Article
Medicine, General & Internal
Anders Gummesson, Elias Bjornson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Baeckhed, Jochen M. Schwenk, Per-Anders Jansson, Mathias Uhlen, Goran Bergstrom
Summary: The study found distinct protein patterns in early-stage type 2 diabetes patients, reflecting key metabolic syndrome features. These patterns improved after treatment, indicating that comprehensive protein profiling can be a useful tool in elucidating the biological effects of diabetes treatments.
Article
Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Environmental Sciences
Atena Arab YarMohammadi, Sepideh Arbabi Bidgoli, Parisa Ziarati
Summary: Despite similarities in sociodemographic, diet, and lifestyle factors between males and females and their T2DM subgroups, a 4-fold difference in urinary arsenic levels was observed between T2DM (93.7 ng/L (32)) and healthy counterparts (23.7 ng/L (2.3)), without meaningful associations with gender, age, BMI, diet, and lifestyle.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Yan Sun, Yong-Xia Xu, Nan Wang, Feng Wang, Can-Can Hui, Yu-Wei Cheng, Meng-Jie Cui, Qin-Yi Huang, Jian-Guo Xu, Xiao-Ming Kong
Summary: We developed a time-resolved strand displacement amplification (TR-SDA) method for the molecular detection of miR-146a, a potential biomarker for Type 2 diabetes mellitus (T2DM). The method relies on the use of a multi-functionalized cytosine-rich hairpin probe (C-HP) that enables both intra- and intermolecular replications, leading to a time-resolved amplification pattern. The detection of miR-146a is achieved by detecting the fluorescence emission of G-quadruplex after intercalation with ThT.
Article
Pharmacology & Pharmacy
K. Tuncer Kara, M. Kizil, E. Cakmak, T. T. Yildirim, F. Kilinc, T. Kuloglu, N. Gozel
Summary: This study compares the plasma and salivary levels of Metrnl in patients newly diagnosed with type-2 diabetes who were treated with metformin for three months with those of a healthy volunteer group, and analyzes the immunoreactivity of Metrnl in salivary glands through immunohistochemical staining. The results show that plasma Metrnl levels are higher in the newly diagnosed diabetes group, and salivary Metrnl levels are higher after three months of metformin treatment. Immunohistochemical staining reveals Metrnl immunoreactivity in specific locations of the parotid and submandibular glands.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yuting Guo, Juan Chen, Nan Liu, Zheng Liu, Bimin Shi, Hong Sun
Summary: Circulating TXNIP levels are positively associated with the severity of NAFLD among patients with type 2 diabetes mellitus. TXNIP may serve as a promising biomarker for NAFLD, offering an efficient way to evaluate and monitor fatty liver progression.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Chiara Zusi, Alessandro Csermely, Elisabetta Rinaldi, Kezia Bertoldo, Sara Bonetti, Maria Linda Boselli, Daniela Travia, Enzo Bonora, Riccardo C. Bonadonna, Maddalena Trombetta
Summary: The aim of this study is to evaluate the relationship between genetic variability of ADIPOQ, LEP, and LEPR genes with the glucose-insulin system and markers of subclinical atherosclerosis (ATS) in patients with newly diagnosed type 2 diabetes. The results showed that two SNPs within the ADIPOQ gene were associated with adiponectin levels. Haplotypes of ADIPOQ, LEP, and LEPR genes were associated with circulating levels of adiponectin, leptin, and markers of ATS, providing insight into the role of adipokines in glucose metabolism and atherosclerosis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Xin Zhou, Mei Luo, Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu
Summary: The study revealed that plasma alarin levels are associated with various biochemical markers in newly diagnosed obese and non-obese type 2 diabetes mellitus patients, suggesting a potential role in the development of T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Qiu Wang, Lirong Ma, Yuanying Zhang, Lin Zhang, Yu An, Jia Liu, Guang Wang
Summary: The study showed that sitagliptin treatment significantly increased serum irisin levels in patients with type 2 diabetes mellitus and this increase was associated with reductions in fasting blood glucose and glycosylated hemoglobin levels.
Article
Endocrinology & Metabolism
Enzo Bonora, Maddalena Trombetta, Marco Dauriz, Corinna Brangani, Vittorio Cacciatori, Carlo Negri, Isabella Pichiri, Vincenzo Stoico, Elisabetta Rinaldi, Giuliana Da Prato, Maria Linda Boselli, Lorenza Santi, Federica Moschetta, Monica Zardini, Riccardo C. Bonadonna
Summary: In newly diagnosed type 2 diabetes, insulin resistance and beta-cell dysfunction are very common with a wide range of expression but no specific pattern of aggregation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Endocrinology & Metabolism
Rui Min, Yancheng Xu, Bocheng Peng
Summary: This study evaluated the clinical value of glycosylated hemoglobin (HbA1c) in newly diagnosed ketosis-prone type 2 diabetes (KPD). The results showed that HbA1c was correlated with ketosis, insulin, and islet function. Patients with HbA1c > 10.15% were more likely to develop KPD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Eleanor L. Ramos, Colin M. Dayan, Lucienne Chatenoud, Zdenek Sumnik, Kimber M. Simmons, Agnieszka Szypowska, Stephen E. Gitelman, Laura A. Knecht, Elisabeth Niemoeller, Wei Tian, Kevan C. Herold, PROTECT Study Investigators
Summary: Two 12-day courses of teplizumab in children and adolescents with newly diagnosed type 1 diabetes showed benefit with respect to the preservation of beta-cell function, but no significant differences between the groups were observed with respect to the secondary endpoints.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Rodolfo Mastropasqua, Rossella D'Aloisio, Erica Costantini, Annamaria Porreca, Giada Ferro, Daniele Libertini, Marcella Reale, Marta Di Nicola, Pasquale Viggiano, Gennaro Falconio, Lisa Toto
Summary: The study evaluated the expression levels of different miRNAs in diabetic patients and found significant differences in expression levels between diabetic patients with and without DR. Significant associations between miRNAs and anatomical/perfusion parameters and functional parameters were observed in the diabetic groups.
Article
Endocrinology & Metabolism
Guo-Chong Chen, Rhonda Arthur, Victor Kamensky, Jin Choul Chai, Bing Yu, Aladdin H. Shadyab, Matthew Allison, Yangbo Sun, Nazmus Saquib, Robert A. Wild, Wei Bao, Andrew J. Dannenberg, Thomas E. Rohan, Robert C. Kaplan, Sylvia Wassertheil-Smoller, Qibin Qi
Summary: Among postmenopausal women in the United States, upper-body fat is positively associated with the risk of lower-extremity arterial disease (LEAD), while lower-body fat is inversely associated with the risk of LEAD.
Review
Environmental Sciences
Katrina Stadler, Xueshu Li, Buyun Liu, Wei Bao, Kai Wang, Hans-Joachim Lehmler
Summary: Toxicological and epidemiological studies suggest potential health risks from exposure to DTC fungicides, but limited information is available on human exposure. This systematic review examines global human exposure levels to DTC pesticides and finds that levels in the NHANES 2003-2008 population appear lower compared to most identified studies. More recent data on exposure are needed, especially in countries where DTC pesticides are still in use.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Leonardo Trasande, Buyun Liu, Wei Bao
Summary: The study found that high-molecular weight phthalate metabolites, especially DEHP, were associated with increased mortality. Extrapolating to the 55-64 year old American population, the estimated attributable deaths related to phthalate exposure exceeded 90,000, with lost economic productivity in the billions of dollars.
ENVIRONMENTAL POLLUTION
(2022)
Article
Nutrition & Dietetics
Yangbo Sun, Shuang Rong, Buyun Liu, Yang Du, Yuxiao Wu, Liangkai Chen, Qian Xiao, Linda Snetselaar, Robert Wallace, Wei Bao
Summary: This study examined the associations between meal frequency, skipping, and intervals with all-cause and cardiovascular disease mortality. Eating one meal per day was associated with increased risk of all-cause and CVD mortality compared to eating three meals per day. Skipping breakfast was associated with increased risk of CVD mortality, while skipping lunch or dinner was associated with increased risk of all-cause mortality.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Review
Clinical Neurology
Linda G. Snetselaar, Joshua J. Cheek, Sara Shuger Fox, Heather S. Healy, Marin L. Schweizer, Wei Bao, John Kamholz, Tyler J. Titcomb
Summary: This study conducted a systematic review and network meta-analysis to assess the efficacy of different dietary approaches in managing MS-related fatigue and quality of life. The findings suggest that the Paleolithic, low-fat, and Mediterranean diets may reduce fatigue and improve physical and mental QoL. However, the low quality of the included trials limits the strength of these conclusions.
Review
Endocrinology & Metabolism
Bo Li, Shan Gao, Wei Bao, Ming Li
Summary: This systematic review summarizes the efficacy of lifestyle interventions in reducing BMI and metabolic risk factors for overweight/obese Chinese children. The findings suggest that lifestyle interventions are effective, especially when they include multiple components, last longer than one year, and are conducted among teenagers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Jiaxi Yang, Deirdre K. Tobias, Shanshan Li, Shilpa N. Bhupathiraju, Sylvia H. Ley, Stefanie N. Hinkle, Frank Qian, Zhangling Chen, Yeyi Zhu, Wei Bao, Jorge E. Chavarro, Frank B. Hu, Cuilin Zhang
Summary: The study found that among females with a history of GDM, greater consumption of caffeinated coffee was associated with a lower risk of T2D.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Benchao Li, Liangkai Chen, Xueting Hu, Ting Tan, Jiajia Yang, Wei Bao, Shuang Rong
Summary: This study found that serum uric acid (SUA) level is associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes. Higher SUA levels are associated with increased risks of all-cause and CVD mortality. Interventional studies are needed to evaluate the health effect of treatments to lower SUA levels in clinical practice.
Article
Endocrinology & Metabolism
Jinhua Yan, Yongwen Zhou, Xueying Zheng, Mao Zheng, Jing Lu, Sihui Luo, Daizhi Yang, Hongrong Deng, Wen Xu, Yan Bi, Wei Bao, Jianping Weng
Summary: This study aimed to investigate whether intermittently scanned continuous glucose monitoring without alarms (isCGM) improves glycaemic control over capillary blood glucose monitoring (BGM) among adult type 1 diabetes mellitus (T1DM) patients with suboptimal control. The results showed that compared with BGM, the use of isCGM resulted in a statistically significant improvement in glycaemic control after a 24-week intervention.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Oncology
Ikuko Kato, Jun Sun, Theresa A. Hastert, Judy Abrams, Joseph C. Larson, Wei Bao, Aladdin H. Shadyab, Charles Mouton, Lihong Qi, Lisa Warsinger Martin, JoAnn E. Manson
Summary: Low circulating vitamin D levels are more prevalent in Black than White individuals. Calcium plus vitamin D supplementation does not reduce risks of cancer, CVD, or other major causes of death in Black women overall. Other medical, behavioral, or social interventions should be considered to narrow health disparities related to these outcomes. However, further investigation is needed for colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Benchao Li, Buyun Liu, Wei Bao, Shuang Rong
Summary: This study aimed to examine the association between serum 25(OH)D concentrations and respiratory infection. The findings showed that individuals with lower serum 25(OH)D concentrations had a higher risk of respiratory infection, particularly head or chest cold, as well as influenza, pneumonia, and ear infections. Lower serum 25(OH)D concentrations were associated with a higher risk of head or chest cold in obese adults. This study highlights the potential protective effect of vitamin D on respiratory health.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Buyun Liu, Cynthia L. Curl, Anne Lise Brantsaeter, Hanne Torjusen, Yangbo Sun, Yang Du, Hans-Joachim Lehmler, Annica Balentine, Linda G. Snetselaar, Wei Bao
Summary: Consuming organic foods during pregnancy may reduce pesticide exposure and potentially improve the health outcomes of both mothers and offspring. However, the effects of organic food consumption during pregnancy have not been firmly established, and further research is needed to replicate the findings in different populations.
ADVANCES IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Yangbo Sun, Buyun Liu, Linda G. Snetselaar, Robert B. Wallace, Aladdin H. Shadyab, Guo-Chong Chen, James M. Shikany, JoAnn E. Manson, Wei Bao
Summary: The aim of this study was to examine the association between chocolate consumption and all-cause and cause-specific mortality. The study found a modest inverse association between moderate chocolate consumption (1-3 servings/week) and mortality from all causes, cardiovascular disease, and dementia. Chocolate consumption was not associated with cancer mortality.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Nutrition & Dietetics
Tyler J. Titcomb, Buyun Liu, Terry L. Wahls, Linda G. Snetselaar, Aladdin H. Shadyab, Fred K. Tabung, Nazmus Saquib, Chrisa Arcan, Lesley F. Tinker, Robert B. Wallace, Wei Bao
Summary: This study examines the association between the ketogenic ratio and the risk of type 2 diabetes mellitus in postmenopausal women. The results show that higher ketogenic ratios are associated with an increased risk of developing diabetes. However, the number of participants following a ketogenic diet in this study was very limited.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Environmental Sciences
Gabriela Vieyra, Susan E. Hankinson, Youssef Oulhote, Laura N. Vandenberg, Lesley Tinker, JoAnn E. Manson, Aladdin H. Shadyab, Cynthia A. Thomson, Wei Bao, Matthew Allison, Andrew O. Odegaard, Katherine W. Reeves
Summary: This study evaluated the associations between urinary phthalate biomarkers and visceral and subcutaneous adipose tissue. The findings showed positive associations between certain phthalate biomarkers and visceral adipose tissue three years later, as well as a positive association between another phthalate biomarker and subcutaneous adipose tissue. The study provides supportive evidence for the relationship between phthalate compounds and abdominal fat accumulation, contributing to a better understanding of the link between obesity and chronic diseases.
ENVIRONMENTAL RESEARCH
(2023)
