Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eric Goetzman, Zhenwei Gong, Dhivyaa Rajasundaram, Ishan Muzumdar, Traci Goodchild, David Lefer, Radhika Muzumdar
Summary: Acute myocardial infarction is a leading cause of death worldwide. This study investigated the metabolic changes in serum during ischemia and reperfusion injury in a swine model, aiming to identify metabolomic biomarkers for myocardial injury at different phases. The results showed distinct profiles of serum metabolites during ischemia and early and late reperfusion, with impaired mitochondrial function and amino acid modifications during ischemia, and changes in branched-chain amino acid metabolites and bile acid pathway derivatives during reperfusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Summary: This article outlines the strengths, limitations, and outcomes of small and large animal models of heart failure with reduced ejection fraction currently used in basic and translational research. Animal models play a critical role in understanding the molecular mechanisms of heart failure, although no model completely recapitulates the full human disease.
CIRCULATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Sergey V. Popov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Alexandr S. Gorbunov, Michail Kilin, Viacheslav N. Azev, Maria S. Khlestkina, Galina Z. Sufianova
Summary: The in-hospital mortality rate for patients with ST-segment elevation myocardial infarction (STEMI) is 5-6%. Therefore, there is a need to develop novel drugs that can reduce mortality in patients with acute myocardial infarction. Apelins could serve as the prototype for such drugs. Chronic administration of apelins has been shown to mitigate adverse myocardial remodeling in animals with myocardial infarction or pressure overload. The cardioprotective effect of apelins involves the inhibition of multiple pathways and processes, including apoptosis, ferroptosis, and the activation of various kinases and enzymes.
Article
Cardiac & Cardiovascular Systems
Olga M. Rusiecka, Filippo Molica, Morten S. Nielsen, Axel Tollance, Sandrine Morel, Maud Frieden, Marc Chanson, Kerstin Boengler, Brenda R. Kwak
Summary: This study found that deletion of the Pannexin1 (Panx1) gene in cardiac endothelial cells can alleviate cardiac ischaemia/reperfusion (I/R) injury and improve left ventricular function recovery. This cardioprotective effect seems to be mediated through its influence on cardiac mitochondria rather than reducing the inflammatory response. Therefore, Panx1 may represent a new target for controlling cardiac reperfusion damage.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alice Marino, Derek J. Hausenloy, Ioanna Andreadou, Sandrine Horman, Luc Bertrand, Christophe Beauloye
Summary: Heart failure is a major cause of death and disability globally, with left ventricular remodeling, fibrosis, and ischemia/reperfusion injury contributing to cardiac dysfunction. AMPK acts as a universal energy sensor in response to low ATP levels, playing a crucial role in the heart. Excessive reactive oxygen species can activate AMPK, providing an additional role as a redox sensor for preventing heart failure progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Keiko Morita, Mariko Wada, Kohta Nakatani, Yuki Matsumoto, Nahoki Hayashi, Ikuko Yamahata, Kotone Mitsunari, Nagi Mukae, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Michiko Shirane
Summary: Our study demonstrates that the accumulation of CEs in the brain of PDZD8-deficient mice is due to impaired lipophagy. PDZD8 likely plays a role in promoting the fusion and degradation of CE-containing lipid droplets by mediating the exchange of cholesterol and phosphatidylserine between ER and Rab7-positive organelles. This function of PDZD8 is crucial for the clearance of CEs from the brain and the maintenance of neuronal integrity.
Article
Cardiac & Cardiovascular Systems
Lining Wu, Junma Yu, Qiuyue Wang, Yao Lu
Summary: The study showed that nalbuphine does not interfere with the cardioprotective effect of morphine in rats. Therefore, it is safe to use nalbuphine in combination with morphine for the treatment of patients with acute myocardial infarction. This finding has important clinical implications for improving patient care.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Virginia Actis Dato, Aleyda Benitez-Amaro, Eduardo Garcia, Lene Claudi, Maria Teresa LaChica Lhoest, Antoni Iborra, Jose Maria Guerra, Joan Carles Escola-Gil, Valerie Samouillan, Carlos Enrich, Gustavo Chiabrando, Vicenta Llorente-Cortes
Summary: The study found that targeting the P3 sequence on LRP1 through anti-P3 antibodies can specifically reduce CE accumulation in the heart and restore InsR and GLUT4 levels in the hearts of rabbits fed with a high-fat diet.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Michaela Orlitova, Tom Verbelen, Anna E. Frick, Arno Vanstapel, Dieter Van Beersel, Sofie Ordies, Jan Van Slambrouck, Janne Kaes, Xin Jin, Walter Coudyzer, Stijn E. Verleden, Geert M. Verleden, Bart M. Vanaudenaerde, Dirk E. Van Raemdonck, Robin Vos, Laurens J. Ceulemans, Piet Claus, Arne P. Neyrinck
Summary: Lung transplantation is a challenging procedure and can result in severe damage to the transplanted pulmonary graft. The interaction between right ventricular function and lung injury during the transplantation process is poorly understood. Through a translational porcine model, it was found that right ventricular failure can occur as a result of forcing the entire cardiac output through a lung suffering from ischemia-reperfusion injury. The study also revealed a delicate balance between the development of pulmonary ischemia-reperfusion injury and right ventricular function, highlighting the potential benefits of extracorporeal life support technology in these cases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy
Summary: Mitophagy plays a crucial role in maintaining cardiac homeostasis by selectively eliminating dysfunctional mitochondria. It is mainly regulated by the PINK1/parkin pathway and also by the FUNDC1, BNIP3, and BNIP3L/NIX pathways. Dysregulated mitophagy is associated with cardiac dysfunction, while moderate mitophagy has a cardioprotective effect.
Review
Pharmacology & Pharmacy
Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiomyocyte death plays a major role in the development of myocardial infarction and myocardial ischemia/reperfusion injury. Pyroptosis, a regulated programmed cell death pathway, has been shown to be involved in these conditions. Activation of gasdermin D (GSDMD) through the canonical or non-canonical pathways is an important step in pyroptosis. Inhibition of GSDMD provides cardioprotection against myocardial infarction and myocardial ischemia/reperfusion injury.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cardiac & Cardiovascular Systems
Ana C. M. Omoto, Jussara M. do Carmo, Benjamin Nelson, Nikaela Aitken, Xuemei Dai, Sydney Moak, Elizabeth Flynn, Zhen Wang, Alan J. Mouton, Xuan Li, John E. Hall, Alexandre A. da Silva
Summary: This study found that central nervous system actions of leptin can significantly improve cardiac function and mitochondrial metabolism after myocardial ischemia/reperfusion injury, regardless of sex. These effects are largely independent of cardiac sympathetic innervation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Immunology
Hao Zheng, Yale Su, Cuilin Zhu, Douglas Quan, Anton Skaro, Vivian McAlister, James C. Lacefield, Jifu Jiang, Peng Xue, Yefu Wang, Xiufen Zheng
Summary: Inhibition of ERK signaling with U0126 effectively attenuates prolonged cold IRI in heart transplantation. Both in vitro and in vivo experiments demonstrated the role of U0126 in reducing cell death, reactive oxygen species generation, and mitochondrial membrane potential loss. Preservation of donor hearts with U0126-supplemented solution improves graft function and reduces IRI.
Article
Biochemistry & Molecular Biology
Sehwan Jang, Xavier R. Chapa-Dubocq, Yulia Y. Tyurina, Claudette M. St Croix, Alexandr A. Kapralov, Vladimir A. Tyurin, Hulya Bayir, Valerian E. Kagan, Sabzali Javadov
Summary: Ferroptosis is a programmed iron-dependent cell death associated with lipid peroxidation, particularly phospholipids. Mitochondria play a crucial role in ferroptosis by being sensitive to ferroptotic stimuli and contributing to lipid peroxidation. The transport of reduced glutathione to mitochondria through DIC and OGC carrier proteins plays a key role in ferroptosis, and inhibiting these carriers can aggravate the process. Additionally, dihydrolipoic acid acts as an essential cofactor for mitochondrial enzymes and can attenuate ferroptosis by directly reducing peroxidized phospholipids.
Article
Nutrition & Dietetics
Iris Trefflich, Hanns-Ulrich Marschall, Romina di Giuseppe, Marcus Stahlman, Andreas Michalsen, Alfonso Lampen, Klaus Abraham, Cornelia Weikert
Article
Cardiac & Cardiovascular Systems
Elias Bjornson, Ylva Ostlund, Marcus Stahlman, Martin Adiels, Elmir Omerovic, Anders Jeppsson, Jan Boren, Malin C. Levin
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Hematology
Marja-Riitta Taskinen, Elias Bjornson, Juhani Kahri, Sanni Soderlund, Niina Matikainen, Kimmo Porthan, Mari Ainola, Antti Hakkarainen, Nina Lundbom, Valentina Fermanelli, Johannes Fuchs, Annika Thorsell, Florian Kronenberg, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren
Summary: This study investigated the metabolic effects of PCSK9 inhibitors on dyslipidemia in subjects with type 2 diabetes. The findings showed that evolocumab had minimal effects on lipoproteins involved in triglyceride transport but had a significant impact on lipoproteins carrying cholesterol.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kristell Le Gal, Clotilde Wiel, Mohamed X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, Martin O. Bergo
Summary: Research suggests that mitochondria-targeted antioxidants have no anti-cancer effects in malignant melanoma and lung cancer.
Article
Endocrinology & Metabolism
Marja-Riitta Taskinen, Elias Bjornson, Niina Matikainen, Sanni Soderlund, Kirsi H. Pietilainen, Mari Ainola, Antti Hakkarainen, Nina Lundbom, Johannes Fuchs, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren
Summary: In subjects with type 2 diabetes, liraglutide demonstrated positive effects on postprandial apoB48 metabolism, including reducing apoB48 synthesis, improving chylomicron size, and decreasing direct clearance of chylomicrons, as well as lowering VLDL1-triglyceride secretion. The impact of liraglutide on insulin sensitivity altered certain associations related to chylomicron-apoB48 production and particle size, ultimately contributing to decreased generation of remnant lipoproteins.
DIABETES OBESITY & METABOLISM
(2021)
Article
Pathology
Ankur Pandita, Matias Ekstrand, Sara Bjursten, Zhiyuan Zhao, Per Fogelstrand, Kristell Le Gal, Lars Ny, Martin O. Bergo, Joakim Karlsson, Jonas A. Nilsson, Levent M. Akyurek, Malin C. Levin, Jan Boren, Andrew J. Ewald, Keith E. Mostov, Max Levin
Summary: Intussusceptive angiogenesis, characterized by intravascular pillars, may play a role in the growth of human melanoma metastases. Inhibition of matrix metalloproteinase 9 (MMP9) could potentially block pillar formation and serve as a promising anti-angiogenic drug target for metastatic melanoma.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Linda Andersson, Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Muhammad Arif, Ara Koh, Malin Lindbom, Marion Laudette, Entela Bollano, Elmir Omerovic, Martina Klevstig, Marcus Henricsson, Per Fogelstrand, Karl Sward, Matias Ekstrand, Max Levin, Johannes Wikstrom, Stephen Doran, Tuulia Hyotylainen, Lisanna Sinisalu, Matej Oresic, Asa Tivesten, Martin Adiels, Martin O. Bergo, Richard Proia, Adil Mardinoglu, Anders Jeppsson, Jan Boren, Malin C. Levin
Summary: This study found that glycosphingolipids are crucial for maintaining beta-adrenergic signaling and contractile capacity in cardiomyocytes, and for preserving normal heart function. Low levels of glucosylceramide and lactosylceramide in non-ischaemic human hearts with normal function elevate during remodelling, and this phenomenon was also observed in mouse models. Mice with cardiomyocyte-specific deficiency in Ugcg gene encoding glucosylceramide synthase exhibited reduced contractile capacity under stress and developed severe heart failure and left ventricular dilatation even under baseline conditions.
EUROPEAN HEART JOURNAL
(2021)
Article
Nutrition & Dietetics
Jamie van Son, Mireille J. Serlie, Marcus Stahlman, Fredrik Backhed, Max Nieuwdorp, Judith Aron-Wisnewsky
Summary: In overweight and obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.
Article
Oncology
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Frojd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Jan Boren, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin
Summary: This case report highlights the rapid eradication of melanoma brain metastases and the development of near-fatal encephalomyelitis following double immune checkpoint blockade. The expression of ICOS on CD4+ and CD8+ T cells may play a potential role in mediating encephalomyelitis and other serious immune-related adverse events. Early diagnosis of encephalitis could be facilitated by monitoring brain damage markers in blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Anwar Ali, Bjorn Redfors, Jessica Alkhoury, Jonatan Oras, Marcus Henricsson, Jan Boren, Elias Bjornson, Aaron Espinosa, Malin Levin, Li-Ming Gan, Elmir Omerovic
Summary: This study aimed to investigate the effect of sacubitril/valsartan in preventing isoprenaline-induced TTS-like phenotype in rats. The results showed that pretreatment with sacubitril/valsartan reduced mortality and attenuated cardiac dysfunction in the TTS-like model induced by isoprenaline. This suggests that sacubitril/valsartan could be a potential treatment option for patients with TTS.
Article
Cardiac & Cardiovascular Systems
Ulla Walfridsson, Anders Hassel Jonsson, Lars O. Karlsson, Ioan Liuba, Henrik Almroth, Emma Sandgren, Hakan Walfridsson, Emmanouil Charitakis
Summary: The study aimed to investigate the long-term effects of catheter ablation (CA) on symptoms and health-related quality of life (HRQoL) in AF patients. It found that after 5 years, CA had a lasting impact on symptoms and HRQoL, with factors like female gender, obesity, and ischemic heart disease predicting symptoms post-CA. The study highlights the importance of lifestyle management in improving outcomes for AF patients post CA.
CLINICAL CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Marta Lantero Rodriguez, Maaike Schilperoort, Inger Johansson, Elin Svedlund Eriksson, Vilborg Palsdottir, Jan Kroon, Marcus Henricsson, Sander Kooijman, Mia Ericson, Jan Boren, Claes OhIsson, John-Olov Jansson, Malin C. Levin, Patrick C. N. Rensen, Asa Tivesten
Summary: Testosterone acts as a negative regulator of metabolic BAT activity in male mice, modulating BAT activity through an indirect pathway. Castration promotes the expression of thermogenic markers, decreases lipid content, and increases fatty acid uptake in BAT. BAT-specific AR deficiency and AR agonist treatment do not affect BAT activity, indicating that androgens do not directly modulate BAT activity via the AR pathway.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Hematology
Lars Glise, Mikael Rutberg, Liliana Haversen, Malin C. Levin, Max Levin, Anders Jeppsson, Jan Boren, Per Fogelstrand
Summary: This study identifies histidine protonation as an important component for electrostatic LDL binding to human coronary arteries. Our findings show that the local pH will have a profound impact on LDL's affinity for sulfated glycosaminoglycans, which may influence the retention and accumulation pattern of LDL in the arterial vasculature.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Ali Mahdi, Tigist Wodaje, Oskar Kovamees, John Tengbom, Allan Zhao, Tong Jiao, Marcus Henricsson, Jiangning Yang, Zhichao Zhou, Anni Nieminen, Malin Levin, Aida Collado, Jonas Brinck, John Pernow
Summary: This study demonstrates that red blood cells (FH-RBCs) from patients with familial hypercholesterolemia (FH) and elevated low-density lipoprotein cholesterol (LDL-c) levels induce endothelial dysfunction, which is associated with an increased risk of premature atherosclerosis. This is mainly achieved through increased levels of arginase 1 and reactive oxygen species (ROS).
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Elin Svedlund Eriksson, Inger Johansson, Anna K. F. Martensson, Marta Lantero Rodriguez, Maaike Schilperoort, Jan Kroon, Sander Kooijman, Elmir Omerovic, Linda Andersson, Malin C. Levin, Patrick C. N. Rensen, Asa Tivesten
Summary: Androgen deprivation therapy for prostate cancer, which reduces serum testosterone levels, is associated with increased risk of heart failure. This study found that castration in male mice alters cardiac energy substrate uptake, leading to metabolic remodeling and increased expression of fetal genes in the heart. Castration also resulted in reduced cardiac performance during pharmacological stress.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
