Article
Urology & Nephrology
Chunyan Yi, Wenbo Zhang, Hongjian Ye, Haishan Wu, Xuan Huang, Jianxiong Lin, Xiao Yang
Summary: The study found that higher baPWV was independently associated with cognitive impairment (CI) in PD patients.
Article
Medicine, General & Internal
Yan-Feng Zhou, Yanxiu Wang, Guodong Wang, Zhen Zhou, Shuohua Chen, Tingting Geng, Yan-Bo Zhang, Yi Wang, Jun-Xiang Chen, An Pan, Shouling Wu
Summary: This study aimed to investigate the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk. The results showed that statin use was associated with lower baseline baPWV and slower progression of baPWV.
Article
Medicine, General & Internal
Rithvik Swamynathan, Vinithra Varadarajan, Hieu Nguyen, Colin O. Wu, Kiang Liu, David A. Bluemke, Nadjia Kachenoura, Alban Redheuil, Joao A. C. Lima, Bharath Ambale-Venkatesh
Summary: This study investigates the association between chronic inflammation and subclinical vascular dysfunction. The results show that higher levels of CRP at baseline are independently associated with a 10-year increase in aortic stiffness, as measured by decreased aortic distensibility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Hongwei Zheng, Shouling Wu, Xiaokun Liu, Guoyu Qiu, Shuohua Chen, Yuntao Wu, Junjuan Li, Chunhui Yin, Qi Zhang
Summary: Arterial stiffness is independently associated with an increased risk of new-onset heart failure, regardless of age and blood pressure. This study provides important scientific evidence by investigating a large community population.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Sae Young Jae, Kevin S. Heffernan, Sudhir Kurl, Setor K. Kunutsor, Jari A. Laukkanen
Summary: This study found that estimated pulse wave velocity (ePWV) is independently associated with the risk of stroke in middle-aged men, with higher ePWV values being associated with an increased risk of stroke (including ischemic and hemorrhagic stroke).
INTERNATIONAL JOURNAL OF STROKE
(2021)
Review
Geriatrics & Gerontology
Qian Liu, Jinghuan Fang, Chaohua Cui, Shuju Dong, Lijie Gao, Jiajia Bao, Yanbo Li, Mengmeng Ma, Ning Chen, Li He
Summary: Increased aortic stiffness measured by aortic pulse wave velocity was found to be inversely associated with memory and processing speed, and could be an independent predictor for cognitive impairment risk, especially in older individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Geriatrics & Gerontology
Tai Anh Vu, Preeti Gupta, Felicia Z. Y. Leow, Eva K. Fenwick, Ryan E. K. Man, Yih-Chung Tham, Xin Xu, Debra Q. Y. Quek, Chaoxu Qian, Charumathi Sabanayagam, Christopher L. H. Chen, Tien Yin Wong, Ching-Yu Cheng, Ecosse L. Lamoureux
Summary: The study found that older adults with cognitive impairment had more than double the odds of developing visual impairment and poorer visual acuity over a 6-year period, with cataract and under-corrected refractive error being the leading causes of incident visual impairment.
Article
Cardiac & Cardiovascular Systems
Yinong Jiang, Aijun Xing, Tesfaldet Habtemariam Hidru, Jiatian Li, Xiaolei Yang, Shuohua Chen, Yun-Long Xia, Shouling Wu
Summary: This study aimed to investigate the association between increased arterial stiffness measured by baPWV and cancer occurrence. After following up with 45,627 Chinese adults for six years, it was found that individuals in the highest baPWV group had an increased risk of cancer, particularly digestive cancer.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Physiology
Alicia Saz-Lara, Ivan Cavero-Redondo, Vicente Martinez-Vizcaino, Maribel Luceron-Lucas-Torres, Carlos Pascual-Morena, Irese Sequi-Dominguez
Summary: This study evaluated the association between orthostatic hypotension and arterial stiffness. The results showed that increased arterial stiffness raises the risk of orthostatic hypotension by 40% among the adult population. Considering the close relationship between orthostatic hypotension and the risk of cardiovascular events, appropriate control of arterial stiffness could be a clinical strategy to prevent cardiovascular morbidity and mortality.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mandi Luo, Dan Yan, Xiaolu Liang, Yi Huang, Pengcheng Luo, Zhen Yang, Yucong Zhang, Ting Xu, Shangbang Gao, Le Zhang, Yiwu Zhou, Qing Shi, Cuntai Zhang, Lei Ruan
Summary: Arterial stiffness is the basis for cardiovascular diseases and its early detection and intervention are crucial for improving global burden of CVD. In this study, the researchers used quantitative proteomics to analyze plasma samples and found that fibulin-1 was significantly upregulated in individuals with high arterial stiffness, and it was positively correlated with arterial stiffness.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Madonna Salib, Arnaud Simon, Nicolas Girerd, Anna Kearney-Schwartz, Patrick Rossignol, Athanase Benetos, Luc Frimat, Sophie Girerd
Summary: The deterioration of arterial stiffness in the late post-transplantation period is associated with an increased risk of cardiovascular events, while early changes in pulse-wave velocity (PWV) are not significantly associated with cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Luca D'Onofrio, Rocco Amendolara, Carmen Mignogna, Gaetano Leto, Lida Tartaglione, Sandro Mazzaferro, Ernesto Maddaloni, Raffaella Buzzetti
Summary: This study evaluated CHIT activity as an early biomarker of arterial stiffness in T2D patients without overt vascular complications. The results showed no association between CHIT activity and arterial stiffness, but the high-PWV group had other CVD risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Brandon G. Fico, Kathleen B. Miller, Leonardo A. Rivera-Rivera, Adam T. Corkery, Andrew G. Pearson, Nicole A. Eisenmann, Anna J. Howery, Howard A. Rowley, Kevin M. Johnson, Sterling C. Johnson, Oliver Wieben, Jill N. Barnes
Summary: Age and aortic stiffness are significant predictors of cerebral artery pulsatility index in healthy adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Adrian Noriega de la Colina, Atef Badji, Maxime Lamarre-Cliche, Louis Bherer, Helene Girouard, Navin Kaushal
Summary: The study found that physical activity has beneficial effects on cognition in older adults, but its impact is moderated by the interaction of arterial stiffness and age. Physical activity has a positive effect on cognition when arterial stiffness is high and age is low, as well as when arterial stiffness is low and age is high. However, the effect of physical activity on cognition is limited when both arterial stiffness and age are high or when both are low.
JOURNAL OF HYPERTENSION
(2022)
Article
Psychiatry
Preeyaporn Srasuebkul, Adrian R. Walker, Rachael C. Cvejic, Julian N. Trollor, Julia M. Lappin, Jackie Curtis, Katherine Samaras, Kimberlie Dean, Philip B. Ward, Simone Reppermund
Summary: This study examines the differences in physical and mental comorbidities, as well as hospital service use patterns, among individuals diagnosed with different psychotic disorder subtypes. The findings reveal that these differences are heterogeneous. Targeted health policies are needed to meet the specific health needs of these patients.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Kate M. Chitty, Rachael C. Cvejic, Teresa Heintze, Preeyaporn Srasuebkul, Kirsten Morley, Andrew Dawson, Gregory Carter, Michael Dinh, Nicholas A. Buckley, Julian N. Trollor
Summary: This study investigated the association between problematic alcohol and/or drug use and the incidence of self-harm and suicidal ideation. The results showed that individuals with problematic alcohol use and drug use were more likely to have subsequent episodes of self-harm and suicidal ideation within a year. Problematic alcohol users were also more likely to be assigned to the most urgent triage categories.
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2023)
Article
Geriatrics & Gerontology
Annabel P. P. Matison, Anbupalam Thalamuthu, Victoria M. M. Flood, Julian N. N. Trollor, Vibeke S. S. Catts, Margaret J. J. Wright, David Ames, Henry Brodaty, Perminder S. S. Sachdev, Simone Reppermund, Karen A. A. Mather
Summary: Previous research suggests that a higher intake of fruits and vegetables may protect against depression in older adults. This study aims to estimate the genetic and environmental influences on fruit and vegetable consumption in older adults, and explore the potential shared genetic influences on consumption and depression.
Article
Geriatrics & Gerontology
Maud Hevink, Claire Wolfs, Rudolf Ponds, Shelley Doucet, Carrie McAiney, Isabelle Vedel, Maria Mackowiak, Joanna Rymaszewska, Greta Rait, Louise Robinson, Marie Poole, Meredith Gresham, Yun-Hee Jeon, Lyn Phillipson, Lee-Fay Low, Henry Brodaty, Marjolein de Vugt, Frans Verhey
Summary: This study aims to describe the experiences of people with dementia and informal caregivers in receiving support after diagnosis, and compare these experiences. The study finds that there are differences in support experiences between satisfied and dissatisfied individuals.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Psychology, Clinical
Thanwarat Chantanachai, Daina L. Sturnieks, Stephen R. Lord, Jasmine Menant, Kim Delbaere, Perminder S. Sachdev, Henry Brodaty, Peter Humburg, Morag E. Taylor
Summary: This study examined longitudinal changes in cognitive and physical function, as well as the associations between these changes and falls in people with and without mild cognitive impairment (MCI). The results showed that the MCI and cognitively fluctuating groups experienced declines in cognitive function, while the cognitively normal group did not. The MCI group had worse physical function at baseline but similar decline over time compared to other groups. Decline in global cognitive function and sensorimotor performance were associated with multiple falls in the cognitively normal group, and decline in mobility was associated with falls in the entire sample. Therefore, exercise should be recommended for maintaining physical function in older adults, and interventions aimed at mitigating cognitive decline should be encouraged for people with MCI.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Psychology, Clinical
Shafi Kalam, Katya Numbers, Darren M. Lipnicki, Ben C. P. Lam, Henry Brodaty, Simone Reppermund
Summary: This study investigated the associations between olfactory dysfunction and depression with dementia risk in older adults. The results showed that both factors independently predicted incident dementia over 12 years, and using both olfactory function testing and depression screening improved the ability to predict dementia.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Cailen J. Calkin, Katya Numbers, Henry Brodaty, Perminder S. Sachdev, Oleg N. Medvedev
Summary: This study examined the psychometric properties of the K-10 scale in older populations using Rasch methodology. After minor modifications, the K-10 demonstrated good measurement properties and allowed for the transformation of raw scores into interval-level data, increasing its reliability.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Gerontology
Issra Allam, Meredith Gresham, Lyn Phillipson, Henry Brodaty, Lee-Fay Low
Summary: This study aims to understand the perceptions of dementia symptoms, help-seeking and support in the Australian Arabic-speaking community. By conducting qualitative interviews, seven themes were identified. Dementia was described as confusion and memory loss symptoms. Barriers to help-seeking and support included cultural norms, lack of knowledge on where to seek help, and fear of community judgement. Building trust through culturally appropriate support and educating the community are two ways to facilitate help-seeking and support.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Article
Rehabilitation
Jacky Zheng, Meredith Gresham, Lyn Phillipson, Danika Hall, Yun-Hee Jeon, Henry Brodaty, Lee-Fay Low
Summary: This study examines the usability, usefulness, and user experience of the Forward with Dementia website for individuals with dementia and family caregivers. It also identifies strategies to improve web design for this population. The website was tested by 12 participants, and data collection involved observations, interviews, and questionnaires. Findings suggest that simplifying functions, streamlining navigation, and decluttering page layouts were effective strategies to improve the website's usability and user experience. The study highlights the importance of dementia-related websites in providing information and assistance to individuals managing dementia.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Psychology, Developmental
Princess Neila Litkouhi, Katya Numbers, Michael Valenzuela, John D. Crawford, Ben C. P. Lam, Princess Noosha Litkouhi, Perminder S. Sachdev, Nicole A. Kochan, Henry Brodaty
Summary: Cognitive, social, and physical activities, especially during young adulthood, are associated with better late-life cognitive outcomes. Formal education plays a significant role in the relationship between young adulthood cognitive activity and late-life global cognition.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Article
Medicine, Research & Experimental
Carmela Salomon, Jessica Bellamy, Elizabeth Evans, Renae Reid, Michelle Hsu, Scott Teasdale, Julian Trollor
Summary: This study aimed to assess the feasibility and preliminary efficacy of a tailored healthy lifestyle intervention for individuals with intellectual disabilities (ID). The results showed that the intervention was feasible and well received by the participants, and it had the potential to positively impact important cardiometabolic risk factors such as waist circumference, cardiovascular fitness, and physical strength. However, some data collection instruments need modification or replacement before conducting a larger study.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Psychology, Clinical
Amanda L. Richdale, Lauren P. Lawson, Alexa Chalmers, Mirko Uljarevic, Eric M. J. Morris, Samuel R. C. Arnold, Julian N. Trollor
Summary: Individuals with autism commonly experience anxiety and depression. This study explored the relationships between anxiety, depression, autistic traits, insomnia, intolerance of uncertainty, sensory sensitivities, and autonomic arousal in autistic individuals. The results showed multiple pathways to anxiety and depression, suggesting the need for careful evaluation and individualized treatment plans for autistic adults with these mental health conditions. Prevention programs focusing on reducing arousal, maintaining good sleep, and reducing intolerance of uncertainty may be beneficial for autistic adults.
DEPRESSION AND ANXIETY
(2023)
Article
Cell Biology
Rodrigo Cataldi, Perminder S. Sachdev, Neerja Chowdhary, Katrin Seeher, Adam Bentvelzen, Vasee Moorthy, Tarun Dua
Summary: The WHO blueprint for dementia research is a guide for addressing challenges and reshaping the approach to dementia research. This Comment focuses on operationalizing the research drivers highlighted in the blueprint to ensure equity, impact, and global reach.
Review
Geriatrics & Gerontology
Alice Powell, Zara A. Page, Jacqueline C. T. Close, Perminder S. Sachdev, Henry Brodaty
Summary: A consistent approach to defining cognitive super-ageing is needed to increase the value of research insights that may be gained from studying this population including ageing well and preventing and treating neurodegenerative conditions. This review aims to evaluate the existing definitions of 'super-ageing' with a focus on cognition.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Eric L. Stulberg, Perminder S. Sachdev, Anne M. Murray, Steven C. Cramer, Farzaneh A. Sorond, Kamakshi Lakshminarayan, Behnam Sabayan
Summary: This study provides a narrative review on post-stroke brain health, defining and evaluating it based on literature databases. Clinical recommendations for monitoring and managing post-stroke brain health are presented, as well as potential future work in the field.
JOURNAL OF CLINICAL MEDICINE
(2023)