Article
Infectious Diseases
Anna Jaakola, Michel Roger, Marie-Claude Faucher, Kari Syrjanen, Seija Grenman, Stina Syrjanen, Karolina Louvanto
Summary: Host HLA-G genotypes may impact the outcomes of oral HPV infections in women, but have little effect on genital HPV status or infection outcomes.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Zhan Zhang, Ting Li, Dai Zhang, Xiaonan Zong, Huihui Bai, Hui Bi, Zhaohui Liu
Summary: The study revealed significant differences in personal habits and sexual activity among hrHPV(+) subjects. The alpha diversity of the cervical microbiota was higher than that of the vaginal microbiota. Proteobacteria were found in higher proportions in the cervical microbiota compared to the vaginal microbiota, and were associated with hrHPV infection and cervical cancer.
Article
Multidisciplinary Sciences
Elaina Kaufman, Tyler Williamson, Marie-Helene Mayrand, Ann N. Burchell, Marina Klein, Louise Charest, Sophie Rodrigues-Coutlee, Francois Coutlee, Alexandra de Pokomandy
Summary: In this study, multivariable logistic regression analysis was used to analyze the baseline data of anal HPV 16 infection, and it was found that current smoking, nadir CD4 count, prevalent cervical HPV 16 infection, and anogenital herpes in the previous 6 months were associated with prevalent anal HPV 16 infection.
Article
Otorhinolaryngology
Dasa Gluvajic, Lea Hosnjak, Vida Stegel, Srdjan Novakovic, Nina Gale, Mario Poljak, Irena Hocevar Boltezar
Summary: This study assessed the incidence and risk factors for HG-D and LSCC in patients with LSP, revealing that older age and lack of HPV infection are risk factors for the development of HG-D and LSCC. The presence of HG-D was associated with progression to LSCC, and host gene mutations may play a role in LSCC transformation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Biotechnology & Applied Microbiology
Vinodh Bhoopathi, Pradeep Bhagavatula, Maharaj Singh
Summary: This study examined the association between health literacy levels and receipt of at least one dose of HPV vaccination. The results showed that higher levels of health literacy were associated with a higher likelihood of receiving the vaccine. Age, gender, marital status, race/ethnicity, insurance status, and having regular access to a personal doctor were predictors of HPV vaccination status.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Virology
Alicia Zhingre, Cesar Bedoya-Pilozo, Diana Gutierrez-Pallo, Ines Badano, Andres Herrera-Yela, Zoila Salazar, Damaris Alarcon, Natali Arguello-Bravo, Maylen Espinoza, Patricio Ponce, Yudira Soto, Andres Carrazco-Montalvo
Summary: This study aimed to analyze the E6 and E7 oncogenes of HPV16 in women with cancerous and precancerous cervical lesions from the Ecuadorian coast. The study found that the E6 350G or L83V and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V variants are associated with an increased risk of cervical cancer. Furthermore, the D (26.1%) and A (73.9%) lineages of HPV16 were found to be circulating, with the frequency of D being higher than previous studies in Ecuador and Latin America.
Article
Oncology
Stanie Gaete, Aviane Auguste, Bernard Bhakkan, Jessica Peruvien, Cecile Herrmann-Storck, Youri Socrier, Abdoulaye Diedhiou, Jacqueline Deloumeaux
Summary: The study reveals a distinct distribution of oncogenic HPV genotypes in Guadeloupe, with HPV31, HPV33, and HPV16 being the most common types. Additionally, there is a high frequency of multiple infections among patients. Despite lower coverage, the nine-valent vaccine remains suitable for this population.
Article
Health Care Sciences & Services
Serena Varesano, Alessandra Pulliero, Emanuele Martorana, Gabriele Pizzino, Gabriele Raciti, Simona Coco, Valerio Gaetano Vellone, Alberto Izzotti
Summary: Cervical cancer is the second most common cancer among women aged 15 to 44, affecting more than 500,000 women each year. The aim of the proposed study is to implement routine diagnostics of HPV precancerous cervical lesions by introducing new molecular diagnostic tools. MicroRNA analysis panel can improve early diagnosis, understand the nature of the lesion, and improve the clinical management of patients with HPV precancerous cervical lesions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Prerna Tewari, Prakashini Banka, Niamh Kernan, Stephen Reynolds, Christine White, Loretto Pilkington, Sharon O'Toole, Linda Sharp, Tom D'Arcy, Cliona Murphy, Catherine Comiskey, Cara M. Martin, John J. O'Leary
Summary: This study found that concomitant oral HPV infections were present in 10.0% of women referred to colposcopy with pre-existing cervical HPV infections and cytological abnormalities. There was some level of concordance between oral and cervical HPV infections, with age and education level significantly associated with prevalent oral HPV infection.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Obstetrics & Gynecology
Andrea Busnelli, Andrea Garolla, Chiara Tersigni, Vittorio Parodi, Annalisa Inversetti, Paolo Emanuele Levi-Setti, Giovanni Scambia, Nicoletta Di Simone
Summary: This study aimed to test the association between human papilloma virus (HPV) sperm infection and idiopathic recurrent pregnancy loss (RPL). The results showed that the prevalence of HPV DNA sperm infection was significantly higher in couples affected by RPL than in their fertile counterparts. Approximately 1 out of 5 males in the affected couples had HPV sperm infection.
FERTILITY AND STERILITY
(2023)
Article
Health Care Sciences & Services
Chia-Hsin Liu, Chi-You Liao, Ming-Hsin Yeh, James Cheng-Chung Wei
Summary: This study aimed to analyze the National Health Insurance Research Database (NHIRD) in Taiwan, investigate the association between human papillomavirus (HPV) infection and the risk of breast carcinoma. The findings revealed that patients with HPV had a higher risk of developing breast cancer, particularly in older age groups. Additionally, hypertension, chronic obstructive pulmonary disease, and diabetes mellitus were significant risk factors for breast cancer.
Article
Cardiac & Cardiovascular Systems
Gerhard-Paul Diller, Astrid Elisabeth Lammers, Alicia Fischer, Stefan Orwat, Klara Nienhaus, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Johannes Roth, Joachim Gerss, Eike Bormann, Helmut Baumgartner
Summary: The study aims to provide population-based data on the prevalence and clinical significance of immune deficiency syndromes (IDS) associated with congenital heart disease (CHD). By utilizing administrative German Health System data, the prevalence of increased susceptibility to infection (ISI) or confirmed IDS was assessed in CHD patients and compared with an age-matched non-congenital control group. The study found that 27.5% of CHD patients had ISI and 5.6% had a documented IDS, higher than the general population.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Milena Lopicic, Janja Raonic, Marija Antunovic, Biljana Milicic, Gordana Mijovic
Summary: Cervical cancer is the third leading cause of death in women in Montenegro, with HPV being the causative agent. The study found that vaccine-related high-risk HPV has a higher prevalence in cervical dysplasia, especially HPV 16 and 33. This suggests that prophylactic nonavalent vaccine can potentially prevent a significant number of HR-HPV infections and cervical dysplasia cases in Montenegrin women.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2021)
Article
Immunology
Mkunde Chachage, Ajay P. Parikh, Anifrid Mahenge, Emmanuel Bahemana, Jonathan Mnkai, Wilbert Mbuya, Ruby Mcharo, Lucas Maganga, Jaqueline Mwamwaja, Reginald Gervas, Hannah Kibuuka, Jonah Maswai, Valentine Singoei, Michael Iroezindu, Abiola Fasina, Allahna Esber, Nicole Dear, Michelle Imbach, Trevor A. Crowell, Jaclyn Hern, Xiaofang Song, Michael Hoelscher, Christina S. Polyak, Julie A. Ake, Christof Geldmacher
Summary: This study evaluated HR-HPV genotypes among women with and without HIV in four African countries to inform cervical cancer preventive strategies. The results showed that HR-HPV was more common in WLWH, particularly among women with low CD4(+) cell count. Scaling up HPV vaccination and developing vaccines with broader activity against less common HR-HPV types may improve cervical cancer prevention in Africa.
Article
Oncology
William Chu, Amandeep Taggar, Yee Ung, Kelvin K. W. Chan, Craig C. C. Earle, Aliaksandr Karotki, Mark Pasetka, Joe Presutti, John Wong, Liying Zhang, C. Shun Wong
Summary: This study reports a planned interim analysis of a prospective registry study that tailors chemoradiation for anal cancer according to HPV status. De-escalation of CRT for HPV+ anal cancer may result in decreased acute toxicities and similar cancer outcomes compared to standard CRT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yuki Lama, Yan Qin, Xiaoli Nan, Cheryl Knott, Clement Adebamowo, Shana O. Ntiri, Min Qi Wang
Summary: The study found that the vaccination decisions of African American parents are influenced by various factors, including the need for information, the unfamiliarity of vaccination, and mistrust towards government and healthcare providers. Parents prefer campaign messages that clarify the risks and benefits of vaccination, use straightforward language, and include diverse representation. They also emphasize the importance of clear language on side effects, eligibility, and additional resources for further information.
JOURNAL OF CANCER EDUCATION
(2022)
Review
Oncology
Galya Bigman, Linda Otieno, Sally N. Adebamowo, Clement Adebamowo
Summary: This study systematically reviewed and summarized the literature on the relationship between dietary intake and cancer incidence in Sub-Saharan Africa. The findings suggest a lack of sufficient evidence and important confounders in the existing studies. Further large-scale and comprehensive research is needed to better understand the link between African diet and cancer risk.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Infectious Diseases
Nanma T. Cosmas, Lohya Nimzing, Daniel Egah, Ayo Famooto, Sally N. Adebamowo, Clement A. Adebamowo
Summary: This study aimed to investigate the prevalence of HPV infection among adolescent and early adult girls in central Nigeria. The results showed a high prevalence of HPV infection, starting from 9 years of age. This suggests that HPV vaccination should start at 9 years old or younger in Nigerian girls to provide maximum protection.
BMC INFECTIOUS DISEASES
(2022)
Article
Oncology
Sally N. Adebamowo, Brian Befano, Li C. Cheung, Ana Cecilia Rodriguez, Maria Demarco, Greg Rydzak, Xiaojian Chen, Carolina Porras, Rolando Herrero, Jane J. Kim, Philip E. Castle, Nicolas Wentzensen, Aimee R. Kreimer, Mark Schiffman, Nicole G. Campos
Summary: This study compared the early natural history of different HPV types in the development of cervical cancer, using prospective data from three research projects. The results showed that the time to clearance of HPV infections was similar across different HPV types, indicating that relative prevalence can predict relative incidence. The study also found that the time to clearance of incident HPV infections was similar among different risk classes and did not differ based on age groups. These findings have important implications for the refinement of health decision models and cost-effectiveness evaluation of prevention technologies.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Genetics & Heredity
Clement A. Adebamowo, Adebowale Adeyemo, Adeyinka Ashaye, Onoja M. Akpa, Tinashe Chikowore, Ananyo Choudhury, Yasmina J. Fakim, Segun Fatumo, Neil Hanchard, Michael Hauser, Braxton Mitchell, Nicola Mulder, Solomon F. Ofori-Acquah, Mayowa Owolabi, Michele Ramsay, Bamidele Tayo, Archana Bhavani VasanthKumar, Yuji Zhang, Sally N. Adebamowo
Summary: The CARDINAL study site is a well-powered resource that aims to develop, refine, and validate methods for researching polygenic risk scores, taking into account local ancestry, to improve risk prediction in diverse populations.
Article
Oncology
Galya Bigman, Sally N. Adebamowo, King-David Terna Yawe, Monday Yilkudi, Oluwole Olaomi, Olawale Badejo, Ayo Famooto, Emmanuel Ezeome, Iliya Karniliyus Salu, Elijah Miner, Ikechukwu Anosike, Benjamin Achusi, Clement Adebamowo
Summary: This study investigated the association between leisure-time physical activity (LTPA) and breast cancer, as well as its subtypes, in Nigerian women. The results suggest that LTPA may reduce the risk of breast cancer, particularly the TNBC subtype, which is more aggressive and prevalent in Sub-Saharan Africa.
CANCER EPIDEMIOLOGY
(2022)
Article
Genetics & Heredity
Ekanem N. Ekure, Ogochukwu Sokunbi, Paul Kruszka, Maximilian Muenke, Adebowale A. Adeyemo
Summary: Hajdu-Cheney syndrome is an ultra-rare genetic disorder characterized by osteoporosis, distinct facial appearance, and joint laxity. This study presents the first reported case of an African child with this syndrome and identifies a previously unreported association with congenital heart disease.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Pharmacology & Pharmacy
David Twesigomwe, Britt Drogemoller, Galen E. B. Wright, Clement Adebamowo, Godfred Agongo, Palwende R. Boua, Mogomotsi Matshaba, Maria Paximadis, Michele Ramsay, Gustave Simo, Martin C. Simuunza, Caroline T. Tiemessen, Zane Lombard, Scott Hazelhurst
Summary: This study investigates the distribution of CYP2D6 star alleles and predicted drug metabolizer phenotypes in multiple sub-Saharan African populations. The results show varying frequencies of known alleles and phenotypes across different African ethnolinguistic groups, and identify 27 novel star alleles. This research highlights the importance of studying key pharmacogenes in the African context to better understand population-specific allele frequencies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Communication
Xiaoli Nan, Yuan Wang, Kathryn Thier, Clement Adebamowo, Sandra Quinn, Shana Ntiri
Summary: This study examines the role of moral values in predicting COVID-19 vaccine hesitancy among Black Americans. Results indicate that the care and loyalty moral foundations consistently predict less vaccine hesitancy, whereas the purity and liberty moral foundations are consistently associated with greater vaccine hesitancy. The relationships between the moral foundations and vaccine hesitancy are mediated by perceived vaccine effectiveness and safety.
JOURNAL OF HEALTH COMMUNICATION
(2022)
Article
Communication
Yuan Wang, Kathryn Thier, Shana O. Ntiri, Sandra Crouse Quinn, Clement Adebamowo, Xiaoli Nan
Summary: This study examines the prevalence, predictors, and consequences of beliefs in COVID-19 vaccine misinformation among unvaccinated Black Americans. Results show that such beliefs are prevalent, with a significant percentage of participants agreeing or strongly agreeing with false claims about COVID-19 vaccines. Conservative ideology, conspiracy thinking, religiosity, and racial consciousness in healthcare settings predicted greater beliefs in misinformation, which were associated with lower vaccine confidence and acceptance. The findings have theoretical and practical implications.
HEALTH COMMUNICATION
(2023)
Review
Endocrinology & Metabolism
Ayo P. Doumatey, Amy R. Bentley, Rufus Akinyemi, Timothy O. Olanrewaju, Adebowale Adeyemo, Charles Rotimi
Summary: The past two decades have seen a significant increase in cardiometabolic diseases globally, but the prevalence and incidence of these diseases vary across populations. Populations of African descent are among the most affected but least studied. This underrepresentation is a missed opportunity that could worsen health disparities and hinder the equitable implementation of precision medicine.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Multidisciplinary Sciences
Clement A. Adebamowo, Shawneequa Callier, Simisola Akintola, Oluchi Maduka, Ayodele Jegede, Christopher Arima, Temidayo Ogundiran, Sally N. Adebamowo
Summary: This Review article discusses the emerging efforts to build ethical governance frameworks for data science health research in Africa, and the opportunities to advance these through investments by African governments and institutions, international funding organizations, and collaborations for research and capacity development.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
David Twesigomwe, Britt I. Droegemoeller, Galen E. B. Wright, Clement Adebamowo, Godfred Agongo, Palwende R. Boua, Mogomotsi Matshaba, Maria Paximadis, Michele Ramsay, Gustave Simo, Martin C. Simuunza, Caroline T. Tiemessen, Zane Lombard, Scott Hazelhurst
Summary: This study provides important findings on the distribution and predicted phenotypes of star alleles in CYP2B6 and CYP2A6 genes in African populations. It also identifies potential novel African-ancestry star alleles. These results are significant for guiding personalized medicine strategies and the design of pharmacogenetic testing platforms.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
