Article
Neurosciences
Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu, Jian Wang, Ying Wang, Zhihui Huang, Honglin Teng
Summary: TBK1 plays an important role in the pathogenesis of spinal cord injury (SCI) by mediating innate immune pathways in astrocytes through YAP signaling. Inhibition of TBK1 activity alleviates neuroinflammation, reduces motor neuron loss, and improves functional recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Jingxuan Wang, Cai Cheng, Zhongbing Liu, Yan Lin, Lingling Yang, Zijun Zhang, Xiaoduan Sun, Meiling Zhou, Pei Jing, Zhirong Zhong
Summary: Spinal cord injury is a serious injury to the central nervous system that causes significant physical and psychological trauma to the patient. The ability of the human nerve to repair itself after an injury is limited by glial scar formation. Stimulating A2 astrocytes may provide a new treatment for spinal cord injury.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Liming Li, Heping Zheng, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin
Summary: Nerve tissue regeneration faces obstacles due to inhibitory glycosaminoglycan chains in the microenvironment. This study identifies Chst15 as a therapeutic target for spinal cord injury (SCI). Inhibition of Chst15 significantly reduces deposition of inhibitory CSPGs and astrocyte migration, promoting motor functional restoration and nerve tissue regeneration in rats with transected spinal cords. This study highlights Chst15 as a potential target for neuroregenerative therapy.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhang Bo-Yin, Zhu Qingsan, Ma Yihang, Yang Fan, Zhu Yuhang, Chang Pengyu
Summary: After spinal cord injury, JMJD3 acts as a crucial epigenetic regulator in manipulating the endogenous oligodendrogenesis process. Inhibition of JMJD3 promotes oligodendrocyte lineage commitment by mediating SAPK/JNK signaling pathway inactivation. This study provides novel evidence of JMJD3-mediated oligodendrocyte-lineage commitment orchestration post SCI, offering a potential epigenetic approach for inducing mature mammalian endogenous recovery.
NEUROCHEMICAL RESEARCH
(2021)
Article
Immunology
Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis, Adib Zendedel
Summary: This study suggests that activation of Nrf2 in astrocytes protects against spinal cord injury by reducing oxidative damage and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Simonetta Papa, Valeria Veneruso, Emanuele Mauri, Giada Cremonesi, Xhuljana Mingaj, Alessandro Mariani, Massimiliano De Paola, Arianna Rossetti, Alessandro Sacchetti, Filippo Rossi, Gianluigi Forloni, Pietro Veglianese
Summary: Astroglial cells have a unique reaction during spinal cord damage, and there is a need for treatment targeting activated astrocytes to ensure some preservative effect during progressive damage. Functionalized nanogel-based nanovectors have shown selectivity towards astrocytes and limited uptake by macrophages, with potential therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Anissa Elahi, Jacen Emerson, Jacob Rudlong, Jeffrey W. Keillor, Garrick Salois, Adam Visca, Peter Girardi, Gail V. W. Johnson, Christoph Proschel
Summary: The study revealed that deletion of TG2 from astrocytes significantly improved motor function in a spinal cord contusion injury (SCI) model, reducing astrocyte markers and SOX9 positive cell numbers. Activation of fatty acid metabolism and energy pathways promotes metabolic coupling between neurons and astrocytes.
Article
Immunology
Sen Lin, Chang Xu, Xuechen Yin, He Tian, Xifan Mei
Summary: Spinal cord injury (SCI) causes chronic functional impairment in patients, especially older adults who often have shorter lifespans. Overexpression of p75 leads to neuroinflammation and motor dysfunction following SCI in adult mice. In this study, it was found that p75 deletion could promote motor/sensory function recovery and improve survival in both adult and aged mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Susana R. Cerqueira, Sofia Benavides, Ha Eun Lee, Nagi G. Ayad, Jae K. Lee
Summary: Inhibiting BET proteins after spinal cord injury (SCI) can reduce lesion size and provide neuroprotection, but the improvement observed is not related to macrophages. Further research on the role of BET proteins after SCI is necessary to identify new therapeutic targets.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Siyi Liu, Ge Lin, Qiao Yang, Penghui Wang, Chao Ma, Xiaowei Qian, Xiaomei He, Zhangji Dong, Yan Liu, Mei Liu, Ronghua Wu, Liu Yang
Summary: This study aimed to evaluate the effects of SASH1 knockdown on functional recovery after SCI and investigate its mechanism in facilitating axonal growth. The results show that SASH1 downregulation improved hindlimb motor function and reduced glial activation. In cultured spinal astrocytes, SASH1 knockdown decreased interferon-gamma release and increased BDNF release, leading to increased axonal growth. Furthermore, SASH1 depletion maintained high levels of Nestin protein and increased BDNF release in differentiated NSCs.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Shutian Zhang, Yufeng Yan, Yongze Wang, Zhaodong Sun, Chengzhi Han, Xinyi Qian, Xiaorong Ren, Yi Feng, Jian Cai, Chunmei Xia
Summary: This study demonstrated that inhibiting MALT1 can modulate glial endoplasmic reticulum stress and alleviate neuroinflammation in spinal cord ischemia/reperfusion injury, suggesting a potential therapeutic target for this condition.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Terese A. Garcia, Carrie R. Jonak, Devin K. Binder
Summary: Edema formation following traumatic spinal cord injury (SCI) worsens secondary injury and is correlated with worse neurological outcome. The aquaporin-4 (AQP4) water channel plays an important role in water homeostasis and has the potential to modulate edema resolution and functional recovery after SCI. Further research is needed to understand the expression and subcellular localization of AQP4 during specific phases after SCI for therapeutic optimization.
Article
Biochemistry & Molecular Biology
Jinxing Hou, Huiru Bi, Qiting Ge, Huajian Teng, Guoqiang Wan, Bin Yu, Qing Jiang, Xiaosong Gu
Summary: Astrocytes play important roles in spinal cord injury and show heterogeneity. This study identified six distinct astrocyte subtypes following injury and characterized their distribution and dynamic evolution, providing new targets for spinal cord injury repair.
Article
Medicine, Research & Experimental
Yidan Zhang, Yuanzeng Wang, Wen Zhao, Luyao Li, Lei Li, Yanyan Sun, Jinping Shao, Xiuhua Ren, Weidong Zang, Jing Cao
Summary: This study reveals that the analgesic effect of EA is associated with the suppression of RIP3 and NLRP3 expression in the SDH, providing potential insights into the underlying spinal mechanisms involved in the analgesic effect of EA.