Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Said Boujraf, Mohamed Chikri
Summary: Understanding the role of white adipose tissue (WAT) in metabolic syndrome, including obesity and type 2 diabetes (T2D), is important. Insulin resistance plays a key role in the development of T2D. The comparison of WAT differences between obese diabetics and obese individuals with normal glucose tolerance and insulin resistance can provide insights into the molecular pathways underlying the development of obesity-related T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Tiago Bertola Lobato, Matheus Gennari-Felipe, Janaina Ribeiro Barbosa Pauferro, Ilana Souza Correa, Beatriz Ferreira Santos, Beatriz Belmiro Dias, Joao Carlos de Oliveira Borges, Camila Soares dos Santos, Elvirah Samantha de Sousa Santos, Maria Janaina Leite de Araujo, Liliane Araujo Ferreira, Sara Araujo Pereira, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Leandro Borges, Maria Fernanda Cury-Boaventura, Marco Aurelio Ramirez Vinolo, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Rui Curi, Sandro Massao Hirabara, Renata Gorjao
Summary: This review explores the impact of obesity and type 2 diabetes on metabolic changes in leukocytes during SARS-CoV-2 infection, and highlights that obese and diabetic patients are at higher risk of worse prognosis, possibly due to the occurrence of cytokine storms.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Mona Mohamed Ibrahim Abdalla
Summary: The increasing global burden of type 2 diabetes highlights the need for more reliable and quicker strategies to improve early identification of insulin resistance in high-risk groups. Salivary biomarkers offer a promising alternative to serum collection, with adipocytokines like leptin being potential biomarkers for insulin resistance. Studies on salivary resistin as a biomarker for IR show conflicting findings on its potential role in linking obesity and IR.
WORLD JOURNAL OF DIABETES
(2021)
Article
Cardiac & Cardiovascular Systems
Lale A. Ertuglu, Melis Sahinoz, Aseel Alsouqi, Serpil Muge Deger, Andrew Guide, Thomas G. Stewart, Mindy Pike, Cassianne Robinson-Cohen, Elvis Akwo, Michael Pridmore, Rachelle Crescenzi, Meena S. Madhur, David G. Harrison, Friedrich C. Luft, Jens Titze, T. Alp Ikizler
Summary: This study investigates the association between high tissue sodium accumulation and obesity-related insulin resistance, and explores the potential role of excess tissue sodium accumulation in systemic inflammation and leptin dysregulation. The results show that higher muscle and skin sodium content are associated with insulin resistance in obese patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Rodrigo Fernandez-Verdejo, Lorena Malo-Vintimilla, Juan Gutierrez-Pino, Antonio Lopez-Fuenzalida, Pablo Olmos, Pablo Irarrazaval, Jose E. Galgani
Summary: The study compared individuals with low and high metabolic flexibility in response to an oral glucose tolerance test and found that while metabolic health markers were similar between the two groups, individuals with high metabolic flexibility had higher diastolic blood pressure, enhanced circulating triglyceride clearance, and increased subcutaneous fat.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Eric Slywitch, Carine Savalli, Antonio Claudio Duarte, Maria Arlete Meil Schimith Escrivao
Summary: Our study evaluated the association between increasing BMI and different dietary groups, as well as the impact on various biochemical markers. The results showed that higher BMI was associated with worse metabolic parameters in both vegetarians and omnivores. However, vegetarians displayed better antioxidant and inflammatory status, suggesting potential protection against overweight-related illnesses.
Review
Biochemistry & Molecular Biology
Mohammad Shafi Kuchay, Jose Ignacio Martinez-Montoro, Narendra Singh Choudhary, Jose Carlos Fernandez-Garcia, Bruno Ramos-Molina
Summary: Lean/non-obese NAFLD affects a significant portion of the global population and poses a public health concern. Despite similarities in metabolic abnormalities with obese NAFLD, lean NAFLD individuals exhibit differences in genetic predisposition, body composition, gut microbiota, and environmental susceptibility. Current treatment strategies focus on improving overall health and reducing visceral adiposity, with potential pharmacological options being explored for lean NAFLD management.
Article
Endocrinology & Metabolism
Asmaa A. El Sehmawy, Fatma Elzhraa Ahmed Diab, Donia Ahmed Hassan, Doaa Sayed Mohammed, Mona Gamal El Din Al Anany, Noha A. Eldesoky, Reham Yousri Elamir
Summary: The study found that obese children had higher weight Z scores, waist-to-height ratios, serum cholesterol, LDL, and TG levels, as well as lower HDL levels. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 levels were observed in the obese group. The results suggest that measuring general and central adiposity markers as well as serum lipocalin-2 can predict insulin resistance in obese children.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Milena Burhop, Jan Philipp Schuchardt, Josefine Nebl, Mattea Mueller, Ralf Lichtinghagen, Andreas Hahn
Summary: The study found that Calanus oil has beneficial effects on glucose metabolism and insulin resistance in obese patients, but further research is needed to verify its clinical relevance and explore its mechanisms of action.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Al Thani, Mohamed A. Elrayess
Summary: Healthy non-obese insulin resistant individuals have a higher risk of metabolic syndrome. Physical activity can lower insulin resistance, but the metabolic pathways involved are still unknown. This study analyzed data from 305 non-obese participants and found that active insulin resistant individuals showed differences in fatty acid metabolism, while sedentary insulin resistant individuals showed changes in glucose metabolism. These findings have important implications for the prevention and treatment of metabolic syndrome. Rating: 8 out of 10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema
Summary: This study aims to explore the association between peptide hormones and body weight and glucose homeostasis. The results show significant differences in peptide hormone levels between obese and lean adults, and GLP-1 levels are independently associated with markers of obesity and insulin resistance.
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigates whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals. The results show that hyperinsulinemia, hypoglycemia, and hyperglycemia lead to a decrease in multiple inflammatory markers, and the inflammatory response is more pronounced in obese individuals during hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Xi Chen, Enrique Maldonado, Ralph A. DeFronzo, Devjit Tripathy
Summary: The study revealed that there is a relationship between plasma glucagon levels and insulin sensitivity and insulin secretion in obese individuals. As glucose intolerance worsens, the insulin-mediated suppression of glucagon secretion is impaired, which corresponds to the severity of insulin resistance and beta-cell dysfunction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xinmei Huang, Yue Li, Xiaoxu Tong, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Zaoping Chen, Tiange Sun, Fang Wang, Qian Yang, Zhangyan Li, Cuijun Gao, Ling Ma, Heyuan Ding, Shufei Zang, Ni Yang, Tie-Ning Zhang, Jun Liu
Summary: Increased circulating IL-32 throughout pregnancy is closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Kirti S. Prabhu, Afsheen Raza, Thasni Karedath, Syed Shadab Raza, Hamna Fathima, Eiman I. Ahmed, Shilpa Kuttikrishnan, Lubna Therachiyil, Michal Kulinski, Said Dermime, Kulsoom Junejo, Martin Steinhoff, Shahab Uddin
Review
Medicine, Research & Experimental
Afsheen Raza, Maysaloun Merhi, Varghese Philipose Inchakalody, Roopesh Krishnankutty, Allan Relecom, Shahab Uddin, Said Dermime
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Maha M. Hammad, Mohamed Abu-Farha, Abdullah Al-Taiar, Nada Alam-Eldin, Reem Al-Sabah, Lemia Shaban, Fahd Al-Mulla, Jehad Abubaker, Abdur Rahman
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Gulab Sher, Nadia Aziz Salman, Michal Kulinski, Rayyan Abdulaziz Fadel, Vinod Kumar Gupta, Ambika Anand, Salahddin Gehani, Sheraz Abayazeed, Omer Al-Yahri, Fakhar Shahid, Salman Alshaibani, Sara Hassan, M. Zafar Chawdhery, Giles Davies, Said Dermime, Shahab Uddin, G. Hossein Ashrafi, Kulsoom Junejo
Article
Endocrinology & Metabolism
Amal Hasan, Waleed Aldhahi
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Review
Immunology
Nabil E. Omar, Kareem A. El-Fass, Abdelrahman I. Abushouk, Noha Elbaghdady, Abd Elmonem M. Barakat, Ahmed E. Noreldin, Dina Johar, Mohamed Yassin, Anas Hamad, Shereen Elazzazy, Said Dermime
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S. Siveen, Deepak Kumar, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi, Said Dermime
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Endocrinology & Metabolism
Amal Hasan, Shihab Kochumon, Ebaa Al-Ozairi, Jaakko Tuomilehto, Fahd Al-Mulla, Rasheed Ahmad
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Letter
Biotechnology & Applied Microbiology
Amal Hasan, Mohammad R. Al-Mulla, Jehad Abubaker, Fahd Al-Mulla
Summary: Current vaccines induce antibody response against SARS-CoV-2 spike protein, but new variants require development of T-cell-based vaccines targeting mutant spikes along with other proteins for inducing highly neutralizing antibodies and memory CD8(+)T-cell immunity without the risk of antibody-dependent enhancement.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Amal Hasan, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: TNF-α induces IP-10 expression in MCF-7 breast cancer cells through activation of the JNK/c-Jun signaling pathway.
Article
Immunology
Amal Hasan, Hossein Arefanian, Arshad Mohamed Channanath, Irina AlKhairi, Preethi Cherian, Sriraman Devarajan, Thangavel Alphonse Thanaraj, Mohamed Abu-Farha, Jehad Abubaker, Fahd Al-Mulla
Summary: COVID-19 vaccines can cause elevation of coagulation factors and antithrombin, with differences observed between different vaccines. The clinical significance of the disruption of coagulation homeostasis remains unclear and requires further research.
Article
Cell Biology
Shihab Kochumon, Amal Hasan, Fatema Al-Rashed, Sardar Sindhu, Reeby Thomas, Texy Jacob, Amnah Al-Sayyar, Hossein Arefanian, Ashraf Al Madhoun, Ebaa Al-Ozairi, Fawaz Alzaid, Heikki A. Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Rasheed Ahmad
Summary: Chronic low-grade inflammation induced by obesity is a central risk factor for the development of metabolic syndrome. This study found that high LDL-c levels were associated with increased expression of adipose IL-23, suggesting that IL-23 may act as an inflammatory biomarker for disease progression in people with high LDL-c.
Article
Immunology
Amal Hasan, Ebaa Al-Ozairi, Nosiba Y. M. Hassan, Shamsha Ali, Rasheed Ahmad, Nada Al-Shatti, Salem Alshemmari, Fahd Al-Mulla
Summary: Severe COVID-19 is associated with a lower frequency of pDCs compared to other circulating DCs, and lower expression levels of HLA-DR, CD123, or CD11c on DCs.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Surgery
Tarek Mahmoud, Jude Yagan, Amal Hasan, Osama A. Gheith, Mohamed Mostafa, Suzann Rida, Nabil El-Serwi, Mohamad Shaker, Mahmoud Khalid
Summary: The use of SGLT2i and GLP-1RA medications in diabetic kidney transplant recipients shows good outcomes and safety in controlling blood sugar and reducing proteinuria.
CLINICAL TRANSPLANTATION
(2023)
Review
Immunology
Amal Hasan, Ebaa Al-Ozairi, Zahraa Al-Baqsumi, Rasheed Ahmad, Fahd Al-Mulla
Summary: Severe Covid-19 is attributed to a dysfunctional innate immune response with delayed and/or deficient type I interferon response, coupled with an exaggerated and/or dysfunctional adaptive immunity. Differences in T-cell and B-cell responses, as well as neutralizing antibody responses, have been identified in severe disease compared to mild cases. Preexisting autoantibodies against type I interferon have been described as a major cause of severe/critical disease. Additionally, factors such as prior vaccine exposure, trained innate immunity, cross-reactive immunity, and serological immune imprinting may all contribute towards disease severity and outcome.
IMMUNOTARGETS AND THERAPY
(2021)