Jorgensen, L. Byrne, A. F. W. Mikhail, T. J. Dallman, K. Carroll, L. Ahyow, Q. Vahora, G. Godbole, S. Balasegaram
Summary: Recurrent outbreaks of haemolytic uraemic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) serotype O55:H7 occurred in England between 2014 and 2018. The cases were predominantly female and over half developed HUS, resulting in two fatal cases, although no common exposure sources were identified.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
E. Stelmashook, M. R. Kapkaeva, N. A. Rozanova, O. P. Alexandrova, E. E. Genrikhs, V. V. Obmolov, S. Novikova, N. K. Isaev
Summary: There is a close relationship between brain capillaries and neurons and glial cells, forming a neurovascular unit. The study found that astrocytes are the main producers of nitric oxide during neuroinflammation, while neurons are the most sensitive to oxidative stress.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Environmental Sciences
Jean-Christophe Augustin, Pauline Kooh, Lapo Mughini-Gras, Laurent Guillier, Anne Thebault, Frederique Audiat-Perrin, Vasco Cadavez, Ursula Gonzales-Barron, Moez Sanaa
Summary: Shiga toxin-producing Escherichia coli (STEC) is an important cause of foodborne disease, with foreign travel, contact with ill people, farm animals, food consumption, and exposure to untreated drinking water identified as major risk factors. Known risk factors for foodborne transmission include consumption of beef, other meats, processed meat, ready-to-eat meat, and raw milk. Newly identified food vehicles for STEC infection were chicken and fish, while produce (fruits/vegetables) was not associated with sporadic STEC infection.
MICROBIAL RISK ANALYSIS
(2021)
Article
Pediatrics
K. Minary, C. Tanne, T. Kwon, C. Faudeux, S. Clave, L. Langevin, C. Pietrement, C. Enoch, C. Parmentier, P. Mariani-Kurkdjian, FX. Weilli, G. Jones, N. Djouadi, D. Morin, M. Fila
Summary: In spring 2019, an outbreak of STEC HUS associated with E. coli O26:H11 occurred in France. The outbreak was linked to the consumption of raw cow's milk cheese. The patients presented with severe clinical symptoms, particularly involving the central nervous system and the heart. However, most cases had a favorable outcome after one month. The young age of the patients highlights the importance of improving information and caregiver awareness regarding at-risk foods for young children as preventative measures against STEC infections.
ARCHIVES DE PEDIATRIE
(2022)
Article
Gastroenterology & Hepatology
June Tome, Daniel Barry Maselli, Roeun Im, Matthew Brian Amdahl, Daniel Pfeifle, Catherine Hagen, Magnus Halland
Summary: Most cases of Shiga toxin-producing E. coli infection are self-limited, but can sometimes lead to severe complications such as thrombotic microangiopathy and Shiga toxin-induced hemolytic uremic syndrome (ST-HUS). ST-HUS, characterized by thrombocytopenia, hemolysis, and renal failure, is primarily seen in pediatric patients but should also be considered in adults. Proper differentiation from other thrombotic microangiopathies is essential for appropriate management.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Urology & Nephrology
John Fredy Nieto-Rios, Monica Zuluaga-Quintero, Julio Cesar Valencia-Maturana, Diana Carolina Bello-Marquez, Arbey Aristizabal-Alzate, Gustavo Adolfo Zuluaga-Valencia, Lina Maria Serna-Higuita, Luis Fernando Arias
Summary: Thrombotic microangiopathies are rare disorders characterized by nonimmune microangiopathic hemolytic anemia, thrombocytopenia, and multi-systemic failure. Typical hemolytic uremic syndrome in adults is rare but associated with high morbidity and mortality, often triggered by Shiga toxin-producing bacteria infections.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Physiology
Jorge Goldstein, Tomas R. Carden, Maria J. Perez, Carlos A. Taira, Christian Hocht, Mariela M. Gironacci
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2016)
Article
Microbiology
Luciana D'Alessio, Alipio Pinto, Adriana Cangelosi, Patricia A. Geoghegan, Carla Tironi-Farinati, Gabriela J. Brener, Jorge Goldstein
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Neurosciences
Alipio Pinto, Adriana Cangelosi, Patricia A. Geoghegan, Jorge Goldstein
Article
Pharmacology & Pharmacy
Winston E. Morris, Jorge Goldstein, Leandro M. Redondo, Adriana Cangelosi, Patricia Geoghegan, Marcela Brocco, Fabian C. Loidl, Mariano E. Fernandez-Miyakawa
Review
Medicine, Research & Experimental
Mariela M. Gironacci, Flavia M. Cerniello, Nadia A. Longo Carbajosa, Jorge Goldstein, Bruno D. Cerrato
Article
Immunology
Gabriel Cabrera, Romina J. Fernandez-Brando, Maria Jimena Abrey-Recalde, Ariela Baschkier, Alipio Pinto, Jorge Goldstein, Elsa Zotta, Roberto Meiss, Marta Rivas, Marina S. Palermo
INFECTION AND IMMUNITY
(2014)
Article
Microbiology
Alipio Pinto, Clara Berdasco, David Arenas-Mosquera, Adriana Cangelosi, Patricia A. Geoghegan, Myriam C. Nunez, Jorge Goldstein
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2018)
Article
Microbiology
Manuel E. Del Cogliano, Alipio Pinto, Jorge Goldstein, Elsa Zotta, Federico Ochoa, Romina Jimena Fernandez-Brando, Maite Muniesa, Pablo D. Ghiringhelli, Marina S. Palermo, Leticia Bentancor
FRONTIERS IN MICROBIOLOGY
(2018)
Review
Neurosciences
Jorge Goldstein, Krista Nunez-Goluboay, Alipio Pinto
Summary: Infection with Shiga toxin-producing Escherichia coli can result in hemorrhagic colitis, hemolytic uremic syndrome (HUS) and encephalopathy, with a high mortality rate when the central nervous system is involved. Recent research focuses on inhibiting Stx production and release, preventing Stx transport in the bloodstream, blocking Stx entry into the CNS, inhibiting Stx action in neural cells, and preventing immune system activation and CNS inflammation. Early diagnosis and establishment of CNS biomarkers are crucial for timely neuropharmacological treatment.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Immunology
Clara Berdasco, Maite Duhalde Vega, Maria Victoria Rosato-Siri, Jorge Goldstein
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Ana Beatriz Celi, Jorge Goldstein, Maria Victoria Rosato-Siri, Alipio Pinto
Summary: At first glance, globoside (Gb) clusters appear to serve as receptors for bacterial toxins, mediating the interaction between host and pathogen. However, further examination reveals that Gb clusters are present on various eukaryotic cell membranes, suggesting a role in physiological regulation and pathological processes. The molecular structure, ligand binding, and intracellular trafficking of Gb may contribute to its widespread functional arrangement.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
David Arenas-Mosquera, Alipio Pinto, Natacha Cerny, Clara Berdasco, Adriana Cangelosi, Patricia Andrea Geoghegan, Emilio Luis Malchiodi, Mauricio De Marzi, Jorge Goldstein
Summary: This study aims to investigate the pathogenesis of encephalopathy associated with hemolytic uremic syndrome. The findings suggest that toxins released by enterohemorrhagic E. coli infection can trigger neuroinflammatory response and alterations in the neurovascular unit, which are associated with neurological compromise and abnormal motor behavior.
Article
Cell Biology
Clara Berdasco, Alipio Pinto, Valeria Calabro, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson, Jorge Goldstein
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
Review
Microbiology
Alfredo G. Torres, Maria M. Amaral, Leticia Bentancor, Lucia Galli, Jorge Goldstein, Alejandra Kruger, Maricarmen Rojas-Lopez
Article
Behavioral Sciences
M. E. Jacobsen, M. Barros, R. S. Maior
BEHAVIOURAL BRAIN RESEARCH
(2017)