Three-Dimensional Collagen I Promotes Gemcitabine Resistance In Vitro in Pancreatic Cancer Cells through HMGA2-Dependent Histone Acetyltransferase Expression

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

(2012) Salvatore Piscuoglio et al.   HISTOPATHOLOGY

Interplay between β1-Integrin and Rho Signaling Regulates Differential Scattering and Motility of Pancreatic Cancer Cells by Snail and Slug Proteins

(2012) Mario A. Shields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells

(2012) Lang Zha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic Cancer

(2012) Guan Wang et al.   PLoS One

HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR/p70S6K signaling pathway

(2012) Kyung-Rok Yu et al.   Stem Cell Research

Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

(2011) Mario A. Shields et al.   BIOCHEMICAL JOURNAL

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

(2011) Mario A. Shields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote Tumorigenesis

(2011) A. Y.-J. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

(2011) F. R. Santer et al.   MOLECULAR CANCER THERAPEUTICS

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

(2011) D Palmieri et al.   ONCOGENE

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

(2011) H Ogiwara et al.   ONCOGENE

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification

(2010) K. Storch et al.   CANCER RESEARCH

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Rho-ROCK-Myosin Signaling Meditates Membrane Type 1 Matrix Metalloproteinase-induced Cellular Aggregation of Keratinocytes

(2010) Surabhi Dangi-Garimella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rationale for Possible Targeting of Histone Deacetylase Signaling in Cancer Diseases with a Special Reference to Pancreatic Cancer

(2010) Mehdi Ouaïssi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704

(2010) Ananya Manuyakorn et al.   JOURNAL OF CLINICAL ONCOLOGY

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage

(2010) Ruifeng Guo et al.   NUCLEIC ACIDS RESEARCH

Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

(2010) S Dangi-Garimella et al.   ONCOGENE

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

NFAT-Induced Histone Acetylation Relay Switch Promotes c-Myc-Dependent Growth in Pancreatic Cancer Cells

(2009) Alexander Köenig et al.   GASTROENTEROLOGY

Epigenetics in cancer: Targeting chromatin modifications

(2009) L. Ellis et al.   MOLECULAR CANCER THERAPEUTICS

Expression of Hypoxia-Inducible Factor-1α, Histone Deacetylase 1, and Metastasis-Associated Protein 1 in Pancreatic Carcinoma

(2009) Kotaro Miyake et al.   PANCREAS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The High Mobility Group Protein HMGA2: A Co-Regulator of Chromatin Structure and Pluripotency in Stem Cells?

(2009) Kurt Pfannkuche et al.   Stem Cell Reviews and Reports

High Histone Deacetylase 7 (HDAC7) Expression Is Significantly Associated with Adenocarcinomas of the Pancreas

(2008) Mehdi Ouaïssi et al.   ANNALS OF SURGICAL ONCOLOGY

Chromatin-modifying enzymes as therapeutic targets – Part 2

(2008) Brian R Keppler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Chromatin-modifying enzymes as therapeutic targets – Part 1

(2008) Brian R Keppler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma

(2008) Alexandra C Hristov et al.   MODERN PATHOLOGY

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

(2008) Yongkun Wei et al.   MOLECULAR CARCINOGENESIS