Article
Immunology
Ivan J. Cohen, Fresia Pareja, Nicholas D. Socci, Ronglai Shen, Ashley S. Doane, Jazmin Schwartz, Raya Khanin, Elizabeth A. Morris, Elizabeth J. Sutton, Ronald G. Blasberg
Summary: This study reveals an inverse relationship between tumor glycolysis and immune infiltration in a large cohort of multiple solid tumor types.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Emil Lou, Joanne Xiu, Yasmine Baca, Andrew C. Nelson, Benjamin A. Weinberg, Muhammad Shaalan Beg, Mohamed E. Salem, Heinz-Josef Lenz, Philip Philip, Wafik S. El-Deiry, W. Michael Korn
Summary: This study utilized a large genomic database to identify the prevalence of the rare KRAS variant A59T in CRC, and characterized the predictive immunologic biomarkers associated with this variant. The results provide supportive evidence that A59T, along with other similarly rare KRAS variants, co-occur with predictive biomarkers of response to immunotherapy.
Review
Oncology
Beate Koeberle, Sarah Schoch
Summary: Cisplatin is effective in treating various solid tumors, but not in colorectal cancer due to alterations in DNA damage signaling and repair mechanisms. Improvement in cisplatin-based chemotherapy for colorectal cancer may be achieved through newly designed analogues and biochemical modulators. Overcoming resistance in cancers can involve targeting DNA damage signaling pathways and utilizing improved platinum compounds.
Review
Biochemistry & Molecular Biology
Kwun Wah Wen, Linlin Wang, Joshua R. Menke, Blossom Damania
Summary: EBV and KSHV, both human gammaherpesviruses with oncogenic properties, are associated with various lymphoproliferative diseases and plasmacytic/plasmablastic neoplasms. These viruses can also infect epithelial cells and cause carcinomas. The pathogenesis of these two viruses is closely linked to the expression of viral proteins.
Article
Medicine, General & Internal
Yoshihito Nakagawa, Yukihiro Akao, Hiromi Yamashita, Tomomitsu Tahara, Kohei Funasaka, Mitsuo Nagasaka, Teiji Kuzuya, Ryoji Miyahara, Senju Hashimoto, Tomoyuki Shibata, Yoshiki Hirooka
Summary: The miRNA expression profile of small intestinal tumors (SIT) is significantly different from that of colorectal tumors. MiR-143 and miR-145 are frequently downregulated in SIT and colorectal tumors, but not in sessile serrated adenoma/polyp tumors. The expressions of miR-7, miR-21, and miR-34a are considerably different between SIT and colorectal carcinomas.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Sang-Ho Choi, Jin Won Huh, Sang-Bum Hong, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Heungsup Sung, Eun Jin Chae, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh
Summary: In Seoul, South Korea, severe human bocavirus-associated pneumonia cases were reported in adults, with a mortality rate of 54.5%. Higher death rates were observed in cases of co-infection (83.3%) and immunocompromise (80.0%).
EMERGING INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Summary: The study showed that increased expression of SPRY2 in colorectal cancer enhances cancer phenotype and Epithelial-Mesenchymal-Transition. Additionally, the upregulation of SPRY2 protein expression was observed in CRC patient samples, along with the first-time identification of SPRY2 hypomethylation and increased 5hmC deposition in the promoter region of SPRY2 in CRC.
Review
Immunology
Monica Parodi, Simonetta Astigiano, Paolo Carrega, Gabriella Pietra, Chiara Vitale, Laura Damele, Melania Grottoli, Maria de la Luz Guevara Lopez, Riccardo Ferracini, Giulia Bertolini, Ilaria Roato, Massimo Vitale, Paola Orecchia
Summary: Since the first studies, mouse models have played a crucial role in understanding NK cells, their development, function, and behavior in normal and tumor tissues. Initially used to study murine NK cells, more sophisticated human-in-mice models have been developed to investigate human NK cells and minimize murine interference. This review provides an overview of the different models used to study NK cells, with a focus on the popular NOG and NSG models, which are used for human-in-mice tumor models, studying transferred human NK cells, and evaluating enhancers of human NK cell function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yi Luan, Mingli Li, Yi Zhao, Qianqian Li, Jia Wen, Siqi Gao, Yang Yang
Summary: ***
The centrosome is a special organelle in human cells, with abnormalities potentially promoting cancer progression by affecting processes like mitosis and cell migration. Further research into the impact of centrosome abnormalities on tumors may help identify new therapeutic strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Genevieve M. Gerhard, Ruben Bill, Marius Messemaker, Allon M. Klein, Mikael J. Pittet
Summary: This article discusses the expanding view of dendritic cell heterogeneity in human tumors, as revealed through meta-analysis of single-cell transcriptome profiling studies. It further examines the conserved tumor-infiltrating DC states across patients, cancer types, and species, and considers the fundamental and clinical relevance of these findings. Finally, an outlook on research opportunities to explore mechanisms governing tumor-infiltrating DC behavior and functions is provided.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Pathology
Marion Jaffrelot, Nadim Fares, Anne Cecile Brunac, Anne Pascale Laurenty, Marie Danjoux, David Grand, Samira Icher, Julie Meilleroux, Eliane Mery, Etienne Buscail, Charlotte Maulat, Christine Toulas, Pierre Vande Perre, Edith Chipoulet, Delphine Bonnet, Anne Staub, Rosine Guimbaud, Janick Selves
Summary: This study established a classification of unusual MMR-D tumors, with 15% of MMR-D tumors identified as unusual and showing a high frequency of TMB-high or -intermediate and genetic syndromes. Patients with unusual MMR-D tumors who received immune checkpoint inhibitor treatment had prolonged clinical benefit.
Article
Oncology
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Summary: This study found that the co-expression of HER3 and MET in colorectal cancer cell lines is associated with cell proliferation. Stimulation of both receptors enhanced cell proliferation more than individual stimulation alone. Moreover, inhibiting HER3 and MET effectively suppressed cell proliferation and tumor growth in colorectal cancer. Therefore, dual targeting of HER3 and MET has potential as a therapy for colorectal cancer.
Article
Medicine, Research & Experimental
Qi Xu, Jia-Lin Xu, Wen-Quan Chen, Wen-Xiu Xu, Yu-Xin Song, Wen-Juan Tang, Di Xu, Meng-Ping Jiang, Jinhai Tang
Summary: miR-195-5p, as a noncoding RNA, plays an important regulatory role in cancer by affecting various pathways and behaviors of tumor cells. Through studying its expression and mechanisms in different tumors, we believe that miR-195-5p may serve as a novel diagnostic biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Marion Arnaud, Johanna Chiffelle, Raphael Genolet, Blanca Navarro Rodrigo, Marta A. S. Perez, Florian Huber, Morgane Magnin, Tu Nguyen-Ngoc, Philippe Guillaume, Petra Baumgaertner, Chloe Chong, Brian J. Stevenson, David Gfeller, Melita Irving, Daniel E. Speiser, Julien Schmidt, Vincent Zoete, Lana E. Kandalaft, Michal Bassani-Sternberg, Sara Bobisse, George Coukos, Alexandre Harari
Summary: NeoScreen is a method that enables sensitive identification of rare tumor antigens and corresponding T cell receptors, which can be used for personalized cancer vaccines and T cell therapies. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen can regress established tumors in patient-derived xenograft mice.
NATURE BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Zhiwei Liu, Allan Hildesheim
Summary: The study found no evidence to suggest a strong relationship between HLA zygosity and the risk of non-virus-associated solid tumors based on genome-wide association study data from over 28,000 individuals of European ancestry.
FRONTIERS IN GENETICS
(2021)
Article
Pathology
Umberto Malapelle, Pasquale Pisapia, Antonino Iaccarino, Massimo Barberis, Claudio Bellevicine, Hans Brunnstrom, Dario de Biase, Giovanna De Maglio, Kajsa Ericson Lindquist, Matteo Fassan, Gabriella Fontanini, Elisa Gruppioni, Paul Hofman, Sabine Merkelbach-Bruse, Miguel A. Molina Vila, Anais Pujals, Ida Rapa, Luisella Righi, Rafael Rosell, Oliver Schildgen, Verena Schildgen, Fernando C. Schmitt, Giovanni Tallini, Sara Vander Borght, Elena Vigliar, Marco Volante, Svenja Wagener-Ryczek, Birgit Weynand, Giancarlo Troncone
Summary: The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Ophthalmology
R. Michael Dutescu, Peter Banasik, Oliver Schildgen, Norbert Schrage, Daniel Uthoff
Summary: This study found a higher percentage of coronavirus RNA in tears of SARS-CoV-2 positive patients using tear fluid sampling technique similar to oropharyngeal lavage compared to earlier reports using conjunctival swabs. Although patients in intensive care showed ocular symptoms, viral conjunctivitis was not observed in any patients.
Letter
Public, Environmental & Occupational Health
Jessica Luesebrink, Verena Schildgen, Oliver Schildgen
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Vanessa Vedder, Verena Schildgen, Jessica Lusebrink, Ramona Liza Tillmann, Birgitta Domscheit, Wolfram Windisch, Christian Karagiannidis, Michael Brockmann, Oliver Schildgen
Summary: The study compared the cytological profiles of BALs from patients infected with various respiratory pathogens, finding that different pathogens caused distinct cell pattern changes but no general cell distribution pattern. Although the cytology pattern of BAL fluid is not specific enough to be used as the sole diagnostic criterion for COVID-19, it may support clinical decision-making.
Article
Microbiology
Verena Schildgen, Sabrina Demuth, Jessica Luesebrink, Oliver Schildgen
Summary: This study analyzed the performance of three different rapid antigen tests in a clinical setting, showing varying specificities and sensitivities which did not entirely meet all expectations. Therefore, careful evaluation is needed when considering their benefits for specific testing strategies and settings.
Correction
Oncology
Verena Schildgen, Monika Pieper, Soumaya Khalfaoui, Wolfgang H. Arnold, Oliver Schildgen
Letter
Anesthesiology
Ulrich Limper, Jerome Defosse, Oliver Schildgen, Frank Wappler
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Letter
Infectious Diseases
Andreas Kretschmer, Annelene Kossow, Barbara Gruene, Oliver Schildgen, Tim Mathes, Verena Schildgen
JOURNAL OF INFECTION
(2022)
Expression of Concern
Virology
Eric O. Freed, Oliver Schildgen
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
JOURNAL OF INFECTION
(2022)
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
M. Nitsch, T. Stahlhut, O. Schildgen, V. Schildgen
NEW MICROBES AND NEW INFECTIONS
(2022)
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
NEW MICROBES AND NEW INFECTIONS
(2022)
Letter
Respiratory System
Matthias Obenaus, Oliver Schildgen, Dirk Schuermann, Ann-Christin von Bruenneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Joerg Hofmann, Stephan Mathas
Letter
Infectious Diseases
S. Demuth, S. Damaschek, O. Schildgen, V. Schildgen
Summary: European strategies on SARS-CoV-2 antigen testing focus on rapid tests conducted by healthcare professionals and self-tests, but evidence shows weak performance even under laboratory conditions.
NEW MICROBES AND NEW INFECTIONS
(2021)