Article
Engineering, Biomedical
Xiu-Zhen Zhang, Yan-Lin Jiang, Jun-Gen Hu, Long-Mei Zhao, Qiu-Zhu Chen, Yan Liang, Yi Zhang, Xiong-Xin Lei, Rui Wang, Yi Lei, Qing-Yi Zhang, Jesse Li-Ling, Hui-Qi Xie
Summary: The study successfully repaired full-thickness bladder defects using procyanidins (PC) crosslinked small intestine submucosa (SIS) biomaterial scaffold, reducing complications and enhancing bladder functions.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Abubakr H. Mossa, Jacob Abdaem, Philippe Cammisotto, Lysanne Campeau
Summary: The activation of proNGF/p75(NTR) axis induces degenerative changes to the urothelial layer impacting its barrier and signaling integrity, while promoting adaptive proliferative changes in detrusor SM cells that can interfere with the contractile phenotype essential for proper bladder function. This study highlights the different effects of proNGF on urothelial and smooth muscle cells in the bladder, suggesting a potential role in bladder dysfunction.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Xiujie Xie, Lian-Wang Guo, K. Craig Kent
Summary: Communication between endothelial cells and smooth muscle cells is crucial for vascular homeostasis, with miR548ai potentially serving as a molecular target for protection against dysfunction induced by proliferative cell-derived exosomes.
CELL DEATH DISCOVERY
(2021)
Article
Multidisciplinary Sciences
Nevin Witman, Chikai Zhou, Timm Haeneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmer, Niels Grote Beverborg, Kenneth R. Chien, Makoto Sahara
Summary: Cardiogenic growth factors, such as PLGF, play crucial roles in heart development. PLGF exhibits both autocrine and paracrine functions during cardiomyogenesis and vasculogenesis, and it may have potential therapeutic applications for heart disease. Further studies have revealed the previously unrecognized transcriptional networks related to PLGF, driven by EOMES and SOX17.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Zhe Wei, Hoshun Chong, Qixia Jiang, Yuhang Tang, Jinhong Xu, Haoquan Wang, Yanteng Shi, Le Cui, Jing Li, Yujing Zhang, Yunxing Xue, Jutang Li, George Liu, Xi Chen, Dongjin Wang, Chen-Yu Zhang, Xiaohong Jiang
Summary: The study found that overexpression of PGC1 alpha in VSMCs significantly reduced aortic atherosclerosis in rabbits and preserved the contractile phenotype of VSMCs, highlighting the therapeutic potential of PGC1 alpha for atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Biomedical
Chengyuan Wang, Hui Wang, Qianping Guo, Xiaojie Ang, Bin Li, Fengxuan Han, Yingxi Fu, Weiguo Chen
Summary: This study successfully promoted bladder muscle regeneration using a bilayer scaffold, indicating that bilayer scaffolds delivering heparin and carrying stem cells could be a novel strategy for bladder tissue engineering.
BIOMEDICAL MATERIALS
(2021)
Article
Medicine, Research & Experimental
Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Dustin R. Fraidenburg, Balaji Ganesh, Mark Maienschein-Cline, Karl Obrietan, J. Usha Raj
Summary: MicroRNA miR-212-5p has been identified as an anti-proliferative miRNA that is induced in pulmonary artery smooth muscle cells and lungs of pulmonary hypertension patients and experimental animals. It acts as an endogenous inhibitor of pulmonary hypertension by suppressing smooth muscle cell proliferation. In addition, engineered endothelium-derived extracellular vesicles carrying miR-212-5p have shown potential as a delivery system for treating severe pulmonary hypertension.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Developmental Biology
Michael Donadon, Massimo M. Santoro
Summary: The article primarily describes the developmental origin of smooth muscle cells in different organs, as well as their specification and differentiation in the cardiovascular, respiratory, and intestinal systems. It discusses the important roles of smooth muscle in organ development and how they instruct the development of other organs through signaling and mechanical feedback mechanisms. By understanding smooth muscle cell development, the aim is to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.
Article
Plant Sciences
Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng
Summary: This study investigated the therapeutic efficiency of gastrodin as an antihypertensive and determined the mechanisms underlying its effects. The results showed that gastrodin lowered blood pressure, suppressed vascular contraction, and inhibited activation of the MLCK/p-MLC2 pathway, demonstrating its therapeutic efficacy as an antihypertensive.
PHARMACEUTICAL BIOLOGY
(2023)
Editorial Material
Cell Biology
Renzhi Hou, Aliaksandr A. Astrowski, Maksim V. Plikus
Summary: The heightened ability of spiny mice to regenerate after injury is attributed to molecular changes in the Hippo-YAP pathway that protect wound fibroblasts from a persistent contractile state, as revealed in this issue of Developmental Cell.
DEVELOPMENTAL CELL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Weiqun Yu
Summary: Inhibition of bladder contraction with antimuscarinics is a common approach for treating bladder hyperactivity. The L-type voltage-gated calcium channel alpha(1C) (Cav1.2) plays a crucial role in bladder contractility. However, clinical trials using calcium channel blockers (CCBs) for treating bladder overactivity have been unsuccessful, contrary to expectations. Recent findings suggest that ketamine and nifedipine can function as Cav1.2 antagonists, and a Cav1.2 agonist can increase void volume and reduce voiding frequency. This perspective discusses the unsuccessful use of CCBs in urological trials and the potential of Cav1.2 agonists as novel therapies for bladder dysfunctions.
Article
Materials Science, Biomaterials
Shuwei Xiao, Pengchao Wang, Jian Zhao, Zhengyun Ling, Ziyan An, Zhouyang Fu, Weijun Fu, Xu Zhang
Summary: A scaffold encapsulated with adipose-derived stem cells was developed for bladder augmentation in rats. The scaffold promoted vascularization and regeneration of bladder wall structure, with the stem cells contributing to the regeneration of smooth muscle, neurons, and blood vessels as well as restoration of physiological function.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jaime Gutierrez, David Gonzalez, Rodrigo Escalona-Rivano, Chiaki Takahashi, Enrique Brandan
Summary: RECK plays a role as a potential myogenic repressor during muscle formation and regeneration, with transient up-regulation accelerating muscle regeneration. RECK-deficient mice show reduced fibrosis in a model of chronic muscle damage, suggesting RECK as a potential target for treating muscle-wasting diseases.
Review
Biochemistry & Molecular Biology
Jaciara F. G. Gama, Rayza D. Romualdo, Mayara L. de Assis, Luana M. de Oliveira, Thereza Quirico-Santos, Luiz A. Alves, Jussara Lagrota-Candido
Summary: This systematic review summarizes the role of Treg in muscle repair and their therapeutic potential in skeletal muscle injuries. The review provides comprehensive analysis of the literature and guidance on methodology.
Review
Geriatrics & Gerontology
Wei Chen, Yushi Chen, Yuxi Liu, Xinxia Wang
Summary: Autophagy is a physiological process that plays a crucial role in degrading cellular components and regulating cellular structure. It has been found to have various mechanisms and functions in muscle regeneration, including influencing the fate of muscle stem cells and regulating muscle cell functions. Understanding the role and mechanism of autophagy in muscle regeneration can lead to the development of more effective therapeutic strategies.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)