Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat

(2011) Samuel E. Schriner et al.   BIOGERONTOLOGY

The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae

(2011) Maria M. Bayliak et al.   PHYTOMEDICINE

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

(2010) Susan J. Broughton et al.   AGING CELL

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Glycolytic inhibition as a strategy for developing calorie restriction mimetics

(2010) Donald K. Ingram et al.   EXPERIMENTAL GERONTOLOGY

Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

(2010) A. Panossian et al.   PHYTOMEDICINE

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster

(2010) Kyu-Sun Lee et al.   REJUVENATION RESEARCH

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

(2009) Dickon M. Humphrey et al.   EXPERIMENTAL GERONTOLOGY

Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses

(2009) Samuel E. Schriner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased mitochondrial superoxide levels and enhanced protection against paraquat inDrosophilamelanogastersupplemented withRhodiola rosea

(2009) Samuel E. Schriner et al.   FREE RADICAL RESEARCH

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

(2009) Richard C. Grandison et al.   PLoS One

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Plant adaptogens increase lifespan and stress resistance in C. elegans

(2008) F. A. C. Wiegant et al.   BIOGERONTOLOGY

Diet and Aging

(2008) Matthew D.W. Piper et al.   Cell Metabolism

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS