Article
Cell Biology
Minjeong Ji, Hyun Ji Kim, Chi Bum Ahn, Kuk Hui Son, Jeong Hee Hong
Summary: Hypergravity affects cardiac function by increasing IL-6 and Nkcc activity, potentially mediating cardiac tissue edema and calcium loading through modulation of ion channels and elevation of intracellular calcium levels.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Dominik Langgartner, Raphael Winkler, Jonas Brunner-Weisser, Nicolas Rohleder, Marc N. N. Jarczok, Harald Guendel, Katja Weimer, Stefan O. O. Reber
Summary: Ex vivo culturing of isolated PBMCs from individuals vaccinated with the COVID-19 vaccine BNT162b1 showed enhanced T cell response to the RBD of the SARS-CoV-2 spike protein. The study also investigated the long-lasting effects of COVID-19 vaccination on various physiological and immunological parameters. The results showed significant increases in IL-6 secretion in vaccinated individuals compared to non-vaccinated individuals.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Susumu Yoneda, Matthew J. Silva
Summary: IL-6 plays a role in the inflammatory phase of fracture repair, but its impact on successful repair is not fully understood. In experiments using IL-6 KO mice, it was found that IL-6 knockout enhanced callus formation and bone response after stress fracture injury, possibly through direct action on osteoblast function.
Article
Multidisciplinary Sciences
Aidana Amrenova, Keiji Suzuki, Vladimir Saenko, Shunichi Yamashita, Norisato Mitsutake
Summary: Cell competition between cancer cells and normal cells can suppress the progression of anaplastic thyroid cancer. Radiation exposure to normal cells can negate the competitive effect, indicating that modulation of reciprocal stress response in vivo may be associated with tumor initiation, propagation, and metastasis.
Article
Oncology
Guo-Qiang Zhang, Chuang Xi, Chen-Tian Shen, Hong-Jun Song, Quan-Yong Luo, Zhong-Ling Qiu
Summary: IL-6 inhibits the transcription of NIS in PTC cells by activating signaling pathways, which affects the efficacy of papillary thyroid cancer treatment.
ENDOCRINE-RELATED CANCER
(2023)
Article
Engineering, Mechanical
Lai Wei, Yi Sun, Jing Zeng, Sheng Qu
Summary: This paper describes the high-frequency vibration fatigue failure of metro bogie cowcatchers due to short-pitch track irregularities through field testing and numerical simulations. The dynamic stress and vibrational environment of bogie cowcatchers are investigated by full-scale testing. Internal and external contributors to the issue are analyzed through modal experiments and track irregularity measurements. The paper also proposes potential solutions and verifies them to solve the fatigue failure issue.
ENGINEERING FAILURE ANALYSIS
(2022)
Article
Engineering, Civil
Tianyu Chen, Quanyu Jiang, Jian Xue, Christopher M. Harvey, Xiang Zhang, Vadim V. Silberschmidt, Yiding Liu, Kun Zhang, Simon Wang, Bingchen Wei
Summary: This article introduces concepts and research content such as beam dynamics, three-point bending test, dynamic shear stress, dynamic normal stress, and structural vibration.
THIN-WALLED STRUCTURES
(2023)
Article
Biochemistry & Molecular Biology
Qing He, Yifei Lin, Banghua Liao, Liang Zhou, Jianzhong Ai, Xi Jin, Hong Li, Kunjie Wang
Summary: This study found that IL-6 plays a crucial role in the mechanical stress-induced ECM remodeling of HBSMCs, indicating that IL-6 may play an essential role in BOO.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Janaina A. Simplicio, Thales M. H. Dourado, Wanessa M. C. Awata, Gabriel T. do Vale, Vinicius R. Dias, Paula R. Barros, Bruno S. de Martinis, Rita C. Tostes, Carlos R. Tirapelli
Summary: Perivascular adipose tissue (PVAT) exerts anticontractile effect, but under non-physiological conditions it may contribute to vascular dysfunction by releasing pro-inflammatory cytokines. IL-6 contributes to the pro-contractile effect of PVAT and mediates intravascular recruitment of neutrophils in response to ethanol, playing a role in the early stages of ethanol-induced hypertension. These findings provide novel evidence for the involvement of IL-6 in the vascular dysfunction induced by ethanol.
Article
Immunology
Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang
Summary: This study suggests that Saikosaponin C (SSc), a traditional Chinese medicine compound, has potential therapeutic effects on depressive symptoms by reducing inflammatory cytokines levels, enhancing synaptic plasticity, and alleviating chronic social defeat stress-induced depression-like behavior in mice. The mechanism of action may involve the inhibition of DNMT1 protein expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Mechanical
Fansong Li, Hao Wu, Pingbo Wu
Summary: The study introduces a method for calculating dynamic stress in vibration fatigue under non-stationary state using modal superposition and finite element analysis. The results show good agreement between simulated and experimental dynamic stress, indicating the effectiveness of the proposed method for dynamic stress simulation in structural vibration fatigue.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2021)
Article
Multidisciplinary Sciences
Nozomi Endo, Manabu Makinodan, Takayo Mannari-Sasagawa, Noriko Horii-Hayashi, Nami Somayama, Takashi Komori, Toshifumi Kishimoto, Mayumi Nishi
Summary: Early adverse experiences can impact neuronal circuits and lead to psychiatric disorders. A study found that repeated maternal separation in mice led to inappropriate social distance and behavioral abnormalities in a group-housing setting.
SCIENTIFIC REPORTS
(2021)
Article
Construction & Building Technology
Agustin Spalvier, Leandro Domenech, Nicolas Perez, Gonzalo P. Cetrangolo
Summary: The nonlinear-elastic behavior of concrete and other cement-based materials has the potential for determining quasistatic stresses using nondestructive testing techniques. Two groups of NDT techniques have emerged, one based on ultrasonic wave propagation and the other based on resonance vibration. This research provides a unified theoretical description of both techniques using the 1-D classical nonlinear parameter 6G. Experimental results show that both torsional frequency of vibration and S-wave speed increase with compressive stress. Resonance vibration yields a significantly higher 6G value compared to ultrasound.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Psychiatry
Galia Bahadori-Birgani, Shahram Molavynejad, Mahbobe Rashidi, Fereshteh Amiri, Elham Maraghi, Bahman Dashtbozorgi, Zulvikar Syambani Ulhaq, Gholamreza Alizadeh-Attar
Summary: This study aimed to determine the association of physical, mental, and psychological problems with the levels of interleukin-1 and -6 in COVID-19 patients. The analysis of the data showed a significant correlation between interleukin-1 and -6 levels and physical indices and psychological problems. The conclusion is that the levels of interleukin-1 and -6 can be used to estimate the severity of physical and psychological symptoms in COVID-19 patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Agronomy
Khaled M. A. Ramadan, Hossam S. El-Beltagi, Taia A. Abd El-Mageed, Hani S. Saudy, Hala Hazam Al-Otaibi, Mohamed A. A. Mahmoud
Summary: Implementing deficit irrigation has become a major strategy in crop production, but it can lead to changes in plant physiology and decreased productivity. This study aimed to assess the effects of humic acid and cytokinin on faba bean under water deficit. The results showed that the combination of H-10 and C-25 improved faba bean growth and increased physiological traits under low water supply. The application of H-10 and C-25 also achieved nutrient homeostasis in faba bean under water deficit.
Review
Biochemistry & Molecular Biology
Linnea Hojer Wang, Markus Wehland, Petra M. M. Wise, Manfred Infanger, Daniela Grimm, Michael C. C. Kreissl
Summary: This manuscript investigates four tyrosine kinase inhibitors (TKIs), cabozantinib, vandetanib, pralsetinib, and selpercatinib, used for treating advanced and/or metastatic medullary thyroid cancer (MTC). The focus is on treatment-related hypertension, a well-known adverse effect (AE) of these TKIs. While TKI-induced hypertension is rarely a dose-limiting side effect, complications associated with hypertension can increase with longer patient survival without proper medication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Justina Joksiene, Jayashree Sahana, Markus Wehland, Herbert Schulz, Jose Luis Cortes-Sanchez, Judit Prat-Duran, Daniela Grimm, Ulf Simonsen
Summary: A diabetogenic state induced by spaceflight causes stress and health problems in astronauts. Microgravity is a main stressor in space that leads to hyperglycaemia. The molecular pathways and synergistic effects of microgravity and hyperglycaemia are not fully understood.
Review
Cell Biology
Thomas J. Corydon, Herbert Schulz, Peter Richter, Sebastian M. Strauch, Maik Boehmer, Dario A. Ricciardi, Markus Wehland, Marcus Krueger, Gilmar S. Erzinger, Michael Lebert, Manfred Infanger, Petra M. Wise, Daniela Grimm
Summary: Microgravity has a significant impact on the health of space explorers, affecting cell proliferation, differentiation, and growth. With the planning of deep space exploration and the commercialization of space travel, researchers are focusing on gene regulation in cells and organisms exposed to real and simulated microgravity. Cancer and metastasis research in particular benefit from these findings.
Review
Biochemistry & Molecular Biology
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Summary: Despite recent advances in HF therapy, CV mortality, morbidity, and HFH remain challenges. Vericiguat activates sGC to improve CV function and has shown efficacy in reducing CV death and HFH in HFrEF patients. However, it has no therapeutic effect on HFpEF. Common adverse events of vericiguat include hypotension, syncope, and anemia. Larger studies are needed to investigate the potential effect in HFpEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Daniela Grimm
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugenie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl'Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raul Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Summary: This white paper presents the indications and recommendations of the SciSpacE Science Community on filling the gaps of knowledge regarding the effects of gravity alterations on animal and human systems at a cellular and tissue level. Despite previous studies, a comprehensive integrated model of the changes occurring at different system and functional levels is still lacking, making it difficult to predict the long-term consequences of human adaptation to the space environment and implement effective medical support plans.
Review
Biochemistry & Molecular Biology
Silvana Miranda, Shannon Marchal, Lina Cumps, Jenne Dierckx, Marcus Kruger, Daniela Grimm, Sarah Baatout, Kevin Tabury, Bjorn Baselet
Summary: The lunar dust problem arose from NASA's Apollo missions in 1969, as exposure to lunar dust became unavoidable. Several astronauts suffered allergy-like symptoms due to lunar dust inhalation. Research into the toxic effects of lunar dust gained significant interest and expanded to include other organ systems. With plans for future moon missions and potentially Mars missions, dust mitigation strategies are crucial for sustainable space exploration.
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jayashree Sahana, Jose Luis Cortes-Sanchez, Viviann Sandt, Daniela Melnik, Thomas J. Corydon, Herbert Schulz, Zexi Cai, Katja Evert, Daniela Grimm, Markus Wehland
Summary: This study cultured breast cancer cell lines MCF-7 and MDA-MB-231 under simulated microgravity conditions and investigated the gene expression pattern and cellular signaling pathways involved. The results showed that the engineered three-dimensional multicellular spheroid model can be used to study breast cancer cell behavior and evaluate the efficacy of drugs against breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jose Luis Cortes-Sanchez, Daniela Melnik, Viviann Sandt, Stefan Kahlert, Shannon Marchal, Ian R. D. Johnson, Marco Calvaruso, Christian Liemersdorf, Simon L. Wuest, Daniela Grimm, Marcus Krueger
Summary: In the preparation of space and microgravity experiments, the use of ground-based facilities for initial experiments and feasibility studies is common. One approach to simulate microgravity conditions on Earth is to use a random positioning machine (RPM) as a rotary bioreactor. Combined with a suitable low-mass model system, such as cell cultures, these devices have been shown to produce results similar to those obtained in actual space experiments under real microgravity conditions. The RPM serves as a simulator of microgravity by randomizing the impact of Earth's gravity vector especially for suspended cells, and it also simulates physiological shear forces on the adherent cell layer.