Article
Pediatrics
Mathilde Letouzey, Laurence Foix-L'Helias, Heloise Torchin, Ayoub Mitha, Andrei S. Morgan, Jennifer Zeitlin, Gilles Kayem, Emeline Maisonneuve, Pierre Delorme, Babak Khoshnood, Monique Kaminski, Pierre-Yves Ancel, Pascal Boileau, Elsa Lorthe
Summary: The study found that the risk of late-onset sepsis in very preterm infants differs according to the cause of preterm birth, with infants born after hypertensive disorders or fetal growth restriction having a higher risk compared to those born after preterm labor. Antenatal factors, particularly the various causes leading to preterm birth, should be considered to better prevent and manage neonatal infectious morbidity and inform parents.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Lisette Jansen, Andrea van Steenis, Annette A. van den Berg-Huysmans, Sica T. Wiggers-de Bruine, Monique Rijken, Linda S. de Vries, Robert R. J. M. Vermeiren, Cacha M. P. C. D. Peeters-Scholte, Sylke J. Steggerda
Summary: A longitudinal study found that neonatal brain injury is correlated with short-term neurodevelopmental outcomes, mainly in motor skills and behavior during childhood. Environmental factors, such as maternal education level, become increasingly important for cognitive development as children grow older, especially for those with mild brain injuries.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Thibaut Chapron, Georges Caputo, Veronique Pierrat, Elsa Kermorvant, Amandine Barjol, Melanie Durox, Pierre-Yves Ancel, Heloise Torchin
Summary: In this study, it was found that nearly one-third of very preterm infants were not screened for ROP. Among those screened, the majority were screened according to the recommended timeline. Neonatal units using wide-angle imaging systems showed higher compliance and support for their use.
Article
Pediatrics
Marie-Laure Charkaluk, Jessica Rousseau, Marine Dehouck-Vallois, Pierre-Henri Jarreau, Alexandra Nuytten, Ludovic Treluyer, Pierre-YvesY Ancel, Heloise Torchin
Summary: ARIs are common in very preterm infants during their first year of life, with oxygen therapy frequently required. Risk factors for ARI include male sex, bronchopulmonary dysplasia, presence of siblings, childcare in the community with incomplete palivizumab treatment. Factors associated with more frequent oxygen requirement during ARI include mechanical ventilation in the neonatal period, bronchopulmonary dysplasia, and discharge between October and March.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Mathilde Letouzey, Elsa Lorthe, Laetitia Marchand-Martin, Gilles Kayem, Caroline Charlier, Marine Butin, Ayoub Mitha, Monique Kaminski, Valerie Benhammou, Pierre-Yves Ancel, Pascal Boileau, Laurence Foix-L'Helias
Summary: This study aims to assess the association between early empirical antibiotic therapy and adverse outcomes in very preterm infants. The study found that early antibiotic exposure was associated with an increased risk of severe cerebral lesions and moderate-severe bronchopulmonary dysplasia in very preterm infants at low risk of early-onset sepsis.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Aurelie Pascal, Nele de Bruyn, Gunnar Naulaers, Els Ortibus, Britta Hanssen, Ann Oostra, Kris de Coen, Michel Sonnaert, Eva Cloet, Alexandra Casaer, James D'Haese, Sabine Laroche, An Jonckheere, Katleen Plaskie, Christine van Mol, Els Bruneel, Marie-Rose van Hoestenberghe, Bieke Samijn, Paul Govaert, Christine Van den Broeck
Summary: This study investigated the incidence of intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) in relation to gestational age, as well as the impact on mortality and neurodevelopmental outcomes in very preterm/very low birthweight infants. The results showed that both the prevalence and severity of IVH/PVL decreased significantly as gestational age advanced. More than 75% of infants with low grades of IVH/PVL had normal motor and cognitive outcomes at 2 years of age. High-grade PVL/IVH has become less common and is associated with adverse outcomes.
JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Megan Dibble, Jin Zhe Ang, Liam Mariga, Eleanor J. Molloy, Arun L. W. Bokde
Summary: White matter abnormalities, as measured by diffusion tensor imaging, are more significant in very preterm infants compared to moderate-late preterm infants and full-term controls at term-equivalent age. These microstructural changes may contribute to the increased risk of neurodevelopmental disability in preterm infants later in life, making diffusion tensor imaging a potentially useful prognostic tool.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Thibaut Chapron, Veronique Pierrat, Georges Caputo, Mathilde Letouzey, Elsa Kermorvant-Duchemin, Youssef Abdelmassih, William Beaumont, Amandine Barjol, Guylene Le Meur, Valerie Benhamou, Laetitia Marchand-Martin, Pierre-Yves Ancel, Heloise Torchin
Summary: We reported the 5(1/2) year prevalence of visual and oculomotor impairments in preterm children born at 24-34 weeks' gestation using a population-based cohort study. The study found a high prevalence of refractive errors and strabismus in preterm children regardless of gestational weeks, indicating the need for specific attention in this population. The high prevalence of suboptimal visual acuity could be challenging for these children during reading and writing acquisition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Veronique Pierrat, Laetitia Marchand-Martin, Stephane Marret, Catherine Arnaud, Valerie Benhammou, Gilles Cambonie, Thierry Debillon, Marie-Noelle Dufourg, Catherine Gire, Francois Goffinet, Monique Kaminski, Alexandre Lapillonne, Andrei Scott Morgan, Jean-Christophe Roze, Sabrina Twilhaar, Marie-Aline Charles, Pierre-Wes Ancel
Summary: This study aimed to describe neurodevelopment at age 5 among children born preterm. The results showed that rates of neurodevelopment disabilities increased as gestational age decreased and were higher in families with low socioeconomic status. The findings indicate that early interventions and support are crucial for preterm children to optimize their development outcomes.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Pediatrics
Sandra Herrera, Veronique Pierrat, Monique Kaminski, Valerie Benhammou, Laetitia Marchand-Martin, Andrei S. Morgan, Elvire Le Norcy, Pierre-Yves Ancel, Alice Germa
Summary: This study aimed to describe the frequency of high-arched palate and posterior crossbite at the age of 5 in children born very preterm and identify their respective risk factors. The study found that low gestational age, thumb-sucking habits at the age of 2, and cerebral palsy were specific risk factors for high-arched palate among very preterm children, while pacifier-sucking habits at the age of 2 increased the odds of posterior crossbite.
FRONTIERS IN PEDIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Thomas Desplanches, Andrei S. Morgan, Peter Jones, Caroline Diguisto, Jennifer Zeitlin, Laetitia Martin-Marchand, Valerie Benhammou, Benedicte Lecomte, Jean-Christophe Roze, Patrick Truffert, Pierre-Yves Ancel, Paul Sagot, Adrien Roussot, Jeanne Fresson, Beatrice Blondel
Summary: The study identified modifiable risk factors for outborn deliveries, such as gestational age, inadequate antenatal care, placental abruption, and increased distance to level III units. Approximately 16.7% of outborn deliveries were probably avoidable, and 25.6% were possibly avoidable, potentially increasing the proportion of inborn deliveries to between 85.9% and 92.9%.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2021)
Article
Psychology, Developmental
E. Sabrina Twilhaar, Veronique Pierrat, Laetitia Marchand-Martin, Valerie Benhammou, Monique Kaminski, Pierre-Yves Ancel
Summary: Distinct subgroups with different profiles of functioning can be identified among 5.5-year-old very preterm born children. Male sex, bronchopulmonary dysplasia, low parental education level, and parental non-European immigrant status are associated with a higher likelihood of unfavorable outcome profiles.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Pediatrics
Thiviya Selvanathan, Pearl Zaki, Mia A. McLean, Stephanie H. Au-Young, Cecil M. Y. Chau, Vann Chau, Anne R. Synnes, Linh G. Ly, Edmond Kelly, Ruth E. Grunau, Steven P. Miller
Summary: We assessed variability of analgesic use across three tertiary neonatal intensive care units accounting for early-life pain, and determined whether analgesia exposure modifies associations between early-life pain and neurodevelopment.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Thangaraj Abiramalatha, Usha Devi, Suhas Nagaraj, Gurujala Mahadeva Ramya, Susmitha Tangirala, Ashok Chandrasekaran
Summary: This study aimed to investigate the perinatal risk factors for preterm brain injury and assess their strength of association. Based on a retrospective cohort study, severe intraventricular hemorrhage, culture-positive sepsis, prolonged ventilation, and small for gestational age were identified as significant risk factors for preterm brain injury.
Article
Public, Environmental & Occupational Health
Sandra Herrera, Veronique Pierrat, Monique Kaminski, Valerie Benhammou, Anne-Laure Bonnet, Pierre-Yves Ancel, Alice Germa
Summary: The study found that non-nutritive sucking habits at age 2 years in very preterm children are associated with cultural background, developmental care programs, and breastfeeding. Further research is needed to determine if these habits are linked to future maxillofacial growth anomalies.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2021)
Article
Pediatrics
Laure Simon, Alice Hadchouel, Catherine Arnaud, Anne Frondas-Chauty, Stephane Marret, Cyril Flamant, Dominique Darmaun, Christophe Delacourt, Laetitia Marchand-Martin, Pierre Yves Ancel, Jean-Christophe Roze
Summary: This study aimed to investigate the association between early life growth and later overweight or obesity. The study found that birth weight, increase in weight during neonatal hospital stay, and increase in BMI between discharge and 2 years of age were positively associated with overweight or obesity at 15 years, while increase in length during neonatal hospital stay was negatively associated. These associations were also confirmed at 5 years, suggesting that BMI at 2 years was already related to later overweight or obesity in very preterm born children.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Thierry Debillon, Loic Sentilhes, Gilles Kayem, Marie Chevallier, Jennifer Zeitlin, Olivier Baud, Antoine Vilotitch, Veronique Pierrat, Isabelle Guellec, Pierre Yves Ancel, Nathalie Bednarek, Anne Ego
Summary: In newborns with hypoxic-ischemic encephalopathy (HIE), early neurological and biological examinations were found to be associated with unfavorable outcomes, including death and abnormal MRI results, despite the widespread use of hypothermia treatment (HT).
PEDIATRIC RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Catherine Arnaud, Virginie Ehlinger, Annie Perraud, Agnieszka Kinsner-Ovaskainen, Dana Klapouszczak, Kate Himmelmann, Mariana Petra, Gija Rackauskaite, Monica Lanzoni, Mary-Jane Platt, Malika Delobel-Ayoub
Summary: This study proposed six public health indicators for cerebral palsy (CP) and used population-based data from European CP registries to estimate the extent of CP, effectiveness of perinatal organization, burden of the condition, access to health services and preventive health strategies. The results showed a decreasing prevalence of CP in both preterm and full-term-born children, and the burden of CP was dependent on subtype and associated impairments. The study demonstrated the importance of CP registries in generating key outcomes for public health policies for children with disabilities.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Pediatrics
Catherine Gire, Ninon Fournier, Johanna Pirrello, Stephane Marret, Hugues Patural, Cyril Flamant, Veronique Pierrat, Monique Kaminski, Pierre-Yves Ancel, Barthelemy Tosello, Julie Berbis
Summary: This study examined the relationship between hemoglobin levels in very preterm infants within the first 24 hours of birth and the neurodevelopment outcomes at 24 months of corrected age. The results showed that early low hemoglobin levels were associated with major neonatal morbidities but not with neurodevelopment outcomes at two years of age, except in male infants born at gestational age of more than 26 weeks.
Article
Obstetrics & Gynecology
Charlotte Thomas, Inessa Timofeeva, Elyes Bouchoucha, Thibault Canceill, Camille Champion, Marion Groussolles, Catherine Arnaud, Christophe Vayssiere, Cathy Nabet, Sara Laurencin-Dalicieux
Summary: Periodontal diseases, such as gingivitis and periodontitis, are chronic inflammatory diseases that can increase the risk of adverse pregnancy outcomes. Early oral and periodontal assessment and treatment are necessary to prevent disease aggravation and potential adverse outcomes in pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Pediatrics
Elodie Zana-Taieb, Elsa Kermorvant, Alain Beuchee, Juliana Patkai, Jean-Christophe Roze, Heloise Torchin
Summary: This survey has revealed that French neonatologists have a heavy workload, with long working hours and frequent on-call shifts, which negatively impacts their personal lives. They rated their work satisfaction at 5.7 out of 10, with primary sources of dissatisfaction being excessive working hours and inadequate compensation for on-call duty.
Article
Obstetrics & Gynecology
Elizabeth A. Thom, George R. Saade, Lisa M. Askie, Lynda G. Ugwu, Ben W. J. Mol, Christophe E. Vayssiere, Jane E. Norman, Eva Pajkrt, Rebecca G. Clifton, Joseph R. Biggio, Catherine Arnaud, Vincenzo Berghella, Maria G. Canino, Elena Carreras, Lorraine K. Dugoff, Matthew K. Hoffman, Rodolfo C. Pacagnella, Uma M. Reddy, Gabriele Saccone, Janneke van 't Hooft, Vinh Q. Dang
Summary: Premature birth is a major cause of perinatal and infant mortality worldwide, with long-term neurological disabilities and other health problems in children. The use of Arabin pessary as cervical support for women with a short cervix has shown mixed results in reducing the risk of preterm birth. This study aims to form an international collaboration to conduct a prospective individual patient data meta-analysis of randomized trials on pessary use in singleton and twin gestations with a short cervix.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Ludovic Treluyer, Alexandra Nuytten, Isabelle Guellec, Pierre-Henri Jarreau, Valerie Benhammou, Gilles Cambonie, Patrick Truffert, Laetitia Marchand-Martin, Pierre Yves Ancel, Heloise Torchin
Summary: This study aimed to investigate the neurodevelopmental outcomes and healthcare utilization of very preterm children with bronchopulmonary dysplasia (BPD) at age 5-6 years. The results showed that BPD was strongly associated with various neurodevelopmental disabilities, including behavioral difficulties, developmental coordination disorders, and lower IQ scores.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Behavioral Sciences
Joaquin Fuentes, Mara Parellada, Christina Georgoula, Guiomar Oliveira, Stephane Marret, Veronique Crutel, Cristina Albarran, Estelle Lambert, Pierre-Francois Penelaud, Denis Ravel, Yehezkel Ben Ari
Summary: The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum disorder (ASD) in children and adolescents was evaluated in two international, multi-center, randomized, double-blind, placebo-controlled phase III trials. The results showed that bumetanide did not demonstrate a significant benefit compared to placebo in the overall studied populations. The sponsor has discontinued the development of bumetanide for the treatment of pediatric ASD.
Article
Clinical Neurology
Bastien Estublier, Helene Colineaux, Catherine Arnaud, Pascal Cintas, Eloise Baudou, Yves Chaix, Francois Rivier, Maelle Biotteau, Pierre Meyer, Emmanuel Cheuret
Summary: This prospective observational study aimed to investigate the long-term sequelae in children with Guillain-Barre syndrome (GBS). The results showed that about two-thirds of the children developed late-onset sequelae, with most of them being minor but still affecting their everyday lives. Factors associated with more severe late-onset conditions were initial severity and female sex.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Luise Pudig, Malika Delobel-Ayoub, Karen Horridge, Anja Troha Gergeli, Elodie Sellier, Virginie Ehlinger, Katalin Hollody, Daniel Virella, Torstein Vik, Catherine Arnaud
Summary: This paper introduces the SCPE classification system for postneonatally acquired cerebral palsy, assesses its reliability, and describes the cases identified in the SCPE database. The classification system consists of six main categories and 19 subcategories. The primary events identified include infections, head injuries, surgery or medical interventions, cerebrovascular accidents, hypoxic brain damaging events, and other miscellaneous causes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Microbiology
Gael Toubon, Marie-Jose Butel, Jean-Christophe Roze, Ioannis Nicolis, Johanne Delannoy, Cecile Zaros, Pierre-Yves Ancel, Julio Aires, Marie-Aline Charles
Summary: Early life gut microbiota-influencing factors are crucial for long-term health, and this study aimed to investigate the associations between 20 early life factors and gut microbiota composition at 3.5 years old. The results showed that gestational age, mode of delivery, and breastfeeding were significantly associated with gut microbiota differences. Having a sibling and attending daycare center were also linked to specific enterotypes. Maternal factors such as country of birth and preconception body mass index influenced the microbiota characteristics of the children.
Article
Microbiology
Julio Aires, Zehra Esra Ilhan, Lancelot Nicolas, Laurent Ferraris, Johanne Delannoy, Maxime Bredel, Anne Chauvire-Drouard, Frederic Barbut, Jean-Christophe Roze, Patricia Lepage, Marie-Jose Butel
Summary: This study reports data from a French case-control prospective multicenter study, which found differences in gut microbiota composition between NEC cases and controls. The relative abundance of Lactobacillus genus was significantly lower in the NEC group, while that of the Clostridium cluster III was significantly higher. The study also found a statistical association between gut microbiota and cesarean delivery and antifungal therapy.
Article
Pediatrics
Jonathan Beck, Thierry Debillon, Isabelle Guellec, Antoine Vilotitch, Gauthier Loron, Nathalie Bednarek, Pierre-Yves Ancel, Veronique Pierrat, Anne Ego
Summary: The initiation of therapeutic hypothermia within 6 hours of life is crucial for treating neonatal hypoxic ischemic encephalopathy. This study aimed to identify clinical and healthcare organizational factors associated with delayed therapeutic hypothermia in a French population-based cohort. Delayed therapeutic hypothermia was more common in neonates with moderate HIE and in maternity units with lower annual birth volumes. Early identification of neonates who could benefit from therapeutic hypothermia and access to appropriate care before transfer are important factors in improving outcomes for neonates with HIE.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
