Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinha
Summary: Cerebellar dysfunction, which is related to impaired motor coordination and balance, may be influenced by neuroinflammation and aging. This study showed that chronic neuroinflammation in aged mice led to mitochondrial dynamic alteration in the cerebellum, with changes in fusion and fission-related genes. The findings suggest that the interaction between mitochondrial dynamics and activated microglia under chronic neuroinflammatory conditions is crucial for understanding the molecular mechanism of the cerebellum.
NEUROSCIENCE LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Edmundas Kadusevicius
Summary: Inflammation plays a key role in various degenerative diseases, leading to increased research interest in the potential use of NSAIDs. Understanding the complex molecular and cellular factors involved in the pathogenesis of these diseases is crucial for further exploration of NSAID applications. The diverse pharmacokinetics and pharmacodynamics of NSAIDs highlight the need for precise pharmacotherapy models to explore new potential indications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lorrane Kelle da Silva Moreira, Larissa Cordova Turones, Hericles Mesquita Campos, Aline Martins Nazareth, Douglas Vieira Thomaz, Eric de Souza Gil, Paulo Cesar Ghedini, Fabio Fagundes da Rocha, Ricardo Menegatti, James Oluwagbamigbe Fajemiroye, Elson Alves Costa
Summary: LQFM212 has antioxidant activity and ameliorates behavioral, inflammatory, and oxidative changes in LPS-induced neuroinflammation model. However, it does not attenuate inflammatory changes in LPS-induced pleurisy model.
Article
Biochemistry & Molecular Biology
Xinjian Zhu, Yuanyuan Yao, Jiurong Yang, Canyu Zhang, Xinyan Li, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan
Summary: ADAM10, a metalloproteinase, plays a crucial role in preventing neurotoxic amyloid beta deposition and demyelination by generating sAPP(alpha). Overexpression of ADAM10 suppresses demyelination, neuroinflammation, and oxidative stress in cuprizone-induced demyelination model, while pharmacological inhibition of ADAM10 activity abrogates its protective effect. Moreover, ADAM10-derived sAPP(alpha) reduces seizure susceptibility by ameliorating neuroinflammation and oxidative stress in demyelination model.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alessia Filippone, Deborah Mannino, Laura Cucinotta, Irene Paterniti, Emanuela Esposito, Michela Campolo
Summary: This study aimed to investigate the role of PF06447475 as a pharmacological LRRK2 antagonist in counteracting the pathological consequences of spinal cord trauma. By using an in vivo model of SCI induced by extradural compression, it was found that treatment with PF-475 significantly reduced spinal cord tissue injury, glycogen accumulation, and demyelination of neurons associated with trauma. Additionally, LRRK2 antagonist treatment decreased oxidative stress and cytokine expression levels, suggesting that targeting LRRK2 activity could have direct effects on intervening in neuroinflammatory disorders.
Article
Immunology
Jing Nie, Yuan Fang, Ying Chen, Aisikeer Aidina, Qi Qiu, Lu Zhao, Xiang Liu, Lin Sun, Yun Li, Chuwen Zhong, Yuan Li, Xia Li
Summary: This study investigated the differences and similarities of peripheral inflammatory parameters in late-life depression (LLD) and amnestic mild cognitive impairment (aMCI). The results showed increased IL-6 levels in the plasma of LLD patients and decreased levels of chemokines (CXCL11 and CCL13), which were associated with abnormal cognitive function and depression scores. A novel model based on proinflammatory cytokines and brief screening tests showed fair accuracy in discriminating between LLD and aMCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Monika Jankowska-Kieltyka, Adam Roman, Irena Nalepa
Summary: Air pollution, particularly particulate matter, is closely associated with cardiopulmonary disorders and neurodegenerative diseases. Studies have shown a noticeable link between exposure to PM and neurotoxicity, with potential mechanisms including oxidative stress, inflammation, and neuronal death in both the peripheral and central nervous systems. Further research is needed to fully understand the impact of air pollutants on neurodegeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Yan Wang, David Pleasure, Wenbin Deng, Fuzheng Guo
Summary: PARP1 plays a critical role in DNA repair and gene expression, and its dysregulation is associated with immune activation and disease severity. Studies have shown that PARP1 dysfunction is present in the immune and central nervous system of MS patients and animal models, and its function is complex and context-dependent.
Article
Biochemistry & Molecular Biology
Moises Rubio-Osornio, Carmen T. Gomez-De Leon, Sergio Montes, Carmen Rubio, Camilo Rios, Antonio Monroy, Jorge Morales-Montor
Summary: Parkinson's disease is characterized by oxidative stress and immune activation. Simvastatin, a cholesterol-regulating drug, can protect against atherosclerosis disease. Pretreatment with simvastatin reduced MPP+-induced damage in rats and decreased inflammation response proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen
Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Grace Samtani, Sunja Kim, Danielle Michaud, Andrew E. Hillhouse, Joseph A. Szule, Kranti Konganti, Jianrong Li
Summary: Multiple sclerosis (MS) is a common demyelinating disease in the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions. The mechanisms of myelin repair, especially after chronic demyelination, remain poorly understood.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Immunology
Giuseppina Tesco, Selene Lomoio
Summary: Neurodegenerative diseases are characterized by the loss of specific neuronal populations and are associated with aging. Axonal transport and neuroinflammation play important roles in the pathogenesis of these diseases. However, the causal relationship between these mechanisms and neuronal degeneration is still uncertain. This article reviews the latest evidence on the interplay between axonal transport perturbations and CNS inflammation in neurodegenerative diseases, their potential as therapeutic targets, and the need for early biomarkers.
SEMINARS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Prashant Sharma, Abhinoy Kishore, Indranil De, Swarnima Negi, Gulshan Kumar, Sahil Bhardwaj, Manish Singh
Summary: Parkinson's disease is a prevalent neuroinflammatory illness characterized by progressive loss of neurons in the brain. Proinflammatory cytokines play a crucial role in initiating and perpetuating neuroinflammation, which can lead to permanent brain damage. Phytochemicals derived from plants offer a potential and natural alternative for managing neuroinflammation in Parkinson's disease and other neurodegenerative diseases by reducing free radicals and proinflammatory cytokines levels in the brain.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Eneritz Lopez-Muguruza, Carlos Matute
Summary: Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and neurodegeneration. Metabolic changes, including mitochondrial dysfunction and alterations in glucose and lipid metabolism, contribute significantly to the pathogenesis of MS. Understanding these mechanisms is crucial for developing targeted therapies to preserve myelin and promote neurological recovery in individuals with MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elena Coccia, Laura Planells-Ferrer, Raquel Badillos-Rodriguez, Marta Pascual, Miguel F. Segura, Rita Fernandez-Hernandez, Joaquin Lopez-Soriano, Eloi Gari, Eduardo Soriano, Bruna Barneda-Zahonero, Rana S. Moubarak, M. Jose Perez-Garcia, Joan X. Comella
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Paloma Gomez-Fernandez, Aitzkoa Lopez de Lapuente Portilla, Ianire Astobiza, Jorge Mena, Andoni Urtasun, Vivian Altmann, Fuencisla Matesanz, David Otaegui, Elena Urcelay, Alfredo Antiguedad, Sunny Malhotra, Xavier Montalban, Tamara Castillo-Trivino, Laura Espino-Paisan, Orhan Aktas, Mathias Buttmann, Andrew Chan, Bertrand Fontaine, Pierre-Antoine Gourraud, Michael Hecker, Sabine Hoffjan, Christian Kubisch, Tania Kuempfel, Felix Luessi, Uwe K. Zettl, Frauke Zipp, Iraide Alloza, Manuel Comabella, Christina M. Lill, Koen Vandenbroeck
Article
Biotechnology & Applied Microbiology
Javier Caballero, Nerea Jimenez-Moreno, Irene Orera, Trevor Williams, Ana B. Fernandez, Maite Villanueva, Juan Ferre, Primitivo Caballero, Carmen Ancin-Azpilicueta
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Food Science & Technology
Daniel Valtierra-de-Luis, Maite Villanueva, Liliana Lai, Trevor Williams, Primitivo Caballero
Article
Biochemistry & Molecular Biology
Shifa Jebari-Benslaiman, Kepa B. Uribe, Asier Benito-Vicente, Unai Galicia-Garcia, Asier Larrea-Sebal, Iraide Alloza, Koen Vandenbroeck, Helena Ostolaza, Cesar Martin
Editorial Material
Clinical Neurology
Oihana Errea, Maria Cruz Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Article
Cell Biology
Elena Coccia, Marc Masanas, Joaquin Lopez-Soriano, Miguel F. Segura, Joan X. Comella, M. Jose Perez-Garcia
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Matthew Bennett, Igor Ulitsky, Iraide Alloza, Koen Vandenbroeck, Vladislav Miscianinov, Amira Dia Mahmoud, Margaret Ballantyne, Julie Rodor, Andrew H. Baker
Summary: This study improved the representation of lncRNAs in pathological states of VSMCs by analyzing non-reference transcripts, discovering that non-reference lncRNAs contributed 21-32% in responding to pro-mitogenic stimuli and showed particular relevance to VSMC processes and regulation of neighboring protein-coding genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alba Sansa, Sandra de la Fuente, Joan X. Comella, Ana Garcera, Rosa M. Soler
Summary: Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1), leading to degeneration of spinal cord motoneurons and progressive muscular atrophy. The activation of apoptosis in SMA MNs and reduction of Akt phosphorylation may play a crucial role in regulating cell degeneration. Our observations suggest potential mechanisms for controlling cell loss in SMA.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Infectious Diseases
Maite Villanueva, Melanie Roch, Inigo Lasa, Adriana Renzoni, William L. Kelley
Summary: This study revealed that S. aureus utilizes specific two-component environmental signal systems, ArlRS and VraSR, for defense against ceftaroline. Dual disruption of both systems resulted in a strong ceftaroline hypersensitivity phenotype, showing the potential for enhancing antibiotic efficacy by inhibiting these systems.
Article
Biochemistry & Molecular Biology
Laurene Bastet, Pilar Bustos-Sanmamed, Arancha Catalan-Moreno, Carlos J. Caballero, Sergio Cuesta, Leticia Matilla-Cuenca, Maite Villanueva, Jaione Valle, Inigo Lasa, Alejandro Toledo-Arana
Summary: This study reveals that a bacterial antisense RNA (lexA-asRNA) in Staphylococcus aureus is generated through a transcriptional read-through event. The read-through occurs on the intrinsic terminator of the sbrB gene, which is located downstream of the lexA gene. A natural mutation destabilizes the terminator structure and affects its efficiency, leading to the production of the antisense RNA. The expression of lexA-asRNA is linked to cellular stress and regulated by the stress transcription factor SigB. Comparative analysis also suggests strain-specific nucleotide polymorphisms within the terminator sequence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Anna Sires, Mireia Turch-Anguera, Patricia Bogdanov, Joel Sampedro, Hugo Ramos, Agustin Ruiz Lasa, Jianxin Huo, Shengli Xu, Kong-Peng Lam, Joaquin Lopez-Soriano, M. Jose Perez-Garcia, Cristina Hernandez, Rafael Simo, Montse Sole, Joan X. Comella
Summary: FAIM is crucial for maintaining retinal homeostasis, as its depletion in mice leads to persistent retinal damage and late-onset photoreceptor death in older mice. This suggests that FAIM may serve as an early marker for late photoreceptor and neuronal degeneration.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Cell Biology
Elena Coccia, Montse Sole, Joan X. Comella
Summary: Apoptosis is crucial for correct development of the nervous system. In adulthood, the same protein machinery can control neuronal adaptiveness through modulation of synaptic pruning and plasticity processes, with caspases playing a key role in these pathways. Regulators like FAIM-L and SIVA-1 modulate non-apoptotic caspase activity in neurons, influencing functions like long-term depression and neurite pruning. Additionally, the non-apoptotic functions of FAIM-L are associated with neurodegeneration processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Anna Sires, Mateo Pazo-Gonzalez, Joaquin Lopez-Soriano, Ana Mendez, Enrique J. J. de la Rosa, Pedro de la Villa, Joan X. X. Comella, Catalina Hernandez-Sanchez, Montse Sole
Summary: The short and long isoforms of FAIM play important roles in the central nervous system and are highly expressed in the retina. Knockout of Faim gene in mice leads to functional loss of rod photoreceptor and ganglion cells, as well as a delay in dark adaptation. Abnormal redistribution of Arrestin-1 and its ubiquitination may contribute to the impairments observed in Faim knockout mice.
Article
Endocrinology & Metabolism
Karis Little, Aditi Singh, Angel Del Marco, Maria Llorian-Salvador, Maria Vargas-Soria, Mireia Turch-Anguera, Montse Sole, Noelle Bakker, Sarah Scullion, Joan X. Comella, Ingeborg Klaassen, Rafael Simo, Monica Garcia-Alloza, Vijay K. Tiwari, Alan W. Stitt
Summary: Type 2 diabetes affects the cellular and molecular architecture of the cerebral cortex, leading to dysfunctions in the neurovascular unit and cognitive decline. This study identifies gene expression changes and cell population alterations in the cerebral cortex of diabetic mice and individuals with type 2 diabetes, providing insights into the pathogenesis of cognitive decline in diabetes.