Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway

C-terminal acidic domain of ubiquitin-conjugating enzymes: A multi-functional conserved intrinsically disordered domain in family 3 of E2 enzymes

(2012) Alberto Arrigoni et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unstructural biology coming of age

(2011) Peter Tompa   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsic Disorder in Ubiquitination Substrates

(2011) Tzachi Hagai et al.   JOURNAL OF MOLECULAR BIOLOGY

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Defining the geometry of the two-component proteasome degron

(2011) Tomonao Inobe et al.   Nature Chemical Biology

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

ELM--the database of eukaryotic linear motifs

(2011) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

Rad23 escapes degradation because it lacks a proteasome initiation region

(2011) Susan Fishbain et al.   Nature Communications

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age: Figure 1.

(2010) Stephen C. Kales et al.   CANCER RESEARCH

Structural assembly of cullin-RING ubiquitin ligase complexes

(2010) Erik S Zimmerman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme

(2010) Philip E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Power Law Distribution Defines Structural Disorder as a Structural Element Directly Linked with Function

(2010) Peter Tompa et al.   JOURNAL OF MOLECULAR BIOLOGY

An interdomain sector mediating allostery in Hsp70 molecular chaperones

(2010) Robert G Smock et al.   Molecular Systems Biology

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase

(2010) Tanja Mittag et al.   STRUCTURE

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Degradation of Some Polyubiquitinated Proteins Requires an Intrinsic Proteasomal Binding Element in the Substrates

(2009) Minglian Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Searching DNA via a “Monkey Bar” Mechanism: The Significance of Disordered Tails

(2009) Dana Vuzman et al.   JOURNAL OF MOLECULAR BIOLOGY

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

(2009) Sjoerd J L van Wijk et al.   Molecular Systems Biology

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

SuperLooper--a prediction server for the modeling of loops in globular and membrane proteins

(2009) P. W. Hildebrand et al.   NUCLEIC ACIDS RESEARCH

Talking to chromatin: post-translational modulation of polycomb group function

(2009) Hanneke EC Niessen et al.   Epigenetics & Chromatin

The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation

(2009) Jin Liu et al.   PLoS Computational Biology

Intrinsic Disorder in Protein Interactions: Insights From a Comprehensive Structural Analysis

(2009) Jessica H. Fong et al.   PLoS Computational Biology

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Calcium-induced tripartite binding of intrinsically disordered calpastatin to its cognate enzyme, calpain

(2008) Róbert Kiss et al.   FEBS LETTERS

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES