Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
出版年份 2013 全文链接
标题
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
作者
关键词
-
出版物
PLoS One
Volume 8, Issue 6, Pages e67433
出版商
Public Library of Science (PLoS)
发表日期
2013-06-27
DOI
10.1371/journal.pone.0067433
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
- (2013) Kohji Mori et al. ACTA NEUROPATHOLOGICA
- CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration
- (2013) Nicole F. Liachko et al. ANNALS OF NEUROLOGY
- TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
- (2013) Shinji Higashi et al. JOURNAL OF NEUROCHEMISTRY
- Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease
- (2012) D. E. Hurtado et al. JOURNAL OF NEUROSCIENCE
- Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
- (2012) Sarah J. Parker et al. NEUROCHEMISTRY INTERNATIONAL
- Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes
- (2012) Sarah J. Parker et al. PLoS One
- Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS
- (2011) Victòria Ayala et al. ACTA NEUROPATHOLOGICA
- FTD and ALS: A Tale of Two Diseases
- (2011) R. Ferrari et al. Current Alzheimer Research
- The Potential Role of Glycogen Synthase Kinase 3 Inhibitors as Amyotrophic Lateral Sclerosis Pharmacological Therapy
- (2011) V. Palomo et al. CURRENT MEDICINAL CHEMISTRY
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- A “Two-hit” Hypothesis for Inclusion Formation by Carboxyl-terminal Fragments of TDP-43 Protein Linked to RNA Depletion and Impaired Microtubule-dependent Transport
- (2011) G. Scott Pesiridis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of sororin by Cdk1-mediated phosphorylation
- (2011) Megan R. Dreier et al. JOURNAL OF CELL SCIENCE
- C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
- (2011) Jodi Meyerowitz et al. Molecular Neurodegeneration
- Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS
- (2011) D. Ito et al. NEUROLOGY
- CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury
- (2011) Shruti V. Kabadi et al. Neurotherapeutics
- Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways
- (2011) Sami J. Barmada et al. REVIEWS IN THE NEUROSCIENCES
- Cdk5: a multifaceted kinase in neurodegenerative diseases
- (2011) Zelda H. Cheung et al. TRENDS IN CELL BIOLOGY
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
- (2010) Christine Hostetter et al. CANCER BIOLOGY & THERAPY
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Molecular mechanisms of neurodegeneration in Alzheimer's disease
- (2010) L. Crews et al. HUMAN MOLECULAR GENETICS
- Functional Significance for a Heterogenous Ribonucleoprotein A18 Signature RNA Motif in the 3′-Untranslated Region of Ataxia Telangiectasia Mutated and Rad3-related (ATR) Transcript
- (2010) Ruiqing Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TAR DNA-binding protein 43 in neurodegenerative disease
- (2010) Alice S. Chen-Plotkin et al. Nature Reviews Neurology
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- p38 MAP Kinase-dependent regulation of the expression level and subcellular distribution of heterogeneous nuclear ribonucleoprotein A1 and its involvement in cellular senescence in normal human fibroblasts
- (2010) Naoko Shimada et al. RNA Biology
- A putative role for cell cycle-related proteins in microtubule-based neuroplasticity
- (2009) Stefanie Schmetsdorf et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR
- (2009) Faraz Farooq et al. HUMAN MOLECULAR GENETICS
- hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation
- (2009) J.-W. Chang et al. INTERNATIONAL IMMUNOLOGY
- Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53
- (2009) Renyuan Zhou et al. INTERNATIONAL JOURNAL OF CANCER
- Oxidative Stress Increases the Number of Stress Granules in Senescent Cells and Triggers a Rapid Decrease in p21waf1/cip1Translation
- (2009) Xian Jin Lian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration
- (2009) E. Perlson et al. JOURNAL OF NEUROSCIENCE
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry
- (2009) Li-Chiou Chuang et al. MOLECULAR CELL
- Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo
- (2009) A. D'Ambrogio et al. NUCLEIC ACIDS RESEARCH
- Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells
- (2009) L-C Chen et al. ONCOGENE
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
- (2008) Takashi Nonaka et al. FEBS LETTERS
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
- (2008) Y. M. Ayala et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice
- (2007) Martina Wiedau-Pazos et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started