Article
Obstetrics & Gynecology
Di Xiao, Weidong Li, Wei-Hong Zhang, Zihao Wen, Weijian Mo, Ciyong Lu, Lan Guo, Li Yang
Summary: This study explores the associations between maternal periconceptional environmental exposures and congenital heart defects (CHDs). The results indicate that living near main roads and housing renovation during the periconceptional period are positively associated with increased risks for all CHDs and isolated CHDs. Further research is needed to investigate the effects of incense burning and family relationships on CHDs in offspring by expanding the sample size.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Pediatrics
Zixi Pang, Lei Jin, Jie Zhang, Wenying Meng, Di Wang, Lei Jin
Summary: Folic acid or multiple micronutrients containing folic acid supplementation during the maternal periconceptional period could reduce the risk for genitourinary system birth defects in offspring. Maternal FA/MMFA supplementation during the periconceptional period may reduce the risk for hypospadias.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Emrah Yurek, Burcu Genc Yavuz, Esra Guzel Tanoglu, Erdem Gurkas, Ibrahim Altundag, Burhanettin Yalcinkaya, Erdal Yilmaz, Sahin Colak
Summary: This study investigated the rate of aspirin resistance (AR) and the factors influencing AR in patients with acute ischemic stroke under regular aspirin use, as well as the relationship between AR and ABCB1 C3435T polymorphism. The study found that 21.3% of the patient group had AR. Hypertension, heterozygous (CT) genotype, increased platelet values, and CRP/albumin values were associated with a greater risk of AR. Considering the ABCB1 C3435T polymorphism is crucial when planning aspirin therapy.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wenli Xu, Ling Yi, Changfei Deng, Ziling Zhao, Longrong Ran, Zhihong Ren, Shunxia Zhao, Tianjin Zhou, Gang Zhang, Hanmin Liu, Li Dai
Summary: Maternal periconceptional folic acid supplementation is significantly associated with reduced risk of nonsyndromic oral clefts, particularly cleft lip and cleft lip with palate. Additional research is needed to determine the potential impact on cleft palate.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Di Wang, Lei Jin, Jie Zhang, Wenying Meng, Aiguo Ren
Summary: Maternal periconceptional supplementation with folic acid or multiple micronutrients containing folic acid appears to decrease the risk for CHDs, especially critical CHD, in offspring. Supplementation before conception confers a greater protective effect against CHDs. There was no significant difference between folic acid and multiple micronutrients containing folic acid in preventing CHDs.
JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Medicine, General & Internal
Lizhu Chen, Yun Xiu, Qijun Wu, Yu Wang, Yixin Zhang, Jia Xue, Qinbo Wang, Zhengwei Yuan
Summary: This study found that maternal serum LMNA may serve as a potential biomarker for prenatal diagnosis of fetal CHD, NTD, and PE.
Article
Nutrition & Dietetics
Jiaomei Yang, Yijun Kang, Qianqian Chang, Binyan Zhang, Xin Liu, Lingxia Zeng, Hong Yan, Shaonong Dang
Summary: This study investigated the associations between maternal total, dietary, and supplemental intakes of zinc, copper, and selenium during pregnancy and congenital heart defects (CHDs). The results showed that higher intakes of zinc and selenium during pregnancy were associated with a reduced risk of CHDs, highlighting the importance of promoting zinc and selenium intakes in reducing the incidence of CHDs in the Chinese population.
Article
Genetics & Heredity
Ewa Toton, Barbara Jacczak, Wojciech Barczak, Pawel Jagielski, Robert Gryczka, Hanna Holysz, Sylwia Grodecka-Gazdecka, Blazej Rubis
Summary: Polymorphisms in the ABCB1 gene may be a contributing factor to cancer development, but they may not be critical in assessing the risk or recovery of breast cancer patients.
Article
Public, Environmental & Occupational Health
Li Sun, Qianlan Wu, Huiying Wang, Juning Liu, Yan Shao, Rong Xu, Tian Gong, Xiaoju Peng, Baoli Zhang
Summary: This study investigates the association between maternal exposure to air pollutants and the risk of congenital heart defects in Suzhou, China. The results suggest that exposure to PM2.5 and NO2 is associated with an increased risk of CHDs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Jevan Cevik, Omar Salehi, James Gaston, Warren M. M. Rozen
Summary: This systematic review examined the association between maternal smoking during pregnancy and the risk of congenital limb anomalies. The analysis indicated a significant increased risk of these anomalies in infants born to mothers who smoked during pregnancy. These findings underscore the importance of smoking cessation interventions for pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ping-Ching Hsu, Suman Maity, Jenil Patel, Philip J. Lupo, Wendy N. Nembhard
Summary: This study is important in understanding the impact of pregnancies affected by congenital heart defects (CHDs) on maternal metabolism. The study found significant metabolic alterations in mothers of infants with hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (ToF), suggesting the need for postpartum dietary supplementation for women giving birth to CHD offspring.
Review
Biochemistry & Molecular Biology
Stephanie Ibrahim, Benedicte Gaborit, Marien Lenoir, Gwenaelle Collod-Beroud, Sonia Stefanovic
Summary: Congenital heart defects (CHDs), the most common form of birth defects in humans, are complex and difficult to understand. While genetic factors can explain only a minority of cases, environmental risk factors also contribute to the development of CHDs. Maternal pregestational diabetes is associated with an increased risk, but the specific molecular mechanisms remain unclear. This review summarizes key findings on the molecular mechanisms altered in cardiac development under hyperglycemic conditions, presents experimental modeling techniques, and suggests new approaches for understanding and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Bo-Yi Yang, Yanji Qu, Yuming Guo, Iana Markevych, Joachim Heinrich, Michael S. Bloom, Zhipeng Bai, Luke C. Knibbs, Shanshan Li, Gongbo Chen, Bin Jalaludin, Lidia Morawska, Meng Gao, Bin Han, Yunjiang Yu, Xiao-Xuan Liu, Yanqiu Ou, Jinzhuang Mai, Xiangmin Gao, Yong Wu, Zhiqiang Nie, Xiao-Wen Zeng, Li-Wen Hu, Xubo Shen, Yuanzhong Zhou, Shao Lin, Xiaoqing Liu, Guang-Hui Dong
Summary: The study found that maternal exposure to air pollution during pregnancy, particularly in the first trimester, is associated with an increased risk of CHD in offspring. No significant associations were observed for exposure to air pollutants during the second and third trimesters. The associations between air pollutants and different CHD subtypes varied.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Myriam El Biali, Rudolf Karch, Cecile Philippe, Helmuth Haslacher, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Doreen Schmidl, Oliver Langer, Martin Bauer
Summary: The study suggests that ABCB1 and ABCG2 together limit the distribution of systemically administered ABCB1/ABCG2 substrate drugs to the human retina, with carriers of the c.421C > A SNP possibly being more susceptible to transporter-mediated drug-drug interactions at the blood-retinal barrier.
FRONTIERS IN PHARMACOLOGY
(2021)