miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Molecular characterization leads the way

(2013) Roger Stupp et al.   Nature Reviews Clinical Oncology

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression

(2012) W. Zhang et al.   NEURO-ONCOLOGY

miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy

(2011) M. Garofalo et al.   CURRENT MOLECULAR MEDICINE

miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ

(2011) C Quintavalle et al.   ONCOGENE

Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

(2009) J Dunn et al.   BRITISH JOURNAL OF CANCER

miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation

(2009) Michela Garofalo et al.   CANCER CELL

MicroRNAs as regulators of death receptors signaling

(2009) M Garofalo et al.   CELL DEATH AND DIFFERENTIATION

miR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors

(2009) Alfredo Conti et al.   JOURNAL OF NEURO-ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

(2009) Michael Weller et al.   Nature Reviews Neurology

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

(2008) Linda E. Sandercock et al.   CARCINOGENESIS

MicroRNAs in diseases and drug response

(2008) M GAROFALO et al.   CURRENT OPINION IN PHARMACOLOGY

Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

(2008) Monika E. Hegi et al.   JOURNAL OF CLINICAL ONCOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Disease: temozolomide and glioblastoma—look to the future

(2008) Maciej M Mrugala et al.   Nature clinical practice. Oncology