Article
Psychiatry
Johannes C. S. Zang, Caroline May, Birte Hellwig, Dirk Moser, Jan G. Hengstler, Steve Cole, Markus Heinrichs, Joerg Rahnenfuehrer, Katrin Marcus, Robert Kumsta
Summary: The experience of childhood adversity has been linked to poor health outcomes in adulthood. Previous research focused on DNA methylation and transcriptomic profiles, while neglecting the level of proteins. Using mass spectrometry, this study examined the proteome of CD14(+) monocytes in adults with childhood adversity before and after psychosocial stress exposure. The results indicated upregulation of specific proteins related to immune processes, protein metabolism, and mitochondrial biology, especially in females.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Plant Sciences
Muhammad Shazly Rosdy, Mohd Salleh Rofiee, Nurdiana Samsulrizal, Mohd Zaki Salleh, Lay Kek Teh
Summary: The study found that chronically stressed zebrafish treated with MOLE exhibited significant changes in behavioral parameters, with increased swimming time. Additionally, unique metabolite profiles were observed in zebrafish with different treatments. MOLE is believed to relieve stress by regulating pathways involved in purine, glutathione, arginine and proline, D-glutamine, and D-glutamate metabolism.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jerry Guintivano, Karolina A. Aberg, Shaunna L. Clark, David R. Rubinow, Patrick F. Sullivan, Samantha Meltzer-Brody, Edwin J. C. G. van den Oord
Summary: This study reveals that B-cell activation and insulin resistance play a role in postpartum depression (PPD). Additionally, it highlights the involvement of DNA methylation loci and disease-associated gene expression regulatory loci in specific cell types in the transcriptional differences between PPD cases and controls.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Sidra Tabassum, Afzal Misrani, Hui-xian Huang, Zai-yong Zhang, Qiao-wei Li, Cheng Long
Summary: Environmental challenges, specifically chronic stress, have a negative impact on the SIRT1/PGC1 alpha/SIRT3 pathway and associated signaling, leading to impaired mitochondrial function and morphology, reduced numbers of interneurons, and increased oxidative stress. However, activation of SIRT1 by resveratrol (RSV) can ameliorate these effects and improve mitochondrial function, GABAergic mechanisms, autophagy, and apoptosis. Furthermore, RSV treatment can rescue anxiety-like and depressive-like behaviors induced by chronic stress.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
K. L. Stauch, S. Totusek, A. J. Trease, L. D. Estrella, K. Emanuel, A. Fangmeier, H. S. Fox
Summary: Our study utilized a combination of longitudinal isotopic metabolic labeling and organelle fraction proteomics to investigate the role of parkin in mitochondrial protein turnover in mice. We found that the half-life of brain striatal synaptic mitochondrial proteins is significantly longer than that of hepatic mitochondrial proteins. Loss of parkin resulted in a modest increase in mitochondrial protein abundance and half-life, and affected both known and novel pathways related to mitochondrial quality control and neurodegeneration. This study adds to the evidence suggesting low dependence on parkin for basal mitophagy in vivo and provides insights for future research on parkin targets.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Daniel J. Panyard, Justin McKetney, Yuetiva K. Deming, Autumn R. Morrow, Gilda E. Ennis, Erin M. Jonaitis, Carol A. Van Hulle, Chengran Yang, Yun Ju Sung, Muhammad Ali, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Barbara B. Bendlin, Henrik Zetterberg, Kaj Blennow, Carlos Cruchaga, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Joshua J. Coon, Corinne D. Engelman
Summary: A hallmark of Alzheimer's disease (AD) is the aggregation of proteins (amyloid beta [A] and hyperphosphorylated tau [T]) in the brain. Proteome-wide analysis of cerebrospinal fluid (CSF) identified 61 proteins significantly associated with the AD pathology and 636 significant protein-biomarker associations. The results suggest that glucose and carbon metabolic dysregulation and increased CSF succinylcarnitine levels are associated with amyloid and tau pathology in AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Barbara D. Fontana, Alistair J. Gibbon, Madeleine Cleal, William H. J. Norton, Matthew O. Parker
Summary: The study found that the 7-day chronic unpredictable early-life stress (CUELS) protocol decreased anxiety in both young and adult zebrafish, while exposure to 14 days of CUELS led to an opposite anxious phenotype. However, memory and cognition, social behavior, and cortisol levels did not show significant changes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Nurhidayah Abdul Rahim, Nurfatihah Nordin, Nur Izzatun Shahira Ahmad Rasedi, Farah Syazwani Mohd Kauli, Wan Norhamidah Wan Ibrahim, Fauziahanim Zakaria
Summary: According to the World Health Organization, approximately 350 million people worldwide suffer from mental health disorders, and the search for new drugs from nature has become a research method. In this study, a standardized extract from Polygonum minus was used to evaluate its anti-stress effect in a zebrafish model, and the results showed that zebrafish is a reliable model for studying the anti-stress effect of compounds or herbal extracts.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Neurosciences
Aya Jishi, Xin Qi
Summary: Increasing evidence suggests that mitochondrial dysfunction plays a key role in the development and progression of various neurodegenerative diseases. The diverse functions of mitochondria require tight regulation of protein import, dynamics, and turnover, which can be affected in several major proteinopathies. Failure of these regulatory mechanisms compromises mitochondrial function and exacerbates pathogenic processes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Giyoung Lee, Amit Banik, Juneyong Eum, Byung Joon Hwang, Seung-Hae Kwon, Yun Kee
Summary: Ipconazole, a widely used agricultural fungicide, has the potential to alter neurodevelopment by dysregulating mitochondrial homeostasis in zebrafish embryos. It was found that ipconazole exposure reduced locomotive activity and dysregulated GABAergic inhibitory neurons, while leaving glutamatergic excitatory and dopaminergic neurons unaffected. Molecular profiling revealed oxidative stress and reduced expression of mitochondria-related genes. Furthermore, ipconazole treatment caused cell death independent of caspase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jin Chen, Mingxuan Zhang, Hongmei Zou, Stanley Aniagu, Yan Jiang, Tao Chen
Summary: This study demonstrates that PM2.5 induces mitochondrial dysfunction in zebrafish embryos' hearts via the AHR-mediated cyp1a1 overexpression, leading to increased mtROS generation, mPTP opening, MMP collapse, reduced ATP levels, and decreased expression of mitochondrial proteins. Inhibition of AHR or mPTP can mitigate these effects and protect against apoptosis and heart defects. Furthermore, inhibiting mtROS generation with MitoQ and knockdown of cyp1a1, but not cyp1b1, attenuate the PM2.5-induced mtROS generation and heart defects.
Article
Environmental Sciences
Jin-Young Lee, Hahyun Park, Whasun Lim, Gwonhwa Song
Summary: The herbicide aclonifen is toxic to experimental animals, causing developmental abnormalities and impaired organogenesis. Mitochondrial dysfunction caused by aclonifen results in various developmental defects in zebrafish embryos, including reduced body length, delayed yolk sac absorption, and disrupted brain and eye formation. This study highlights the importance of understanding the toxicological effects of herbicides in non-target organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Yun-Yi Zou, Xiang-bin Tang, Zhang-Lin Chen, Bin Liu, Lan Zheng, Ming-Yang Song, Qin Xiao, Zuo-Qiong Zhou, Xi-Yang Peng, Chang-Fa Tang
Summary: Recent reports suggest that mitochondrial quality decreases during NAFLD progression, and targeting the mitochondria may be a potential treatment for NAFLD. Exercise has been found to effectively slow NAFLD progression or treat NAFLD. However, the effect of exercise on mitochondrial quality in NAFLD has not been established.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Chunjiao Lu, Yuhang Lv, Guanhua Kou, Yao Liu, Yi Liu, Yang Chen, Xuewei Wu, Fan Yang, Juanjuan Luo, Xiaojun Yang
Summary: Silver nanoparticles (AgNPs) exposure is toxic to zebrafish embryos, causing developmental defects and oxidative stress, leading to mitochondrial dysfunction and developmental toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Nayoung Min, Hahyun Park, Taeyeon Hong, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study evaluated the developmental toxicity of the herbicide prometryn in zebrafish embryos, revealing that it shortened body length, induced organ development defects, reactive oxygen species accumulation, and cell death. It was also found to interfere with mitochondrial function and energy metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Oncology
R. Gajendra Reddy, Unis Ahmad Bhat, Sumana Chakravarty, Arvind Kumar
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Pravin Kumar Mishra, Madhavi Adusumilli, Pallavi Deolal, Graeme F. Mason, Arvind Kumar, Anant Bahadur Patel
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Neurosciences
Harish Iyer, Abhipradnya B. Wahul, P. K. Annapoorna, Bharvi S. Sawant, Arvind Kumar
Summary: Neurological disorders are a leading cause of disability globally, with epigenetic regulation playing a key role. The acetylation machinery components BRPF and BET are believed to play important roles in various diseases. Researchers suggest that these proteins may act as key players in NLDs.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Neurosciences
Sridhar Amalakanti, Unis Ahmad Bhat, Madhavi B. Mylavarapu, Nitin Khandelwal, N. V. Sundarachary, Sumana Chakravarty, Arvind Kumar
Summary: This study investigated changes in hippocampal gene expression in a phenytoin-resistant mouse model of epilepsy using microarray analysis. The results revealed distinct gene expression profiles between phenytoin-resistant and sensitive mice, with differential expression of genes involved in cholesterol biosynthesis highlighted by pathway enrichment analysis.
NEUROMOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
K. Athira, Abhipradnya Bipin Wahul, Kalyani Soren, Tapatee Das, Sandeep Dey, Pavan Kumar Samudrala, Arvind Kumar, Mangala Lahkar, Sumana Chakravarty
Summary: This study investigated the antidepressant potential of vorinostat (VOR) against chronic social defeat stress (CSDS) in mice, revealing molecular deviations between resilient and defeated mice. Defeated mice displayed depression-like symptoms, while resilient mice showed resilience to such symptoms. The differential nuclear levels of GR, HDAC3, and HDAC6 in the hippocampus were associated with the development of resilience or defeat to CSDS.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Biology
Shams Ul Haq, Unis Ahmad Bhat, Arvind Kumar
Summary: Prenatal environment significantly influences mammalian fetal development, with adverse conditions leading to lasting consequences for offspring health. Various prenatal stress factors increase vulnerability to neuropsychiatric disorders, with cortisol playing a key role in stress transfer. The effects of prenatal stress on offspring brain include alterations at molecular, cellular, and structural levels, ultimately impacting behavior and cognition.
JOURNAL OF BIOSCIENCES
(2021)
Article
Behavioral Sciences
Bommana Raghunath Reddy, Nukala Sarath Babu, Tapatee Das, Dwaipayan Bhattacharya, Ch. Lakshmi N. Murthy, Arvind Kumar, Mohammed M. Idris, Sumana Chakravarty
Summary: Chronic stress can lead to mood disorders such as depression, with a zebrafish model providing an effective tool for studying these disorders and antidepressant treatments, involving various signaling pathways in the regulation of neural progenitor cell proliferation or neurogenesis.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biology
Hemakumar M. Reddy, Rupa Bhattacharya, Shrish Tiwari, Kankadeb Mishra, Pranatharthi Annapurna, Zeenath Jehan, Nissankararao Mary Praveena, Jomini Liza Alex, Vishnu M. Dhople, Lalji Singh, Mahadevan Sivaramakrishnan, Anurag Chaturvedi, Nandini Rangaraj, Thomas Michael Shiju, Badanapuram Sreedevi, Sachin Kumar, Ram Reddy Dereddi, Sunayana M. Rayabandla, Rachel A. Jesudasan
Summary: A study identified novel male-specific Y long arm-derived noncoding RNAs in mice, which may regulate the expression of several autosomal genes through piRNAs. The sperm phenotypes of Yq-deleted mice are similar to those reported in inter-specific male-sterile hybrids, suggesting a potential role of these noncoding RNAs in male sterility and speciation.
Review
Biochemistry & Molecular Biology
Rajmohamed Mohamed Asik, Natarajan Suganthy, Mohamed Asik Aarifa, Arvind Kumar, Krisztian Szigeti, Domokos Mathe, Balazs Gulyas, Govindaraju Archunan, Parasuraman Padmanabhan
Summary: Amyloid-beta (Aβ) plays a crucial role in Alzheimer's disease progression by affecting cellular structures and functions through various mechanisms, ultimately leading to neurodegeneration.
Article
Neurosciences
Priya Jhelum, Mydhili Radhakrishnan, A. R. Sam Paul, Sandeep K. Dey, Avijeet Kamle, Arvind Kumar, Abhay Sharma, Sumana Chakravarty
Summary: Glucosamine has been found to exhibit neuroprotective, antineuroinflammatory, and proneurogenic effects in mouse models of brain injury, potentially enhancing its drug repurposing potential in ischemic stroke.
NEUROMOLECULAR MEDICINE
(2022)
Article
Genetics & Heredity
Tapatee Das, Avijeet Kamle, Arvind Kumar, Sumana Chakravarty
Summary: Understanding the molecular basis of sex differences in neural response to acute hypoxic insult is important for preventing and treating ischemic stroke. Using a zebrafish model, this study investigated the quantitative changes in brain proteome during recovery from hypoxic insult and identified differentially expressed regulatory proteins. Analysis revealed distinct sex differences in disease function and validated upstream regulators at the transcriptional level. Upregulation of H3K9me3 in males affected neurogenic markers, potentially explaining delayed recovery compared to females. The study provides potential novel targets for therapeutic strategies.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Liyan Fan, Alexander F. Lesser, David R. Sweet, Komal S. Keerthy, Yuan Lu, Ernest R. Chan, Vinesh Vinayachandran, Olga Ilkayeva, Tapatee Das, Christopher B. Newgard, Mukesh K. Jain
Summary: Brown adipose tissue (BAT) is crucial for maintaining metabolic health and survival by regulating and utilizing nutrient resources. The transcription factor KLF15 plays a critical role in the metabolic flexibility of BAT.
Article
Biochemistry & Molecular Biology
Unis Ahmad Bhat, Sreemantula Arun Kumar, Sumana Chakravarty, Anant Bahadur Patel, Arvind Kumar
Summary: Chronic alcohol use disorder is a major risk factor for neuropsychiatric disorders, and it affects neuronal and glial activities in the brain. The changes in neurochemical profile caused by alcohol are associated with negative emotional state and dysregulated reward. However, the underlying alterations in neuro-astroglial activities and neurochemical dysregulations after chronic alcohol use are poorly understood.
NEUROCHEMICAL RESEARCH
(2023)