ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

(2012) Y.-D. Kwak et al.   JOURNAL OF NEUROSCIENCE

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity

(2012) Sophie E L Chamberlain et al.   NATURE NEUROSCIENCE

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

(2012) Jessica J.R. Hudson et al.   Nature Communications

Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1

(2011) Heidrun Interthal et al.   BIOCHEMICAL JOURNAL

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

(2011) Hava Segal-Raz et al.   EMBO REPORTS

A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway

(2011) Laurence M. Wood et al.   PLoS One

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage

(2010) Shih-Chieh Chiang et al.   CELL CYCLE

Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks

(2010) Claudia Kerzendorfer et al.   HUMAN MOLECULAR GENETICS

Transcription-dependent Activation of Ataxia Telangiectasia Mutated Prevents DNA-dependent Protein Kinase-mediated Cell Death in Response to Topoisomerase I Poison

(2010) Ryo Sakasai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

(2009) Sherif F. El-Khamisy et al.   DNA REPAIR

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus

(2009) Laura Baranello et al.   NUCLEIC ACIDS RESEARCH

A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes

(2008) Chao-Po Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY