Involvement of TRPM2 in Peripheral Nerve Injury-Induced Infiltration of Peripheral Immune Cells into the Spinal Cord in Mouse Neuropathic Pain Model

NAD+Levels Control Ca2+Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes

(2012) Mirko Magnone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice

(2012) K. Haraguchi et al.   JOURNAL OF NEUROSCIENCE

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation

(2012) Nico Melzer et al.   PLoS One

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

(2012) M. Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

(2011) Adriana Sumoza-Toledo et al.   FASEB JOURNAL

Peripheral Nerve Injury Alters Blood-Spinal Cord Barrier Functional and Molecular Integrity through a Selective Inflammatory Pathway

(2011) S. Echeverry et al.   JOURNAL OF NEUROSCIENCE

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

(2011) H. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes

(2010) Janine Wehrhahn et al.   JOURNAL OF IMMUNOLOGY

Peripheral Nerve Injury and TRPV1-Expressing Primary Afferent C-Fibers Cause Opening of the Blood-Brain Barrier

(2010) Simon Beggs et al.   Molecular Pain

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain

(2009) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain

(2008) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

(2008) Ben Buelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Modulation of Mechanical and Thermal Nociceptive Sensitivity in the Laboratory Mouse by Behavioral State

(2007) Brandy L. Callahan et al.   JOURNAL OF PAIN