Article
Biochemistry & Molecular Biology
Ning Wang, Cheng Zhang, Yu Xu, Hor-Yue Tan, Haiyong Chen, Yibin Feng
Summary: The study demonstrated that berberine can decelerate the progression of diabetic retinopathy by inhibiting insulin-induced neovascularization of retinal endothelial cells. In both experimental type I and type II diabetic mice, berberine effectively suppressed the expression of HIF-1 alpha and VEGF, improving diabetic retinopathy under insulin treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, Takashi Takata
Summary: This study evaluated the inhibitory effects of bovine lactoferrin (bLF) on tumor angiogenesis in vivo and in vitro. The results showed that bLF inhibited proliferation, migration, and tube formation in tumor endothelial cells (TECs) while promoting apoptosis. This effect was achieved through the inhibition of p-p65 via binding with TNF receptor-associated factor 6 (TRAF6), leading to the down-regulation of hypoxia inducible factor-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF), specifically in TECs.
Article
Biochemistry & Molecular Biology
Jinzi Zhou, Fenghua Chen, Aimin Yan, Xiaobo Xia
Summary: This study investigated the role of mTOR in regulating HIF-1α and VEGF expression, as well as the impact of rapamycin on this pathway. The findings suggest that mTOR and the HIF-1α-VEGF mechanism play crucial roles in the development of glaucoma.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
Sora Cha, Hyoung-Geun Kim, Hyeonha Jang, Jihoon Lee, Tang Chao, Nam-In Baek, Im-Sook Song, You Mie Lee
Summary: This study discovered a natural compound, steppogenin, that inhibits both HIF-1 alpha and DLL4, leading to the suppression of angiogenesis and tumor growth. The experimental results showed that steppogenin exhibited significant anti-angiogenic and anti-tumor activities in cell and animal experiments. This research provides a potential candidate compound for developing novel therapies for angiogenic diseases, including solid tumors.
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jie-Ning Li, Pai-Sheng Chen, Ching-Feng Chiu, Yu-Jhen Lyu, Chiao Lo, Li-Wei Tsai, Ming-Yang Wang
Summary: This study reveals the regulatory role of TARBP2 in the ubiquitination-proteasomal degradation of HIF-1 alpha protein in breast cancer, showing its significance in cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jiali Yuan, Yiqun Mo, Yue Zhang, Yuanbao Zhang, Qunwei Zhang
Summary: With the rapid development of nanotechnology, the potential adverse health effects of nanoparticles have become global concerns. This study investigated the effects of nickel nanoparticles (Nano-Ni) and titanium dioxide nanoparticles (Nano-TiO2) on autophagy and apoptosis levels in human bronchial epithelial cells. The results showed dysregulation of autophagy and apoptosis-associated proteins in cells exposed to Nano-Ni, while Nano-TiO2 had no significant effects. Nano-Ni exposure led to nuclear accumulation of HIF-1a and decreased phosphorylation of mTOR, and inhibition of HIF-1a abolished Nano-Ni-induced decreased phosphorylation of mTOR. Moreover, Nano-Ni-induced autophagy played a protective role against Nano-Ni-induced apoptosis.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Biochemistry & Molecular Biology
Jae-Wook Lee, Jun-Yeong Cho, Pham Xuan Thuy, Eun-Yi Moon
Summary: This study found that the formation of primary cilia (PC) in cancer cells is regulated by NPHP3 expression through ROS-induced HIF-1α and ERK activation, which plays an important role in cancer cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Li-Jun Wen, Xiao-Lin Hu, Cui-Ying Li, Jie Liu, Zi-Yang Li, Ya-Zi Li, Jue-Yu Zhou
Summary: The study revealed that upregulation of Myo1b in cervical cancer tissues was associated with poor prognosis. Overexpression of Myo1b significantly increased glycolysis, migration, and invasion of CC cells, as well as promoted tumorigenesis and metastasis in vivo.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Neurosciences
Yang Li, Tingting Ma, Xiaoyu Zhu, Mingqi Zhang, Liang Zhao, Peng Wang, Jia Liang
Summary: This study found that zinc improves neurological function recovery during the cerebral ischemia repair stage by promoting astrocyte induced angiogenesis. Zinc alleviates brain atrophy and enhances neurological function recovery. Furthermore, zinc increases the protein levels of HIF-1 alpha, VEGF-A, and VEGF-R2 in astrocytes, thereby promoting angiogenesis during cerebral ischemic repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Ke Zhao, Min Hu, Runfeng Yang, Jing Liu, Pingfan Zeng, Tingkuan Zhao
Summary: This study explored the potential biomarkers for predicting chemotherapy response in locally advanced cervical cancer (LACC). The expression levels of HIF-1a, VEGF-A, and Ki67 were significantly higher in LACC tissues compared to nonneoplastic tissues, but decreased significantly after neoadjuvant chemotherapy (NACT). In the response group, the expression of HIF-1a, VEGF-A, and Ki67 decreased significantly after chemotherapy. Histological grade and expression levels of HIF-1a, VEGF-A, and Ki67 were independent risk factors affecting the efficacy of NACT in LACC.
Article
Chemistry, Multidisciplinary
Xue-gong Fan, Si-ya Pei, Dan Zhou, Peng-cheng Zhou, Yan Huang, Xing-wang Hu, Teng Li, Yang Wang, Ze-bing Huang, Ning Li
Summary: Melittin, a major peptide component of bee venom, shows promising therapeutic effects for acute liver failure (ALF) by targeting PKM2 to inhibit inflammation through suppressing aerobic glycolysis in macrophages.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Chao Yuan, Junli Liu, Ling Liu, Hongying Jia, Qi Gao, Xiaoyan Wang, Jingjie Zhao
Summary: TRIM7 acts as a tumor suppressor in ccRCC cells by negatively regulating HIF-1 signaling pathway through targeting Src, which could provide a promising therapeutic strategy for ccRCC.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Kang M. Lee, Cheorl-Ho Kim, Jong H. Kim, Sung S. Kim, Seung-Hak Cho
Summary: The study developed the e-Membranome database for genome-wide prediction and analysis of outer membrane adhesins in Escherichia coli, providing tools for homology modeling, epitope region exploration, and glycan array investigation. The platform stores important information and supports research on outer membrane proteins and the construction of lectin-glycan interaction networks.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seung-Hak Cho, Jung-Beom Kim, Cheorl-Ho Kim, Young-Seok Bak
Summary: This study analyzed the microbiological contamination on dummies used in CPR institutions in Korea, finding significantly higher levels of bacteria and fungi contamination than the required standard, including MRSA strains. The research showed that within two weeks of training, the contamination level on the dummy's surface exceeded the standard, with artificially contaminated pathogenic strains surviving for at least 40 days.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Immunology
Hakseong Lim, Jun-Young Park, Fukushi Abekura, Hyunju Choi, Hee-Do Kim, Junji Magae, Young-Chae Chang, Young-Choon Lee, Cheorl-Ho Kim
Summary: The study demonstrates that MAC alleviates inflammatory responses induced by lipopolysaccharide in murine macrophages by modulating the MAPK signaling pathway and downregulating NF-kappa B-related genes. MAC treatment decreases the expression of pro-inflammatory indicators and cytokines, potentially offering therapeutic benefits in reducing prolonged inflammation-related damage. The structural differences between ASC and its derivatives, as well as their impact on intracellular signaling, are also discussed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Seung-Hak Cho, Jun-young Park, Cheorl-Ho Kim
Summary: Microorganisms and host cells have carbohydrate chains and lectins that can recognize each other, playing a critical role in defense mechanisms and pathogen infection. This review aims to identify the role of host glycans in the immune response against pathogenic intestinal bacteria through studies on the lectin-glycan interaction, providing a new perspective for the prevention and treatment of infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mi-Jin Choi, Yeo Reum Kim, Nam Gyu Park, Cheorl-Ho Kim, Young Dae Oh, Han Kyu Lim, Jong-Myoung Kim
Summary: This study identified a gene that influences the growth of Pacific abalone and found that it plays an important role in the host defense mechanism. The protein encoded by this gene was also found to exhibit antimicrobial activity against various bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fukushi Abekura, Junyoung Park, Hakseong Lim, Hee-Do Kim, Hyunju Choi, Moon-Jo Lee, Cheorl-Ho Kim
Summary: The study demonstrates that LprG can suppress lipopolysaccharide-induced inflammation by downregulating the expression of related proteins and cytokines. These findings are of great significance for the development of anti-inflammatory medications and the utilization of Mycobacterium tuberculosis as a medical resource.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Jennifer K. Lee, Inyong Kim, Eun-Kyeong Jeon, Jung-Heun Ha, Cher-Won Hwang, Jin-Chul Kim, Woong-Suk Yang, Hyunju Choi, Hee-Do Kim, Cheorl-Ho Kim
Summary: Oat is a widely consumed cereal grain with high nutritional value and potential health benefits. Microbial fermentation enhances the quality and content of functional ingredients in oats, providing natural dietary supplements, antioxidants, and antiaging agents.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yu-Chan Chang, Cheorl-Ho Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Abekura Fukushi, Hee-Do Kim, Yu-Chan Chang, Cheorl-Ho Kim
Summary: Aerobic glycolysis is a characteristic of many human cancers, playing a crucial role in the growth, invasion, immune escape, and drug resistance of cancer cells. The glycolysis pathway consists of multiple enzymatic reactions, with increased levels of glycolytic proteins and enzymatic activities observed in cancer cells. In the Warburg effect, cancer cells rely on glycolysis to generate energy instead of oxidative phosphorylation. The understanding of the Warburg effect can lead to the development of targeted therapies for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jun-Young Park, Cheorl-Ho Kim, Seung-Hak Cho
Summary: In this study, we developed a FimH inhibitor to prevent adhesion of enterohemorrhagic Escherichia coli on human intestinal epithelium during the early stage of infection. By investigating the ligand binding domain of FimH and analyzing its evolutionary characteristics, we identified a potential drug target and found that glycan-like peptides can serve as initial infection inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yi-Fang Yang, Chien-Hsiu Li, Huei-Yu Cai, Bo-Syuan Lin, Cheorl-Ho Kim, Yu-Chan Chang
Summary: Cellular metabolism regulates physiological mechanisms and homeostasis in an individual. Abnormal metabolic reprogramming, caused by various factors such as gene mutations and epigenetic modifications, is associated with the development of diseases, including cancer. Metabolism-related molecules can serve as markers or prevention targets for cancer progression. Translational medicines using metabolic substrates and precursors have been developed for imaging and therapeutic purposes. Isotopically labeled compounds can be used to localize and visualize tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Jun-Young Park, Woong-Suk Yang, Seung-Hoon Yang, Cheorl-Ho Kim
Summary: There are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2). Whitening agent development consists of two ways, melanin synthesis inhibition in melanocytes and downregulation of melanocyte stimulation. Many researchers have recently presented the bioactivity-guided fractionation, discovery, purification, and identification of whitening agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyunju Choi, Hee-Do Kim, Yeon-Woo Choi, Hakseong Lim, Kyung-Woon Kim, Kyoung-Sook Kim, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study isolated the GM3-interacting protein NOLC1 using the T7 phage display method, further elucidating the functional roles of GM3 and providing evidence for the association between GM3 and NOLC1.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
So-Young An, Ji-Won Lee, Hee-Do Kim, Kyoung-Sook Kim, Jong-Hyun Cho, Cheorl-Ho Kim, Young-Choon Lee
Summary: In this study, it was observed that human glioblastoma cells particularly expressed the hST8Sia V gene. The study found that the JNK/AP-1 signaling pathway controls the specific expression of the hST8Sia V gene in U87MG cells.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Junyoung Park, Seung-Hak Cho, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study investigates the immunomodulatory effect of MPT32 in murine macrophage cells, demonstrating the possibility of using it as a TB vaccine and drug candidate for TB prevention.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)