Article
Ophthalmology
Duriye Damla Sevgi, Sunil K. Srivastava, Charles Wykoff, Adrienne W. Scott, Jenna Hach, Margaret O'Connell, Jon Whitney, Amit Vasanji, Jamie L. Reese, Justis P. Ehlers
Summary: The study demonstrates the feasibility of using a deep learning-based vascular segmentation tool to extract vascular parameters for quality assessment and optimized phase selection in angiographic images. Results show successful identification of appropriate images for both early and late phases in 85.2% of sessions, indicating the effectiveness of this technology.
Article
Ophthalmology
Josef Huemer, Hagar Khalid, Siegfried K. Wagner, Luke Nicholson, Dun Jack Fu, Dawn A. Sim, Praveen J. Patel, Konstantinos Balaskas, Ranjan Rajendram, Pearse A. Keane
Summary: Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) can lead to visually significant vitreous hemorrhage. Wide-field optical coherence tomography angiography (WF-OCTA) is a useful noninvasive tool for detecting and characterizing neovascularization secondary to RVO in patients.
Article
Biology
Mariana DuPont, John Hunsicker, Simona Shirley, William Warriner, Annabelle Rowland, Reddhyia Taylor, Michael DuPont Jr, Mark Lagatuz, Taygan Yilmaz, Andrew Foderaro, Tim Lahm, Corey E. Ventetuolo, Maria B. Grant
Summary: Noninvasive imaging such as color fundus (CF) can provide accurate assessment of retinal vascular changes in individuals with pulmonary arterial hypertension (PAH). The use of VESGEN computer software allows for a comparison between FA and CF images, indicating similar results in tortuosity and vessel area density measurements. Deep learning segmentation shows similarities in vascular structure defined by fractal dimension. The findings suggest potential future clinical translational use.
Article
Multidisciplinary Sciences
Joon Seo Lim, Cheolwon Moon, Junyeop Lee
Summary: The presence of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC) is associated with disturbances in retinal blood flow, including reduced venous blood flow velocity and rate, as well as changes in venous diameter. SRF thickness is correlated with a decrease in venous blood flow rate, suggesting that SRF plays a role in altering retinal blood flow dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Naoki Soga, Shin Tanaka, Maiko Inoue, Tatsuya Inoue, Atsushi Hayashi, Eugene de Juan Jr, Kazuaki Kadonosono
Summary: This study compared macular vessel density in CRAO eyes treated with retinal arterial cannulation and standard treatment. The cannulation group showed significant improvement in macular vessel density after 7 days, while the standard treatment group did not show significant improvement. After one month, the cannulation group had significantly improved visual acuity compared to the initial visit after the onset.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Peter M. Maloca, Silvia Feu-Basilio, Julia Schottenhamml, Philippe Valmaggia, Hendrik P. N. Scholl, Josep Rosines-Fonoll, Sara Marin-Martinez, Nadja Inglin, Michael Reich, Clemens Lange, Catherine Egan, Sandrine Zweifel, Adnan Tufail, Richard F. Spaide, Javier Zarranz-Ventura
Summary: This study is the first to investigate three-dimensional vascular parameters, specifically vessel surface area, in a population using OCTA. It found that axial length has the strongest effect on OCTA vessel surface area, with a slight negative correlation with age.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Ramesh Venkatesh, Shama Sharief, Chitturi Venkata Sai Prashanti, Nikitha Gurram Reddy, Rubble Mangla, Yash Parmar, Aaditi Anilkumar, Naresh Kumar Yadav, Jay Chhablani
Summary: Aberrant filling of the retinal vein in patients with branch or hemi-central retinal artery occlusions is associated with less severe retinal ischemia and better visual outcomes. This finding may be attributed to altered retinal vascular anatomy or arteriovenous shunts. The presence of aberrant filling of the retinal vein could indicate a better visual prognosis.
Article
Chemistry, Multidisciplinary
Hiroshi Keino, Tomoki Wakitani, Wataru Sunayama, Yuji Hatanaka
Summary: This study developed an automatic segmentation model using deep learning and FA images to detect retinal vascular leakage. The automated model showed high accuracy and recall in segmenting the leakage area in UWF FA images and exhibited a significant positive correlation with FA vascular leakage score.
APPLIED SCIENCES-BASEL
(2022)
Article
Computer Science, Information Systems
Esin Uysal, Gur Emre Guraksin
Summary: This study proposes a hybrid method utilizing a deep learning model and data augmentation techniques to automatically extract retinal blood vessels. Testing in the DRIVE database showed that the system achieved high accuracy and precision in vessel extraction.
MULTIMEDIA TOOLS AND APPLICATIONS
(2021)
Article
Ophthalmology
P. A. O. L. O. S. SILVA, D. A. N. N. I. LIU, A. D. A. M. R. GLASSMAN, L. L. O. Y. D. P. AIELLO, S. A. N. D. E. E. P. GROVER, R. O. N. A. L. D. M. KINGSLEY, M. I. C. H. E. L. E. MELIA, J. E. N. N. I. F. E. R. K. SUN
Summary: This study evaluated the association between retinal nonperfusion on ultrawide field fluorescein angiography and the severity of diabetic retinopathy and predominantly peripheral lesions. The results showed that increased nonperfusion was associated with worse diabetic retinopathy severity and the presence of predominantly peripheral lesions.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Review
Medicine, General & Internal
Aniruddha Agarwal, Anne Ruebsam, Lynn zur Bonsen, Francesco Pichi, Piergiorgio Neri, Uwe Pleyer
Summary: In this review, the etiologies, clinical manifestations, and imaging advances in retinal vasculitis, such as OCTA and widefield imaging, have been comprehensively discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jie Peng, Jianing Ren, Xuerui Zhang, Yuan Yang, Yihua Zou, Haodong Xiao, Yu Xu, Peiquan Zhao
Summary: The two-step fundus fluorescein angiography (FFA) procedure is effective in diagnosing and treating pediatric retinal vasculopathy, especially for neovascularization.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kicky G. van Leeuwen, Frederick J. A. Meijer, Steven Schalekamp, Matthieu J. C. M. Rutten, Ewoud J. van Dijk, Bram van Ginneken, Tim M. Govers, Maarten de Rooij
Summary: This study used early health technology assessment to evaluate the potential value of AI software in radiology, specifically in detecting intracranial large vessel occlusions in stroke. The results demonstrated that AI tools for LVO detection in emergency care have the potential to improve healthcare outcomes and save costs.
INSIGHTS INTO IMAGING
(2021)
Article
Computer Science, Information Systems
Muhammad Zubair, Muhammad Umair, Rizwan Ali Naqvi, Dildar Hussain, Muhammad Owais, Naoufel Werghi
Summary: This study proposes an efficient and complete model for early diagnosis and staging of DME. By introducing improved image processing techniques and advanced clustering algorithms, the model achieves significant performance improvement in localization, segmentation, and classification.
JOURNAL OF KING SAUD UNIVERSITY-COMPUTER AND INFORMATION SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Wenwen Kong, Pengxiao Zang, Sijie Niu, Dengwang Li
Summary: This paper proposes an automated registration method for multi-modality retinal fundus photographs based on the directional vessel skeleton, aiming to provide clinicians with multi-modality information to diagnose retinal diseases or make treatment decisions. The method shows advantageous performance in both registration success rate and accuracy when evaluated with various types of fundus photographs in the macular regions of patients with diseases.
IET IMAGE PROCESSING
(2021)
Article
Ophthalmology
Amgad El Nokrashy, Sue Lightman, Oren Tomkins-Netzer
Summary: Infliximab shows value in controlling and reducing relapse rates of orbital myositis, making it a potential treatment option for refractory orbital myositis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Adi Einan-Lifshitz, Asaf Achiron, Shira Hed, Idan Hecht, Biana Dubinsky-Pertzov, Boris Knyazer
Summary: The study demonstrates that accelerated corneal collagen cross-linking (A-CXL) can improve visual function, reduce corneal astigmatism and Kmax, and decrease the thinnest corneal thickness in pediatric patients with keratoconus (KC) after three years of follow-up. A-CXL is non-inferior to standard CXL (S-CXL) in terms of best-corrected and uncorrected visual acuity, thinnest pachymetry, and astigmatism, but non-inferiority cannot be concluded for Kmax.
Article
Ophthalmology
Boris E. Malyugin, Alexandra Belodedova, Olga Antonova, Aslan Gelyastanov, Raimo Tuuminen, Eliya Levinger, Asaf Achiron, Boris Knyazer
Summary: Creating an intrastromal tunnel using a new femtosecond laser software in deep anterior lamellar keratoplasty (DALK) resulted in a higher rate of big bubble formation, reduced endothelial cell loss, and shorter surgery time.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Orly Weinstein, Arnon D. Cohen, Jaime Levy, Ofira Zloto, Tamar Freud, Israel Krieger, Doron Comaneshter, Rachel Shemesh
Summary: This study investigates the prevalence of anxiety in patients with neovascular age-related macular degeneration (nAMD) and finds that anxiety is more common in nAMD patients compared to the control group.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Ronit Aviram, Inbar Kima, Yisrael Parmet, Haim Bassan, Thierry Willigenburg, Raziel Riemer, Simona Bar-Haim
Summary: This study evaluated muscle haemodynamics and oxygen metabolism in adults with cerebral palsy (CP) at rest and during exercise. The results showed that participants with CP had lower muscle blood flow at rest and low load, but increased blood flow at high load. Compared to typically developing individuals, participants with CP had higher muscle saturation, suggesting inefficient oxygen utilization.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Robotics
Ela Liberman-Pincu, Yisrael Parmet, Tal Oron-Gilad
Summary: Socially assistive robots (SARs) aim to provide assistance through social interaction. Previous studies mainly focused on users' perceptions and preferences regarding existing commercially available SARs. This study systematically evaluates the effect of isolated visual qualities (VQs) on SARs, using 30 new models with varying VQs. The empirical findings link VQs with perceptions of SAR characteristics, providing potential guidelines for industrial design processes.
ACM TRANSACTIONS ON HUMAN-ROBOT INTERACTION
(2023)
Review
Ophthalmology
Richard P. C. Manns, Asaf Achiron, Boris Knyazer, Omar Elhaddad, Kieran Darcy, Tal Yahalomi, Derek Tole, Venkata S. Avadhanam
Summary: This literature review examines the scientific evidence on the benefits of collagen cross-linking in managing ophthalmic diseases other than keratoconus. The review finds that cross-linking can limit the progression of various corneal ectasias and potentially reduce the need for keratoplasty. However, evidence is limited for certain conditions such as fungal, Acanthamoeba, and herpes virus keratitis.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Yogev Koren, Shirley Handelzalts, Yisrael Parmet, Simona Bar-Haim
Summary: Gazing down a few steps ahead can enhance postural control in older adults and stroke survivors, but extreme downward gazing can impair stability, especially in stroke patients.
Review
Ophthalmology
Yotam Eyni, Tomer Kerman, Itai Hazan, Elli Rosenberg, Omer Lev Ari, Boris Knyazer, Erez Tsumi
Summary: This retrospective case-control study found that systemic and periocular inflammatory and allergic diseases are risk factors for pterygium.
SEMINARS IN OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Shai Tejman-Yarden, Dor Freidin, Netanel Nagar, Yisrael Parmet, Muhamed Abed, Oliana Vazhgovsky, David Yogev, Dov Ganchrow, Efrat Mazor-Drey, Sumit Chatterji, Roy Beinart, Israel Barbash, Victor Guetta, Orly Goitein
Summary: This study explored the feasibility and accuracy of virtual reality (VR) derived from cardiac computed angiography (CCTA) data in predicting the size of left atrial appendage occlusion (LAAO) devices. The results showed that VR measurement of the maximal ostium diameter had the strongest correlation with the diameter of the inserted device, indicating that VR may provide new imaging possibilities for the evaluation of complex pre-procedural structures.
Article
Ophthalmology
Ahmed Al-Janabi, Lazha Sharief, Noura Al Qassimi, Yi-Hsing Chen, Tao Ding, Gareth Ambler, Dimitris Ladas, Sue Lightman, Oren Tomkins-Netzer
Summary: A randomized controlled trial found no significant difference in efficacy between 80 mg/day simvastatin and placebo in noninfectious nonanterior uveitis patients. The study suggests that simvastatin does not have a corticosteroid-sparing effect but may extend the time to disease relapse for patients achieving disease quiescence.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Otorhinolaryngology
Gilad Feinmesser, David Yogev, Tomer Goldberg, Yisrael Parmet, Shay Illouz, Oliana Vazgovsky, Yael Eshet, Shai Tejman-Yarden, Eran Alon
Summary: This study explored the value of using a virtual reality platform for pre-operative planning in head and neck skin cancer patients undergoing sentinel lymph node biopsies, as well as its role in resident training. The results showed that the VR simulation accurately portrayed sentinel lymph nodes and was rated highly by attending surgeons and residents as an effective surgical planning and teaching tool.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hagar Olshaker, Asaf Achiron, Alexander Chorny, Farhad Hafezi, Tal Yahalomi, Assaf Kratz, Erez Tsumi, Nan-Ji Lu, Boris Knyazer
Summary: The study evaluated the efficacy and safety of high fluence PACK-CXL as an adjuvant therapy for infectious keratitis. The results showed that high fluence PACK-CXL is safe and efficient in promoting re-epithelization time and reducing the need for keratoplasties.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
David Hochstein, Shai Tejman-Yarden, Olga Saukhat, Oliana Vazgovski, Yisrael Parmet, Netanel Nagar, Edward Ram, Dan Carter
Summary: Three-dimensional virtual reality technology allows precise reconstruction of CT images and measurement of colonic anatomical parameters. This study aimed to determine if 3D reconstructions of the colon could help identify and quantify the key anatomical features leading to colonoscopy failure.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Ophthalmology
Ortal Buhbut, Asaf Achiron, Boris Knyazer, Shiri Kantor, Carmel Shinar, Lena Abayev, Idan Hecht, Zvia Burgansky-Eliash, Lily Karmona, Guy Kleinmann, Haggay Avizemer
Summary: The study aimed to evaluate the association between pre-operative parameters and surprise phacodonesis in patients with pseudoexfoliation (PXF) undergoing cataract surgery. The results showed that elevated pre-operative intraocular pressure (IOP) and poor posterior segment visibility requiring B scan use were associated with zonular instability.
INTERNATIONAL OPHTHALMOLOGY
(2023)