Article
Cardiac & Cardiovascular Systems
Ibrahim Alrashidi, Hee Ho Chu, Jin Hyoung Kim, Ju Hyun Shim, Sang Min Yoon, Pyeong Hwa Kim, Dong Il Gwon, Heung-Kyu Ko
Summary: The study evaluated the efficacy and safety of transarterial chemoembolization (TACE) plus radiotherapy versus TACE alone for hepatocellular carcinoma (HCC) patients invading the hepatic vein (HV) or inferior vena cava (IVC). Results showed that TACE plus radiotherapy was associated with longer progression-free survival (PFS) and overall survival (OS) compared to TACE alone, especially in certain patient subgroups. Both treatment options showed similar safety profiles in treating non-metastatic HCC invading the HV or IVC.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabrina Dehbi, Remi Grange, Geraldine Poenou, Elie Ayoub, Claire Boutet, Fabrice-Guy Barral, Laurent Bertoletti, Sylvain Grange
Summary: This study aimed to analyze the removal rate and predictors of filter non-removal in a university hospital setting. The overall removal rate of IVCF was 40.5%, and the adjusted removal rate was 62.9%. Advanced age and cancer presence were the major factors influencing IVCF removal rate.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Xiaoquan Ji, Zhe Xu, Jing Sun, Wengang Li, Xuezhang Duan, Quan Wang
Summary: This study compared the efficacy and safety of lenvatinib combined with SBRT versus lenvatinib alone for the treatment of HCC patients with PVTT. The combination treatment group exhibited significantly prolonged overall survival, progression-free survival, intrahepatic progression-free survival, and higher objective remission rate. The adverse events in the combined therapy group were manageable and not significantly different from the monotherapy group.
RADIATION ONCOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Joshua L. Leibowitz, Gregory J. Bittle, Ronson J. Madathil, Khanjan Nagarsheth, David J. Kaczorowski
Summary: This article presents a technique for performing endovascular procedures by accessing the circulatory system through a venovenous extracorporeal membrane oxygenation circuit. The technique was demonstrated in a lung transplant recipient who had deep venous thrombosis, and the patient was successfully managed using the circuit as a point of access before discontinuing ECMO support.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Xiaojie Li, Zhimin Ye, Sheng Lin, Haowen Pang
Summary: This study evaluated treatment response and predictive factors for overall survival in HCC and PVTT patients undergoing SBRT, and developed a personalised prediction model. Clinical T stage, presence of cirrhosis, age, alpha-fetoprotein levels, and haemoglobin levels were identified as independent prognostic factors for survival in these patients.
Article
Medicine, General & Internal
Yuanjun Liu, Kunlin Xie, Jiaxin Li, Zhi Wang, Yong Zeng, Hong Wu
Summary: This case study demonstrates successful treatment of a patient diagnosed with HCC with IVCTT using stereotactic body radiotherapy combined with molecularly targeted drugs followed by surgical treatment, resulting in disease-free survival 12 months post-surgery. These findings suggest a promising strategy for the management of HCC with IVCTT if confirmed in future studies.
Editorial Material
Medicine, General & Internal
Clement Lee, S. William Stavropoulos, William T. Kuo
Summary: This article discusses a case of incidentally discovered inferior vena cava filter, presenting two essays that argue for removal or deferring removal of the filter unless complications occur.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Shintaro Takeuchi, Tatsuya Hayakawa
Summary: This case describes a challenging treatment of intraperitoneal venous thrombosis. It is difficult to suspect this condition in patients admitted for loss of consciousness, thus early anticoagulant therapy and appropriate timing for surgical intervention are necessary. The patient was a 78-year-old male with independent daily activities. Computed tomography (CT) angiography revealed thrombi extending from the inferior vena cava and portal vein to the superior mesenteric vein, leading to anticoagulant therapy initiation. The CT angiography on day 7 showed expansion of the thrombus in the superior mesenteric vein, and emergency laparotomy was performed on day 22 for intestinal necrosis. The treatment was successful, and the patient was discharged on day 48.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Maofeng Gong, Jie Kong, Yadong Shi, Boxiang Zhao, Zhengli Liu, Xu He, Jianping Gu
Summary: This study aimed to investigate risk factors and develop a prediction model to assess the probability of nonfilter-associated inferior vena cava thrombosis (IVCT) in patients with lower extremity deep vein thrombosis (LEDVT). The results showed that age < 63.5 years, male sex, proximal LEDVT, bilateral LEDVT, and D-dimer >4.72 μg/ml were risk factors for IVCT's occurrence. The predictive model had a superior diagnostic efficiency compared to single risk factors alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Ho Chu, Seng-Yong Chun, Jin Hyoung Kim, Pyeong Hwa Kim, Dong Il Gwon, Heung-Kyu Ko, Nayoung Kim
Summary: This study indicates that TACE may be effective for patients with HCC invading the hepatic vein or inferior vena cava. The predictive model can help identify candidates most likely to benefit from TACE.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chonlakiet Khorprasert, Kanokphorn Thonglert, Petch Alisanant, Napapat Amornwichet
Summary: For individuals with HCC and PVTT in Thailand, limited treatment options are available due to disease extent, poor liver function, and lack of coverage for immuno/targeted therapy. Radiotherapy has become increasingly important in these patients and is considered a safe and effective therapeutic option, with overall survival being closely related to factors such as patient age, tumor size, radiation dose, and tumor/PVTT response. Further research is necessary to validate these findings through prospective randomized trials.
Review
Biotechnology & Applied Microbiology
Jingchao He, Zhitao Wang, Yue Xin Zhou, Hongbo Ni, XiaoHanu Sun, Jian Xue, Shanshan Chen, Shuai Wang, Meng Niu
Summary: Deep vein thrombosis is a common peripheral vascular disease that often occurs in orthopaedic patients. The placement of an inferior vena cava filter can prevent pulmonary embolism. However, complications such as recurrent thromboembolism after filter placement highlight the need for careful risk-benefit assessment. Biodegradable filters show promise in reducing complications, but there is a lack of experimental studies on filters made of biodegradable metals.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Surgery
Karim Saab, Anand S. Brahmandam, Alexandria L. Brackett, Mayur M. Desai, Alan Dardik, Raul J. Guzman, Cassius Iyad Ochoa Chaar
Summary: Inferior vena cava (IVC) atresia is a rare condition characterized by the absence of the IVC. It is more common in males and is often associated with deep vein thrombosis (DVT). Most patients present with leg pain and swelling related to DVT. Surgical interventions have shown satisfactory mid-term results in terms of patency and symptomatic relief.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Oncology
Jina Kim, Jason Chia-Hsien Cheng, Taek-Keun Nam, Jin Hee Kim, Byoung Kuk Jang, Wen-Yen Huang, Hiroshi Aikata, Myungsoo Kim, Jung Hyun Kwon, Jinbo Yue, Victor Ho Fun Lee, Zhaochong Zeng, Jinsil Seong
Summary: This study compared the efficacy of liver-directed combined radiotherapy (LD combined RT) with sorafenib in hepatocellular carcinoma patients presenting portal vein tumor thrombosis. The LD combined RT group showed significantly improved overall survival and a higher conversion rate to curative surgery. Despite the multimodality of the treatment, LD combined RT had comparable toxicity rates to sorafenib.
Article
Surgery
Xin Ran Liu, Wei Zhou, Feng Chen
Summary: This study evaluates the association between left iliac vein (LIV) compression and inferior vena cava thrombosis (IVCT) in patients with deep vein thrombosis (DVT) involving the LIV. It finds that patients without IVCT have more severe LIV compression than patients with IVCT, and age and provoked DVT are associated with the risk of IVCT. It suggests that severe LIV compression may be a protective factor for the risk of IVCT.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Oncology
Lin Wang, Jingjing Miao, Huageng Huang, Boyu Chen, Xiao Xiao, Manyi Zhu, Yingshan Liang, Weiwei Xiao, Shaomin Huang, Yinglin Peng, Xiaowu Deng, Xing Lv, Weixiong Xia, Yanqun Xiang, Xiang Guo, Fei Han, Chong Zhao
Summary: This study investigated the long-term survival rates and toxicities of early-stage nasopharyngeal carcinoma (NPC) in an endemic area. The results showed that intensity-modulated radiotherapy (IMRT) can achieve superior tumor control and satisfactory long-term outcomes with mild late toxicities in early-stage NPC patients. Chemotherapy should be carefully performed in stage II patients due to increased toxicities.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Wenzhao Sun, Jun Zhang, Yixuan Wang, Meining Chen, Jianli Wang, Li Chen, Lixia Lu, Xiaowu Deng
Summary: This study compared the effects of helical tomotherapy (HT) and RapidArc (RA) in total dura mater irradiation (TDMI) and found that HT provided a more homogenous dose distribution and lower dose to the central region of the brain. This may contribute to reducing long-term cognitive decline in young patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongyu Zhu, Dehuan Xie, Yiwei Yang, Shaomin Huang, Xingwang Gao, Yinglin Peng, Bin Wang, Jianxin Wang, Dexin Xiao, Dai Wu, Changzhi Li, Chenghua Li, Chao-Nan Qian, Xiaowu Deng
Summary: This study investigated the radiobiological response of ultrahigh dose-rate irradiation (FLASH-IR) using 6 MV X-ray and compared it with conventional dose-rate irradiation (CONV-IR). The results showed that FLASH-IR had a radioprotective effect, causing less acute intestinal damage compared to CONV-IR. Inflammatory responses and redox status also differed between the two groups.
Article
Oncology
Yu-Xian Yang, Yu-Zhen Zheng, Tian-Tian Gao, Shi-Liang Liu, Mian Xi, Meng-Zhong Liu, Jun-Ye Wang, Shu-Nan Qi, Yong Yang, Lei Zhao
Summary: This study systematically evaluated 3-year progression-free survival and overall survival in patients with esophageal squamous cell cancer (ESCC). The results showed that patients who experienced progression within 3 years had poor survival outcomes, while those who achieved 3-year progression-free survival had excellent outcomes. 3-year progression-free survival can be used as a reliable primary endpoint for study design and risk stratification in locally advanced ESCC.
Article
Biochemistry & Molecular Biology
Yuxian Yang, Shiliang Liu, Chunxia Xie, Qiaoqiao Li, Tiantian Gao, Mengzhong Liu, Mian Xi, Lei Zhao
Summary: This study revealed the oncogenic role of TMED3 in esophageal squamous cell carcinoma (ESCC) and identified the overexpression of a TMED3-related protein FAM60A in ESCC tissues. Functional verification experiments demonstrated the important roles of TMED3 and FAM60A in ESCC cell proliferation and tumorigenicity.
BIOMEDICAL JOURNAL
(2023)
Article
Oncology
Shupeng Chen, Yinglin Peng, An Qin, Yimei Liu, Chong Zhao, Xiaowu Deng, Rohan Deraniyagala, Craig Stevens, Xuanfeng Ding
Summary: This study developed an advanced deep convolutional neural network (DCNN) architecture to generate synthetic CT (SCT) images from MR images for intensity-modulated proton therapy (IMPT) treatment planning of nasopharyngeal cancer (NPC) patients. The SCT images generated using GANs achieved clinical acceptable dosimetric accuracy for IMPT of NPC patients. The use of advanced DCNN architecture design further improved SCT image quality and resulted in a small dosimetric improvement.
Review
Oncology
Tian-Tian Gao, Jia-Hui Shan, Yu-Xian Yang, Ze-Wei Zhang, Shi-Liang Liu, Mian Xi, Meng-Zhong Liu, Lei Zhao
Summary: This study compared the efficacy and safety of different immune checkpoint inhibitors for patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC). The results showed that Toripalimab and Camrelizumab plus chemotherapy were likely to be the best options in the first-line setting, while Sintilimab and Camrelizumab were preferred options for refractory patients. The toxicity related to immunotherapy was manageable.
Article
Oncology
Huageng Huang, Jingjing Miao, Xiao Xiao, Jiang Hu, Guangshun Zhang, Yinglin Peng, Shunzhen Lu, Yingshan Liang, Shaomin Huang, Fei Han, Xiaowu Deng, Chong Zhao, Lin Wang
Summary: This study compares the incidence of xerostomia in nasopharyngeal carcinoma patients treated with superficial parotid lobe-sparing intensity-modulated radiation therapy (SPLS-IMRT) and conventional IMRT (C-IMRT). The results show that SPLS-IMRT significantly reduces the incidence of xerostomia compared to C-IMRT, while also promoting earlier recovery of parotid gland function without compromising survival outcomes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Jingjing Miao, Lin Wang, Sze Huey Tan, Jin-Gao Li, Junlin Yi, Enya H. W. Ong, Laura L. Y. Tan, Ye Zhang, Xiaochang Gong, Qiuyan Chen, Yan-Qun Xiang, Ming-Yuan Chen, Ying Guo, Xing Lv, Wei-Xiong Xia, Linquan Tang, Xiaowu Deng, Xiang Guo, Fei Han, Hai-Qiang Mai, Melvin L. K. Chua, Chong Zhao
Summary: In this randomized clinical trial, adjuvant capecitabine at the full dose following CCRT was well tolerated and improved failure-free survival among patients with LA-NPC and high-risk factors. Further investigations assessing optimal dose and duration are warranted.
Article
Oncology
Yinglin Peng, Yimei Liu, Guanzhu Shen, Zijie Chen, Meining Chen, Jingjing Miao, Chong Zhao, Jincheng Deng, Zhenyu Qi, Xiaowu Deng
Summary: In this study, a modified fully convolutional neural network called OrganNet was used for auto-segmentation of 24 organs at risk (OARs) in the head and neck. The model achieved good segmentation results, with an average Dice similarity coefficient of 83.75%. Specifically, it performed well in both large-volume organs and small-volume organs. Compared to manual-delineation, OrganNet showed comparable or better performance in organ segmentation based on the STAPLE contours.
Article
Oncology
Zewei Zhang, Chunxia Xie, Tiantian Gao, Yuxian Yang, Yong Yang, Lei Zhao
Summary: This study examines whether progression-free survival (PFS) can serve as a surrogate endpoint for overall survival (OS) in advanced Esophageal Squamous Cell Carcinoma (ESCC) treated with immunochemotherapy. The results show weak support for PFS as an OS surrogate in these cases. Additionally, continuous immunotherapy beyond progression may decrease the risk of death in qualified patients with advanced ESCC.
Article
Oncology
Tiantian Gao, Yong Yang, Zewei Zhang, Yuxian Yang, Shiliang Liu, Yonghong Hu, Yujia Zhu, Hong Yang, Jianhua Fu, Junye Wang, Ting Lin, Mian Xi, Qiaoqiao Li, Mengzhong Liu, Lei Zhao
Summary: This study found that disease-free status at 36 months can serve as a valid surrogate endpoint for 5-year overall survival in patients with locally advanced and resectable esophageal squamous cell carcinoma. Patients who maintained disease-free status at 36 months had a favorable overall survival, while those who experienced disease progression within 36 months had a significantly poorer overall survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
XinLei Ai, PengXin Zhang, XinMin Xie, Bo Qiu, YuJia Zhu, Lei Zhao, Mian Xi, YingJia Wu, SuPing Guo, JinYu Guo, FangJie Liu, DaQuan Wang, NaiBin Chen, QianWen He, YongHong Hu, MengZhong Liu, ZhaoXia Ding, Hui Liu
Summary: This study aimed to evaluate the efficacy and cost-effectiveness of pre-treatment percutaneous endoscopic gastrostomy (PEG) in patients with esophageal squamous cell carcinoma (ESCC) undergoing concurrent chemoradiotherapy (CCRT). The results showed that pre-treatment PEG improved the nutritional status and treatment outcomes, and it was cost-effective compared with oral nutritional supplements (ONS) and nasogastric tube feeding (NTF).
Article
Biochemistry & Molecular Biology
Boyu Chen, Runda Huang, Tianliang Xia, Chunyang Wang, Xiao Xiao, Shunzhen Lu, Xiangfu Chen, Ying Ouyang, Xiaowu Deng, Jingjing Miao, Chong Zhao, Lin Wang
Summary: In this study, the researchers found that IGF2BP3 acts as a key m6A reader in nasopharyngeal carcinoma (NPC) and maintains the stability of NOTCH3 mRNA through an m6A-dependent mechanism, thereby promoting tumor metastasis and enhancing the stemness phenotype. IGF2BP3 is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target in NPC metastasis.
Article
Biochemistry & Molecular Biology
Zewei Zhang, Gaowa Jin, Juan Zhao, Shuqin Deng, Feng Chen, Gaowa Wuyun, Lei Zhao, Quanfu Li
Summary: This study analyzed mitochondrial energy metabolism (MEM) in the tumor micro-environment (TME) of esophageal squamous cell carcinoma (ESCC), identified relevant genes and cell populations, and found a relationship between immunosuppression and metabolic reprogramming. Prognostic models and potential immunotherapeutic targets contribute to personalized treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
