Article
Geriatrics & Gerontology
Nicole Comfort, Meethila Gade, Madeleine Strait, Samantha J. Merwin, Daphne Antoniou, Chiara Parodi, Lina Marcinczyk, Lea Jean-Francois, Tessa R. Bloomquist, Anna Memou, Hardy J. Rideout, Stefania Corti, Shingo Kariya, Diane B. Re
Summary: This study conducted a longitudinal transcriptomic analysis on aging mice, and found that the central nervous system may play a crucial role in skeletal muscle aging. These findings provide new insights into the mechanisms of muscle aging.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Cell Biology
N. F. Shur, L. Creedon, S. Skirrow, P. J. Atherton, I. A. MacDonald, J. Lund, P. L. Greenhaff
Summary: In the UK, it is projected that by 2035, people over the age of 65 will make up 23% of the population, with those over 85 accounting for 5%. Ageing is associated with changes in muscle metabolism and structure, but it is unclear how much of these changes are due to aging itself or sedentary behavior. Research on aging, physical activity, and muscle health is crucial for understanding the aging process and improving overall well-being.
AGEING RESEARCH REVIEWS
(2021)
Article
Multidisciplinary Sciences
Laura M. de Smalen, Anastasiya Borsch, Aurel B. Leuchtmann, Jonathan F. Gill, Danilo Ritz, Mihaela Zavolan, Christoph Handschin
Summary: Sarcopenia, the age-related loss of skeletal muscle mass and function, can significantly impact quality of life and mortality. This study found that mitochondrial proteostasis plays an important role in muscle aging and highlights the positive effects of exercise on mitochondrial protein synthesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Nutrition & Dietetics
Matthew D. Watson, Brett L. Cross, Gregory J. Grosicki
Summary: Globally, the population aged 65 and older is growing rapidly, facing issues such as changes in body composition, declines in cardiorespiratory fitness, and reductions in muscle size and function. Decreased muscle protein synthesis in response to anabolic stimuli plays a key role in the development of sarcopenia in aging individuals. Recent studies suggest a bidirectional gut-muscle axis affecting aging muscle health, with lifestyle habits potentially impacting changes in the microbiome.
Article
Cell Biology
James F. Markworth, Lemuel A. Brown, Eunice Lim, Jesus A. Castor-Macias, Jacqueline Larouche, Peter C. D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooks
Summary: Aging impairs the local biosynthesis of specialized pro-resolving mediators in muscle, leading to increased inflammation, inhibited myofiber regeneration, and delayed recovery of muscle function. Immunoresolvents may be promising therapeutics for muscular injuries and associated pain in the elderly, as they improve muscle function recovery without inhibiting tissue regeneration like non-steroidal anti-inflammatory drugs.
Article
Geriatrics & Gerontology
Luke Slade, Shelby E. Bollen, Joseph J. Bass, Bethan E. Phillips, Kenneth Smith, Daniel J. Wilkinson, Nathaniel J. Szewczyk, Philip J. Atherton, Timothy Etheridge
Summary: The study suggests that bisphosphonates can delay age-related muscle decline and improve neuromuscular function. This finding provides a realistic clinical option for bisphosphonates as an anti-sarcopenic therapy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Tamaki Kurosawa, Keitaro Minato, Madoka Ikemoto-Uezumi, Jun Hino, Kunihiro Tsuchida, Akiyoshi Uezumi
Summary: Transgenic expression of Bmp3b in mesenchymal progenitors alleviates age-related muscle deterioration, including maintaining muscle weight, myofiber cross-sectional areas, decreasing fibrosis, and preserving neuromuscular junctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Nafiseh Shokri-Mashhadi, Fatemeh Navab, Shakila Ansari, Mohammad Hossein Rouhani, Zahra Hajhashemy, Sahar Saraf-Bank
Summary: The prevalence of age-related diseases is increasing globally, emphasizing the need to recognize factors that improve muscle health. However, there is limited evidence on the effects of probiotic administration on sarcopenia. This meta-analysis examined the impact of probiotic supplementation on sarcopenia, based on 17 included studies. The findings suggest that probiotic supplementation has a beneficial effect on muscle mass, muscle function, and muscle strength after 12 weeks of supplementation.
FOOD SCIENCE & NUTRITION
(2023)
Article
Geriatrics & Gerontology
Marco Narici, Jamie McPhee, Maria Conte, Martino V. Franchi, Kyle Mitchell, Sara Tagliaferri, Elena Monti, Giuseppe Marcolin, Philip J. Atherton, Kenneth Smith, Bethan Phillips, Jonathan Lund, Claudio Franceschi, Marcello Maggio, Gillian S. Butler-Browne
Summary: The study introduced an ultrasound imaging method for diagnosing sarcopenia based on changes in muscle geometric proportions. The ultrasound sarcopenic index (USI) was proposed as a novel marker for the loss of muscle mass associated with sarcopenia, providing a useful 'signature of sarcopenia' and allowing for stratification of individuals according to muscle sarcopenia presence and severity. The USI was found to be a useful clinical tool for confirming the diagnosis of sarcopenia, with DXA-derived skeletal muscle index (SMI) showing significant correlation with USI.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Ying Wang, Steven S. Welc, Michelle Wehling-Henricks, Ying Kong, Connor Thomas, Enca Montecino-Rodriguez, Kenneth Dorshkind, James G. Tidball
Summary: Intramuscular macrophages play key roles in regulating skeletal muscle response to injury and disease. Changes in the numbers and phenotype of these macrophages during aging can influence the aging process. A study using a mouse model with a myeloid cell-specific mutation of Spi1 showed that this mutation reduced the numbers of M2 phenotype macrophages in aging muscles, and also reduced age-related muscle fibrosis and sarcopenia. These findings highlight the significance of intramuscular M2-biased macrophages in promoting detrimental, age-related changes in muscle.
Review
Biochemistry & Molecular Biology
Jason Tallis, Sharn Shelley, Hans Degens, Cameron Hill
Summary: Obesity and aging have negative impacts on skeletal muscle function, with their combined effects yet to be thoroughly explored. Poor muscle function is associated with chronic diseases, poor quality of life, and all-cause mortality, highlighting the importance of studying and intervening in these effects for overall health and physical function.
Article
Nutrition & Dietetics
Feng-Min Zhang, Chun-Hua Song, Zeng-Qing Guo, Zhen Yu, Min Weng, Fu-Xiang Zhou, Ming Liu, Ming-Hua Cong, Tao Li, Zeng-Ning Li, Jun-Qiang Chen, Jiu-Wei Cui, Hong-Xia Xu, Wei Li, Han-Ping Shi, Cheng-Le Zhuang
Summary: This study aimed to evaluate the distribution and influencing factors of sarcopenia and explore its relationship with cancer prognosis. The study found that the prevalence of sarcopenia in cancer patients was 33%, and age was the most important risk factor. Sarcopenia was strongly associated with reduced overall survival and poor quality of life.
Review
Geriatrics & Gerontology
Francesca M. Alves, Scott Ayton, Ashley Bush, Gordon S. Lynch, Rene Koopman
Summary: Sarcopenia is an age-related condition characterized by the progressive loss of muscle mass and strength, leading to frailty, increased risk of hospitalization and mortality, and increased healthcare costs. The review outlines the mechanisms of iron accumulation in muscle and evaluates the evidence for the role of iron overload in sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Brian C. Clark
Summary: This article discusses the neural mechanisms underlying age-related muscle weakness, and their relevance to the development of therapies for sarcopenia and mobility limitations in the elderly. It highlights the role of impaired neural activation in age-related weakness and explores the multifactorial nature of these mechanisms.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Mohini Gharpure, Jie Chen, Resheek Nerella, Sagar Vyavahare, Sandeep Kumar, Carlos M. Isales, Mark Hamrick, Satish Adusumilli, Sadanand Fulzele
Summary: Sarcopenia, a condition characterized by decreased muscle mass, altered muscle composition, and reduced muscle strength, disproportionately affects males and females with age. This study identified differentially regulated genes in aged skeletal muscle from males and females, with 269 genes showing at least a twofold expression difference. Gene Ontology analysis revealed distinct pathways involved in aged female and male skeletal muscle, suggesting the potential for sex-specific therapeutic targets to combat sarcopenia and promote healthy aging.
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Marco Merlo, Piero Gentile, Aldostefano Porcari, Anna Palmisano, Davide Vignale, Paola Sormani, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Paolo Della Bella, Simone Sala, Enrico Ammirati, Gianfranco Sinagra, Antonio Esposito, Patrizia Pedrotti
Summary: This study evaluated the diagnostic sensitivity of cardiac magnetic resonance imaging based on Lake Louise criteria in patients with acute myocarditis. The results showed that using updated Lake Louise criteria increased the sensitivity of the diagnosis. It was also found that septal abnormalities were more common in patients with complicated acute myocarditis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Pica, Gabriele Crimi, Serenella Castelvecchio, Vittorio Pazzanese, Anna Palmisano, Massimo Lombardi, Lara Tondi, Antonio Esposito, Pietro Ameri, Claudia Canale, Alberto Cappelletti, Luca P. Alberti, Davide Tavano, Rita Camporotondo, Ilaria Costantino, Jenness Campodonico, Gianluca Pontone, Alessandra Villani, Gianluca Pio Gallone, Rocco A. Montone, Giampaolo Niccoli, Paola Gargiulo, Bruna Punzo, Marco Vicenzi, Stefano Carugo, Lorenzo Menicanti, Giuseppe Ambrosio, Paolo G. Camici
Summary: This study investigated the presence of left ventricular (LV) remodelling after ST-elevation myocardial infarction (STEMI) using cardiac magnetic resonance (CMR) imaging. The results showed that LV remodelling in the subacute phase may not be detrimental, but rather a compensatory response associated with improved LV ejection fraction (EF) at follow-up. However, LV remodelling accompanied by an increase in end-systolic volume index (LV-REMESV) was associated with a decrease in LV-EF, driven by the infarct size.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Acoustics
Anna Palmisano, Davide Vignale, Elisa Bruno, Giovanni Peretto, Giacomo De Luca, Corrado Campochiaro, Alessandro Tomelleri, Eustachio Agricola, Matteo Montorfano, Antonio Esposito
Summary: In this study, CMR findings in patients with myocarditis-like syndrome during the acute and post-acute phase of COVID-19 were reported. The majority of cases were confirmed as myocarditis by CMR, with mild extent of lesions. Additionally, some patients had myocardial infarction and cardiomyopathies. CMR can improve diagnostic accuracy and evaluate subclinical cardiomyopathies.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Piroli, Antonio Boccellino, Giacomo Ingallina, Marco Rolando, Francesco Melillo, Francesco Ancona, Stefano Stella, Federico Biondi, Anna Palmisano, Antonio Esposito, Paolo Denti, Matteo Montorfano, Francesco Maisano, Alessandro Castiglioni, Eustachio Agricola
Summary: This study evaluated the feasibility and reliability of comprehensive 3D-TOE screening in TMVR candidates. The results showed that 3D-TOE measurements were highly correlated with CT measurements and accurately predicted TMVR screening success.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Vignale, Anna Palmisano, Chiara Gnasso, Davide Margonato, Davide Romagnolo, Simone Barbieri, Giacomo Ingallina, Stefano Stella, Marco Bruno Ancona, Matteo Montorfano, Francesco Maisano, Eustachio Agricola, Antonio Esposito
Summary: The prognostic value of the interstitial fibrosis marker ECV measured at planning CT before TAVI was assessed. The study found that ECV higher than 31.3% was associated with an increased risk of heart failure hospitalization or death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Giulia Grazzini, Silvia Pradella, Alice Rossi, Rocco Pio Basile, Matteo Ruggieri, Daniele Galli, Anna Palmisano, Pierpaolo Palumbo, Antonio Esposito, Vittorio Miele
Summary: It is important to evaluate and characterize cardiac masses using non-invasive imaging methods following their accidental discovery during an echocardiographic examination. Echocardiography, CT, CMR, and PET are the main imaging modalities used for their evaluation. Among them, CMR is the best technique for non-invasive tissue characterization, aided by its different MR sequences. This article provides detailed descriptions of each CMR sequence employed in the evaluation of cardiac masses, offering useful guidance to radiologists.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Rheumatology
Giacomo De Luca, Corrado Campochiaro, Anna Palmisano, Elisa Bruno, Davide Vignale, Giovanni Peretto, Simone Sala, Arianna Ferlito, Maria Bernardette Cilona, Antonio Esposito, Marco Matucci-Cerinic, Lorenzo Dagna
Summary: Myocarditis is a common manifestation in patients with anti-synthetase syndrome (ASS), especially at the clinical onset. Patients with ASS myocarditis often present with fever and an inflammatory phenotype. The use of cardiac MRI (CMRI) mapping techniques can improve the diagnostic sensitivity for myocarditis in ASS.
Article
Oncology
Sabrina Gloria Giulia Testoni, Claudia Minici, Elisa Benetti, Francesca Clemente, Daniela Boselli, Clara Sciorati, Lucia De Monte, Maria Chiara Petrone, Markus Enderle, Walter Linzenbold, Maria Pia Protti, Angelo Manfredi, Francesco De Cobelli, Michele Reni, Massimo Falconi, Gabriele Capurso, Paolo Giorgio Arcidiacono, Emanuel Della-Torre
Summary: Thermal ablation under endoscopic ultrasound (EUS)-guidance has shown potential to enhance immune response in pancreatic ductal adenocarcinoma (PDAC). In a recent trial, EUS-guided ablation with HybridTherm Probe (HTP) in combination with chemotherapy improved disease progression compared to chemotherapy alone. This study explored the effects of EUS-HTP on systemic immune response in PDAC and found that it selectively affected immunological predictors of poor outcome.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Davide Vignale, Anna Palmisano, Caterina Colantoni, Lisa Brunetti, Valeria Nicoletti, Chiara Gnasso, Antonio Esposito
Article
Cardiac & Cardiovascular Systems
Guido Ascione, Nicolo Azzola Guicciardi, Roberto Lorusso, Antonio Boccellino, Elisabetta Lapenna, Benedetto Del Forno, Davide Carino, Arturo Bisogno, Anna Palmisano, Giuseppe D'Angelo, Paolo Della Bella, Antonio Esposito, Eustachio Agricola, Ottavio Alfieri, Alessandro Castiglioni, Francesco Maisano, Pasquale Vergara, Michele De Bonis
Summary: The objective of this study was to evaluate the arrhythmic burden in patients with Barlow's disease and significant mitral regurgitation, and to assess the impact of mitral repair on ventricular arrhythmias. The study found that one-third of the patients had arrhythmic burden at baseline, and about half of them became arrhythmia-free after mitral surgery. However, a minority of patients without arrhythmic burden at baseline experienced significant ventricular arrhythmias at follow-up.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Palmisano, Corrado Campochiaro, Davide Vignale, Alessandro Tomelleri, Giacomo De Luca, Elisa Bruno, Caterina B. Monti, Giulio Cavalli, Lorenzo Dagna, Antonio Esposito
Summary: AV groove localization in ECD patients is associated with LV wall fibrosis in downstream coronary territories, while atrial pseudomass localization impacts atrial contractility and is associated with atrio-caval junction stenosis.
Review
Radiology, Nuclear Medicine & Medical Imaging
Antonio Esposito, Marco Gatti, Maria Giovanna Trivieri, Eustachio Agricola, Giovanni Peretto, Guglielmo Gallone, Federica Catapano, Silvia Pradella, Ana Devesa, Elisa Bruno, Giorgio Fiore, Marco Francone, Anna Palmisano
Summary: Mitral valve prolapse is the most common valve disease in the western world and has recently been associated with sudden cardiac death. Echocardiography plays a crucial role in diagnosis and assessment of MVP, while cardiac magnetic resonance provides comprehensive risk stratification.
EUROPEAN RADIOLOGY
(2023)