Article
Oncology
Lenka Stolarova, Petra Kleiblova, Petra Zemankova, Barbora Stastna, Marketa Janatova, Jana Soukupova, Maria Isabel Achatz, Christine Ambrosone, Paraskevi Apostolou, Banu K. Arun, Paul Auer, Mollie Barnard, Birgitte Bertelsen, Biobank Japan, Marinus J. Blok, Nicholas Boddicker, Joan Brunet, Elizabeth S. Burnside, Mariarosaria Calvello, Ian Campbell, Sock Hoai Chan, Fei Chen, Jian Bang Chiang, Anna Coppa, Laura Cortesi, Ana Crujeiras-Gonzalez, Consortium Czecanca, Kim De Leeneer, Robin De Putter, Allison DePersia, Lisa Devereux, Susan Domchek, Anna Efremidis, Christoph Engel, Corinna Ernst, D. Gareth R. Evans, Lidia Feliubadalo, Florentia Fostira, Olivia Fuentes-Rios, Encarna B. Gomez-Garcia, Sara Gonzalez, Christopher Haiman, Thomas van Overeem Hansen, Jan Hauke, James Hodge, Chunling Hu, Hongyan Huang, Nur Diana Binte Ishak, Yusuke Iwasaki, Irene Konstantopoulou, Peter Kraft, James Lacey, Conxi Lazaro, Na Li, Weng Khong Lim, Sara Lindstrom, Adriana Lori, Elana Martinez, Alexandra Martins, Koichi Matsuda, Giuseppe Matullo, Simone McInerny, Kyriaki Michailidou, Marco Montagna, Alvaro N. A. Monteiro, Luigi Mori, Katherine Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Julie Palmer, Barbara Pasini, Alpa Patel, Maria Piane, Bruce Poppe, Paolo Radice, Alessandra Renieri, Nicoletta Resta, Marcy E. Richardson, Toon Rosseel, Kathryn J. Ruddy, Marta Santamarina, Elizabeth Santana Dos Santos, Lauren Teras, Amanda E. Toland, Amy Trentham-Dietz, Celine M. Vachon, Alexander E. Volk, Nana Weber-Lassalle, Jeffrey N. Weitzel, Lisa Wiesmuller, Stacey Winham, Siddhartha Yadav, Drakoulis Yannoukakos, Song Yao, Valentina Zampiga, Magnus Zethoven, Ze Wen Zhang, Tomas Zima, Amanda B. Spurdle, Vega Ana, Maria Rossing, Jesus Del Valle, Arcangela De Nicolo, Eric Hahnen, Kathleen B. M. Claes, Joanne Ngeow, Yukihide Momozawa, Paul A. James, Fergus J. Couch, Libor Macurek, Zdenek Kleibl
Summary: This study determined the functional consequences of CHEK2 missense variants in patients with breast cancer. The study found that carriers of functionally impaired variants were associated with a moderate risk, while carriers of functionally wild-type/intermediate variants had no clinically relevant breast cancer risk.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Till F. M. Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria Jose Gonzalez, Susana Gil Flores, Francisco J. Cabaleiro Fabeiro, Francisco del Rio Noriega, Fermin Perez Perez, Jesus Haro Gonzalez, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Kustner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C. Foo, Jens Treutlein, Stephanie H. Witt, Sven Cichon, Manolis Kogevinas, Fabio Rivas, Fermin Mayoral, Bertram Mueller-Myhsok, Andreas J. Forstner, Markus M. Nothen, Marcella Rietschel
Summary: This study analyzed whether the risk for bipolar disorder in BD multiplex families is influenced by common genetic variants. The results showed that familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders, indicating a high baseline risk in the families; familial BD cases had significantly higher BD PRS than unaffected family members and unrelated BD cases, suggesting that development of BD in these families is attributable to common variants with specific risk for BD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yan Liu, Shuangyu Li, Hongjia Yang, Yaru Chen, Dong Fan
Summary: This study identified and analyzed 12 carboxylesterase sequences from the oriental armyworm, finding that different insecticide treatments impact their expression levels. RNA interference successfully inhibited their expression, indicating a potential new method to increase insect susceptibility to insecticides.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Oncology
Rick A. C. M. Boonen, Wouter W. Wiegant, Nandi Celosse, Bas Vroling, Stephan Heijl, Zsofia Kote-Jarai, Martina Mijuskovic, Simona Cristea, Nienke Solleveld-Westerink, Tom van Wezel, Niko Beerenwinkel, Rosalind Eeles, Peter Devilee, Maaike P. G. Vreeswijk, Giancarlo Marra, Haico van Attikum
Summary: This study describes a method using mouse embryonic stem cells to quantitatively determine the functional impact of 50 uncertain missense variants in the gene CHEK2. The results show that some missense variants impair protein function to a similar extent as truncating variants and are associated with an increased risk of breast cancer.
Article
Veterinary Sciences
Kinga Joo, Roxana Laura Truzsi, Csenge Kalman, Szilard Jakab, Andras Baba
Summary: Due to increasing drug resistance, traditional parasite control strategies for adult horses are no longer effective and recommendations need to be re-evaluated. The major parasites of adult horses have shifted from large strongyles to small strongyles and tapeworms, while foals and weanlings are still primarily affected by ascarids. Customized parasite control strategies and special attention to horses under 3 years old will enhance animal welfare and offer economic benefits.
MAGYAR ALLATORVOSOK LAPJA
(2021)
Article
Oncology
Yongqin Yang, Shan Yuan, Shouchun Yan, Kuaini Dong, Yonghui Yang
Summary: This study found that three missense variants in the CYP4B1 gene (rs2297810, rs4646491, and rs2297809) are associated with an increased risk of lung cancer (LC).
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
S. Jo Moore, Christina M. Carlson, Jay R. Schneider, Christopher J. Johnson, Justin J. Greenlee
Summary: This study found that the behavior of the CWD agent changed after it was passaged through different hosts, leading to increased attack rates and decreased incubation periods in raccoons.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Daniel Laubitz, Michael A. Gurney, Monica Midura-Kiela, Christy Clutter, David G. Besselsen, Hao Chen, Fayez K. Ghishan, Pawel R. Kiela
Summary: Dysregulation of NHE3 expression in colorectal cancer is associated with poorer survival and leads to increased tumor numbers, enhanced DNA damage, increased cell proliferation, and decreased apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Wei Guan, Nan Yang, Xianglin Zuo, Xuchun Wang, Pingping Cao, Ying Chu, Zhongyong Qin, He Cheng, Xiao Shi, Tingzheng Ma, Zekuan Xu, Yujie Sun
Summary: This study identified two causal variations in the 1q22 region using tag-SNP rs2075570 as a genetic marker. These variations may affect the occurrence and progression of gastric cancer by reinforcing the expression of the 1q22-Enh enhancer-regulated UBAP2L target gene.
MOLECULAR CANCER RESEARCH
(2021)
Article
Microbiology
Anthony Mannion, JoAnn Dzink-Fox, Zeli Shen, M. Blanca Piazuelo, Keith T. Wilson, Pelayo Correa, Richard M. Peek, M. Constanza Camargo, James G. Fox
Summary: Colombia in South America has a high burden of Helicobacter pylori infection and gastric cancer. Multidrug antibiotic regimens can effectively eradicate H. pylori, but treatment efficacy is threatened by the emergence of antibiotic-resistant strains. This study found that H. pylori isolates from Colombia exhibit multidrug antibiotic resistance.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Veronica Sui, Faye McKenna, Hilary Bertisch, Pippa Storey, Rebecca Anthopolos, Donald C. Goff, Alexey Samsonov, Mariana Lazar
Summary: This study used quantitative MRI to compare iron content in several iron-rich subcortical structures between individuals with PSD and healthy controls. The results showed significantly reduced iron content in PSD patients compared to controls, particularly in patients with schizophrenia. These findings suggest that decreased iron in subcortical regions is associated with PSD risk and symptomatology, and may play a role in the pathology of PSD.
MOLECULAR PSYCHIATRY
(2022)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Ecology
Leona J. M. Milec, Veijo Jormalainen, Luca Rugiu, Ricardo T. Pereyra, Eva Rothausler, Jon Havenhand, Pierre R. De Wit
Summary: The research suggests that future desalination of the Baltic Sea will affect algae growth, particularly in terms of grazing behavior and phlorotannin content, with genotypic variation present. The study also reveals that Fucus radicans is more sensitive to grazing, while Fucus vesiculosus exhibits higher grazing in high genetic diversity groups. Therefore, under future climate change-induced hyposalinity, Fucus populations will face challenges due to changes in grazing behavior and growth deterioration.
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yalcin Yaman, Veysel Bay, Semih Sevim, Ramazan Aymaz, Murat Keles, A. Taner Onaldi, Mehmet Ozuicli, Bayram Senlik, Seyrani Koncagul, Onur Yilmaz, Cemal Un
Summary: This study investigated the relationship between PAPPA2 coding variants and gastrointestinal nematode fecal egg count score in adult Turkish sheep. The FEC score was determined in sheep from six different breeds. Fourteen synonymous and three non-synonymous single-nucleotide polymorphisms (SNPs) in the PAPPA2 gene were identified, including three variants that were reported for the first time. A specific haplotype in exon 2 was found to be significantly associated with fecal egg shedding status in adult Turkish sheep.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Gustavo Rojas-Velasco, Alberto Lopez-Reyes, Laura Martinez-Gomez, Silvestre Ortega-Pena, Isela Montufar-Robles, Rosa Elda Barbosa-Cobos, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: In a case-control study, ABO gene polymorphisms were found to be associated with a higher risk of developing COVID-19. Specific genotypes and haplotypes were also related to the risk of disease development and platelet concentration in COVID-19 patients.
Article
Microbiology
Murat Oezben, Georg Von Samson-Himmelstjerna, Malene K. B. Freiin von Streit, Edwina J. A. Wilkes, Kristopher J. Hughes, Juergen Krucken
Summary: This study suggests that different mechanisms may lead to benzimidazoles resistance in ascarids and strongyle nematodes.
Article
Biochemistry & Molecular Biology
Natalie Jakobs, Esra Yilmaz, Juergen Kruecken
Summary: The number of reported cases of macrocyclic lactones (ML) resistance is increasing in livestock hosts. Studies have suggested the involvement of cytochrome P450s (Cyps) enzymes in ML resistance in the parasitic nematode Haemonchus contortus. However, there is a lack of functional data regarding the individual contribution of these enzymes to resistance or substrate specificity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Parasitology
Joshua Malsa, Elise Courtot, Michel Boisseau, Bertrand Dumont, Pascale Gombault, Tetiana A. Kuzmina, Marta Basiaga, Jerome Lluch, Gwenolah Annonay, Sophie Dhorne-Pollet, Nuria Mach, Jean-Francois Sutra, Laurence Wimel, Cedric Dubois, Fabrice Guegnard, Delphine Serreau, Anne Lespine, Guillaume Salle, Geraldine Fleurance
Summary: This study analyzed the impact of a sainfoin-rich diet on the population of cyathostomin parasites in horses and the efficacy of oral ivermectin treatment. The results showed that while the sainfoin diet did not decrease cyathostomin fecal egg counts, it slightly reduced larval development. Additionally, the consumption of dehydrated sainfoin pellets negatively affected the pharmacokinetics of ivermectin.
Article
Infectious Diseases
Christina S. Helm, Christiane Weingart, Sabrina Ramuenke, Ingo Schaefer, Elisabeth Mueller, Georg von Samson-Himmelstjerna, Barbara Kohn, Juergen Kruecken
Summary: Since 2015, there has been an increase in autochthonous canine babesiosis cases caused by Babesia canis in the Berlin/Brandenburg area in Germany. Genetic analysis revealed high parasite variability and potential multiple origins for the infections.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Laura Juergenschellert, Juergen Kruecken, Eric Bousquet, Juergen Bartz, Nina Heyer, Martin K. Nielsen, Georg von Samson-Himmelstjerna
Summary: The prevalence of strongylid nematode infection in horses, particularly Strongylus vulgaris, was investigated in Berlin/Brandenburg, Germany. The study found a high prevalence of strongylid nematodes in horses, with S. vulgaris being the most pathogenic. Age and access to pasture were identified as risk factors for egg shedding and infection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Christiane Weingart, Christina S. Helm, Elisabeth Mueller, Ingo Schaefer, Marianne Skrodzki, Georg Von Samson-Himmelstjerna, Jurgen Kruecken, Barbara Kohn
Summary: Vector-borne diseases, including autochthonous Babesia canis infection, are increasing in importance in Germany, particularly in the Berlin/Brandenburg region. This study examined 49 dogs with autochthonous B. canis infection and found severe clinical symptoms and pathological changes. It is recommended to monitor treatment effectiveness through PCR testing during and after treatment, and to implement blood donor screening in high-risk areas and year-round tick protection.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Parasitology
Heike Boelow, Juergen Kruecken, Georg Von Samson-Himmelstjerna
Summary: Gastrointestinal nematodes, especially Parascaris spp. and strongyles, are commonly found parasites in grazing equines. However, there is a lack of epidemiological data on the presence and egg-shedding intensities of these parasites. Based on samples collected from German horse farms, 46.5% of the samples were positive for strongyles with a median egg-shedding intensity of 40, while for Parascaris spp., the prevalence was 4.6% with a median egg-shedding intensity of 0. Various variables were found to influence the prevalence and egg-shedding intensity of both Parascaris and strongyles.
PARASITOLOGY RESEARCH
(2023)
Article
Entomology
Billy L. Amugune, Abneel K. Matharu, Paul Ouma, Francis Mutebi, Lynne Elson, Ulrike Fillinger, Juergen Kruecken
Summary: Tunga penetrans is an invasive flea that causes tungiasis, and a low-cost PCR-based tool for the identification of T. penetrans is needed to understand its ecology and monitor its development in soil.
Article
Microbiology
Abdurakhim E. Kuchboev, Juergen Kruecken
Summary: The aim of this study was to characterize the diversity of Metastrongylus spp. in wild boars and the earthworm intermediate host species. The prevalence of Metastrongylus spp. in wild boars was found to be high, with multiple species coexisting. Additionally, earthworms were identified as potential hosts for Metastrongylus. Age group and season did not significantly affect prevalence, but intensity of infection was higher in autumn compared to spring and summer. However, there was no clear association between earthworm species' phylogenetic relationship and ecological microhabitats and prevalence.
Letter
Dermatology
Niklas Weber, Julian Trujillo-Trujillo, Juergen Kruecken, Felipe Castillo, Hermann Feldmeier, Cord Sunderkoetter
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Elise Courtot, Michel Boisseau, Sophie Dhorne-Pollet, Delphine Serreau, Amandine Gesbert, Fabrice Reigner, Marta Basiaga, Jerome Lluch, Tetiana Kuzmina, Gwenolah Annonay, Claire Kuchly, Irina Diekmann, Juergen Kruecken, Georg von Samson-Himmelstjerna, Nuria Mach, Guillaume Salle
Summary: Basic knowledge on the biology and epidemiology of equine strongylid species needs to be improved for better parasite control strategies. Nemabiome metabarcoding is a tool to quantify and identify species in bulk samples. This study compares the performance of ITS-2 and COI barcodes for cyathostomin communities.
Article
Entomology
Ayako Hyuga, Paul Ouma, Abneel K. Matharu, Juergen Kruecken, Satoshi Kaneko, Kensuke Goto, Ulrike Fillinger
Summary: This study evaluated the jumping capabilities of female and male T. penetrans, and found that they have similar jumping abilities to other flea species. The fact that they mostly affect the feet of hosts is likely an adaptation to host behavior, rather than a result of their limited jumping ability.
JOURNAL OF MEDICAL ENTOMOLOGY
(2023)
Article
Parasitology
Ingo Schaefer, Christina Sabine Helm, Georg von Samson-Himmelstjerna, Juergen Kruecken, Tanja Kottmann, Annette Holtdirk, Barbara Kohn, Guy Hendrickx, Cedric Marsboom, Elisabeth Mueller
Summary: This study assessed the prevalence of Babesia spp. infections in dogs in Germany and identified potential risk factors for infection. The results showed that Babesia canis is endemic in Germany and the prevalence of infection is influenced by season, sex, age, tick attachment, and ectoparasite prophylaxis. Travel and importation of dogs are also considered major factors associated with canine babesiosis in Germany.
PARASITES & VECTORS
(2023)
Article
Parasitology
Barbara Hinney, Sandra Wiedermann, Antonio Bosco, Laura Rinaldi, Martin Hofer, Anja Joachim, Juergen Kruecken, Ralf Steinborn
Summary: Haemonchus contortus, the most pathogenic nematode in small ruminants, is hampered by anthelmintic resistance (AR). Detection of AR status using phenotypic tests cannot achieve early detection, but single nucleotide polymorphisms (SNPs) in the isotype 1 & beta;-tubulin gene allow early detection of AR-associated alleles in benzimidazoles (BZs). A novel digital PCR (dPCR) was developed to detect these SNPs in H. contortus, with a detection limit of 15 copies/& mu;l and high accuracy. The developed assays showed elevated frequencies of F200Y resistance alleles in Austrian samples and identified polymorphisms in codon 167 and codon 198 for the first time in H. contortus from Austria. In Italian samples, the frequency of resistance alleles was comparatively low but traceable. The dPCR assays provide a valuable tool for early onset SNP-based surveillance of AR development in H. contortus.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2023)
Article
Microbiology
Moritz Stummer, Vicky Frisch, Frauke Glitz, Barbara Hinney, Joachim Spergser, Juergen Kruecken, Irina Diekmann, Katharina Dimmel, Christiane Riedel, Jessika-Maximiliane V. Cavalleri, Till Ruemenapf, Anja Joachim, Manolis Lyrakis, Angelika Auer
Summary: Acute abdominal pain in horses is a significant global health threat, requiring intensive veterinary care and often surgery. Equine coronavirus (ECoV) infections, although rarely considered, can cause colic in horses. A study was conducted to determine the frequency of undetected ECoV infections in horses with acute colic, revealing that 5.7% of colic horses and 2.8% of control horses tested positive for Betacoronaviruses. Furthermore, sequences closely related to bovine coronaviruses (BCoV) were found in three out of six coronavirus-positive horses with colic, indicating a need for further investigation into the pathogenic potential of BCoV in horses.