Dynamics of DNA Damage Induced Pathways to Cancer

A Boolean network model of the FA/BRCA pathway

(2012) Alfredo Rodríguez et al.   BIOINFORMATICS

Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention

(2012) Rainer Poltz et al.   BMC Systems Biology

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Global tumor protein p53/p63 interactome

(2012) Yiping Huang et al.   CELL CYCLE

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia

(2012) D W-C Chen et al.   ONCOGENE

Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage

(2012) M. Choi et al.   Science Signaling

A CoD-based stationary control policy for intervening in large gene regulatory networks

(2011) Noushin Ghaffari et al.   BMC BIOINFORMATICS

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

p53-mediated induction of Noxa and p53AIP1 requires NFκB

(2011) Jim O’Prey et al.   CELL CYCLE

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis

(2010) Manabu Taura et al.   CANCER SCIENCE

Ras Puts the Brake on Doxorubicin-mediated Cell Death in p53-expressing Cells

(2010) Sunil K. Manna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network

(2010) A. Lunardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-based Cancer Therapy

(2010) D. P. Lane et al.   Cold Spring Harbor Perspectives in Biology

Reconstruction and logical modeling of glucose repression signaling pathways in Saccharomyces cerevisiae

(2009) Tobias S Christensen et al.   BMC Systems Biology

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

(2009) Anna Kucharska et al.   CELLULAR SIGNALLING

ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

(2009) Naoe Taira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Boolean Network Approach to Negative Feedback Loops of the p53 Pathways: Synchronized Dynamics and Stochastic Limit Cycles

(2009) Hao Ge et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Boolean network-based analysis of the apoptosis network: Irreversible apoptosis and stable surviving

(2009) Zhongxing Mai et al.   JOURNAL OF THEORETICAL BIOLOGY

CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

(2009) Clark C Chen et al.   Molecular Cancer

A Mathematical Model for the Detection Mechanism of DNA Double-Strand Breaks Depending on Autophosphorylation of ATM

(2009) Kazunari Mouri et al.   PLoS One

In silico models of cancer

(2009) Lucas B. Edelman et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

ON/OFF and Beyond - A Boolean Model of Apoptosis

(2009) Rebekka Schlatter et al.   PLoS Computational Biology

Doxycycline treatment prevents alveolar destruction in VEGF-deficient mouse lung

(2008) Harry B. Rossiter et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines

(2008) M. Taura et al.   MOLECULAR AND CELLULAR BIOLOGY

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

(2008) Sanjeev Shangary et al.   MOLECULAR CANCER THERAPEUTICS

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH

Network model of survival signaling in large granular lymphocyte leukemia

(2008) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feature context-dependency and complexity-reduction in probability landscapes for integrative genomics.

(2008) Annick Lesne et al.   Theoretical Biology and Medical Modelling

Drug Insight: intracellular inhibitors of HER2—clinical development of lapatinib in breast cancer

(2008) David A Cameron et al.   Nature clinical practice. Oncology

p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint

(2007) Ande Satyanarayana et al.   MOLECULAR BIOLOGY OF THE CELL