Review
Biotechnology & Applied Microbiology
Chaofan Zhang, Yunzhi Lin, Chun Hoi Yan, Wenming Zhang
Summary: This review discusses the role of adipokines in obesity-induced osteoarthritis and highlights potential signaling pathways. Adipokines play important roles in regulating inflammation, matrix remodeling, and cell apoptosis. Pharmaceutical interventions targeting these pathways have shown promising results. However, further research is needed to understand the complexity and interactions of these pathways.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiyi Chen, Yujie Dong, Jie Yan, Lan Wang, Shirley Yu, Kangwei Jiao, Francois Paquet-Durand
Summary: This study systematically mapped the transcriptional changes that occur in the degenerating mouse retina at the single cell level using single-cell RNA-sequencing. The results highlight the relevance of Ca2+-signaling and metabolic pathways to hereditary photoreceptor degeneration, and suggest that metabolic changes in rd1 mutation may be regulated through the MAPK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Pavel Tregub, Natalia Malinovskaya, Elena Hilazheva, Andrey Morgun, Vladimir Kulikov
Summary: In this study, we aimed to investigate the effects of hypercapnia, alone or in combination with hypoxia, on the activation of signaling pathways related to cell apoptosis. The degree of apoptosis was evaluated in both in vivo and in vitro ischemic models. The results showed that hypercapnic component can reduce apoptosis in the ischemic penumbra, decrease the levels of caspase-3, AIF, and Bax, and increase the level of Bcl-2.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nuttapong Yawoot, Wijitra Chumboatong, Jirakhamon Sengking, Chainarong Tocharus, Jiraporn Tocharus
Summary: This study aimed to investigate the impact of high-fat diet consumption on ischemic stroke and found that it exacerbates pyroptotic and necroptotic cell death, leading to poor post-stroke outcomes.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Qing Zhang, Lu Wang, Shiqi Wang, Hongxin Cheng, Lin Xu, Gaiqin Pei, Yang Wang, Chenying Fu, Yangfu Jiang, Chengqi He, Quan Wei
Summary: Myocardial infarction (MI) remains a global disease with high morbidity and mortality rates. Therapeutic strategies targeting signaling pathways involved in inflammation, oxidative stress, fibrosis, and angiogenesis have emerged to inhibit cardiomyocyte death, attenuate inflammation, and enhance angiogenesis in order to repair damaged hearts.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Hao Sun, Fangzhou Liu, Zhencan Lin, Zongrui Jiang, Xingzhao Wen, Jie Xu, Zhiqi Zhang, Ruofan Ma
Summary: This study discovers the initiation of meniscus fibrosis in humans at 24 weeks of embryogenesis. Smooth muscle cell clusters are found in the embryonic meniscus, which are proposed to be precursors of progenitor cells in the mature meniscus. The expression of NOTCH3 in smooth muscle cells is identified throughout embryogenesis to adulthood. Inhibition of NOTCH3 signaling inhibits meniscus fibrosis and exacerbates degeneration, indicating its potential as a therapeutic target.
Article
Medicine, Research & Experimental
Jian Zhou, Yang Zhao, Ya-Jing Guo, Ya-Shuo Zhao, Han Liu, Jing Ren, Jie-Ru Li, En-Sheng Ji
Summary: This study established a rapid juvenile murine NASH model and found that the combination of CIH and a western-style diet can fully display key pathologic features of NASH.
Article
Biochemistry & Molecular Biology
Zuhair M. Mohammedsaleh, Emad H. M. Hassanein, Fares E. M. Ali, Hanan S. Althagafy, Nouf S. Al-Abbas, Ahmed M. Atwa
Summary: The study shows that Perindopril can mitigate the kidney damage caused by cadmium exposure. It achieves this by modulating inflammation, Ang II/Ang 1-7 axis, and apoptosis signals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Fan Liu, Yali Di, Wei Ma, Xiaoli Kang, Xia Li, Zheng Ji
Summary: This study found that the expression of histone deacetylase 9 (HDAC9) is upregulated during the development of myocardial infarction (MI). Downregulation of HDAC9 can change heart function and activate the Nrf2/Keap1/HO-1 pathway. Additionally, the HDAC9/Nrf2 axis also affects the proliferation, apoptosis, and myogenesis of cardiomyocytes. Therefore, the HDAC9/Nrf2 axis may serve as a novel marker for the treatment of MI.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Wang, Rongjun Wan, Chengping Hu
Summary: This study found that obesity-related neutrophilic airway inflammation in asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. The research revealed that leptin/obR signaling plays an important role in the pathogenesis of obesity-related neutrophilic airway inflammation.
MOLECULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sarah Kim, Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken, Frank J. Gonzalez, Julia Yue Cui, Maxwell A. Gyamfi
Summary: The study found that the presence of PXR exacerbates hepatic steatosis and inflammation, especially in males, with a gut microbiome signature prone to obesity and inflammation. This suggests that the gut microbiome may contribute to the exacerbation of NAFLD by PXR.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kendra L. Francis, Kimberly M. Alonge, Maria Cristina Pacheco, Shannon J. Hu, Cody A. Krutzsch, Gregory J. Morton, Michael W. Schwartz, Jarrad M. Scarlett
Summary: This study found that diabetes worsened clinical and histopathologic outcomes of colitis in mice with diet-induced obesity, possibly due to hyperglycemia-induced intestinal barrier dysfunction. These findings suggest that effective diabetes management may decrease the clinical severity of inflammatory bowel disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Urology & Nephrology
David Z. I. Cherney, Francesco Cosentino, Samuel Dagogo-Jack, Darren K. McGuire, Richard Pratley, Robert Frederich, Mario Maldonado, Chih-Chin Liu, Jie Liu, Annpey Pong, Christopher P. Cannon
Summary: The study compared the effects of ertugliflozin and placebo on eGFR slope in patients with type 2 diabetes mellitus, showing that ertugliflozin preserved kidney function and slowed down kidney disease progression. The results demonstrated the favorable impact of ertugliflozin on eGFR slope, indicating potential clinical benefits for patients with type 2 diabetes and atherosclerotic cardiovascular disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Surgery
Donna S-H Lin, Hao-Yun Lo, An-Li Yu, Jen-Kuang Lee, Wei-Shiung Yang, Juey-Jen Hwang
Summary: The study showed that higher BMI values in patients with PAD are associated with lower all-cause mortality risk, with this relationship being more pronounced in long-term survival and less apparent in short-term mortality and patients receiving endovascular therapy.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Endocrinology & Metabolism
Ping-Huei Tseng, Chi-Sheng Hung, Chia-Hung Tu, Chien-Chuan Chen, Wan-Chung Liao, Yi-Chia Lee, Han-Mo Chiu, Wei-Shiung Yang, Ming-Shiang Wu
Summary: The study found that higher levels of plasma hemoglobin A1c (HbA1c) are associated with a higher risk of gastrointestinal disorders, particularly acid-related upper GI disorders. Efforts to improve glycemic control may help prevent the development of such complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Yi-Chia Lee, Ying-Ting Chao, Pei-Ju Lin, Yen-Yun Yang, Yu-Cih Yang, Cheng-Chieh Chu, Yu -Chun Wang, Chin-Hao Chang, Shu-Lin Chuang, Wei -Chun Chen, Hsing-Jen Sun, Hsin-Cheng Tsou, Cheng-Fu Chou, Wei-Shiung Yang
Summary: This study explores the need for creating medical big data based on electronic health records and proposes a method for identifying and correcting errors during data transmission. It highlights the importance of systematic validation and the use of primary keys for error detection.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Clinical Neurology
Ping-Huei Tseng, Chi-Chao Chao, Ya-Yin Cheng, Chieh-Chang Chen, Ping-Hao Yang, Wei-Kang Yang, Shao-Wei Wu, Yen-Wen Wu, Mei-Fang Cheng, Wei-Shiung Yang, Ming-Shiang Wu, Sung-Tsang Hsieh
Summary: This study quantitatively examined the gastric mucosal innervation density (MID) and its relationship with gastroparesis symptoms and gastric emptying in patients with diabetes. The study found that the gastric MID in patients with diabetes was significantly lower compared to healthy controls, and this reduction was correlated with gastroparesis symptoms and glycemic control. The study also showed prolonged gastric emptying in patients with diabetes. These findings provide important pathology and functional biomarkers for diabetic gastroparesis and shed light on the underlying pathophysiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Wei-Shiung Yang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Tong-Yuan Tai, Chi-Ling Chen, Keh-Song Tsai, Shih-Te Tu, Jin-Shang Wu, Wei-Shiung Yang
Summary: This study investigated the relationship between serum adiponectin levels and the bone mineral density (BMD) of proximal femur and vertebrae bones. The results showed that an increase in adiponectin levels was associated with a decline in proximal femur BMD.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Yuan-Ping Chao, Wen-Hui Fang, Wei-Liang Chen, Tao-Chun Peng, Wei-Shiung Yang, Tung-Wei Kao
Summary: Age-related decline in muscle mass and function is a critical issue for the health of older adults. This study observed the natural progression of muscle health and found that age, fat-to-muscle ratio, and serum albumin level were associated with the risk of dynapenia.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Wan-Chen Wu, Kang-Yung Peng, Jin-Ying Lu, Chieh-Kai Chan, Chih-Yuan Wang, Fen-Yu Tseng, Wei-Shiung Yang, Yen-Hung Lin, Po-Chih Lin, Ting-Chu Chen, Kuo-How Huang, Jeff S. Chueh, Vin-Cent Wu
Summary: The study found that CPA-related mutations were detected in 36.7% of uPA/ACS adenomas. The presence of these mutations was associated with higher post-DST cortisol levels, larger adenoma sizes, and a high percentage of non-classical uPA. However, these mutations did not significantly affect the clinical and biochemical outcomes after adrenalectomy of uPA/ACS patients but they showed a better trend.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Immunology
Mao-Jan Lin, Yu-Chun Lin, Nae-Chyun Chen, Allen Chilun Luo, Sheng-Kai Lai, Chia-Lang Hsu, Jacob Shujui Hsu, Chien-Yu Chen, Wei-Shiung Yang, Pei-Lung Chen
Summary: The study of adaptive immune receptor repertoire (AIRR) is crucial for understanding adaptive immune responses. The authors developed the gAIRR Suite, which includes three modules: gAIRR-seq, gAIRR-call, and gAIRR-annotate. Using this suite, they were able to accurately profile and annotate the germline genes encoding AIRR, leading to the discovery of new alleles and comparison of gene differences across genomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Chia-Jung Lee, Ting-Huei Chen, Aylwin Ming Wee Lim, Chien-Ching Chang, Jia-Jyun Sie, Pei-Lung Chen, Su-Wei Chang, Shang-Jung Wu, Chia-Lin Hsu, Ai-Ru Hsieh, Wei-Shiung Yang, Cathy S. J. Fann
Summary: This study conducted a comprehensive PheWAS to identify genetic loci associated with specific diseases and traits in the Taiwanese population, contributing to a better understanding of complex diseases and genetic pleiotropy. The findings were further supported by transcriptomics data, enhancing the relevance to metabolic disorders. Additionally, genetic risk scores were developed for predicting the absolute risk of type 2 diabetes in the Taiwanese population.
COMMUNICATIONS BIOLOGY
(2022)
Article
Medical Laboratory Technology
Jiun-Yang Chiang, Lin Lin, Chih-Cheng Wu, Juey-Jen Hwang, Wei-Shiung Yang, Yen-Wen Wu
Summary: This study found that serum levels of myostatin were positively correlated with myocardial scar burden, suggesting it may be a predictor of myocardial scarring.
CLINICA CHIMICA ACTA
(2022)
Article
Endocrinology & Metabolism
Hung-Ju Lin, Jui Wang, Po-Yuan Tseng, Li-Chen Fu, Yi-Chia Lee, Ming-Shiang Wu, Wei-Shiung Yang, Han-Mo Chiu
Summary: Lower glycemic levels than currently accepted could lead to optimal risk reduction of incident diabetes among individuals with prediabetes, highlighting the importance of stringent glycemic management for diabetes prevention.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Ming-Kuem Lin, Ya-Ting Yang, Li-Jen Lin, Wei-Hsuan Yu, Huan-Yuan Chen
Summary: The study found that Pulsatilla decoction can attenuate intestinal inflammation and decrease the infiltration of innate immune cells in the colon by suppressing the expression of matrix metalloproteinase-7 (MMP-7).
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)