Article
Cardiac & Cardiovascular Systems
Anubodh S. Varshney, Ersilia M. DeFilippis, Jennifer A. Cowger, Ivan Netuka, Sean P. Pinney, Michael M. Givertz
Summary: With the increasing prevalence of advanced heart failure, treatment options such as heart transplantation and LVAD support have shown to improve quality of life and extend survival. Recent advancements, including the use of HeartMate 3 in clinical practice and revisions to the organ allocation system, have led to better management of LVAD-related complications. Although contemporary LVAD recipients have higher illness severity preoperatively, they have higher survival rates and lower adverse event rates compared to previous eras. However, challenges such as bleeding, infection, neurologic events, and right ventricular failure still limit the wider implementation of LVAD support. Ongoing efforts to optimize management of current LVAD devices and develop next-generation devices are expected to further enhance outcomes for patients with advanced heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang
Summary: This study aimed to investigate the changes in myocardial gene expression profile after LVAD implantation and their molecular biological significance. The results showed that inflammatory signaling pathway is crucial for the pathophysiology after LVAD implantation and chemokines mediate cardiac inflammatory response and tissue remodeling through GPCR-ligand binding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Xinyi Gao, Zhike Xu, Chenghan Chen, Pengfei Hao, Feng He, Xiwen Zhang
Summary: Ventricular assist devices (VAD) are widely used in the treatment of end-stage heart failure patients to improve circulatory dysfunction. A multi-Domain model of the left ventricular coupled axial flow artificial heart was used to study its impact on aortic hemodynamics. The results showed that LVAD significantly increased vorticity intensity compared to patients' conditions and approached that of a healthy ventricle. During LVAD surgery, high-speed blood flow was mainly concentrated near the lining of the ascending aorta.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew N. Rosenbaum, Bradley W. Ternus, Siddharth Pahwa, John M. Stulak, Alfredo L. Clavell, Sarah D. Schettle, Atta Behfar, Jacob C. Jentzer
Summary: In patients undergoing left ventricular assist device implantation, right ventricular stroke work index, right heart catheterization, cardiopulmonary bypass time, and ultrafiltration are strongly associated with incident INT-LD and decreased 1-year survival. Optimization of these factors may reduce the risk of liver dysfunction but further validation is needed.
ANNALS OF THORACIC SURGERY
(2021)
Article
Hematology
Kristin Klaeske, Maja-Theresa Dieterlen, Sandra Eifert, Ute Scholz, Jens Garbade, Khalil Jawad, Franz Sieg, Michael A. Borger, Anna L. Meyer
Summary: This study compared platelet receptor expression patterns and oxidative stress levels between LVAD patients with non-surgical bleeding (NSB) and those without coagulation disorders. The findings suggested that changes in three platelet receptors (GPIb alpha, P-selectin, and PECAM-1) and elevated oxidative stress may play a role in bleeding complications following LVAD implantation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Medicine, General & Internal
Alessia Gambaro, Gianmarco Lombardi, Francesco Onorati, Leonardo Gottin, Flavio Luciano Ribichini
Summary: LVAD implantation has complex effects on the kidneys, particularly regarding renal function. Creatinine-based eGFR formulas help in assessing patient prognosis, while deterioration in renal function in LVAD patients negatively impacts outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ofer Havakuk, Aviram Hochstadt, Sapir Sadon, Michal Laurel Perl, Ben Sadeh, Assi Milwidsky, Orly Ran Sapir, Yoav Granot, Lior Lupu, Erez Levi, Ariel Farkash, Yanai Ben Gal, Shmuel Banai, Yan Topilsky
Summary: This study demonstrates that long-term stabilization of patients entering a left ventricular assist device (LVAD) program is possible with the use of aggressive conservative therapy.
Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Caroline K. Olt, Lucy W. Thuita, Edward G. Soltesz, Michael Z. Tong, Aaron J. Weiss, Kay Kendall, Jerry D. Estep, Eugene H. Blackstone, Eileen M. Hsich
Summary: The objective of this study was to determine whether the Stanford Integrated Psychosocial Assessment is predictive of hospital readmissions and death in patients with left ventricular assist devices. The study found that certain components of the assessment were associated with outcomes, suggesting the potential for a specific psychosocial tool for left ventricular assist device programs.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Computer Science, Interdisciplinary Applications
Vikas Kannojiya, Arup Kumar Das, Prasanta Kumar Das
Summary: This article describes the numerical efforts made to investigate the influence of a left ventricular assist device (LVAD) on the patient-specific left heart's hemodynamics. Two different computational geometries with left heart have been simulated over the entire cardiac cycle (case 1: healthy heart without LVAD and case 2: diseased heart with LVAD). The simulation results show that the implantation of LVAD pump has a significant influence on the heart's hemodynamics, providing a cardiac output of 4.87 L/min even during the diastolic phase. The study observes major changes in the fluidics inside the aortic region, with increased wall shear stress at the aorta during the ventricular systole.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Medicine, General & Internal
Alexander A. Brescia, Tessa M. F. Watt, Francis D. Pagani, Thomas M. Cascino, Min Zhang, Jeffrey S. McCullough, Supriya Shore, Donald S. Likosky, Keith D. Aaronson, Michael P. Thompson
Summary: The study found that a significant proportion of LVAD recipients are ineligible for clinical trials, and that mortality rates are higher among those who are ineligible compared to those who are eligible. The results suggest that criteria for clinical trial eligibility should be more reflective of real-world experience.
Article
Cardiac & Cardiovascular Systems
Annika Ingvarsson, Grunde Gjesdal, Saeideh Borgenvik, Anna Werther Evaldsson, Johan Waktare, Oscar Braun, Gustav J. Smith, Anders Roijer, Goran Radegran, Carl Meurling
Summary: Pre-treatment with LVAD can reduce PVR and improve RV function early following OHT. However, within the first year after transplantation, RV function gradually improves in the non-LVAD group, with no difference compared to the LVAD group.
Review
Cardiac & Cardiovascular Systems
Claudio A. Bravo, Andrew G. Navarro, Karanpreet K. Dhaliwal, Maziar Khorsandi, Jeffrey E. Keenan, Parvathi Mudigonda, Kevin D. O'Brien, Claudius Mahr
Summary: Left ventricular assist device (LVAD) therapy is a life-saving option for patients with advanced heart failure who do not respond to medical treatment. However, a significant percentage of LVAD patients develop right heart failure (RHF), which is associated with poor outcomes. The mechanisms of RHF are complex, involving patient factors, surgical factors, and hemodynamic factors. Despite advances in surgical techniques and LVAD technology, RHF remains a major cause of morbidity and mortality among LVAD patients. Current medical therapies for RHF are limited, and cardiac transplantation or supportive management are the only options for these patients. Efforts to predict the risk of RHF in LVAD patients have been challenging, with varying definitions of RHF in different studies. Additionally, most research in this field has focused on early-onset RHF, while late-onset RHF is increasingly recognized as a significant problem. This review aims to describe the unique physiology of the right ventricle and the changes caused by LVADs that may contribute to both early- and late-onset RHF. The available treatments for RHF, including mechanical circulatory support and medical therapies, will also be analyzed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jan D. Schmitto, Steven Shaw, Jens Garbade, Finn Gustafsson, Michiel Morshuis, Daniel Zimpfer, Jacob Lavee, Yuriy Pya, Michael Berchtold-Herz, Aijia Wang, Carlo Gazzola, Evgenij Potapov, Diyar Saeed
Summary: The long-term survival rate for primary implants of HeartMate 3 is 63.3%, and improvements in adverse events reduction, quality of life, and functional capacity were observed in patients with advanced heart failure during extended follow-up.
EUROPEAN HEART JOURNAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Muhannad Aboud Abbasi, Arif Albulushi, Kajari Dhar, Brian Lowes, Ronald Zolty
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Kinnamon, Elizabeth J. Jordan, Garrie Haas, Mark Hofmeyer, Evan A. Kransdorf, Gregory A. Ewald, Alanna Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia H. Garg, Barry Trachtenberg, Palak V. Shah, Salpy K. Pamboukian, Nancy T. Sweitzer, Matthew E. Wheeler, Jane Wilcox, Stuart Katz, Stephen Pan, Javier D. Jimenez, Keith P. Aaronson, Daniel Fishbein, Frank Smart, Jessica S. Wang, Stephen P. Gottlieb, Daniel K. Judge, Charles O. Moore, Jonathan S. Mead, Gordon Huggins, Hanyu Ni, Wylie E. Burke, Ray Hershberger, DCM Consortium
Summary: Family Heart Talk, a booklet that helps patients with dilated cardiomyopathy communicate genetic risk and the need for cardiovascular screening to their relatives, was found to be effective in increasing cardiovascular clinical screening among first-degree relatives. The odds of screening completion were higher in the group that received the booklet, even after adjustment for patient characteristics. The booklet can be provided to patients without significant additional time investment by clinicians.
Article
Surgery
Marian Urban, Morgan Moody, Elizabeth Lyden, Lecia Kinen, Anthony W. Castleberry, Aleem Siddique, Brian D. Lowes, Douglas A. Stoller, Scott W. Lungren, John Y. Um
Summary: Donation after circulatory death (DCD) heart transplantation has comparable outcomes to transplantation using brain death donors (DBDs). This study evaluates the impact of DCD heart transplantation on waitlist mortality and transplant rates. The results show that DCD donor hearts significantly increased heart transplant rates in our institution.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Hanyu Ni, Elizabeth Jordan, Daniel D. Kinnamon, Jinwen Cao, Garrie J. Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Gordon S. Huggins, Ray E. Hershberger
Summary: This study examined the yield of clinical screening among reportedly unaffected first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM). The results showed that among the screened FDRs, 14.1% had new diagnoses of DCM, LVSD, or LVE. Regardless of race and ethnicity, cardiovascular screening identified these patients, highlighting the value of clinical screening in all FDRs.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark Hofmeyer, Garrie J. Haas, Elizabeth Jordan, Jinwen Cao, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Gordon S. Huggins, Daniel D. Kinnamon, Hanyu Ni, Ray E. Hershberger
Summary: Advanced dilated cardiomyopathy (DCM) is associated with a higher probability of pathogenic or likely pathogenic rare variants in DCM genes, which can help assess the risk of outcomes in managing DCM patients and their at-risk family members.
Article
Medicine, General & Internal
Elizabeth Jordan, Daniel D. Kinnamon, Garrie J. Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Jonathan O. Mead, Natalie Hurst, Jinwen Cao, Gordon S. Huggins, Jason Cowan, Hanyu Ni, Heidi L. Rehm, Gail P. Jarvik, Matteo Vatta, Wylie Burke, Ray E. Hershberger
Summary: This study compares the rare variant genetic architecture of dilated cardiomyopathy (DCM) among patients with DCM who are of African ancestry compared with European ancestry. The study found that African patients with DCM were less likely to have clinically actionable variants in DCM genes than those of European ancestry due to differences in genetic architecture and a lack of representation of African ancestry in clinical data sets.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kajari Dhar, Hesham Basma, John Um, Fang Qiu, Brian D. Lowes
Article
Cardiac & Cardiovascular Systems
Nicholas W. Markin, M. Megan Chacon, Anthony W. Castleberry, Lance Fristoe, Brian D. Lowes, John Y. Um, Marian Urban
Summary: This study aimed to determine whether hearts reanimated with normothermic regional perfusion (NRP) have clinically detectable changes in function using echocardiography. The results showed that the cardiac function parameters did not change significantly after heart transplantation from donation after circulatory death (DCD) with NRP, suggesting that the limited period of warm ischemia following circulatory arrest does not adversely impact the outcomes of DCD cardiac allografts reanimated with thoracoabdominal NRP.
Meeting Abstract
Surgery
P. Shah, R. Cheng, H. Eisen, B. D. Lowes, L. Lourenco Jenkins, Y. Fu, K. Qu, J. Teuteberg, E. DePasquale
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Urban, M. Moody, A. Castleberry, B. Lowes, A. Siddique, J. Um
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Urban, M. Moody, A. Castleberry, B. Lowes, A. Siddique, J. Um
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Urban, M. Moody, A. Castleberry, B. Lowes, A. Siddique, J. Um
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Roberts, D. A. Stoller, E. Lyden, B. Lowes, R. Zolty, J. Um, S. Lundgren
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Stoller, R. Zolty, A. Burdorf, M. Hyden, S. Lundgren, F. Qui, G. Gajanan, S. Malik, B. Lowes
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Sundaravel, R. Zolty, D. Stoller, B. Lowes, S. Lundgren
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)