Article
Chemistry, Analytical
Chia-Wen Chang, Yu-Hsuan Lin, Cheng-Han Tsai, Sivasankar Kulandaivel, Yi-Chun Yeh
Summary: A novel heat-stable enzyme was developed for a protein-and cell-based biosensor, enabling the detection of L-DOPA for the first time. The detection of L-DOPA was achieved through a red fluorescent signal within 30 minutes. Furthermore, a sequential analysis method using dual-fluorescent signals was developed for the sensitive detection of dopamine and L-DOPA coexistence, allowing for monitoring of the therapy for Parkinson's disease patients treated with L-DOPA.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Vladimir M. Pogorelov, Michael L. Martini, Jian Jin, William C. Wetsel, Marc G. Caron
Summary: L-DOPA is the main treatment for Parkinson's disease, but it can lead to dyskinesia over time. In this study, dopamine-depleted dopamine-transporter KO (DDD) mice were used as an acute PD model to screen novel compounds for anti-parkinsonian and L-DOPA-induced dyskinesia. The researchers found that oral stereotypies could be used as an index for LID in DDD mice.
Article
Neurosciences
Oliver Grimm, Magdalena Nagele, Lea Kupper-Tetzel, Moritz de Greck, Michael Plichta, Andreas Reif
Summary: The study found that the dopamine agonist L-DOPA and antagonist amisulpride did not have a significant impact on the reward system as expected, challenging the sensitivity of reward anticipation contrast in healthy volunteers for assessing dopamine-specific changes through pharmacological fMRI.
PSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiqiang Sha, Antonietta Pepe, Dick Schijven, Amaia Carrion-Castillo, James M. Roe, Rene Westerhausen, Marc Joliot, Simon E. Fisher, Fabrice Crivello, Clyde Francks
Summary: This study examined the neuroanatomical and genetic differences between left-handers and right-handers, identifying higher asymmetries in certain regions among left-handers. It also found that some genetic variations were associated with left-handedness and structural brain asymmetries.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Kazumasa Uehara, Justin M. M. Fine, Marco Santello
Summary: Previous studies have shown that beta oscillations in the primary motor cortex are involved in regulating motor response vigor. In this study, we combined EEG with rhythmic TMS to investigate the functional role of beta oscillations in motor responses. The results demonstrate that beta-rhTMS modulated neural oscillations and reduced peak force rate, indicating the influence of beta oscillations on motor response regulation. Our findings also suggest that rhTMS is a promising tool for tuning neural oscillations to the target frequency.
HUMAN BRAIN MAPPING
(2023)
Review
Cell Biology
Pei Yee Ma, Jing En Tan, Edd Wyn Hee, Dylan Wang Xi Yong, Yi Shuan Heng, Wei Xiang Low, Xun Hui Wu, Christy Cletus, Dinesh Kumar Chellappan, Kyan Aung, Chean Yeah Yong, Yun Khoon Liew
Summary: This review examines a broad range of candidate genetic polymorphisms associated with susceptibility to and severity of enteric fever, focusing on specific genes that may impact disease progression. Limitations in the studies and the potential for future research directions are also highlighted. Ultimately, the knowledge gained from this review may contribute to the development of risk prediction tools, novel therapies, and personalized typhoid vaccine strategies.
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Biochemistry & Molecular Biology
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. H. Greig, Jin Jung, Ho- Choi, Lars Olson, Barry J. J. Hoffer, Kuan-Yin Tseng
Summary: This study evaluated the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors and neurochemistry in a progressive Parkinson's disease MitoPark mouse model. The results showed that early administration of PT320 significantly reduced the severity of L-DOPA-induced abnormal involuntary movements, particularly in excessive standing and abnormal paw movements. However, late administration of PT320 did not improve any L-DOPA-induced dyskinesia measurements. Furthermore, early treatment with PT320 increased both tonic and phasic release of dopamine in striatal slices, indicating its potential role in alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N. Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi
Summary: The striatum, the main structure of the basal ganglia, is subdivided into seven subregions with distinct roles in motor and emotional functions. Dopamine D1 receptor signaling is region-specifically regulated in the striatum, with aberrant activation in the IC associated with L-DOPA-induced dyskinesia. Future research focusing on D1 receptor signaling in the IC may lead to novel therapeutics for LID.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Riccardo Viaro, Francesco Longo, Fabrizio Vincenzi, Katia Varani, Michele Morari
Summary: Previous studies have demonstrated that L-DOPA can enhance dopamine release through SCH23390-sensitive D1 receptors and potentially promote dopamine efflux via conversion to dopamine and reversal of the DA transporter.
Article
Biochemistry & Molecular Biology
Damian M. Herz, Manuel Bange, Gabriel Gonzalez-Escamilla, Miriam Auer, Muthuraman Muthuraman, Martin Glaser, Rafal Bogacz, Alek Pogosyan, Huiling Tan, Sergiu Groppa, Peter Brown
Summary: This study investigates the role of the basal ganglia in action adaptation in humans. It shows that dynamic modulation of the subthalamic nucleus and interconnected cortical areas facilitates adaptive behavior.
Article
Biology
Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
Summary: Dopaminergic medication in PD patients affects oscillatory whole-brain networks, leading to coherence within the medial and orbitofrontal cortex in the delta/theta frequency range, and a switch in beta band activity from an STN-mediated motor network to a frontoparietal-mediated one.
Article
Clinical Neurology
Jan Kasper, Simon B. Eickhoff, Svenja Caspers, Jessica Peter, Imis Dogan, Robert Christian Wolf, Kathrin Reetz, Juergen Dukart, Michael Orth
Summary: Kasper et al. found that in Huntington's disease, the functional integrity of the dopamine receptor-rich caudate nucleus plays a crucial role in maintaining network function. Loss of caudate functional integrity leads to motor signs independent of atrophy. This finding may have implications for other neurodegenerative diseases.
Article
Biotechnology & Applied Microbiology
Kiros Haddish, Jong Won Yun
Summary: L-Dopa induces browning in white fat cells by increasing the expression levels of beige-specific marker genes and thermogenesis-related proteins. It activates the dopamine receptor D1 and beta 3-AR, leading to the activation of the PKA/p38 MAPK/ERK signaling pathway.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2022)
Article
Immunology
Marie-Eve Laliberte-Gagne, Marilene Bolduc, Caroline Garneau, Santa-Mariela Olivera-Ugarte, Pierre Savard, Denis Leclerc
Summary: This study evaluated the impact of peptide antigen fusion at different positions on the PapMV CP on the immune response, finding that coupling at the N-terminus (PapMV-N) led to enhanced immune response compared to coupling at the C-terminus. The difference in immune response between the two platforms is associated with the enhanced TLR7/8 stimulation capacity of the PapMV-N vaccine platform. Additionally, it was demonstrated that the strength of the immune response increases with the density of coupling at the surface of the nanoparticles.
Article
Statistics & Probability
Lingge Li, Andrew Holbrook, Babak Shahbaba, Pierre Baldi
COMPUTATIONAL STATISTICS
(2019)
Article
Statistics & Probability
Pierre Baldi, Babak Shahbaba
AMERICAN STATISTICIAN
(2020)
Meeting Abstract
Hematology
Maher Albitar, Zijun Yidan Xu-Monette, Babak Shahbaba, Ivan De Dios, Yingjun Wang, Deng Manman, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Karen Dybkaer, Wayne Tam, Eric D. Hsi, Maurilio Ponzoni, Andres J. M. Ferreri, Michael Moller, Miguel A. Piris, Joannes H. J. M. Van Krieken, Youli Zu, Wanlong Ma, Hagop M. Kantarjian, Yong Li, Ken H. Young
Article
Hematology
Zijun Y. Xu-Monette, Hongwei Zhang, Feng Zhu, Alexandar Tzankov, Govind Bhagat, Carlo Visco, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Hua You, Jooryung Huh, Maurilio Ponzoni, Andres J. M. Ferreri, Michael B. Moller, Benjamin M. Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Fredrick B. Hagemeister, Babak Shahbaba, Ivan De Dios, Hong Zhang, Yong Li, Bing Xu, Maher Albitar, Ken H. Young
Article
Multidisciplinary Sciences
Babak Shahbaba, Lingge Li, Forest Agostinelli, Mansi Saraf, Keiland W. Cooper, Derenik Haghverdian, Gabriel A. Elias, Pierre Baldi, Norbert J. Fortin
Summary: The hippocampus plays a critical role in the temporal organization of experiences, encoding and predicting the sequential order of nonspatial event sequences.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Louis Ehwerhemuepha, Bradley Roth, Anita K. Patel, Olivia Heutlinger, Carly Heffernan, Antonio C. Arrieta, Terence Sanger, Dan M. Cooper, Babak Shahbaba, Anthony C. Chang, William Feaster, Sharief Taraman, Hiroki Morizono, Rachel Marano
Summary: This study examined the association between previous or preexisting cardiovascular conditions and the severity of COVID-19 in pediatric patients. The findings suggest that certain cardiovascular conditions may increase the severity of COVID-19 in children, particularly those with a history of cardiac arrest who are younger than 12 years old. The study highlights the importance of identifying these associations to inform treatment for pediatric patients with COVID-19.
Article
Statistics & Probability
Francesco Denti, Ricardo Azevedo, Chelsie Lo, Damian G. Wheeler, Sunil P. Gandhi, Michele Guindani, Babak Shahbaba
Summary: This paper focuses on identifying differentially activated brain regions using light sheet fluorescence microscopy. A new Bayesian approach is introduced to classify brain regions into tiers with varying degrees of relevance, providing more biologically meaningful and interpretable results.
ANNALS OF APPLIED STATISTICS
(2023)
Article
Clinical Neurology
Yueqi Ren, Babak Shahbaba, Craig E. L. Stark
Summary: In this study, we developed a framework to use inexpensive and accessible data to classify and predict the progression of Alzheimer's disease. The results showed that these data can accurately guide clinical diagnosis and predict disease states.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Clinical Neurology
Steven C. Cramer, Jill See, Brent Liu, Matthew Edwardson, Ximing Wang, Shlomit Radom-Aizik, Fadia Haddad, Babak Shahbaba, Steven L. Wolf, Alexander W. Dromerick, Carolee J. Winstein
Summary: The study found that BDNF and ApoE gene polymorphisms did not have a significant impact on response to rehabilitation therapy, but the BDNF gene polymorphism was associated with cerebral atrophy, while the ApoE gene polymorphism was linked to a younger age at stroke onset.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Multidisciplinary Sciences
Luis Martinez Lomeli, Abdon Iniguez, Prasanthi Tata, Nilamani Jena, Zhong-Ying Liu, Richard Van Etten, Arthur D. Lander, Babak Shahbaba, John S. Lowengrub, Vladimir N. Minin
Summary: This study aims to uncover the mechanisms in haematopoiesis through perturbation experiments, using a novel Bayesian hierarchical framework for optimal experimental design and data analysis. The research utilizes a deterministic model and principles of Bayesian experimental design to overcome the obstacle of non-longitudinal experimental data, showing that optimal design can lead to better parameter estimates.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
Babak Shahbaba, Shiwei Lan, Jeffrey D. Streets, Andrew J. Holbrook
CONFERENCE ON UNCERTAINTY IN ARTIFICIAL INTELLIGENCE (UAI 2020)
(2020)
Article
Mathematics, Interdisciplinary Applications
Shiwei Lan, Andrew Holbrook, Gabriel A. Elias, Norbert J. Fortin, Hernando Ombao, Babak Shahbaba
Article
Clinical Neurology
Fareshte Erani, Nadezhda Zolotova, Benjamin Vanderschelden, Nima Khoshab, Hagop Sarian, Laila Nazarzai, Jennifer Wu, Bharath Chakravarthy, Wirachin Hoonpongsimanont, Wengui Yu, Babak Shahbaba, Ramesh Srinivasan, Steven C. Cramer
Article
Statistics & Probability
Xu Gao, Weining Shen, Babak Shahbaba, Norbert J. Fortin, Hernando Ombao
Meeting Abstract
Clinical Neurology
Fareshte Erani, Nadezhda Zolotova, Benjamin Vanderschelden, Jennifer C. Wu, Anirudh Wodeyar, Hagop Sarian, Bharath Chakravarthy, Wirachin Hoonpongsimanont, Wengui Yu, Ramesh Srinivasan, Babak Shahbaba, Steven C. Cramer