Article
Nutrition & Dietetics
Bojung Seo, Keming Yang, Ka Kahe, Abrar A. Qureshi, Andrew T. Chan, Immaculata De Vivo, Eunyoung Cho, Edward L. Giovannucci, Hongmei Nan
Summary: This study suggests that higher intakes of DHA and consumption of canned tuna are associated with longer leukocyte telomere length (LTL) in US males.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Article
Pharmacology & Pharmacy
Elias Marlin, Miguel Valencia, Nuria Peregrin, Roberto Ferrero, Maria Jesus Nicolas, Rodrigo Vinueza-Gavilanes, Antonio Pineda-Lucena, Julio Artieda, Montserrat Arrasate, Tomas Aragon
Summary: In this study, two eIF2B activators, 2BAct and PRXS571, were found to anticipate disease onset in SOD1G93A mice, exacerbating muscle denervation and motor neuronal death. The compounds relieved translational inhibition imposed by ISR while maintaining high ATF4 levels in primary neurons. The findings suggest that ISR may function as a neuroprotective pathway in ALS motor neurons, but caution on the potential toxicity of eIF2B activators in ALS patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Lena Stiefvatter, Katja Lehnert, Konstantin Frick, Alexander Montoya-Arroyo, Jan Frank, Walter Vetter, Ulrike Schmid-Staiger, Stephan C. Bischoff
Summary: The microalgae Phaeodactylum tricornutum (PT) is a valuable source of nutrients such as proteins, polyunsaturated omega-3 fatty acids (n-3 PUFA), particularly eicosapentaenoic acid (EPA), carotenoids like fucoxanthin (FX), and beta-glucans. Intake of PT leads to an increase in n-3 PUFA and EPA levels, while also decreasing the n-6:n-3 ratio in plasma. The study shows that PT is a safe and effective source of EPA and other nutrients, suggesting its potential as a sustainable food source.
Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Safi U. Khan, Ahmad N. Lone, Muhammad Shahzeb Khan, Salim S. Virani, Roger S. Blumenthal, Khurram Nasir, Michael Miller, Erin D. Michos, Christie M. Ballantyne, William E. Boden, Deepak L. Bhatt
Summary: Omega-3 fatty acids reduce cardiovascular mortality and improve cardiovascular outcomes, with higher efficacy observed with EPA monotherapy compared to EPA+DHA combination therapy.
Article
Sport Sciences
Jon-Kyle Davis, Eric C. Freese, Anthony S. Wolfe, Steven A. Basham, Kimberly M. W. Stein
Summary: The study evaluated the omega-3 PUFA blood concentrations, dietary, and supplement intake of 119 professional basketball players, with many players having insufficient fish consumption per week and only a few players supplementing with omega-3 PUFA.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Review
Nutrition & Dietetics
Meghan Dempsey, Michelle S. Rockwell, Laurel M. Wentz
Summary: The majority of the population lack adequate omega-3 fatty acids (n-3 FA), leading to global deficiencies and poor omega-3 status. This study aimed to evaluate the effect of n-3 FA interventions on omega3-index (O3i) and estimate sufficient intake to meet recommendations.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Juan Li, Meiru Mao, Jiacheng Li, Ziteng Chen, Ying Ji, Jianglong Kong, Zhijie Wang, Jiaxin Zhang, Yujiao Wang, Wei Liang, Haojun Liang, Linwen Lv, Qiuyang Liu, Ruyu Yan, Hui Yuan, Kui Chen, Yanan Chang, Guogang Chen, Gengmei Xing
Summary: This study assessed the effects of omega-3 fatty acids on alleviating inflammation and lung injury induced by PM2.5 inhalation exposure. It was found that oral administration of DHA and EPA effectively restored normal inflammatory cytokine levels and reduced lung parenchymal lesions in mice exposed to PM2.5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenjia Gu, John M. M. Kavanagh, Dale D. D. McClure
Summary: There is an increasing demand for sustainable sources of omega-3 fatty acids, and microalgae can be used to produce eicosapentaenoic acid (EPA) on a large scale. The choice of suitable strains is crucial for successful production. However, findings from small-scale systems do not always translate to larger photobioreactors. In this study, the productivity and fatty acid composition of eleven microalgal strains were examined in both flask and photobioreactor cultures. The results showed that predictions based on flask screening were not accurate for photobioreactors, highlighting the need for improved screening tools. Among the species tested, Phaeodactylum tricornutum showed the most potential when grown in photobioreactors. The study also investigated the impact of environmental conditions (temperature and salinity) on EPA production and found that EPA content remained relatively constant within the tested temperature and salinity ranges. Finally, nutritional information about the biomass was provided, which can be used as a starting point for formulating food products.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Nutrition & Dietetics
Martin E. Reiner, Philipp Baumgartner, Andrea Wiencierz, Michael Coslovsky, Nicole R. Bonetti, Mark G. Filipovic, Giulia Montrasio, Stefanie Aeschbacher, Nicolas Rodondi, Oliver Baretella, Michael Kuehne, Giorgio Moschovitis, Pascal Meyre, Leo H. Bonati, Thomas F. Luescher, Giovanni G. Camici, Stefan Osswald, David Conen, Juerg H. Beer
Summary: The study showed that EPA and DPA were associated with large noncortical or cortical infarcts (LNCCIs) in patients with atrial fibrillation, with EPA negatively correlated and DPA positively correlated with LNCCIs. However, there was no significant correlation between EPA and DPA with markers of small vessel disease in atrial fibrillation patients.
Article
Biochemistry & Molecular Biology
Kiwako Mori, Sayoko Kuroha, Jing Hou, Heonuk Jeong, Mamoru Ogawa, Shin-ichi Ikeda, Jing X. Kang, Kazuno Negishi, Hidemasa Torii, Makoto Arita, Toshihide Kurihara, Kazuo Tsubota
Summary: This study demonstrates the inhibitory effect of n-3 polyunsaturated fatty acids (PUFAs) on the progression of myopia and its association with choroidal thinning.
Article
Cardiac & Cardiovascular Systems
Kevin C. Maki, Harold E. Bays, Christie M. Ballantyne, James A. Underberg, John J. P. Kastelein, Judith B. Johnson, James J. Ferguson
Summary: This study compared the efficacy and plasma fatty acid levels of EPA+DPA-FFA and EPA-EE in hypertriglyceridemic patients. The results showed that EPA+DPA-FFA significantly improved plasma levels of EPA, DPA, and total omega-3, while reducing triglycerides and high-sensitivity C-reactive protein without increasing low-density lipoprotein cholesterol.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Neurosciences
Alessia Loffreda, Monica Nizzardo, Alessandro Arosio, Marc-David Ruepp, Raffaele A. Calogero, Stefano Volinia, Marco Galasso, Caterina Bendotti, Carlo Ferrarese, Christian Lunetta, Mafalda Rizzuti, Antonella E. Ronchi, Oliver Muhlemann, Lucio Tremolizzo, Stefania Corti, Silvia M. L. Barabino
PROGRESS IN NEUROBIOLOGY
(2020)
Article
Cell Biology
Marco Ceccanti, Valeria Pozzilli, Chiara Cambieri, Laura Libonati, Emanuela Onesti, Vittorio Frasca, Ilenia Fiorini, Antonio Petrucci, Matteo Garibaldi, Eleonora Palma, Caterina Bendotti, Paola Fabbrizio, Maria Chiara Trolese, Giovanni Nardo, Maurizio Inghilleri
Review
Clinical Neurology
Caterina Bendotti, Valentina Bonetto, Elisabetta Pupillo, Giancarlo Logroscino, Ammar Al-Chalabi, Christian Lunetta, Nilo Riva, Gabriela Mora, Giuseppe Lauria, Jochen H. Weishaupt, Federica Agosta, Andrea Malaspina, Manuela Basso, Linda Greensmith, Ludo van den Bosch, Antonia Ratti, Massimo Corbo, Orla Hardiman, Adriano Chio, Vincenzo Silani, Ettore Beghi
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2020)
Article
Nutrition & Dietetics
I. Nessel, M. Khashu, S. C. Dyall
Summary: The study found that storage conditions of preterm formula milk do not support in utero accretion rates for LCPUFAs. Although it is clear that powdered formula is more susceptible to lipid peroxidation during refrigeration, specific recommendations still require further research.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2021)
Article
Medicine, General & Internal
Maria Chiara Trolese, Alessandro Mariani, Mineko Terao, Massimiliano de Paola, Paola Fabbrizio, Francesca Sironi, Mami Kurosaki, Silvia Bonanno, Silvia Marcuzzo, Pia Bernasconi, Francesca Trojsi, Eleonora Aronica, Caterina Bendotti, Giovanni Nardo
Article
Biochemistry & Molecular Biology
Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Giulia Napoli, Mattia Freschi, Francesca Sironi, Paolo Pevarello, Paola Tarroni, Chiara Liberati, Caterina Bendotti, Cinzia Volonte
Summary: Amyotrophic lateral sclerosis (ALS) is a neuroinflammatory disease where the role of P2X7 receptor has been highlighted, and the novel P2X7 antagonist AXX71 shows potential therapeutic value in ALS by targeting microglia-related proinflammatory markers and autophagy during the early symptomatic phase of the disease. This suggests that P2X7 modulation could be further explored as a therapeutic strategy in preclinical studies and applied in ALS clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Christos F. Kelaiditis, E. Leigh Gibson, Simon C. Dyall
Summary: This study aims to investigate the effects of a high eicosapentaenoic acid multinutrient supplement on anxiety and depression in healthy university students through a randomized double-blind placebo-controlled trial. The primary outcome is improvement in anxiety assessed via the Generalised Anxiety Disorder Assessment-7 scale. The study will last for 24 weeks with participants receiving active treatment or placebo.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Review
Nutrition & Dietetics
Paul Fairbairn, Simon C. Dyall, Fotini Tsofliou
Summary: There is evidence to suggest that increasing intake of both B vitamins and n-3 PUFA may benefit cognition in older adults. This systematic review found that a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula improves cognitive function in older adults compared to a placebo.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Simon C. Dyall, Laurence Balas, Nicolas G. Bazan, J. Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean-Marie Galano, Pamela J. Lein, Charles N. Serhan, Ameer Y. Taha
Summary: Polyunsaturated fatty acids are important components of cell membranes and play a role in cellular function. They can also serve as precursors for lipid mediators called oxylipins. Oxylipins are formed through enzymatic or non-enzymatic pathways and include eicosanoids and other lipid mediators. This review summarizes current knowledge about the structure and functions of nonclassical oxylipins.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Neurosciences
Francesca Sironi, Fabiola De Marchi, Letizia Mazzini, Caterina Bendotti
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons and neuromuscular impairment. Stem cell therapy shows promise in protecting motor units through various mechanisms. However, more coordinated effort and research is needed to address challenges in stem cell source selection, mechanism of action, and expected clinical outcomes. This review covers recent advances in stem cell therapies in ALS animal models and ongoing human clinical trials.
BRAIN RESEARCH BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Christos F. Kelaiditis, E. Leigh Gibson, Simon C. Dyall
Summary: This study conducted a systematic review and meta-analysis of ten randomized controlled trials with a total of 1426 participants. The results showed that EPA-enriched interventions with proportions > 60% of total EPA + DHA and doses between > 1 g/day and < 2 g/day significantly reduced the severity of depression. However, EPA doses > 2 g/day did not show significant therapeutic effects. The efficacy of EPA, DHA, and DPAn-3 in reducing anxiety severity was uncertain. More high-quality trials are needed to further explore the therapeutic potential of these omega-3 PUFAs.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2023)
Article
Cell Biology
Paola Fabbrizio, Cassandra Margotta, Jessica D'Agostino, Giuseppe Suanno, Lorenzo Quetti, Caterina Bendotti, Giovanni Nardo
Summary: Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease with a poor prognosis and unmet therapeutic need. Recent research suggests that the modulation of macrophage muscle response and enhancement of satellite cell differentiation can delay muscle atrophy and motor neuron loss in ALS. IL-10 treatment was found to improve motor performance in ALS mice by promoting satellite cells and muscle pro-regenerative activity of macrophages.
Article
Physics, Multidisciplinary
Michael A. Crawford, Andrew J. Sinclair, Yiqun Wang, Walter F. Schmidt, C. Leigh Broadhurst, Simon C. Dyall, Larry Horn, J. Thomas Brenna, Mark R. Johnson
Summary: In George Wald's Nobel Prize acceptance speech, he proposed a hypothesis that docosahexaenoic acid (DHA) traps the energy released during the visual process and carries it to the brain, explaining the previously unresolved issues of information transfer speed and photon wavelength conservation.
Article
Biochemistry & Molecular Biology
Antonio Vallarola, Massimo Tortarolo, Roberta De Gioia, Luisa Iamele, Hugo de Jonge, Giovanni de Nola, Enrica Bovio, Laura Pasetto, Valentina Bonetto, Mattia Freschi, Caterina Bendotti, Ermanno Gherardi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Orli Thau-Zuchman, Linda Svendsen, Simon C. Dyall, Ursula Paredes-Esquivel, Molly Rhodes, John Priestley, Rene G. Feichtinger, Barbara Kofler, Susanne Lotstra, J. Martin Verkuyl, Robert J. Hageman, Laus M. Broersen, Nick van Wijk, Jose P. Silva, Jordi L. Tremoleda, Adina T. Michael-Titus
Summary: The new ketogenic diet (KD) with a ratio of 2:1 of fat to carbohydrate plus protein showed neuroprotective potential in adult traumatic brain injury (TBI). It significantly improved sensorimotor deficits and spatial memory, reduced lesion size, inflammation, oxidation, and oligodendrocyte loss. The new formulation demonstrated therapeutic potential in adult TBI by enhancing the mTOR pathway and histone modifications.