Article
Clinical Neurology
Kasper Lolk, Julie W. Dreier, Jakob Christensen
Summary: The study found that the risk of epilepsy following traumatic brain injury increases with the repetition and severity of the injury, with females more likely to develop epilepsy after mild injuries and males more likely after severe injuries. These risks remain elevated for decades post-injury.
Article
Clinical Neurology
Lulu Zhang, Wenzhe Yang, Xuerui Li, Abigail Dove, Xiuying Qi, Kuan-Yu Pan, Weili Xu
Summary: This study found that traumatic brain injury (TBI), especially between ages 50-69, is associated with an increased risk of dementia, and this association is exacerbated among individuals with cardiometabolic diseases (CMDs). Genetic and early-life environmental factors may not fully account for the association between TBI and dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Raquel C. Gardner, D. E. Barnes, Y. Li, J. Boscardin, C. Peltz, K. Yaffe
Summary: Comparing veterans with and without traumatic brain injury (TBI), it was found that those with TBI were more likely to have common medical/psychiatric comorbidities, which were also risk factors for dementia. Targeting these comorbidities may be especially important for dementia risk reduction among veterans with TBI.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Zhuozhi Dai, Zhiqi Yang, Zhaolin Li, Mu Li, Hongfu Sun, Zerui Zhuang, Weichao Yang, Zehuan Hu, Xiaofeng Chen, Daiying Lin, Xianheng Wu
Summary: The aim of this study was to investigate the changes in glymphatic system activity in patients with mild traumatic brain injury (mTBI), particularly in those with negative MRI scans, using analysis along the perivascular space (ALPS) technology. The results suggest that the activity level of the glymphatic system was enhanced in mTBI patients, including those with negative MRI scans, based on ALPS index analysis. These findings provide important insights for understanding the pathophysiology of mild TBI.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Jieyu Zhang, Yongkang Zhang, Juntao Zou, Fei Cao
Summary: Several epidemiological studies suggest that traumatic brain injury may be associated with an increased risk of Alzheimer's disease, especially in cases of moderate and severe traumatic brain injury. The risk ratio was 1.17.
Article
Dermatology
Yu Ri Woo, Minah Cho, Kyung Do Han, Sang Hyun Cho, Ji Hyun Lee
Summary: This study analyzed the incidence and risk factors of dementia in patients with atopic dermatitis (AD) and found that the risk of dementia is increased in AD patients. The effect of age and diabetes on the development of dementia in AD patients varies.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Neurosciences
Leslie Grasset, Melinda C. Power, Fabrice Crivello, Christophe Tzourio, Genevieve Chene, Carole Dufouil
Summary: This study found no evidence of an association between a history of traumatic brain injury (TBI) with loss of consciousness (LOC) and the risk of dementia or Alzheimer's disease (AD) over 12 years of follow-up, as well as brain atrophy or markers of small vessel disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
J. Kent Werner, Pashtun Shahim, Josephine U. Pucci, Chen Lai, Sorana Raiciulescu, Jessica M. Gill, Risa Nakase-Richardson, Ramon Diaz-Arrastia, Kimbra Kenney
Summary: This study found that poor sleep quality in patients with mild traumatic brain injury was associated with higher levels of neurodegeneration markers and lower cognitive function. Poor sleep quality may be related to the risk of obstructive sleep apnea.
Review
Clinical Neurology
Emma Clark, Saurab Faruque, Cedric Mutebi, Newton V. Nagirimadugu, Alyssa Kim, Malavika Mahendran, Elaine Sullo, Rajendra Morey, Robert W. Turner
Summary: This systematic review aimed to synthesize recent literature on the relationship between mild traumatic brain injury (mTBI) and Alzheimer's disease and related dementias (ADRD). Of the eight relevant articles identified, four showed a significant relationship between mTBI and disease outcomes, highlighting the need for future research on this causal relationship. Future studies should standardize definitions and methodologies to produce more reliable and comprehensive results.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jean-Nicolas Tourigny, Valerie Boucher, Veronique Paquet, Emile Fortier, Christian Malo, Eric Mercier, Jean-Marc Chauny, Gregory Clark, Pierre-Gilles Blanchard, Pierre-Hugues Carmichael, Jean-Luc Gariepy, Myreille D'Astous, Marcel Emond
Summary: The study validated the sensitivity and specificity of the updated BIG in predicting the need for interhospital transfer in patients with complicated mild traumatic brain injury. The results showed that patients in the uBIG-1 group could be safely managed at their initial center without the need for transfer.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Matias Vaajala, Ilari Kuitunen, Rasmus Liukkonen, Ville Ponkilainen, Maiju Kekki, Ville M. M. Mattila
Summary: This study aims to investigate the association between traumatic brain injury (TBI) and the risk for the development of gestational diabetes (GDM). The results of a retrospective cohort study show that TBI is associated with an increased risk of GDM, with the highest risk observed at least 9 years after the injury.
ACTA DIABETOLOGICA
(2023)
Article
Obstetrics & Gynecology
Matias Vaajala, Rasmus Liukkonen, Ilari Kuitunen, Ville Ponkilainen, Maiju Kekki, Ville M. Mattila
Summary: Through a study using nationwide registers, it was found that there is no significant association between traumatic brain injuries (TBIs) and subsequent multifetal gestations. TBIs do not appear to affect the functions of the entire reproductive system. This study provides baseline information on the effects of TBIs on the risk for multifetal gestations, but further research is necessary.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Surgery
Varun Bansal, Priti Patil, Isabella Faria, Monty Khajanchi, Deen Garba, Nakul P. Raykar, Rashi Jhunjhunwala, Mohan R. Sharma, Shamita Chatterjee, Martin Gerdin Warnberg, Nobhojit Roy
Summary: This study aimed to evaluate the outcomes of patients with isolated traumatic brain injury (iTBI) in low-income and middle-income countries. The results showed that age, Glasgow Coma Scale (GCS) scores, and systolic blood pressure (SBP) at arrival were associated with in-hospital mortality risk.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Immunology
Che-Sheng Chu, Chih-Sung Liang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: The study found that bacterial pneumonia is associated with an increased risk of dementia. Different pathogens are associated with different risks of Alzheimer's disease, vascular dementia, and unspecified dementia. In addition, repeated hospitalization due to bacterial pneumonia is dose-dependently associated with the risks of dementia and vascular dementia.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, General & Internal
Mei-Hui Chen, Yueh-Feng Sung, Wu-Chien Chien, Chi-Hsiang Chung, Jeng-Wen Chen
Summary: Traumatic brain injury (TBI) can lead to long-term disabilities, one of which is headaches. While there is a known association between TBI and subsequent migraine, the specific link and the effects of treatment are not well understood. This retrospective cohort study analyzed data from Taiwan's Health Insurance Database and found that patients with TBI had a higher risk of developing migraine compared to non-TBI patients. Additionally, major trauma was associated with a higher migraine risk than minor trauma, but treatment did not significantly affect the risk of migraine.
JOURNAL OF CLINICAL MEDICINE
(2023)