A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration

(2011) Michal Kramer et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel findings in age-related macular degeneration and Alzheimer’s disease

(2011) Kyoko Ohno-Matsui   PROGRESS IN RETINAL AND EYE RESEARCH

A Hapten Generated from an Oxidation Fragment of Docosahexaenoic Acid Is Sufficient to Initiate Age-Related Macular Degeneration

(2010) Joe G. Hollyfield et al.   MOLECULAR NEUROBIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Mass spectrometry provides accurate and sensitive quantitation of A2E

(2010) Danielle B. Gutierrez et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

THE PHOTOCHEMISTRY OF HUMAN RETINAL LIPOFUSCIN AS STUDIED BY EPR

(2010) Krzysztof Reszka et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Amyloid-β(1-42) alters structure and function of retinal pigmented epithelial cells

(2009) Julien Bruban et al.   AGING CELL

Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration

(2009) Liang Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration

(2009) Jiaqian Ni et al.   MOLECULAR & CELLULAR PROTEOMICS

A2E, a Pigment of the Lipofuscin of Retinal Pigment Epithelial Cells, Is an Endogenous Ligand for Retinoic Acid Receptor

(2008) Aya Iriyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

(2008) K. Kaarniranta et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Age-related macular degeneration

(2008) Hanna R Coleman et al.   LANCET

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

(2008) Thuzar M Shin et al.   Molecular Neurodegeneration

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

CFH and LOC387715/ARMS2 Genotypes and Treatment with Antioxidants and Zinc for Age-Related Macular Degeneration

(2008) Michael L. Klein et al.   OPHTHALMOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE