Article
Immunology
Bing Wu, Yanwei Wu, Chen Fan, Chunlan Feng, Haoyu Wang, Fang Bai, Jianping Zuo, Wei Tang
Summary: Heme plays an important role in the pathogenesis of systemic lupus erythematosus (SLE), and supplementation of heme can significantly improve lupus symptoms, reduce proteinuria levels, and alleviate organ enlargement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Chengxin Shi, Fengli Yue, Feiyu Shi, Qian Qin, Lizhao Wang, Guanghui Wang, Lijun Mu, Dan Liu, Yaguang Li, Tianyu Yu, Junjun She
Summary: The study demonstrated that selenocysteine and selenocystine can ameliorate DSS-induced IBD by reducing oxidative stress and intestinal inflammation, suggesting that selenium-containing amino acids could be a novel therapeutic option for patients with IBD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
Summary: This study evaluated the performance of IgG N-glycosylation in diagnosing lupus nephritis (LN) in female systemic lupus erythematosus (SLE) patients. The results showed that specific glycans and anemia were associated with LN. These IgG N-glycans can serve as potential biomarkers to differentiate LN among SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Xin-yu Zhao, Shuang-shuang Li, Ying-xin He, Li-jie Yan, Fu Lv, Qi-meng Liang, Yu-hui Gan, Li-pei Han, Hong-de Xu, Yong-chun Li, Yuan-yuan Qi
Summary: The study reveals that SGLT2 inhibitors provide renal protection in patients with lupus nephritis. The use of SGLT2 inhibitors decreases anti-dsDNA IgG-specific antibody levels, serum creatinine, and proteinuria. Furthermore, SGLT2 inhibitors alleviate glomerular and tubulointerstitial damages. This study provides more evidence for non-immunosuppressive therapies to improve renal function in classic autoimmune kidney diseases such as lupus nephritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Jicui Li, Manyu Luo, Bing Li, Yan Lou, Yuexin Zhu, Xue Bai, Baichao Sun, Xuehong Lu, Ping Luo
Summary: Lupus nephritis (LN) is a significant cause of acute and chronic renal diseases, characterized by abnormal activation of immune responses and dysregulation of inflammatory signaling pathways. Mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress the proliferation and functions of immune cells, contributing to the improvement of LN pathology and restoration of kidney function in lupus mice and LN patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wei Zhang, Lu Xiang, Peng Luo, Dili Xie
Summary: Cardiovascular aging is a significant factor contributing to cardiovascular disease, and alpha-lactalbumin has been found to have anti-aging potential in attenuating cardiovascular aging, inflammation, and oxidative stress. Both in vitro and in vivo experiments support this finding, suggesting that alpha-lactalbumin could be a promising anti-aging functional food in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hamad Mohammed AbuZahra, Peramaiyan Rajendran, Mohammad Bani Ismail
Summary: Zerumbone has shown potential in alleviating ZEA-induced liver damage, reducing inflammation, and inhibiting cell apoptosis through various pathways, providing a basis for its application in treating liver injuries caused by contaminants, such as Zearalenone.
Article
Biology
Zemin Lin, Yuting Liu, Li Chen, Shiqi Cao, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu, Wei Tang, Shijun He, Jianping Zuo
Summary: This study revealed the etiology and therapeutic mechanism of antiphospholipid syndrome nephropathy and for the first time demonstrated the therapeutic potential of SM934 in treating this condition.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Plant Sciences
Li-ying He, Shu-qi Niu, Cai-xia Yang, Pan Tang, Jiao-jiao Fu, Li Tan, Yong Li, Ya-nan Hua, Si-jing Liu, Jin-lin Guo
Summary: This study aimed to examine the therapeutic potential of Cordyceps proteins (CP) in lupus nephritis (LN) and uncover the underlying molecular mechanism. The results showed that CP had a favorable bidirectional immunomodulatory effect, reducing proteinuria, renal inflammation, and fibrosis in LN mice. CP's regulatory effects surpassed artificial Cordyceps fungus powder (BC) and prednisolone acetate (PA), modulating the STAT3/mTOR/NF-kB signaling pathway and lowering the levels of IL-6 and IL-1 beta.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Liu Liu, Lei Zhang, Ming Li
Summary: Lupus nephritis is a renal disease caused by systemic lupus erythematosus and has serious implications for patients. Traditional Chinese medicine has shown promising effects in alleviating the symptoms and improving the prognosis of LN patients. This review provides supplementary evidence for the development of TCM treatment for LN and serves as a reference for future research and clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chen Cheng, Rongrong Zhu, Mingjian Liu, Hao Yang, Fangfang Guo, Qunqun Du, Xiaolan Wang, Minmin Li, Gaopeng Song, Renan Qin, Shuwen Liu
Summary: This study aimed to explore the efficacy and potential mechanisms of Kunxian capsule (KXC) through pharmacological network, in vitro and in vivo studies. It was found that KXC inhibits renal damage and T-cell infiltration in lupus nephritis by blocking the JAK1-STAT1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Feliciano Chanana Paquissi, Hugo Abensur
Summary: Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and hyperreactivity of the immune response, with lupus nephritis (LN) being a worrying manifestation. The Th17/IL-17 axis plays a significant role in kidney diseases, promoting inflammation and fibrotic pathways that lead to organ damage.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zhigang Liu, Zhen Zhang, Tingfeng Zou, Mengyuan Fang, Tianxiang Wang, Huawen Meng, Yuanli Chen, Yajun Duan, Lingling Wei, Jihong Han, Qingshan Li, Xiaoxiao Yang
Summary: This study designed and synthesized a series of novel thiazole derivatives, and evaluated their anti-inflammatory and antioxidation activities. Compound F5 exhibited the most potent activity, reversed the expression of inflammation-related genes in cells, and showed protective effects in a heart failure model. The results suggest that compound F5 could be a promising agent for heart failure treatment through attenuating oxidative stress and inflammation.
BIOORGANIC CHEMISTRY
(2022)
Article
Rheumatology
Jennifer C. Davies, Emil Carlsson, Angela Midgley, Eve M. D. Smith, Ian N. Bruce, Michael W. Beresford, Christian M. Hedrich
Summary: This study validated the use of a urinary protein panel to predict active renal involvement in SLE patients and potentially predict response to rituximab treatment. The levels of certain proteins in urine were significantly higher in SLE patients with active LN, supporting the potential of these biomarkers in non-invasive routine testing for SLE patients.
Review
Urology & Nephrology
Wenchao Li, Weiwei Chen, Lingyun Sun
Summary: Bone marrow MSCs from SLE patients show impaired capabilities of migration, differentiation, and immune regulation, as well as a senescent phenotype. Allogeneic MSCs suppress autoimmunity and restore renal function in mouse models and LN patients by inducing regulatory immune cells and suppressing certain immune cell responses. Moreover, MSCs can migrate to the kidney, integrate into tubular cells, and differentiate into mesangial cells. There is still a need for further confirmation of the efficacy of MSCs in LN treatment, and advancements in stem cell science may lead to the use of more potent stimulated or primed pretreated MSCs for LN therapy.
Article
Nutrition & Dietetics
Yong Du, Huihua Ding, Kamala Vanarsa, Sanam Soomro, Sahar Baig, John Hicks, Chandra Mohan
Article
Radiology, Nuclear Medicine & Medical Imaging
Achuth Nair, Chih Hao Liu, Manmohan Singh, Susobhan Das, Triet Le, Yong Du, Sanam Soomro, Salavat Aglyamov, Chandra Mohan, Kirill Larin
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Yong Du, Chun Xie, Sneha Ravikumar, Jacob Orme, Li Li, Xin J. Zhou, Chandra Mohan
Summary: This study revealed the essential role of the TGF-beta/SMAD signaling pathway in the development of immune-mediated nephritis in 129sv mice, with Smad3 deletion ameliorating the nephritis, including crescentic glomerulonephritis. These findings suggest that SMAD3 could be a potential therapeutic target for immune-mediated nephritis in this mouse strain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yong Du, Laura Paglicawan, Sanam Soomro, Omar Abunofal, Sahar Baig, Kamala Vanarsa, John Hicks, Chandra Mohan
Summary: The study confirms the beneficial effects of EGCG on NAFLD and reveals a novel mechanism of action involving hepatic M1-to-M2 macrophage polarization.
Article
Immunology
Thao Nguyen, Brittany Payan, Amarayca Zambrano, Yong Du, Maria Bondesson, Chandra Mohan
JOURNAL OF INFLAMMATION RESEARCH
(2019)
Proceedings Paper
Engineering, Biomedical
Achuth Nair, Susobhan Das, Chih-Hao Liu, Manmohan Singh, Triet Le, Salavat Aglyamov, Yong Du, Sanam Soomro, Chandra Mohan, Kirill Larin
OPTICAL ELASTOGRAPHY AND TISSUE BIOMECHANICS VI
(2019)
Article
Chemistry, Multidisciplinary
Jin Hou, Yong Du, Tao Zhang, Chandra Mohan, Oomman K. Varghese
Article
Rheumatology
Ling Qin, Yong Du, Huihua Ding, Anam Haque, John Hicks, Claudia Pedroza, Chandra Mohan
ARTHRITIS RESEARCH & THERAPY
(2019)