Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas
出版年份 2013 全文链接
标题
Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas
作者
关键词
-
出版物
PLoS One
Volume 8, Issue 3, Pages e57523
出版商
Public Library of Science (PLoS)
发表日期
2013-03-09
DOI
10.1371/journal.pone.0057523
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1
- (2012) Marieke Aarts et al. Cancer Discovery
- WEE1 inhibition sensitizes osteosarcoma to radiotherapy
- (2011) Jantine PosthumaDeBoer et al. BMC CANCER
- MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts
- (2011) N. V. Rajeshkumar et al. CLINICAL CANCER RESEARCH
- WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
- (2011) P. C. De Witt Hamer et al. CLINICAL CANCER RESEARCH
- MK1775, a Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity against Sarcoma Cells
- (2011) J. M. Kreahling et al. MOLECULAR CANCER THERAPEUTICS
- Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1
- (2011) Yusé Martín et al. Cell Division
- Targeting the checkpoint kinase WEE1: Selective sensitization of cancer cells to DNA-damaging drugs
- (2010) Paola Indovina et al. CANCER BIOLOGY & THERAPY
- MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
- (2010) Hiroshi Hirai et al. CANCER BIOLOGY & THERAPY
- Development and characterization of a conditionally transformed adult human osteoblastic cell line
- (2010) Peter V.N. Bodine et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome
- (2009) Lyndsay M. Murrow et al. BREAST CANCER RESEARCH AND TREATMENT
- Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
- (2009) Shinji Mizuarai et al. Molecular Cancer
- Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
- (2009) H. Hirai et al. MOLECULAR CANCER THERAPEUTICS
- G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
- (2008) N Bucher et al. BRITISH JOURNAL OF CANCER
- Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033
- (2008) Charles D. Blanke et al. JOURNAL OF CLINICAL ONCOLOGY
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