Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Medicine, Research & Experimental
Jefferson Icaro Soares, Thais Marques da Silva, Jaci Airton Castania, Ulisses Avila Reis, Luiz Felipe Moreira Roque, Adriana Barbosa Ribeiro, Helio Cesar Salgado, Aline Barbosa Ribeiro
Summary: Electrical stimulation of the carotid sinus nerve (CSN) attenuates experimental colitis in rats by reducing inflammation and improving tissue damage.
Article
Neurosciences
Daiana C. Salm, Veronica V. Horewicz, Fernanda Tanaka, Julia K. Ferreira, Bruna H. de Oliveira, Julia Maria Batista Maio, Nathalia N. Donatello, Daniela D. Ludtke, Leidiane Mazzardo-Martins, Aline R. Dutra, Josiel M. Mack, Deborah de C. H. Kunzler, Eduardo Cargnin-Ferreira, Afonso S. I. Salgado, Edsel B. Bittencourt, Gianluca Bianco, Anna Paula Piovezan, Franciane Bobinski, Ari O. O. More, Daniel F. Martins
Summary: This study evaluated the effects of percutaneous vagus nerve electrical stimulation (pVNS) on persistent inflammatory hyperalgesia. Different protocols of time, ear laterality, and frequency were tested on mice. The results showed that pVNS with random frequency in the left ear for 10 minutes had a longer lasting antihyperalgesic effect compared to classical stimulation with alternating frequency. The involvement of the FPR2/ALX receptor was observed in this effect. The study concluded that pVNS with random frequency may be an important adjunctive treatment for persistent inflammatory pain.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Behavioral Sciences
Yue Wang, Gaofeng Zhan, Ziwen Cai, Bo Jiao, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Omer Sharon, Firas Fahoum, Yuval Nir
Summary: In this study, the short-term effects of transcutaneous vagus nerve stimulation (tVNS) in healthy male volunteers were investigated. The results showed that tVNS led to robust pupil dilation and greater attenuation of occipital alpha oscillations compared to sham stimulation, indicating that tVNS can induce arousal markers beyond somatosensory stimulation and mimic the effects of invasive VNS.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Liwei Hou, Peijing Rong, Yang Yang, Jiliang Fang, Junying Wang, Yu Wang, Jinling Zhang, Shuai Zhang, Zixuan Zhang, Jiande D. Z. Chen, Wei Wei
Summary: Transcutaneous auricular vagus nerve stimulation improves gastric motility and hypersensitivity in a rat model of functional dyspepsia through anti-inflammatory mechanisms via the vago-vagal pathways. These findings contribute to the optimization of auricular vagus nerve stimulation methodology and promote it as a non-pharmacological alternative therapy for functional dyspepsia.
Article
Biology
Fernanda Ishida Correa, Paulo Henrique Leite Souza, Laura Uehara, Raphael Mendes Ritti-Dias, Gustavo Oliveira da Silva, Wellington Segheto, Kevin Pacheco-Barrios, Felipe Fregni, Joao Carlos Ferrari Correa
Summary: The study evaluated the effects of transcranial auricular vagus nerve stimulation (taVNS) on inflammation, cardiac autonomic modulation, and clinical symptoms in individuals affected by COVID-19. The results showed that taVNS significantly reduced CRP and IL-6 levels, and led to a significant decrease in depression levels. However, it did not have an impact on other clinical symptoms.
Review
Neurosciences
Erin Trifilio, Destin Shortell, Sarah Olshan, Alexandria O'Neal, Jozee Coyne, Damon Lamb, Eric Porges, John Williamson
Summary: Evidence has been accumulating over the past 15 years on the clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS). This novel non-invasive brain stimulation technique has been applied to various neuropsychiatric disorders and more recently, in healthy aging populations. This review discusses the possible mechanisms, considerations for older adults, and the use of non-invasive VNS in conjunction with existing behavioral interventions to promote healthy aging.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yufan Yang, Longlong Xie, Yinghui Peng, Haipeng Yan, Jiaotian Huang, Zhenghui Xiao, Xiulan Lu
Summary: We identified multiple cell populations that contribute to myocardial injury in sepsis under low-level tragus stimulation, illustrating the comprehensive cardiac cellular landscape. Low-level vagal nerve stimulation improves sepsis-induced myocardial dysfunction by promoting cardiac monocytes to M2 macrophages.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Review
Rheumatology
Alice Courties, Francis Berenbaum, Jeremie Sellam
Summary: Vagus nerve stimulation (VNS) has shown promising effects in treating refractory epilepsy and various musculoskeletal diseases, particularly in dampening inflammatory responses in rheumatoid arthritis patients. Further studies and randomized controlled trials are needed to fully evaluate its efficacy.
Article
Biochemical Research Methods
Ozan Yetis, Ozge Guner, Ibrahim Akkaya, Ensari Guneli, Alper Bagriyanik, Serhat Tozburun
Summary: The study demonstrated the reliable and reproducible nerve stimulation effect of laser nerve stimulation on the rat vagus nerve bundle. Results showed that a temperature above 42 degrees Celsius resulted in acute nerve damage, and there was a strong correlation between laser stimulation time and mean arterial pressure response. The method's advantages, such as non-contact delivery of external stimulus signals and enhanced spatial selectivity, suggest its potential to counteract the side effects of traditional electrical vagus nerve stimulation.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Neurosciences
Matthew J. McGinley, Steven T. Lee
Summary: This article investigates the mechanistic aspects of vagus nerve stimulation (VNS) in clinical applications and finds that VNS timed with positive reinforcement improves motor learning and cortical function through a cholinergic mechanism.
Article
Immunology
Linlin Zhang, Sangsu Bang, Qianru He, Megumi Matsuda, Xin Luo, Yong-Hui Jiang, Ru-Rong Ji
Summary: Excessive inflammation is linked to autism spectrum disorder (ASD), and mutations of the synaptic scaffolding protein SHANK3 are involved in ASD. In this study, it was found that Shank3 deficiency aggravates hypothermia, systemic inflammation, and sepsis mortality induced by lipopolysaccharide (LPS) in mice. Shank3 regulates body temperature, inflammation, and sepsis in vagal sensory neurons.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Kazuma Yamakawa, Goro Tajima, Joshua W. Keegan, Yasutaka Nakahori, Fei Guo, Anupamaa J. Seshadri, Laura A. Cahill, James A. Lederer
Summary: CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, similar to memory T cells. The study found that injury activates a memory-like Treg subpopulation, and that Treg activation by injury is partially dependent on TCR signaling by an MHC class II dependent mechanism. This suggests a complex regulatory role for Tregs in response to trauma.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Letter
Critical Care Medicine
Hidehiko Nakano, Hideki Hashimoto, Masaki Mochizuki, Hiromu Naraba, Yuji Takahashi, Tomohiro Sonoo, Tsunehiro Matsubara, Kazuma Yamakawa, Kensuke Nakamura
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Satoshi Fukui, Koki Higashio, Shuhei Murao, Akira Endo, Takasu Akira, Kazuma Yamakawa
Summary: This study aims to assess the certainty of evidence in determining the optimal target of MAP control for patients with vasodilatory shock in critically ill settings through a systematic review and meta-analysis of randomized controlled trials.
Article
Emergency Medicine
Ryo Yamamoto, Seitaro Fujishima, Junichi Sasaki, Satoshi Gando, Daizoh Saitoh, Atsushi Shiraishi, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Toshihiko Mayumi, Joji Kotani, Taka-aki Nakada, Yasukazu Shiino, Takehiko Tarui, Kohji Okamoto, Yuichiro Sakamoto, Shin-Ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Toru Hifumi, Kazuma Yamakawa, Akiyoshi Hagiwara, Yasuhiro Otomo
Summary: This study found that hyperoxemia during resuscitation of trauma patients was associated with prolonged ICU stay, especially among patients not intubated at the ED, with correlations to inflammatory markers and lung-protective proteins.
WORLD JOURNAL OF EMERGENCY SURGERY
(2021)
Article
Medicine, General & Internal
Shuhei Murao, Kazuma Yamakawa, Daijiro Kabata, Takahiro Kinoshita, Yutaka Umemura, Ayumi Shintani, Satoshi Fujimi
Summary: This study investigated the effects of earlier door-to-computed tomography time and door-to-bleeding control time on clinical outcomes in severe blunt trauma, finding that earlier hemostatic procedures were associated with decreased mortality, while earlier CT examinations were linked to reduced mortality from exsanguination.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kensuke Nakamura, Hidehiko Nakano, Hiromu Naraba, Masaki Mochizuki, Yuji Takahashi, Tomohiro Sonoo, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa, Kazuma Yamakawa
Summary: This study examined the effects of vasopressin loading followed by continuous administration in septic shock patients and found that loading may predict responses to continuous administration. However, further investigation involving safety analysis is needed.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Kensuke Nakamura, Junji Hatakeyama, Keibun Liu, Naoki Kanda, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Shigeaki Inoue, Satoru Hashimoto, Shuhei Maruyama, Daisuke Kawakami, Yoshitaka Ogata, Katsura Hayakawa, Hiroaki Shimizu, Taku Oshima, Tatsuya Fuchigami, Osamu Nishida
Summary: This study examined the association between nutrition delivery in the late stage of the acute phase and in-hospital mortality in patients with COVID-19 on mechanical ventilation for 7 days or longer. The results found that average energy and protein deliveries on days 4-7 were associated with decreased in-hospital mortality.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Health Care Sciences & Services
Yutaka Umemura, Kazuma Yamakawa, Shuhei Murao, Yumi Mitsuyama, Hiroshi Ogura, Satoshi Fujimi
Summary: This study evaluated the prognostic value of different SOFA subscores on mortality in sepsis patients. The total modified SOFA score showed a linear association with increased mortality, while subscores had varied prognostic associations. Interaction effects between subscores were found to enhance prognostic accuracy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Critical Care Medicine
Yumi Mitsuyama, Kazuma Yamakawa, Katsuhide Kayano, Miho Maruyama, Takeshi Wada, Satoshi Fujimi
Summary: Peripheral blood immune responses of lymphocytes in severe COVID-19 patients in different stages of recovery were evaluated using single-cell mass cytometry. Patients with prolonged hospitalization did not show recovery of B lymphocyte and CD4-positive T lymphocyte counts, but did show abundant CD8-positive T lymphocytes. Post-recovery patients had more CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.
JOURNAL OF INTENSIVE CARE
(2021)
Article
Medicine, General & Internal
Jumpei Yoshimura, Kazuma Yamakawa, Yoshinori Ohta, Kensuke Nakamura, Hideki Hashimoto, Masahiro Kawada, Hiroki Takahashi, Takeshi Yamagiwa, Akira Kodate, Kyohei Miyamoto, Satoshi Fujimi, Takeshi Morimoto
Summary: The study compared Gram stain-guided antibiotic therapy with guideline-based therapy in VAP patients, showing noninferiority in clinical response and a significant reduction in broad-spectrum antibiotic use.
Editorial Material
Medicine, General & Internal
Kazuma Yamakawa
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Junji Hatakeyama, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shuhei Maruyama, Yoshitaka Ogata, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Aiko Tanaka, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida, Kensuke Nakamura
Summary: In COVID-19 patients requiring mechanical ventilation, nearly 60% experienced persistent PICS, with delirium and duration of mechanical ventilation identified as the main risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Django Kyo, Shiho Tokuoka, Shunsuke Katano, Ryo Hisamune, Hidero Yoshimoto, Shuhei Murao, Yutaka Umemura, Akira Takasu, Kazuma Yamakawa
Summary: This study investigated the impact of three nutritional indices, GNRI, PNI, and CONUT, on mortality in patients with sepsis in Japan. The results showed that a decrease in GNRI below 100 and PNI below 40 was associated with increased mortality risk. An increased CONUT score was also linearly associated with increased mortality.
Article
Medicine, General & Internal
Kazuma Yamakawa, Ryo Yamamoto, Takero Terayama, Hideki Hashimoto, Tadashi Ishihara, Go Ishimaru, Haruki Imura, Hiromu Okano, Chihiro Narita, Takuya Mayumi, Hideto Yasuda, Kohei Yamada, Hiroyuki Yamada, Tatsuya Kawasaki, Nobuaki Shime, Kent Doi, Moritoki Egi, Hiroshi Ogura, Morio Aihara, Shigeki Kushimoto, Osamu Nishida
Summary: The Japanese guidelines provide recommendations on drug management for COVID-19, including the use of various drugs such as favipiravir, remdesivir, corticosteroids, tocilizumab, anticoagulants, baricitinib, and casirivimab/imdevimab. It is hoped that these guidelines will assist healthcare professionals in the care of patients with COVID-19.
ACUTE MEDICINE & SURGERY
(2021)
Article
Medicine, General & Internal
Kazuma Yamakawa, Ryo Yamamoto, Go Ishimaru, Hideki Hashimoto, Takero Terayama, Yoshitaka Hara, Daisuke Hasegawa, Tadashi Ishihara, Haruki Imura, Hiromu Okano, Chihiro Narita, Takuya Mayumi, Hideto Yasuda, Kohei Yamada, Hiroyuki Yamada, Tatsuya Kawasaki, Nobuaki Shime, Kent Doi, Moritoki Egi, Hiroshi Ogura, Morio Aihara, Hiroshi Tanaka, Osamu Nishida
Summary: The Japanese rapid/living recommendations on drug management for COVID-19 were created based on the experience of creating the J-SSCGs, using the GRADE approach to determine evidence certainty and recommendation strength. Different drugs are recommended for different severity of COVID-19 patients, aiming to assist medical professionals in the care of COVID-19 patients.
ACUTE MEDICINE & SURGERY
(2021)