Article
Cell Biology
Ze-Hui Shi, Xiao-Yan Han, Mu-Di Yao, Chang Liu, Qin Jiang, Biao Yan
Summary: This study identified 72 miRNAs that were differentially expressed in EPCs following high glucose stress, with target genes involved in protein binding, cell differentiation, and cytoskeleton based on GO analysis. KEGG pathway analysis revealed the association between cGMP-PKG signaling pathway and miRNA-mediated EPC function. The up-regulation of miR-375-3p in clinical samples of DR patients was verified, and its inhibition protected EPCs against hyperglycemic or hypoxic stress-induced injury, enhancing cell viability, proliferation, migration, tube formation ability, and delaying apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Olufunke O. Arishe, R. Clinton Webb
Summary: This editorial discusses a study on the effects of VE-PTP inhibition on endothelial dysfunction and hypertension in patients with diabetes.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Hye-Ram Jo, Jae-Hoon Jeong
Summary: This study reveals the crucial regulatory role of high mobility group box 2 (HMGB2) in cellular senescence. HMGB2 expression decreases with age, and its downregulation inhibits cell proliferation and accelerates cellular senescence, while overexpression delays senescence and maintains normal cellular function.
Article
Medicine, General & Internal
Taejoon Won, Megan K. Wood, David M. Hughes, Monica Talor, Zexu Ma, Jowaly Schneider, John T. Skinner, Beejan Asady, Erin Goerlich, Marc K. Halushka, Allison G. Hays, Deok-Ho Kim, Chirag R. Parikh, Avi Z. Rosenberg, Isabelle Coppens, Roger A. Johns, Nisha A. Gilotra, Jody E. Hooper, Andrew Pekosz, Daniela Cihakova
Summary: The article explains the copyright ownership and the license agreement it follows.
Article
Immunology
Wencui Wan, Yang Long, Xuemin Jin, Qiuming Li, Weiwei Wan, Hongzhuo Liu, Yu Zhu
Summary: This study demonstrated that miR-200a may serve as a potential therapeutic target in DR through down-regulating PDLIM1, significantly affecting cell viability and inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Shuchang Ren, Xiaohui Tan, Melinda Z. Fu, Shuyang Ren, Xiaoling Wu, Tao Chen, Patricia S. Latham, Paul Lin, Yan-gao Man, Sidney W. Fu
Summary: In esophageal cancer, miR-375 is frequently downregulated and acts as a tumor suppressor by blocking the ERBB2/VEGFA pathway to inhibit cancer progression.
Article
Biochemistry & Molecular Biology
Chak-Kwong Cheng, Wenbin Shang, Jian Liu, Wai-San Cheang, Yu Wang, Li Xiang, Chi-Wai Lau, Jiang-Yun Luo, Chi-Fai Ng, Yu Huang, Li Wang
Summary: This study found that the level of miR-181b is decreased in renal arteries of diabetic patients and in advanced glycation end products (AGEs)-treated renal arteries of non-diabetic patients. Transfection of miR-181b mimics can improve endothelium-dependent vasodilation in arteries of diabetic mice. Activation of AMPK and chronic exercise can upregulate miR-181b expression. These findings suggest a critical role of the AMPK/miR-181b axis in counteracting diabetes-associated endothelial dysfunction.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yan Wang, Yu-Jian Liu, Dun-Feng Xu, Hui Zhang, Chu-Fan Xu, Yan-Fei Mao, Zhou Lv, Xiao-Yan Zhu, Lai Jiang
Summary: The study shows that dopamine receptor D1 is downregulated in response to mechanical ventilation, and prophylactic administration of dopamine or DRD1 agonist can mitigate mechanical stretch-induced lung endothelial barrier dysfunction and lung injury.
Article
Biochemistry & Molecular Biology
Sabina Licholai, Dorota Studzinska, Hanna Plutecka, Tomasz Gubala, Wojciech Szczeklik, Marek Sanak
Summary: Abdominal aortic aneurysms (AAA) are a complex disease with unclear pathomechanism, where a positive family history is a significant risk factor. This study found significantly elevated levels of miR-191 in AAA patients, but this did not correlate with clinical data. In an in vitro model, it was established that perturbations mediated by miR-191 can be explained by processes observed in literature accompanying the development of AAA.
Article
Medicine, Research & Experimental
Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin, Meizi Yang
Summary: The study found that E3 ubiquitin ligase Cbl alleviates endothelial dysfunction in diabetic rats by modulating the JAK2/STAT4 pathway and inhibiting Runx3 expression. This evidence may pave the way for novel Cbl-based therapies against diabetes mellitus in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Emma L. Solly, Peter J. Psaltis, Christina A. Bursill, Joanne T. M. Tan
Summary: Diabetes is estimated to affect 700 million people by 2045, leading to significant health and economic burden. Current treatments are not satisfactory, highlighting the need for therapies that stimulate angiogenesis to improve ischaemic complications. MicroRNAs, including miR-181c, show promise as therapeutic targets for rescuing diabetes-impaired angiogenesis by regulating key angiogenic pathways and cellular processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Biochemistry & Molecular Biology
Chun-Yi Ng, Khang Leng Lee, Mark Dhinesh Muthiah, Kan Xing Wu, Florence Wen Jing Chioh, Konstanze Tan, Gwyneth Shook Ting Soon, Asim Shabbir, Wai Mun Loo, Zun Siong Low, Qingfeng Chen, Nguan Soon Tan, Huck Hui Ng, Yock Young Dan, Christine Cheung
Summary: The top cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD) is cardiovascular complications. The study reveals that blood outgrowth endothelial cells (BOECs) from NAFLD subjects exhibit global transcriptional upregulation of chemokines and human leukocyte antigens. T cell intensification is observed in NAFLD patients. CXCL12-neutralizing antibody treatment helps to moderate the enhanced chemotactic effect of NAFLD BOECs in recruiting CD8(+) T lymphocytes.