Article
Plant Sciences
Wenfeng Li, Yuanshen Mao, Bao Hua, Xin Gu, Chao Lu, Bin Xu, Weixin Pan
Summary: SQS inhibited EMT in PC by regulating the PI3K/Akt/mTOR and Smad pathways.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jaroon Wandee, Piyarat Srinontong, Auemduan Prawan, Laddawan Senggunprai, Sarinya Kongpetch, Chavi Yenjai, Veerapol Kukongviriyapan
Summary: Derrischalcone (DC) demonstrated cytotoxic, anti-proliferative, anti-migration, and anti-invasion effects on CCA cells through inducing apoptosis, inhibiting cell proliferation, and suppressing cell migration and invasion by modulating ROS formation and the Akt/mTOR/cyclin D1 and FAK signaling pathways. These findings suggest that DC may be a promising novel treatment strategy for cancer therapy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Xiao-Li Li, Xiu-Xiu Zhang, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Carlos L. Cespedes-Acuna, Jian-Guo Zhang, Zhao -Jun Wei
Summary: This study investigated the efficacy of PS on proliferation and migration of Endometrial carcinoma cells. Through experiments using xenograft model and Ishikawa cells, the potential molecular mechanism of dioscin was explored. The results showed that dioscin inhibited Ishikawa cell migration and invasion through the MEK/ERK and JNK signaling pathways. Hub miRNAs and genes identified in this study could be potential molecular targets for future EC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Summary: This study found that notopterol can inhibit the IL-17-induced proliferation and invasion of A549 lung adenocarcinoma cells by suppressing the activation of the MAPK, Akt, STAT3, AP-1, and NF-kappa B signaling pathways, as well as modulating EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Environmental Sciences
Xujun Liu, Tingjie Zhan, Yuchen Gao, Shixuan Cui, Weiping Liu, Chunlong Zhang, Shulin Zhuang
Summary: The study found that benzophenone-1 (BP-1) disrupts estrogen receptor (ER) alpha signaling pathways at environmentally relevant concentrations, triggering abnormal activation and progression of SKOV3 ovarian cancer cells.
ENVIRONMENTAL POLLUTION
(2022)
Article
Oncology
Guifang Jing, Fang Yu, Huandong Xue
Summary: This study found that tepotinib can inhibit the proliferation, invasion, and migration of melanoma cells, and induce their apoptosis. These findings may provide a new treatment approach for improving malignant melanoma.
Article
Pharmacology & Pharmacy
Haima Li, Jia Ouyang, Ruen Liu
Summary: The study demonstrated that Platycodin D (PD) suppresses glioma development by regulating the expression of S phase kinase-related protein 2 (Skp2) in GBM cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Malgorzata Brindell, Ilona Gurgul, Ewelina Janczy-Cempa, Przemyslaw Gajda-Morszewski, Olga Mazuryk
Summary: Research on Ru polypyridyl complexes for anticancer activity has shifted towards evaluating their potential as metastasis inhibitors, with a focus on identifying target proteins and understanding their impact on cell migration, invasion, and adhesion, key components of metastasis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Cell Biology
Canhua Huang, Qian Hao, Getao Shi, Xiang Zhou, Yu Zhang
Summary: BCL7C plays a tumor-suppressive role in ovarian cancer by inhibiting mutant p53 activity, leading to decreased cell proliferation and invasion in cancer cells. Low levels of BCL7C are associated with poor prognosis in ovarian cancer, suggesting its potential as a therapeutic target.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xian Tang, Qing Li, Lijie Li, Jianfa Jiang
Summary: The study found that Talin-1 expression was significantly increased in the ectopic and eutopic endometrial tissues of patients with endometriosis, but its downregulation did not affect the proliferation and apoptosis of ESCs. However, the downregulation of Talin-1 inhibited the adhesion, invasion, and migration of ESCs, leading to a significant decrease in the expression of N-cadherin, MMP-2, and integrin beta 3, while the levels of E-cadherin were significantly increased.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ning Zhu, Xiu-juan Zhang, Hai Zou, Yuan-yuan Zhang, Jing-wen Xia, Peng Zhang, You-zhi Zhang, Jing Li, Liang Dong, Gulinuer Wumaier, Sheng-qing Li
Summary: The study revealed that PTPL1 plays a suppressive role in tumorigenesis and metastasis of non-small cell lung cancer (NSCLC) by counteracting the activation of Smad2/3 and p38 MAPK signaling pathways induced by TGF-beta. This has implications for the prognostic assessment and targeted therapy of metastatic lung cancer.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
R. J. Lurvink, L. Villeneuve, K. Govaerts, I. H. J. T. de Hingh, B. J. Moran, M. Deraco, K. Van der Speeten, O. Glehen, V Kepenekian, S. Kusamura
Summary: The article discusses the consensus statement creation process for PMP and PM, using the Delphi technique and GRADE methodology to reach consensus on treatment strategies among an international panel of experts.
Article
Oncology
S. J. Valle, J. Akhter, A. H. Mekkawy, S. Lodh, K. Pillai, S. Badar, D. Glenn, M. Power, W. Liauw, D. L. Morris
Summary: The study on using BromAc to treat mucinous peritoneal tumors showed manageable safety and some treatment-related adverse events, but no serious allergic reactions or deaths due to treatment. The treatment demonstrated significant objective response to the disease.
Review
Oncology
Sajad Fakhri, Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Hossein Pourgholami
Summary: Angiogenesis plays a critical role in cancer progression, regulated by drugs and natural compounds. Herbal and natural compounds show potential in inhibiting VEGF and angiogenesis for developing novel anticancer drugs.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Editorial Material
Surgery
Abbas El-Hajj Hussein, Joshua D. Lansom, Nayef A. Alzahrani, David L. Morris
ANZ JOURNAL OF SURGERY
(2021)
Article
Oncology
Raphael Shamavonian, Joshua D. Lansom, Josh B. Karpes, Nayef A. Alzahrani, David L. Morris
Summary: This study found that the presence of signet ring cell (SRC) in appendix cancer with peritoneal dissemination is associated with worse overall survival (OS) when compared to patients without SRC undergoing CRS/HIPEC. An increase in SRC count is negatively correlated with overall survival rate.
Article
Pharmacology & Pharmacy
Fatemeh Mahboobifard, Leila Dargahi, Masoumeh Jorjani, Fahimeh Ramezani Tehrani, Mohammad H. Pourgholami
Summary: ER alpha 36, a newly identified isoform of estrogen receptor, is highly expressed in the CNS and plays a role in neuroprotection, as well as maintaining bone density in postmenopausal women. Despite being considered an oncogenic molecule, ER alpha 36 paradoxically may have a protective role in certain tumors according to some studies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Virology
Javed Akhter, Gregory Queromes, Krishna Pillai, Vahan Kepenekian, Samina Badar, Ahmed H. Mekkawy, Emilie Frobert, Sarah J. Valle, David L. Morris
Summary: The study demonstrates that BromAc disrupts the spike and envelope proteins of SARS-CoV-2, reducing infectivity in host cells. This treatment shows potential for imminent clinical testing in patients with early SARS-CoV-2 infection.
Article
Surgery
Shigeki Kusamura, Francesco Barretta, Yutaka Yonemura, Paul Hendrick Sugarbaker, Brendan John Moran, Edward A. Levine, Diane Goere, Dario Baratti, Eran Nizri, David Lawson Morris, Olivier Glehen, Armando Sardi, Pedro Barrios, Francois Quenet, Laurent Villeneuve, Alberto Gomez-Portilla, Ignace de Hingh, Wim Ceelen, Joerg O. W. Pelz, Pompiliu Piso, Santiago Gonzalez-Moreno, Kurt van der Speeten, Marcello Deraco
Summary: This cohort study compared outcomes between PMP patients undergoing CRS with HIPEC and CRS alone, finding HIPEC to be associated with improved overall survival.
Article
Chemistry, Multidisciplinary
Carly J. Carter, Krishna Pillai, Samina Badar, Ahmed H. Mekkawy, Javed Akhter, Thomas Jefferies, Sarah J. Valle, David L. Morris
Summary: The study found that the combination of Bromelain and NAC, known as BromAc, had good dissolution efficacy rates of 80% and above on biofilms produced by three strains of Pseudomonas aeruginosa. The combination exhibited significant impact on all three strains, with Bromelain degrading biofilms more effectively while NAC showed growth enhancement in two strains. The results suggest that BromAc may be a promising treatment option for eradicating biofilms formed by Pseudomonas aeruginosa strains.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Ahmed H. Mekkawy, Mohammad Breakeit, Krishna Pillai, Samina Badar, Javed Akhter, Sarah J. Valle, David L. Morris
Summary: The study investigated the effect of intraperitoneal delivery of BromAc((R)) on colon-anastomosis healing in rats. The results showed that the rats treated with BromAc((R)) did not experience any interference with the healing process. The burst pressure and collagen density in the BromAc((R)) group were slightly higher compared to the control group, although not statistically significant.
Article
Respiratory System
Krishna Pillai, Ahmed H. H. Mekkawy, Javed Akhter, David L. L. Morris
Summary: In this study, the efficacy of BromAc as a mucolytic agent was tested on two gelatinous sputa models. The results showed that BromAc improved the viscosity and flow of the sputum, and had a greater effect compared to individual agents. Therefore, BromAc may be used as an effective mucolytic for clearing airway congestion caused by thick mucinous secretions.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
Article
Oncology
Kevin Ke, Krishna Pillai, Ahmed H. Mekkawy, Javed Akhter, Samina Badar, Sarah J. Valle, David L. Morris
Summary: A phase 1 clinical trial of intraperitoneal BromAc for pseudomyxoma peritonei is currently ongoing, with routine blood parameter analysis of 25 patients revealing elevated inflammatory markers and decreased serum albumin levels post-treatment, suggesting an inflammatory response. However, liver enzymes, coagulation studies, and other parameters remained unaffected, indicating no additional safety concerns were identified through routine blood parameter testing.
Article
Oncology
Farnaz Bahrami, Ahmed H. Mekkawy, Samina Badar, David L. Morris, Mohammad H. Pourgholami
Summary: Epithelial ovarian cancer is the leading cause of gynaecological malignancy-related deaths in women. Research has shown that MPL has potential as an anticancer drug by effectively suppressing growth and proliferation of ovarian cancer cells through inhibition of the mTOR/p70S6K pathway. Further studies are needed to explore the full potential of MPL in cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Samina Badar, Mohamed Azarkan, Ahmed H. Mekkawy, Javed Akhter, Krishna Pillai, Rachida El Mahyaoui, Kevin Ke, Lauren Cavanaugh, David L. Morris
Summary: This study examined the proteolytic, anticancer, and antithrombotic properties of four fractions of bromelain, finding that fraction 3 exhibited the highest activity in various aspects, especially in terms of cytotoxicity. Combination of fraction 3 with various drugs also showed better results.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Ahmed H. Mekkawy, Krishna Pillai, Samina Badar, Javed Akhter, Kevin Ke, Sarah J. Valle, David L. Morris
Summary: The combination of BromAc (R) with Gemcitabine showed potential efficacy and safety in treating colorectal cancer, while preliminary efficacy studies with Oxaliplatin and 5-Fluorouracil were negative. The study indicates that Gemcitabine in combination with BromAc (R) may have a role in future clinical applications.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)