Article
Surgery
Kayleigh A. M. van Dam, Marijn T. F. Jense, Evelien de Witte, Sofie Fransen, Evert-Jan G. Boerma, Jan Willem M. Greve
Summary: This study compared open and laparoscopic conversions of vertical banded gastroplasty (VBG) to Roux-en-Y gastric bypass (RYGB). The results showed that the laparoscopic group had a lower complication rate compared to the open group, and there was improvement in BMI in both groups after 5 years.
Article
Surgery
Ahmad Mahajna, Daniel Dubin, Miriam Obeid, Nasser Sakran, Ahmad Assalia
Summary: This study compared the short-term outcomes of Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) in the surgical correction of failed vertical Silastic ring vertical gastroplasty (SRVG) and vertical banded gastroplasty (VBG). The study showed that BPD is a safe option with lower complication rates for the short-term correction of failed VBG/SRVG procedures.
Article
Surgery
Mohamed D. Sarhan, M. N. AbdelSalam, Mohamed Saber Mostafa, AbdelRahman Yehia, Ismail Anwar, Ehab Fathy
Summary: Conversion of VBG to RYGB is a viable option with significant improvement in VBG-related complications, providing acceptable weight loss and improvement in obesity-related health problems, such as diabetes.
Article
Surgery
Mohamed Hany, Bart Torensma, Mohamed Ibrahim, Ahmed Zidan, Muhammad Gaballah, Ayman Farouk Mohammad Ahmed Aly, Ghada Ahmed Abu-Sheasha
Summary: This study compared the 5-year outcomes of primary and revision Roux-en-Y gastric bypass (RYGB) in patients with vertical banded gastroplasty (VBG) who experienced weight regain. The results showed that revision RYGB had comparable safety and resolution of associated diseases to primary RYGB, although the weight loss was slightly lower. Food tolerance was better in the revision RYGB group in the first year, but comparable to primary RYGB at the fifth year follow-up. Attentive treatment and evaluation of associated factors are necessary for patients undergoing RYGB after VBG.
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Marianne Lerbok Bergmann, Simon Veedfald, Jens Juul Holst, Dorte Worm
Summary: This study evaluated counterregulatory responses during postprandial hypoglycemia in patients with postbariatric hypoglycemia who underwent Rouxen-Y gastric bypass surgery. The findings showed that individuals with postbariatric hypoglycemia had minor increases in counterregulatory hormones during postprandial hypoglycemia, but larger hormone responses occurred when glucose levels were lowered during treatment with sitagliptin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Surgery
Marius Nedelcu, Patrick Noel, Marc Danan, Ramon Vilallonga, Viola Zulian, Anamaria Nedelcu, Sergio Carandina
Summary: This article discusses the revisional surgery of VBG, suggesting the use of RYGB and partial gastrectomy to eliminate additional risks.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Surgery
Marijn T. F. Jense, Inge H. Palm-Meinders, Rochelle Sigterman-Nelissen, Evert-Jan G. Boerma, Ronald S. L. Liem, Dingeman J. Swank, Jan Willem M. Greve
Summary: This study compared the effect of banded and non-banded Roux-en-Y gastric bypass (RYGB) on long-term weight loss results and comorbidities. The results showed that banded RYGB had superior weight loss compared to non-banded RYGB, while there was no significant difference in the effect on comorbidity improvement or remission. Therefore, performing banded RYGB is recommended due to the similar complication rates and significantly greater weight loss.
Review
Endocrinology & Metabolism
Maria Jose Luesma, Jose Fernando, Irene Cantarero, Pilar Lucea, Sonia Santander
Summary: The prevalence of obesity has been increasing rapidly in recent decades, making it one of the most impacting diseases on global health. It is a chronic disease associated with various comorbidities that result in a reduced life expectancy and quality of life. The treatment of obesity requires a multidisciplinary approach by a specialized medical team and can be done through conservative or surgical treatments. Vertical gastrectomy, mixed techniques, and gastric bypass are the most commonly used surgical techniques. The choice of technique should consider the characteristics of each patient and the surgical team's experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Medhat Helmy Khalil, Gad M. Behairy, Ahmed M. Farrag, Mohab G. Elbarbary
Summary: This study found that converting failed Vertical banded gastroplasty (VBG) to Roux-en-Y gastric bypass (RYGB) surgery is an effective repair method with low short-term complication and reoperation rates, and it has a significant positive impact on weight loss.
Article
Endocrinology & Metabolism
Isabella Jonsson, Kirstine N. Bojsen-Moller, Viggo B. Kristiansen, Simon Veedfald, Nicolai J. Wewer Albrechtsen, Trine R. Clausen, Rune E. Kuhre, Jens F. Rehfeld, Jens J. Holst, Sten Madsbad, Maria S. Svane
Summary: The study suggests that exogenous CDCA may enhance postprandial GLP-1 and glucagon secretion in individuals who have undergone RYGB, while the BA sequestrant colesevelam may decrease these hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Axel Denneval, Claire Chalumeau, Sylvain Iceta, Elise Pelascini, Emmanuel Disse, Maud Robert
Summary: Results of a conversion from VBG to RYGB at two specialized bariatric surgery centers showed that it remains the preferred procedure for achieving satisfying weight loss and resolving functional complications. The addition of a fundectomy appeared to have a significant positive impact on weight loss outcomes.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Endocrinology & Metabolism
Tummas Ternhamar, Andreas Moller, Christoffer Martinussen, Maria S. Svane, Morten Hindso, Nils B. Jorgensen, Carsten Dirksen, Jens-Erik Beck Jensen, Bolette Hartmann, Jens J. Holst, Bente Kiens, Sten Madsbad, Kirstine N. Bojsen-Moller
Summary: Moderate intensity cycling shortly after meal intake does not increase the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery. A low glycemic index meal increases nadir glucose and reduces glucose excursions compared with a high glycemic index meal. Participants who underwent Roux-en-Y gastric bypass surgery had lower postexercise glucagon responses compared with controls.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Jack S. Pullman, Lindsay D. Plank, Sherry Nisbet, Rinki Murphy, Michael W. C. Booth
Summary: This study compared the long-term outcomes of gastric bypass surgery and sleeve gastrectomy for treating type 2 diabetes. The results showed that gastric bypass surgery was more effective in achieving diabetes remission and weight loss at 7 years, with similar complication rates.
Article
Surgery
Adam Skidmore, Jonathon Holt
Summary: There is little difference in weight-loss results between Roux-en-Y gastric bypass (RYGB) and banded Roux-en-Y gastric bypass (BRYGB) with non-adjustable bands, and the use of non-adjustable bands may lead to significant complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Endocrinology & Metabolism
David C. C. Llewellyn, Hugh Logan Ellis, Simon J. B. Aylwin, Eduard Ostarijas, Shauna Green, William Sheridan, Nicholas W. S. Chew, Carel W. W. le Roux, Alexander D. D. Miras, Ameet G. G. Patel, Royce P. P. Vincent, Georgios K. K. Dimitriadis
Summary: Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is a recognized complication of bariatric surgery. This systematic review suggests that GLP-1 receptor agonists (GLP-1RAs) may reduce the number of postprandial hypoglycemic episodes and improve glycemic variability.
Article
Endocrinology & Metabolism
Carel W. le Roux, Shuyu Zhang, Louis J. Aronne, Robert F. Kushner, Ariana M. Chao, Sriram Machineni, Julia Dunn, Farai B. Chigutsa, Nadia N. Ahmad, Mathijs C. Bunck
Summary: The SURMOUNT development program aims to evaluate the effectiveness and safety of tirzepatide as a treatment for obesity. The program includes four global phase 3 trials, which have shown that once-weekly administration of tirzepatide can significantly reduce body weight.
Review
Nutrition & Dietetics
Hilary C. Craig, Zoe M. Doran, Carel W. le Roux
Summary: Obesity, a global epidemic, is a major health crisis with significant impacts. Over the years, perception of obesity has evolved from a self-inflicted condition to a recognized disease. An understanding of the underlying issues is crucial for developing comprehensive obesity management strategies, and the promotion of healthy behaviors is important, though not a standalone treatment for obesity.
Review
Medicine, General & Internal
Roshaida Abdul Wahab, Ricardo V. Cohen, Carel W. le Roux
Summary: Obesity is a chronic disease characterized by excess adiposity that negatively impacts health. The high prevalence of obesity increases the risk of long-term medical complications, including type 2 diabetes and chronic kidney disease. Studies have shown that certain medications and surgical procedures, such as sodium-glucose cotransporter 2 inhibitors and bariatric surgery, can have positive effects on diabetic kidney disease. However, more research is needed to effectively treat patients with obesity and chronic kidney disease and reduce morbidity.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Carel W. le Roux, Emily R. Hankosky, Duzhe Wang, Raleigh Malik, Maria Yu, Ana Hickey, Hong Kan, Mathijs C. Bunck, Adam Stefanski, Luis-Emilio Garcia-Perez, Sean Wharton
Summary: By using an indirect treatment comparison, this study found that tirzepatide 10 and 15 mg are more effective for weight loss compared to semaglutide 2.4 mg.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Erik Elebring, Anna Casselbrant, Sara M. T. Persson, Lars Fandriks, Ville Wallenius
Summary: Ingestion of nutrients stimulates the secretion of incretins, such as GLP-1, which regulate postprandial insulin release and satiety. This study investigated the inhibitory effect of beta HB on glucose-induced GLP-1 secretion using cell cultures. The results showed that beta HB significantly inhibited GLP-1 secretion in both murine GLUTag cells and differentiated human jejunal enteroid monolayers. The findings suggest that beta HB may act through multiple downstream mediators to regulate GLP-1 secretion.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Frida Lener, Gudrun Hoskuldsdottir, Kerstin Landin-Wilhelmsen, Cecilia Bjorkelund, Bjorn Eliasson, Lars Fandriks, Ville Wallenius, My Engstrom, Karin Mossberg
Summary: This study investigated the relationship between nutritional deficiencies and anaemia in patients who reported use of supplementation two years after bariatric surgery versus patients who do not. The results indicated that iron deficiency or anaemia may not be prevented by substitutional treatment per current guidelines after bariatric surgery and highlights there is reason to ensure adequate preoperative micronutrient levels.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Ebaa Al-Ozairi, Mohammad Irshad, Etab Taghadom, Litty Sojan, Jumana Al Kandari, Dherar Alroudhan, Carel W. le Roux
Summary: This study assessed the effects of adding sodium-glucose cotransporter-2 inhibitors (SGLT2i) and/or glucagon-like peptide-1 receptor agonists (GLP1-RA) to insulin on weight and glycemic control in individuals with type 1 diabetes. The results showed that both SGLT2i and GLP1-RA alone improved weight and glycemia, but combining these medications resulted in greater weight loss.
Article
Surgery
Andrew J. Beamish, Olivia H. Dengel, Elise F. Palzer, Eva Gronowitz, Aaron S. Kelly, Donald R. Dengel, Kyle D. Rudser, Markus Brissman, Torsten Olbers, Jovanna Dahlgren, Carl -Erik Flodmark, Claude Marcus, Justin R. Ryder
Summary: This study found that Roux-en-Y gastric bypass (RYGB) surgery in obese adolescents resulted in reductions in various body composition measures, with the greatest reduction observed in visceral adipose tissue (VAT). While other fat depots showed regain from 1 to 5 years post-RYGB, VAT remained lower than baseline values. The changes in VAT were associated with changes in triglycerides and fasting plasma insulin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Review
Nutrition & Dietetics
Antonio E. Pontiroli, Lucia Centofanti, Carel W. Le Roux, Silvia Magnani, Elena Tagliabue, Franco Folli
Summary: Overweight and obesity are associated with atrial fibrillation (AF). Bariatric surgery (BS) can induce sustained weight loss and may be an ideal treatment for preventing AF. Previous studies have not definitively established the role of weight loss and BS in preventing AF. This meta-analysis evaluates the role of weight loss through BS in preventing incident AF in obesity.
Review
Endocrinology & Metabolism
Moath S. Alsaqaaby, Carel W. le Roux
Summary: Obesity is now recognized as a disease associated with significant morbidity and mortality. Weight loss has been found to ameliorate the metabolic abnormalities underlying type 2 diabetes and improve glycemic control. Intentional weight loss can benefit patients with type 2 diabetes and obesity by not only improving glycemic control but also reducing cardiometabolic disease risk factors and enhancing well-being.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Ahmed W. Al-Humadi, Khaled Alabduljabbar, Moath S. Alsaqaaby, Hani Talaee, Carel W. le Roux
Summary: The study aimed to identify associations between clinico-demographical characteristics and genetic mutations associated with obesity. The results revealed that gene mutations associated with obesity are common among patients with a BMI > 40 kg/m(2). However, a patient's BMI, age of onset of obesity, or age of onset of hyperphagia did not provide valuable information in predicting the presence of genetic mutations associated with obesity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hilary C. Craig, Dalal Alsaeed, Suzanne Norris, John Holian, Cormac Kennedy, Alix Feldman, Carel Le Roux
Summary: By studying patients' preferences for obesity treatment and the factors influencing them, the adherence and efficacy of treatment can be improved.
OBESITY SCIENCE & PRACTICE
(2023)
Review
Endocrinology & Metabolism
Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
Summary: Obesity, a chronic low-grade inflammatory disease caused by various factors, is a significant global health threat for adults and children. There is a connection between type 1 diabetes and obesity, and managing obesity in this population poses challenges. Healthcare professionals need to balance benefits and risks without specific guidelines and regulatory approval.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Adrian H. Heald, Helene A. Fachim, Bilal Bashir, Bethanie Garside, Safwaan Adam, Zohaib Iqbal, Akheel A. Syed, Rachelle Donn, Carel W. Le Roux, Mahmoud Abdelaal, James White, Handrean Soran
Summary: Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB), improves dyslipidaemia and reduces body weight. This study found that RYGB may modulate gene expression in fat cells to influence the expression of the PCSK9 and LDLR genes. Lower PCSK9 gene expression and higher LDLR gene expression were observed in adipose tissue after RYGB in rats. Additionally, TNF alpha gene expression was positively correlated with PCSK9 gene expression after RYGB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
