Article
Biochemistry & Molecular Biology
Xing Du, Yunsheng Ou, Muzi Zhang, Kai Li, Wei Huang, Dianming Jiang
Summary: This study found that the mevalonate pathway promotes osteosarcoma metastasis by regulating YAP1 activity, and inhibiting this pathway may be an effective strategy for treating osteosarcoma metastasis.
Article
Environmental Sciences
Ming-Ju Hsieh, Jen-Tsun Lin, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, Mu-Kuan Chen
Summary: This study investigated the effect of limocitrin, a natural flavonol compound, on the cytotoxicity of NK cells against aggressive leukemia cells. Limocitrin increased the expressions of cytolytic molecules and induced cell apoptosis in leukemia cells. It also inhibited DNA repair mechanism and increased granzyme B expression in NK cells, ultimately enhancing the cytotoxicity of NK cells against cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Physical
Liping Zhao, Mingxia Jiang, Zhilu Xu, Fengshuo Sun, Xinghan Wu, Mogen Zhang, Xiuwen Guan, Jinlong Ma, Weifen Zhang
Summary: A self-regulating photothermal conversion system based on self-assembling gold nanoparticles was designed for selective thermotherapy. The system demonstrated selective heating effect in both in vitro and in vivo models, achieving good tumor inhibition without damaging normal tissue. This work offers a novel validation protocol for tumor thermotherapy and provides an evaluation methodology for precise cancer therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Donghe Li, Yuyin Zhang, Qingsong Qiu, Jinzeng Wang, Xuemei Zhao, Bo Jiao, Xiuli Zhang, Shanhe Yu, Pengfei Xu, Yuqing Dan, Xinhua Xiao, Peihong Wang, Mingzhu Liu, Zhizhou Xia, Zhangsen Huang, Ruihong Zhang, Jiaoyang Li, Xi Xie, Yan Zhang, Chenxuan Liu, Ping Liu, Ruibao Ren
Summary: IRF8 deficiency leads to a decrease in the number of LT-HSCs in mice, but an increase in the repopulation capacity of individual HSCs. The regulation of TLR9 signaling in diverse innate immune cells by IRF8 influences HSCs.
Article
Biochemistry & Molecular Biology
Yang Liu, Wen Guo, Si-Lu Hong
Summary: This study found that aerobic exercise can improve neuronal apoptosis and spatial memory in aging mice, and its mechanism may be related to the regulation of the DAPK1 pathway.
Article
Biochemistry & Molecular Biology
Fengjiao He, Qiong Liu, Huan Liu, Qian Pei, Hong Zhu
Summary: This study investigated the role of circRNA acetyl-CoA carboxylase alpha (circACACA) in colorectal cancer (CRC). High expression of circACACA was found in CRC tissues and cells and was associated with advanced tumor stage, metastasis, and poor survival rate. Downregulation of circACACA inhibited CRC cell proliferation and metastasis while promoting apoptosis. Mechanistically, circACACA enhanced HDAC3 expression by sponging miR-193a/b-3p, resulting in the activation of the mevalonic acid (MVA) pathway through inhibition of p53 acetylation and transcription. Inhibition of miR-193a/b-3p reversed the effects of circACACA deficiency on CRC growth and metastasis. Moreover, knockdown of HDAC3 abrogated the malignant phenotypes induced by circACACA overexpression. These findings suggest that circACACA promotes CRC progression through the miR-193a/b-3p/HDAC3/p53 axis and activation of the MVA pathway.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Bei Wang, Chun-Hui Nie, Jun Xu, Da-Long Wan, Xiao Xu, Jiang-Juan He
Summary: This study found that BigV can suppress the malignant progression of HCC by activating the MAPT-mediated Fas/FasL pathway.
Review
Immunology
Ryan J. King, Pankaj K. Singh, Kamiya Mehla
Summary: Cholesterol plays a role in cancer, atherosclerosis, and autoimmunity by modulating the immune system. Manipulating cholesterol metabolism may improve immunotherapy responses in cancer treatment. It can have both proinflammatory and anti-inflammatory effects in mammals, acting through various immune cell types depending on the context. Understanding the mechanisms of cholesterol-related metabolites can enhance our knowledge of their functions and effects on the immune system, leading to the development of better therapeutic strategies.
TRENDS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ruizhu Lin, Jianfeng Xu, Xinbao Tian, Yundong Chen, Jian Liu, Yujuan Liu, Yue Wang, Kaibin Wang, Jie Zhang, Lei Wang, Ning Zhu
Summary: HMm treatment significantly reduced bone resorption, damage, and loss of subchondral bone in SANFH rats. It also decreased cell apoptosis, downregulated Fas/FasL signal pathway, and increased Runx-2 expression, suggesting its potential therapeutic effect on SANFH.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Pharmacology & Pharmacy
Du Chao, Wang Chenchen, Zhang Xiyue, Wu Shikui, Wang Yingze
Summary: This study found that Har Gabur can alleviate ethanol-induced gastric ulcers by inhibiting the immune response, with GO identified as the main active ingredient.
CURRENT DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Qiong Liu, Hui Cheng, Tianxiang Chen, Tsz Woon Benedict Lo, Zhangmin Xiang, Fuxian Wang
Summary: This study presents a new strategy for designing carbon nitrides for highly selective and sustainable conversion of CO2 to CH3CHO, achieved through the selective photocatalytic hydrogenation of CO2 to CH3CHO using a modified polymeric carbon nitride under mild conditions.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Article
Cell Biology
Xin-xin Xiang, Yong-liang Liu, Yi-fan Kang, Xiang Lu, Kai Xu
Summary: Mex-3 RNA Binding Family Member A (MEX3A) is significantly upregulated in nasopharyngeal carcinoma (NPC) and negatively associated with prognosis. Depletion of MEX3A inhibits cell proliferation, invasion, and migration while increasing apoptosis in NPC cells. MEX3A may promote NPC development and progression through the miR-3163/SCIN axis by regulating NF-kappa B signaling.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Mervenur Yavuz, Leila Sabour Takanlou, Cigir Biray Avci, Turan Demircan
Summary: Hepatocellular carcinoma (HCC) is a major global health problem with poor prognosis. Androgen Receptor (AR) signaling, which affects genes related to cancer characteristics, has been shown to be misregulated in HCC. Targeting AR signaling using a novel Selective Androgen Receptor Modulator (SARM) called S4, significantly impairs HCC growth, migration, proliferation, and induces apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway. This finding is important as PI3K/AKT/mTOR signaling is frequently activated in HCC and contributes to its aggressiveness and poor prognosis.
Article
Biochemistry & Molecular Biology
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The genetic variant rs1884444 G/T of IL-23R is significantly associated with a reduced risk of bladder urothelial carcinoma (BUC), with the T allele potentially serving as a reliable genetic marker for good prognosis. The G/T variation may regulate BUC risk through modulation of the IL-23/IL-17 pathway.
Article
Integrative & Complementary Medicine
Ning Ding, Qingbo Wei, Qian Xu, Chengyong Liu, Yongcheng Ni, Jun Zhao, Wanli Xu, Weiping Gao
Summary: This study investigates the mechanism of improvement in dry eye diseases (DEDs) treated by acupuncture. The results demonstrate that acupuncture can alleviate corneal inflammation and reduce corneal damage and inflammatory cell infiltration in DEDs. Acupuncture achieves this by regulating the expression of ACh, alpha 7nAChR, and NF-kappa B, suggesting that acupuncture may be a potential therapeutic target for dry eye.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Roberto Benelli, Maria Raffaella Zocchi, Alessandro Poggi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Francesca Tosetti, Massimo Alessio, Alessandro Poggi, Maria Raffaella Zocchi
Summary: Enzymes are no longer considered static molecular machines, as they can move to different locations and change their functions. Recent research focuses on the regulation and function of ADAM endopeptidases at specific subcellular sites or in multimolecular complexes, particularly ADAM10 and TACE/ADAM17.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Alessandro Poggi, Federico Villa, Jordi Leonardo Castrillo Fernadez, Delfina Costa, Maria Raffaella Zocchi, Roberto Benelli
Summary: Studying immune responses against tumors is crucial, and traditional experimental settings using immune cells mixed with tumor cells may not fully represent human conditions. Alternative culture methods and three-dimensional culture systems have been developed to better mimic human situations and investigate NK cell interactions with tumor cells.
Article
Oncology
Massimo Alfano, Irene Locatelli, Cristina D'Arrigo, Marco Mora, Giovanni Vozzi, Aurora De Acutis, Roberta Pece, Sara Tavella, Delfina Costa, Alessandro Poggi, Maria Raffaella Zocchi
Summary: This study reveals that increased stiffness and altered architecture of the extracellular matrix (ECM) are detectable in human lymphomas, and these modifications are related to the type and grading of the lymphoma. The findings suggest that digital pathology may assist in the diagnosis and treatment of lymphomas.
Review
Oncology
Alessandro Poggi, Maria Raffaella Zocchi
Summary: The discovery of immune checkpoints and the development of specific blockers have revolutionized anti-cancer therapy. This review focuses on the potential of NK ICs as targets for dual-checkpoint inhibition, highlighting their role in NK cell survival and anti-tumor immune response.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell Biology
Makram Merimi, Hassan Fahmi, Joery De Kock, Charline Beguin, Arsene Burny, Guido Moll, Alessandro Poggi, Mehdi Najar
Article
Oncology
Roberto Benelli, Delfina Costa, Laura Salvini, Samuele Tardito, Francesca Tosetti, Federico Villa, Maria Raffaella Zocchi, Alessandro Poggi
Summary: This study generated a novel ADC called Cet-ZA, which can specifically target CRC. Importantly, patient-derived CRC organoids or CRC tumor cell suspensions could induce the expansion of Vδ2 T cells from peripheral blood and tumor infiltrating lymphocytes when primed with Cet-ZA, and Cet-ZA can promote Vδ2 T cell-mediated killing of CRC organoids.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Oncology
Serena Matis, Alessandro Poggi, Roberto Benelli
Editorial Material
Oncology
Roberto Benelli, Maria Raffaella Zocchi, Alessandro Poggi
Editorial Material
Oncology
Alessandro Poggi, Serena Matis, Roberto Benelli
Editorial Material
Oncology
Roberto Benelli, Maria Raffaella Zocchi, Alessandro Poggi
Editorial Material
Cell Biology
Alessandro Poggi
Article
Cell Biology
Delfina Costa, Roberta Vene, Simona Coco, Luca Longo, Francesca Tosetti, Stefano Scabini, Luca Mastracci, Federica Grillo, Alessandro Poggi, Roberto Benelli
Summary: The p38 inhibitor SB202190 is an essential component of normal colorectal mucosa cultures. It has been found that this molecule can stabilize EGFR signaling and promote organoid proliferation by increasing phosphorylation of Erk1-2. However, the growth of some colorectal cancer-derived organoid cultures is inhibited by SB202190 through an unknown mechanism.