Article
Biotechnology & Applied Microbiology
Chanchan Gao, Yazhou Wen, Feng Jiang, Xuyu Gu, Xinhua Zhu
Summary: This study found that circ_0008274 is highly expressed in HCC, promoting proliferation, migration, and invasion of HCC cells. Depleting circ_0008274 inhibits malignant behaviors, with the mechanism involving upregulation of GRN to expedite HCC progression.
Article
Oncology
Bin Zhang, Xiang Cheng, Sudong Zhan, Xin Jin, Tao Liu
Summary: Despite advances in cancer treatment, pancreatic cancer prognosis remains poor. Research reveals the importance of the MIB1/ST7/IQGAP1 axis in pancreatic cancer progression, suggesting MIB1 inhibition as a potential therapeutic strategy.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julie Xia Zhou, Ewud Agborbesong, Linda Xiaoyan Li, Xiaogang Li
Summary: This study reveals a novel regulatory mechanism of mutant p53 through BRD4 in triple-negative breast cancer (TNBC). Inhibition of BRD4 reduces the transcription of mutant p53 and suppresses the tumorigenesis of TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yi-Ke Li, Xiao-Ran Zhu, Yue Zhan, Wen-Zhen Yuan, Wei-Lin Jin
Summary: NEK7 is upregulated in gastric cancer, associated with poor prognosis, and promotes cell proliferation. It also impacts immune infiltration in tumor microenvironment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Kwang-Min Lee, Eun-Chan Seo, Jeong-Hyung Lee, Hyo-Jin Kim, Cheol Hwangbo
Summary: Syntenin serves as an important adaptor and scaffold protein, participating in multiple signaling pathways and modulating cellular physiology. It plays a significant role in regulating exosome trafficking and communication between cells. Targeting the regulation mechanism of exosomes by syntenin-1 and microRNAs may provide a novel treatment strategy for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Chadet, Jordan Allard, Lucie Brisson, Osbaldo Lopez-Charcas, Roxane Lemoine, Audrey Heraud, Stephanie Lerondel, Roseline Guibon, Gaelle Fromont, Alain Le Pape, Denis Angoulvant, Lin-Hua Jiang, Ruth Murrell-Lagnado, Sebastien Roger
Summary: The P2X4 purinergic receptor is upregulated in breast cancer patients and primarily localised in endolysosomes. It promotes breast cancer invasion, tumour growth, and metastasis by regulating lysosome acidity, promoting autophagy and cell survival. It is also associated with epithelial-to-mesenchymal transition and plays a more significant role under metabolic challenges.
Article
Genetics & Heredity
Yuki Murakami, Kei Kimura-Masuda, Tsukasa Oda, Ikuko Matsumura, Yuta Masuda, Rei Ishihara, Saki Watanabe, Yuko Kuroda, Tetsuhiro Kasamatsu, Nanami Gotoh, Hisashi Takei, Nobuhiko Kobayashi, Takayuki Saitoh, Hirokazu Murakami, Hiroshi Handa
Summary: MicroRNAs (miRNAs and miRs) play a key role in modulating gene expression, and their dysregulation has been implicated in multiple myeloma (MM). This study focused on the interaction between MYC and the TP53-miR34 axis in MM and found that MYC participates in the suppression of p53-dependent miRNA expressions. The inhibition of miRNA expression leads to MM development and malignant transformation.
Article
Toxicology
Giuseppina Chiappara, Serena Di Vincenzo, Claudia Sangiorgi, Caterina Di Sano, Claudia D'Anna, Giovanni Zito, Chiara Cipollina, Patrizio Vitulo, Alessandro Bertani, Elisabetta Pace
Summary: This study showed that cigarette smoke may promote adenocarcinoma progression by activating the Notch-1 pathway, highlighting its role as a hallmark of lung cancer progression and a potential target for lung cancer treatment.
TOXICOLOGY LETTERS
(2022)
Article
Medical Laboratory Technology
Linwen Zhu, Zhifang Wang, Lebo Sun, Dawei Zheng, Bingchuan Hu, Ni Li, Guofeng Shao
Summary: The study found that has_circ_0000437 is highly expressed in RVHD and has diagnostic value. In RVHD, hsa_circ_0000437 can promote cell proliferation and migration while inhibiting apoptosis. This may be due to the interaction of has_circ_0000437 with target miRNA in the cytoplasm affecting the progression of RVHD.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cell Biology
Xunhua Liu, Jianxiong Chen, Xiaoli Long, Jiawen Lan, Xiaoting Liu, Miao Zhou, Sijing Zhang, Jun Zhou
Summary: The study discovered that RSL1D1 was highly expressed in tumors from colorectal cancer (CRC) patients and that higher expression of RSL1D1 was associated with poorer survival in CRC patients. Functionally, RSL1D1 promoted the proliferation, invasion, and metastasis of CRC cells by suppressing autophagy. The study also found that RSL1D1 interacted with RAN and inhibited the accumulation of nuclear STAT3 through affecting the acetylation of RAN.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Rui Yang, Hang Chen, Lei Xing, Bin Wang, Mengting Hu, Xiaoqiang Ou, Hong Chen, Yumei Deng, Dawei Liu, Rong Jiang, Junxia Chen
Summary: This study identified a novel hypoxia-responsive circRNA named circWSB1, which could interact with USP10 and promote the progression of BC. It may serve as a prognostic biomarker and therapeutic target for BC patients.
Article
Biochemistry & Molecular Biology
Pingfu Hou, Tian Lin, Sen Meng, Meilin Shi, Fang Chen, Tao Jiang, Zhongwei Li, Minle Li, Sufang Chu, Junnian Zheng, Jin Bai
Summary: This study identified SH3PXD2A-AS1 as highly overexpressed in colorectal cancer (CRC), promoting cell proliferation, angiogenesis, and metastasis by directly interacting with p53 protein to regulate p53-mediated gene transcription. These findings suggest SH3PXD2A-AS1 as a potential prognostic biomarker and therapeutic target for CRC clinical management.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Wei Lv, Qiu Meng, Rui Li, Jing Li, Na Chen
Summary: This study explores the mechanism of KIAA0101 in promoting breast cancer development through metabolic reprogramming. The findings show that KIAA0101 is overexpressed in breast cancer patients and mouse models, and it promotes cell migration and invasion. Additionally, KIAA0101 is regulated by P53 and is involved in the regulation of energy metabolism.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Yu Yan, Yu Nie, Chun Peng, Fuchen Xing, Saiguang Ji, Hong Liu, Chuandong Zhu
Summary: This study identified hsa_circ_0001394 as a highly expressed circRNA in HCC. High expression of hsa_circ_0001394 was associated with poor survival and clinicopathological features in HCC patients. Mechanistically, hsa_circ_0001394 promoted HCC progression by regulating the miR-527/UBE2A pathway. Thus, hsa_circ_0001394 may serve as a potential therapeutic target and biomarker in HCC treatment.
CELL DEATH DISCOVERY
(2022)