Article
Pediatrics
Melania Manco, Nadia Panera, Annalisa Crudele, Maria Rita Braghini, Marzia Bianchi, Donatella Comparcola, Rita De Vito, Giuseppe Maggiore, Anna Alisi
Summary: Angiopoietin-2 is a suitable biomarker for NASH in pediatric population, with high predictive value for NASH. CK18, on the other hand, is effective in predicting both NASH and fibrosis. The combination of Ang-2 and CK18 can achieve a positive predictive value of 100% for NASH.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Hirokazu Takahashi, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue
Summary: This study analyzed the relationship between baseline serum albumin level and long-term prognosis in 1383 Japanese patients with NAFLD. The results showed that patients with intermediate or low serum albumin had a significantly higher risk of death or orthotopic liver transplantation.
Article
Chemistry, Multidisciplinary
He-ming Huang, Shi-jie Fan, Xiao-ru Zhou, Yan-jun Liu, Xiao Li, Li-ping Liao, Jing Huang, Cui-cui Shi, Liang Yu, Rong Fu, Jian-gao Fan, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Summary: Givinostat demonstrated therapeutic potential in treating nonalcoholic steatohepatitis (NASH) by alleviating inflammation and attenuating hepatic fibrosis, as shown in both in vivo and in vitro studies.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Gastroenterology & Hepatology
Nobuyoshi Kawamura, Kento Imajo, Kyle J. Kalutkiewicz, Koki Nagai, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi, Masato Yoneda, Satoru Saito, Shinichi Aishima, Hidenori Toyoda, Hideki Hayashi, Yoshio Sumida, Richard L. Ehman, Atsushi Nakajima
Summary: This study found that the heterogeneity of liver stiffness can impact the concordance between MRE-based fibrosis staging and biopsy staging in NAFLD patients. Inconsistent results are often associated with heterogeneous stiffness measurements.
Article
Gastroenterology & Hepatology
Akihisa Nakamura, Koji Yamamoto, Rei Takeda, Ren Yamada, Akinori Kubo, Kenichi Morikawa, Sayaka Ando, Tomoe Shimazaki, Takaaki Izumi, Machiko Umemura, Takashi Kitagataya, Taku Shigesawa, Kazuharu Suzuki, Megumi Kimura, Masato Nakai, Takuya Sho, Goki Suda, Mitsuteru Natsuizaka, Koji Ogawa, Shunsuke Ohnishi, Toshiro Sugiyama, Hiroshi Takeda, Naoya Sakamoto
Summary: This study evaluated the value of soluble CD14 (sCD14) as a diagnostic marker for distinguishing NASH from NAFLD, and found that sCD14 has high accuracy in differentiating between the two conditions. The results indicate that sCD14 could be a useful tool for identifying and screening high-risk groups for NASH development, as well as supporting early therapeutic interventions.
HEPATOLOGY RESEARCH
(2022)
Article
Medicine, General & Internal
Sun Young Kim, Subin Mun, Jung Hwan Yu, Young-Joo Jin, Young Ju Suh, Sang-Heon Cho, Jin-Woo Lee
Summary: This study suggests that small dense low density lipoprotein (sdLDL) may serve as a noninvasive biomarker for diagnosing and evaluating the degree of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).
Article
Gastroenterology & Hepatology
Marica Meroni, Miriam Longo, Rosa Lombardi, Erika Paolini, Chiara Macchi, Alberto Corsini, Cesare R. Sirtori, Anna Ludovica Fracanzani, Massimiliano Ruscica, Paola Dongiovanni
Summary: Elevated Lp(a) levels in patients with NAFLD are modestly associated with circulating lipids, carotid plaques, and hypertension, while low serum Lp(a) levels are associated with insulin resistance, transaminase elevation, and increased risk of severe fibrosis and cirrhosis. Combining Lp(a) with transaminases may provide a novel noninvasive biomarker for predicting advanced fibrosis in NAFLD patients. Additionally, genetic variants known to modulate circulating lipids may influence serum Lp(a) levels.
HEPATOLOGY COMMUNICATIONS
(2022)
Editorial Material
Gastroenterology & Hepatology
Manal F. Abdelmalek
Summary: In 2020, there were significant advances in nonalcoholic fatty liver disease, including new insights into pathophysiology, advancements in non-invasive diagnostics, and the publication of interim results from the first phase III trial showing improvement in hepatic fibrosis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tobias Puengel, Hanyang Liu, Adrien Guillot, Felix Heymann, Frank Tacke, Moritz Peiseler
Summary: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are chronic liver diseases that can lead to end-stage liver disease and hepatocellular carcinoma (HCC) worldwide. The metabolic syndrome is closely linked to NAFLD, and comorbidities such as type 2 diabetes, obesity, and insulin resistance worsen liver disease, while NAFLD increases cardiovascular risk in affected patients. Therapeutic strategies targeting multiple drug targets or drugs with multiple mechanisms of actions are needed for effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ke-qian Chen, Bo-yi Ke, Lu Cheng, Xiao-qing Yu, Zong-bao Wang, Shu-zhi Wang
Summary: With the development of the social economy, unhealthy living habits and eating styles are gradually affecting people's health in recent years. NAFLD, as a chronic liver disease, has become an increasingly serious public health problem due to these factors. Inflammasomes, as a protein complex, play a crucial role in the development of NAFLD and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Elias Badal Rashu, Mikkel Parsberg Werge, Liv Eline Hetland, Anders Ellekaer Junker, Majken Karoline Jensen, Lise Lotte Gluud
Summary: The study evaluated the referral pattern of patients with NAFLD and found that most patients were referred from general practitioners or other hospital departments, with referral letters containing information suggesting a possible diagnosis of NAFLD. Out of 110 patients who underwent liver biopsy, 22% were diagnosed with NASH with significant fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Maggie A. Stanislawski, Leslie A. Lange, Laura M. Raffield, Neil A. Zakai, Mariah Meyer, Kendra Ferrier, Mindy D. Szeto, Colton Leavitt, Jonathan A. Shortt, Timothy A. Thornton, Russell P. Tracy, Paul L. Auer, Alex P. Reiner, Ethan M. Lange, Nels C. Olson
Summary: This study identified a significant association between sCD14 levels and cardiovascular disease outcomes and mortality in a cohort of Black participants from the JHS. Adjusting for cardiovascular disease risk factors and C-reactive protein, higher sCD14 levels were significantly associated with increased risk of mortality, incident coronary heart disease, and incident heart failure. The study also found genetic associations with sCD14, highlighting the importance of genetic factors in these relationships.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Dongli Han, Jie Chen, Shousheng Liu, Zengzhi Zhang, Zhenzhen Zhao, Wenwen Jin, Yongning Xin
Summary: This study comprehensively investigated serum resistin levels in adult patients with NAFLD. The findings suggest that patients with NAFLD have higher serum resistin levels, while patients with NASH have lower serum resistin levels compared to healthy controls. Serum resistin could potentially serve as a biomarker for predicting the risk of developing NAFLD.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Salvatore Petta, Giada Sebastiani, Mauro Vigano, Javier Ampuero, Vincent Wai-Sun Wong, Jerome Boursier, Annalisa Berzigotti, Elisabetta Bugianesi, Anna Ludovica Fracanzani, Calogero Camma, Marco Enea, Marraud des Grottes, Vito Di Marco, Ramy Younes, Aline Keyrouz, Sergio Mazzola, Yuly Mendoza, Grazia Pennisi, Manuel Romero-Gomez, Antonio Craxi, Victor de Ledinghen
Summary: The study found that in patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements and their changes can be used to identify patients at risk for liver-related events and mortality.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Summary: The study showed that autophagy was enhanced in white adipose tissues of mice fed a high-fat diet, and inhibition of autophagy in adipose tissues can ameliorate the liver pathology of NAFLD through adipose-liver crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoshio Sumida, Masashi Yoneda, Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii, Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuichiro Eguchi, Masafumi Ono, Yuichi Nozaki, Hideyuki Hyogo, Masahiro Koseki, Yuichi Yoshida, Takumi Kawaguchi, Yoshihiro Kamada, Takeshi Okanoue, Atsushi Nakajima
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Yasushi Honda, Masato Yoneda, Kento Imajo, Atsushi Nakajima
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Takaomi Kessoku, Takashi Kobayashi, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Michihiro Iwaki, Anna Ozaki, Yuki Kasai, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima
Summary: Recent studies have shown a relationship between gut bacteria and NAFLD. Endotoxins produced by Gram-negative bacilli may play a role in the pathogenesis of NAFLD. Treatment strategies can target both intestinal and hepatic factors in NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Education & Educational Research
Takaomi Kessoku, Yu Uneno, Yuka Urushibara-Miyachi, Kiyofumi Oya, Akihiko Kusakabe, Atsushi Nakajima, Noritoshi Kobayashi, Yasushi Ichikawa, Mitsunori Miyashita, Manabu Muto, Masanori Mori, Tatsuya Morita
Summary: This study aimed to develop a list of competencies and EPAs necessary for death pronouncement practice. Through anonymous modified Delphi study and non-anonymous web conference, a consensus was reached on a list that includes 11 competencies and 9 EPAs.
BMC MEDICAL EDUCATION
(2022)
Article
Gastroenterology & Hepatology
Yuki Kasai, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Michihiro Iwaki, Anna Ozaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Noritoshi Kobayashi, Yoshio Sumida, Akira Honda, Shunsuke Oyamada, Satoru Shinoda, Satoru Saito, Atsushi Nakajima
Summary: The study found that the concentrations of fecal and serum BAs were significantly higher in patients with NAFLD as fibrosis worsened, indicating the involvement of abnormal BA metabolism in the progression of fibrosis in NAFLD. Abnormalities in BA metabolism may be a potential therapeutic target in NAFLD with fibrosis.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Oncology
Anna Ozaki, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuma Takeda, Yuki Kasai, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Takayuki Kato, Akihiro Suzuki, Yasushi Honda, Yuji Ogawa, Akiko Fuyuki, Kento Imajo, Takuma Higurashi, Masato Yoneda, Masataka Taguri, Hiroto Ishiki, Noritoshi Kobayashi, Satoru Saito, Yasushi Ichikawa, Atsushi Nakajima
Summary: Opioids are commonly used in cancer pain management, but can cause constipation as a side effect. Traditional laxatives may not be effective in preventing opioid-induced constipation. However, a new drug called naldemedine has been found to safely and effectively treat this constipation without affecting pain relief. This study compared the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation, and found that naldemedine significantly prevented deterioration in constipation-specific quality of life and reduced gastrointestinal adverse effects compared to magnesium oxide.
Article
Medicine, General & Internal
Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with metabolic abnormalities. Currently, there is no consensus on the efficacy and safety of drugs used to treat NAFLD. Guanabenz acetate is a potential treatment for improving NAFLD and metabolic abnormalities. This study aims to evaluate the efficacy and safety of guanabenz acetate treatment in NAFLD patients.
Review
Nutrition & Dietetics
Takashi Kobayashi, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Satoru Saito, Atsushi Nakajima, Masato Yoneda
Summary: The increasing prevalence of NAFLD and NASH, along with changes in global lifestyle, necessitates further research to understand the mechanisms and develop new treatment strategies. Furthermore, the association between periodontal disease and systemic conditions suggests the need for exploration in this area. This review provides a summary of recent studies on the link between periodontal disease and NAFLD, the concept of the mouth-gut-liver axis, oral and intestinal microbiota, and liver disease, as well as proposing new directions for research and treatment.
Article
Health Care Sciences & Services
Akiko Abe, Koji Amano, Tatsuya Morita, Tomofumi Miura, Naoharu Mori, Ryohei Tatara, Takaomi Kessoku, Yoshinobu Matsuda, Keita Tagami, Hiroyuki Otani, Masanori Mori, Tomohiko Taniyama, Nobuhisa Nakajima, Erika Nakanishi, Jun Kako, Daisuke Kiuchi, Hiroto Ishiki, Hiromichi Matsuoka, Eriko Satomi, Mitsunori Miyashita
Summary: Beliefs and perceptions of parenteral nutrition and hydration (PNH) among advanced cancer patients have not been clarified. However, more than half of the patients believe that PNH is beneficial and a standard medical practice, but many patients feel that they have not received sufficient explanation.
PALLIATIVE MEDICINE REPORTS
(2022)
Article
Medicine, Research & Experimental
Atsushi Yamamoto, Takaomi Kessoku, Kosuke Tanaka, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Kanji Ohkuma, Akiko Fuyuki, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Tomoyuki Iwasaki, Takeo Kurihashi, Machiko Nakatogawa, Ayao Suzuki, Masataka Taguri, Shunsuke Oyamada, Keisuke Ariyoshi, Noritoshi Kobayashi, Yasushi Ichikawa, Atsushi Nakajima
Summary: This study aims to investigate the improvement of loss of defecation desire in patients with chronic constipation after 4 weeks of Elobixibat treatment.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Article
Health Care Sciences & Services
Yusuke Hiratsuka, Mitsunori Miyashita, Yu Uneno, Kiyohumi Oya, Soichiro Okamoto, Takaomi Kessoku, Hironori Mawatari, Shunsuke Oyamada, Junko Nozato, Keita Tagami, Akira Inoue
Summary: This study developed a scale, DPBS-oncol, to evaluate the burden experienced by clinicians related to death pronouncement. The scale was validated and shown to have sufficient reliability. Furthermore, the total score of DPBS-oncol was moderately correlated with other scales measuring clinicians' attitudes towards end-of-life care.
PALLIATIVE MEDICINE REPORTS
(2022)
Review
Medicine, General & Internal
Wataru Tomeno, Kento Imajo, Takuya Takayanagi, Yu Ebisawa, Kosuke Seita, Tsuneyuki Takimoto, Kanami Honda, Takashi Kobayashi, Asako Nogami, Takayuki Kato, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Hiroyuki Kirikoshi, Yasunari Sakamoto, Masato Yoneda, Satoru Saito, Atsushi Nakajima
Article
Gastroenterology & Hepatology
Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima, Yuichiro Eguchi