Article
Biochemistry & Molecular Biology
Lishan Zhang, Shanhui Ge, Wanmei He, Qingui Chen, Caixia Xu, Mian Zeng
Summary: The study demonstrated that ghrelin protects against LPS-induced ARDS by inhibiting apoptosis, promoting cell migration and tube formation, and activating the PI3K/AKT signaling pathway, thereby stabilizing endothelial barrier function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Chaozheng Zhang, Yuening Cao, Yi Zuo, Hongbin Cheng, Changqun Liu, Xila Xia, Bo Ren, Yun Deng, Maolin Wang, Jun Lu
Summary: Bruceine A (BA), derived from Bruceine javanica, displays multiple biological activities and regulates various intracellular signal transduction pathways. However, its pharmacological mechanism in treating colon cancer (CC) remains unclear. In this study, BA was found to exhibit anticancer effects on CC cells by targeting the Akt1 and Jun as well as the PI3K/Akt pathway. Additionally, BA inhibited cell cycle progression, promoted apoptosis, and suppressed cell migration in CC cells. These findings suggest that BA has the potential to be a promising chemotherapy drug for the treatment of CC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qingjie Mu, Kaixuan Lv, Jielun Yu, Shangmin Chu, Lichun Zhang, Lingyu Kong, Linlin Zhang, Yan Tian, Xiaopeng Jia, Benhong Liu, Youzhen Wei, Nana Yang
Summary: This study found that hydrogen can repair the proliferation, migration, and tube formation dysfunctions of lipopolysaccharide (LPS)-induced bone marrow-derived endothelial progenitor cells (EPCs). This repairment is mediated by the PI3K/AKT/eNOS signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Wu Zhang, Yuqin Wu, Hong Chen, Dan Yu, Jinfeng Zhao, Jing Chen
Summary: Ischemic stroke-induced nerve damage significantly impacts patients' quality of life, necessitating the search for effective treatments. Research has shown that SOX5 transcription regulates VEGF expression and activates the PI3K/AKT pathway to repair nerve damage.
Article
Biochemistry & Molecular Biology
Xuan Wu, Yuhong Luo, Shan Wang, Yueying Li, Meiyu Bao, Yuanjiang Shang, Lei Chen, Weiwei Liu
Summary: This study demonstrates the protective role of AKAP12 in acute liver injury and chronic liver fibrosis, at least partially through inhibition of the PI3K/AKT/PCSK6 pathway. These findings provide a new potential treatment for liver injury and have important clinical implications.
Article
Biochemistry & Molecular Biology
Qi Zhang, Sai Cheng, Zhiming Xin, Haohua Deng, Ying Wang, Qiang Li, Gangwei Wu, Wei Chen
Summary: 1,2,3,4,6-O-pentagalloylglucose protects against acute lung injury (ALI) by inhibiting inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yingjie Zhu, Dong Sun, Han Liu, Linzi Sun, Jing Jie, Jingjing Luo, Liping Peng, Lei Song
Summary: Bixin, a natural compound isolated from Bixa Orellana seeds, has shown potential in treating asthma by suppressing allergic airway inflammation, reversing glucocorticoids resistance, and alleviating airway remodeling and hyperresponsiveness. It functions as an antagonist of PI3K/Akt signaling, offering a novel strategy for asthma treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Xi Yu, Shenglan Li, Mingrui Pang, Yang Du, Tao Xu, Tao Bai, Kang Yang, Juncheng Hu, Shaoming Zhu, Lei Wang, Xiuheng Liu
Summary: This study revealed that downregulation of TSPAN7 in bladder cancer is associated with tumor progression and poor prognosis, and demonstrated the inhibitory effects of TSPAN7 on cancer cell proliferation and migration through multiple experiments. TSPAN7 inhibits bladder cancer cell growth by activating Bax, cleaved caspase-3, and PTEN pathways.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yu An Lu, Yunfei Jiang, Hye-Won Yang, Jin Hwang, You-Jin Jeon, Bomi Ryu
Summary: This study is the first to investigate the effects of DPHC from Ishige okamurae on calcium levels and vasodilation. The results suggest that DPHC stimulates NO production by modulating calcium levels and expression of AchR and VEGFR2, potentially ameliorating cardiovascular diseases by improving vascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Qian Wang, Zi-Nuo Shen, Shu-Jing Zhang, Yan Sun, Feng-Jie Zheng, Yu-Hang Li
Summary: Puerarin, a natural isoflavone, has great potential in treating neurological and other diseases by activating the PI3K/Akt signal pathway for neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lianggang Wang, Chunlin Ge, Xinxin Zhang
Summary: Sufentanil can improve myocardial microvascular endothelial cell damage caused by ischemia/reperfusion injury and exert protective effects by activating the PI3K/Akt signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Lina Chen, Yuan Guo, Shuiqing Qu, Kai Li, Ting Yang, Yuanmin Yang, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuoqiu Deng, Yu Zhang, Xiaoxin Zhu, Yujie Li
Summary: Shengmai formula (SMF) can attenuate myocardial injury induced by UFPM + MI by modulating oxidative stress and related signaling pathways. This traditional Chinese medicine exhibits protective effects on myocardial function and histopathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Wei-Wei Ye, Xiang-Ying Meng, Qian Zhao, Jian-Yang Chen, Cong Liu, Feng Chen, Yong Zhou, Yi Wang
Summary: The study found that echinacoside has protective effects against injury induced by type 2 diabetes mellitus (T2DM), possibly through mediating the AKT pathway.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li, Hao Yang, Dingjun Hao
Summary: The present study aimed to investigate the pro-angiogenic potential of OECs activated by CCM and LPS and the underlying mechanisms. The activated OECs were found to effectively promote proliferation, migration, and vessel-like structure formation of vascular endothelial cells. Several pro-angiogenic growth factors were significantly elevated in the conditioned medium (CM), and the PI3K/Akt signaling pathway was involved in these pro-angiogenic events. Transplantation of activated OECs improved angiogenesis and the microenvironment in the injured spinal cord.
CELL AND BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Changchun Ji, Fan Song, Guoyou Huang, Siwang Wang, Han Liu, Shaobao Wang, Liping Huang, Shaoming Liu, Jingyu Zhao, Tian Jian Lu, Feng Xu
Article
Peripheral Vascular Disease
Min Jia, Xuan-Xuan Zhou, Qiaohong Qin, Fang Wang, Jie Li, Cang-Bao Xu, Siwang Wang
MICROVASCULAR RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Mengshan He, Pan Long, Lunfeng Guo, Mingke Zhang, Siwang Wang, Hongling He
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Cell Biology
Xuanxuan Zhou, Qian Yang, Fan Song, Linlin Bi, Jiani Yuan, Shaoyu Guan, Qi Yang, Siwang Wang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cardiac & Cardiovascular Systems
Wenjuan Xing, Yanzhen Tan, Kaifeng Li, Pei Tian, Fei Tian, Haifeng Zhang
Summary: In patients with type 2 diabetes mellitus, high levels of hepatokine fetuin-B exacerbate myocardial ischemia/reperfusion injury by interfering with insulin signaling pathways, leading to increased apoptosis and cardiac dysfunction. Conversely, knockdown of FetB can alleviate MI/R injury and improve insulin-induced signaling in diabetic hearts.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Plant Sciences
Yao Li, Fei Chen, Yanhua Xie, Qian Yang, Huanhuan Luo, Pu Jia, Zhihui Shi, Siwang Wang, Xiaohui Zheng
Summary: The study demonstrated that FYC can significantly alleviate the pathological damage and inflammatory cell infiltration in the colon tissue of UC mice induced by dextran sulfate sodium, restore colon length, reduce DAI score, MPO content, pro-inflammatory factors, and increase anti-inflammatory factors. The protective effect of FYC on UC is achieved by inhibiting the OSM/OSMR pathway and regulating inflammatory factors to improve the intestinal flora.
Article
Multidisciplinary Sciences
Fei-Fei Wu, Kun-Long Zhang, Zheng-Mei Wang, Yi Yang, Shao-Hua Li, Jia-Qi Wang, Jin Ma, Yan-Ling Yang, Hai-Feng Zhang, Ya-Yun Wang
Summary: The study demonstrated that a single exposure to mild or severe hypobaric hypoxia could improve performance in healthy mice. In the cerebellum, 6 out of 8 detected genes showed no change after SHH, while in the hippocampus all genes remained unchanged. In the muscles, 7 out of 8 detected genes did not show any changes after SHH exposure.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Qianqian Dong, Wenjuan Xing, Kaifeng Li, Xuanxuan Zhou, Siwang Wang, Haifeng Zhang
Summary: This study demonstrated that TSG could improve endothelial function and reduce obesity-related hypertension by increasing omentin-1 levels, activating Akt/eNOS signaling pathway, and attenuating oxidative/nitrative stress. The down-regulation of omentin-1 is associated with endothelial dysfunction and hypertension in obesity, highlighting the potential of TSG as an antihypertensive agent for cardiovascular protection in obesity.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Rui Yao, Yu Cao, Ruibin Jiang, Xuan Zhang, Feng Li, Siwang Wang
Summary: The study revealed that the pharmacokinetics of Hydroxysafflor yellow A (HSYA) significantly changed in diabetic cardiomyopathy (DCM) mice, showing higher antioxidative stress effect.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Education, Scientific Disciplines
Kai-Feng Li, Bo-Zhi Liu, Fei-Fei Wu, Xia-Cheng Sun, Fei Tian, You-Sheng Wu, Le-Le Ji, Nan-Nan Liu, Hai-Feng Zhang, Ya-Yun Wang
Summary: The study revealed that the OBSA program significantly improved students' academic performance in BMLCs, especially in terms of surgical operating and collaborative learning. The majority of medical students believed that OBSA could effectively enhance their skills.
ADVANCES IN PHYSIOLOGY EDUCATION
(2021)
Article
Multidisciplinary Sciences
Qiaoyan Jin, Hui Su, Rui Yang, Yanzhen Tan, Buying Li, Wei Yi, Qianqian Dong, Haifeng Zhang, Wenjuan Xing, Xin Sun
Summary: CTRP9 overexpression under chronic hypoxia conditions attenuates the development of HPH and improves endothelium-dependent vasodilation in pulmonary arterioles. By regulating AMPK activation, CTRP9 enhances nitric oxide production and reduces endothelin production.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yan-Qing Zhang, Sen Fan, Wen-Qing Wang, Wayne Bond Lau, Jian-Li Dai, Hai-Feng Zhang, Xiao-Ming Wang, Xiao-Gang Liu, Rong Li
Summary: This study discovered for the first time that increased APOA1 and APOC1 in hyperlipidemic plasma bind and inhibit the activity of adiponectin. This not only identifies a new molecular mechanism responsible for adiponectin resistance during early-stage diabetes, but also provides new insights into the diverse and controversial functions of high-density lipoprotein.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Cell Biology
Fang Yan, Kaifeng Li, Wenjuan Xing, Mingqing Dong, Mingliang Yi, Haifeng Zhang
Summary: Iron is crucial in various biological processes, but its abnormal regulation and accumulation can contribute to pathological processes in cardiovascular diseases. This review summarizes the pathological roles of iron-related oxidative stress in cardiovascular diseases and highlights the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Integrative & Complementary Medicine
Rui Yao, Yu Cao, Changming Wang, Lu Xu, Xuan Zhang, Yuqing Deng, Feng Li, Siwang Wang
Summary: The study demonstrated that THJ could protect DCM mice from hyperglycemia-induced oxidative stress and inflammation by regulating antioxidant proteins and suppressing the NLRP3 inflammasome.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Physiology
Fang Fan, Jinxiao He, Hui Su, Haifeng Zhang, Hao Wang, Qianqian Dong, Minghua Zeng, Wenjuan Xing, Xin Sun
FRONTIERS IN PHYSIOLOGY
(2020)