Article
Cell Biology
Bo Ma, Ni Ni, Wanyu Shao, Jingying Xu, Jiali Ji, Min Luo
Summary: By knocking down Bit1, proliferation and migration of LECs can be inhibited while cell cycle and apoptosis are regulated. The analysis of gene expression and signaling pathways revealed that Bit1 has a significant impact on integrin and TGF beta signaling pathways, with core node molecules identified as FAK, PAK2, ITGA5, and ITGB1.
Article
Biochemistry & Molecular Biology
Navneet Kaur, Michelle A. Lum, Robert E. Lewis, Adrian R. Black, Jennifer D. Black
Summary: The study shows that PKC alpha signaling triggers antiproliferative ERK signaling in intestinal cells, intersecting with the Ras-Raf-MEK-ERK kinase cascade and requiring active Ras, Raf, MEK, and ERK. This differs from EGF-induced pro-proliferative ERK signaling. PKC alpha-induced antiproliferative effects involve prolonged ERK activation and interactions with multiple Raf isoforms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Falguni Das, Nandini Ghosh-Choudhury, Soumya Maity, Balakuntalam S. Kasinath, Goutam Ghosh Choudhury
Summary: The plasticity of proximal tubular epithelial cells contributes to renal fibrosis through the expression of TWIST1 in response to TGF beta. The mechanism of TWIST1 expression has not been clarified. This study demonstrates that both PI3 kinase and its target mTORC2 increase the expression of TWIST1 induced by TGF beta. Moreover, phosphorylation of the hydrophobic motif site Ser-660 in protein kinase C beta II (PKC beta II) is enhanced by TGF beta. Inhibition of TWIST1 arrests TGF beta-induced tubular cell pathology, while its overexpression induces these pathologies.
Article
Endocrinology & Metabolism
H. Alexander Chen, Iris B. Hovens, Xue S. Davis, Zach Hutelin, Kathryn M. Wall, Dana M. Small
Summary: A negative association between BMI and performance on the Penn Line Orientation Task was found, which was confirmed to be reliable and mediated by body fat percentage. The activation level of V1 was negatively associated with body fat percentage, while unrelated to other visual function measures.
Article
Cell Biology
Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng, Jiahao Tang, Zhanjun Li, Wanhua Xie
Summary: This study shows that PHF13 is essential for the growth and metastasis of pancreatic cancer cells, and the integrated analysis of transcriptome and epigenetic profiles provides mechanistic insights into the regulation of genes associated with cell metastasis during the EMT process induced by TGF-beta.
CELL DEATH & DISEASE
(2022)
Article
Biology
Flavia Rosianu, Simeon R. Mihaylov, Noreen Eder, Antonie Martiniuc, Suzanne Claxton, Helen R. Flynn, Shamsinar Jalal, Marie-Charlotte Domart, Lucy Collinson, Mark Skehel, Ambrosius P. Snijders, Matthias Krause, Sharon A. Tooze, Sila K. Ultanir
Summary: This study reveals the importance of NDR1/2 kinases in maintaining neuronal health by regulating endocytosis, protein homeostasis, and autophagy. The loss of NDR1/2 results in neurodegeneration, accumulation of cellular components, and impaired autophagy efficiency.
LIFE SCIENCE ALLIANCE
(2022)
Article
Biochemistry & Molecular Biology
Kisa Sung, Agata Kurowski, Carisse Lansiquot, Kanny K. Wan, Samarjit Patnaik, Martin J. Walsh, Michael B. Lazarus
Summary: This study uncovers a link between autophagy and cell cycle progression and explores the inhibition of autophagy in pancreatic cancer cells using selective small molecule inhibitors. Additionally, new combination treatments were discovered through an unbiased screen.
ACS CHEMICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chen Su, Simon Rousseau, Amin Emad
Summary: The study identified transcriptional regulatory mechanisms involved in host cell response to SARS-CoV-2 infection, focusing on those specific to the virus when compared to other respiratory viruses. Through network-guided analyses, kinases associated with the network were identified, revealing pathways linked to inflammation and immunity that may exacerbate organ damage in COVID-19 complications.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ya Kong, Yutian Zhang, Hanlin Wang, Weijuan Kan, Haoran Guo, Yun Liu, Yi Zang, Jia Li
Summary: The study demonstrates that the inner nuclear membrane component TMEM201 plays a crucial role in regulating breast cancer metastasis through controlling migration and invasion of cancer cells, and inhibiting epithelial-to-mesenchymal transition and TGF-beta signaling. Moreover, TMEM201 physically interacts with SMAD2/3 and is required for the phosphorylation, nuclear translocation, and transcriptional activation of TGF beta.
Review
Pharmacology & Pharmacy
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Summary: Colorectal cancer is characterized by metabolic reprogramming, which plays a crucial role in promoting tumor progression by modulating core metabolic pathways. Activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming, with protein kinases serving as integral components in facilitating interactions between signaling pathways and metabolic pathways in CRC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Min Liu, Aiguo Liu, Jie Wang, Yansong Zhang, Yajuan Li, Ying Su, Alan Jian Zhu
Summary: Protein phosphatase V (PpV) is identified as a homeostatic regulator of Hh signaling, which competes with the catalytic subunit of PP2A for Wdb association to negatively regulate Wdb stability. This competition ensures graded Hh signaling through regulated Wdb stability. PpV functions as a Hh activity sensor to maintain Hh signaling homeostasis by regulating Wdb-mediated PP2A activity through feedback mechanisms.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin
Summary: This study identified DGKZ as a potential prometastatic gene in breast cancer. It was found that high expression of DGKZ was correlated with tumor progression and poor prognosis. Mechanistic studies showed that DGKZ might regulate cell metastasis by promoting epithelial-mesenchymal transition via the TGF-β signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Marissa L. Gredler, Jennifer A. Zallen
Summary: This study reveals that mesenchymal-epithelial transitions drive epithelial organization through the assembly and radial intercalation of three-dimensional rosettes in the mouse embryo. Mutations in Par3 disrupt the formation of expanded apical domain and lumen in axial mesoderm rosettes, resulting in abnormal surface epithelial structure.
DEVELOPMENTAL CELL
(2023)
Review
Geriatrics & Gerontology
Nusrath Yasmeen, Manali Datta, Vikram Kumar, Fahad S. Alshehri, Atiah H. Almalki, Shafiul Haque
Summary: This article reviews the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the pathology of Alzheimer's disease (AD). By analyzing original research and review articles, the authors summarize the correlation between ERUPR signaling and miRNA dysregulation, as well as the involvement of adaptive UPR and apoptotic UPR in restoring protein homeostasis and triggering cell death.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Jianzhong Zheng, Zhiyuan Shi, Pengbo Yang, Yue Zhao, Wenbi Tang, Shaopei Ye, Zuodong Xuan, Chen Chen, Chen Shao, Qingang Wu, Huimin Sun
Summary: The study revealed that ERK-mediated Smurf1 phosphorylation is crucial for RhoA degradation and mesenchymal state achievement in TGF beta-induced EMT. Inhibition of Smurf1 phosphorylation not only suppresses EMT, but also dramatically reduces lung metastasis of breast cancer in mice.
LIFE SCIENCE ALLIANCE
(2022)