Review
Cell Biology
Biying Zhao, Zhenzhen Zhang, Xu Chen, Yajie Shen, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Shanshan Zhang, Xiaojun Long, Yuhong Zhang, Siming An, Hongmei Wu, Yitao Qi
Summary: Leukemia is a severe malignancy of the hematopoietic system, driven by alterations in the SUMOylation process which affects subcellular localization, protein stability, and protein-protein interactions. Targeting the SUMOylation of proteins could potentially provide powerful targeted therapeutic strategies for the treatment of leukemia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maedeh Mohebnasab, Peng Li, Bo Hong, Jennifer Dunlap, Elie Traer, Guang Fan, Richard D. Press, Stephen R. Moore, Wei Xie
Summary: Cytogenetically cryptic acute promyelocytic leukemia (APL) is a rare disease characterized by typical clinical and morphological features, but lacks detectable genetic translocation. Prompt diagnosis and treatment are crucial due to potential life-threatening complications. This study presents four cases of cryptic APL and reviews previous reports, highlighting the importance of parallel testing methods, especially reverse transcriptase polymerase chain reaction (RT-PCR), for accurate and effective diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Caixia Jin, Qingjian Ou, Jie Chen, Tao Wang, Jieping Zhang, Zhe Wang, Yuanyuan Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Juan Wang, Jiao Li, Lixia Lu, Guo-Tong Xu
Summary: IFITM3 regulates the viability and proliferation of mNRPCs mainly through chaperone-mediated autophagy (CMA) but not macroautophagy (MA). IFITM3 plays a significant role in maintaining the self-renewal homeostasis of progenitor cells by sustaining low-level activation of CMA to eliminate harmful factors in cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Haiyan Yang, Qiang Wang, Yuemei Xi, De Xie, Hiroko Morisaki, Takayuki Morisaki, Jidong Cheng
Summary: This study identified a mechanistic link between AMPD2 and hepatic glucose and lipid metabolism. AMPD2-deficient mice exhibited reduced body weight, fat accumulation, and blood glucose levels, while showing increased insulin sensitivity. AMPD2 deficiency also led to altered expression of genes related to fatty acid and cholesterol metabolism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbala Mifsud, Cameron S. Osborne
Summary: The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Jianli Wang, Wenjian Ma, Yu Fang, Hao Liang, Huiting Yang, Yiwen Wang, Xiaofei Dong, Yi Zhan, Xiaoyuan Wang
Summary: This study investigates the mechanisms of antibiotic resistance in Gram-negative bacteria, specifically focusing on the role of lipopolysaccharide in Escherichia coli. Mutants lacking key components of the cell envelope show decreased resistance to multiple antibacterial drugs, highlighting the importance of the core oligosaccharide portion of lipopolysaccharide. Removal of the core oligosaccharide leads to changes in cell morphology, phenotypes, and response to antibiotic stimulation, emphasizing the crucial role of lipopolysaccharide in antibiotic resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Shuang Fu, Mengqi Li, Hongtao Wang
Summary: This article describes a rare case of a 29-year-old man diagnosed with acute promyelocytic leukemia (APL) in 2019, who developed BCR-ABL1-positive acute lymphoblastic leukemia (ALL) 2 years later. The patient responded well to tyrosine kinase inhibitors and chemotherapy, achieving a molecular remission. While APL generally has a good prognosis, the prognosis of its secondary malignancies is uncertain. There are no effective measures to prevent the occurrence of secondary tumors. Increasing the frequency of laboratory testing, especially molecular biomarker monitoring, is crucial for diagnosing and treating secondary malignancies after achieving complete remission.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Hematology
Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palani Kumar, Nair Reeshma Radhakrishnan, Mohammed Yasar, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews
Summary: This study investigates the resistance mechanisms of acute promyelocytic leukemia (APL) to arsenic trioxide (ATO) treatment. The researchers generated ATO-resistant cell lines and found significant differences in immunophenotype, drug transporter expression, anti-apoptotic protein dependence, and PML-RARA mutation compared to sensitive cell lines. Gene expression profiling revealed dysregulation of metabolic pathways in ATO-resistant APL cell lines.
Article
Multidisciplinary Sciences
Seishiro Hirano, Osamu Udagawa
Summary: Promyelocytic leukemia (PML) proteins play a role in the development of acute promyelocytic leukemia (APL) and can be affected by trivalent arsenic (As3+). The exposure to As3+ can lead to changes in PML-NBs, including solubility shift, SUMOylation, and late agglomeration. Understanding these changes is important for the regulation of intranuclear dynamics of PML-NBs.
Article
Biochemistry & Molecular Biology
Junwei Yuan, Shiwei Zhong, Yu Long, Jingling Guo, Yixun Yu, Juanxu Liu
Summary: This study reveals the involvement of shikimate kinase in flavonoid and anthocyanin synthesis in petunia, and also uncovers the feedback regulation mechanism of gene expression in the shikimate pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zheng Wang, Lijun Wen, Ling Zhang, Xiaoyu Xu, Xiaoqian Chen, Li Yao, Man Wang, Zhen Shen, Guangquan Mo, Yao Wang, Dewan Zhao, Wei Cai, Jingzhi Shen, Xiaomeng Chi, Yi Xu, Zhao Zeng, Jinlan Pan, Changgeng Ruan, Depei Wu, Zhilin Jia, Suning Chen
Summary: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the PML-RARA fusion gene. A novel RARA fusion, TNRC18-RARA, was identified in APL cases similar to classic APL. This study emphasizes the importance of utilizing multiple molecular techniques to characterize and effectively manage APL without the classic PML-RARA fusion.
MOLECULAR CARCINOGENESIS
(2021)
Article
Virology
Zhenyu Chen, Huaijin Liu, Jingjing Zhu, Xing Duan, Han Wang, Xiangchen Li, Xiaolong Zhou, Ayong Zhao, Songbai Yang
Summary: In this study, researchers investigated the functional roles of porcine PML isoforms in Japanese encephalitis virus (JEV) infection. They found that PML isoforms 1, 3, 4, and 5 negatively regulate the interferon (IFN)-beta signaling pathway and suppress viral replication during JEV infection. These findings provide insight into the role of porcine PML isoforms in JEV infection and the regulation of the immune response.
Article
Virology
Zhuoran Li, Ya'ni Wu, Hui Li, Wenqian Li, Juan Tan, Wentao Qiao
Summary: EV71 3C protein cleaves PMLIV at specific sites, reducing its antiviral function and disrupting the formation of PML-NBs, promoting virus replication.
Article
Agriculture, Dairy & Animal Science
Changguo Yi, Hualiang Liang, Dongyu Huang, Heng Yu, Chunyu Xue, Jiaze Gu, Xiaoru Chen, Yongli Wang, Mingchun Ren, Lu Zhang
Summary: This experiment aims to investigate the impact of dietary phenylalanine levels on intestinal immunity, antioxidant activity, and apoptosis in largemouth bass. The results indicate that an unbalanced phenylalanine level in the diet can lead to a decrease in intestinal immune and antioxidant capacity and result in aggravated intestinal cell apoptosis.
Article
Biochemistry & Molecular Biology
Jie Meng, Lijun Wang, Chen Wang, Guangdong Zhao, Hongfang Wang, Baohua Xu, Xingqi Guo
Summary: The study revealed that the PDIA6 gene in the Chinese honeybee is upregulated under oxidative stress conditions, potentially playing a role in antioxidant function and improving honeybee survival rates. PDIA6 is involved in regulating the expression of other antioxidant genes and influencing the antioxidant enzymatic activity of SOD.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biophysics
Sing Wan Wong, Brian Chun Ho Cheung, Bruce Tak Keung Pang, Ateline Kwong, Anna Chung, Kenneth Ka Ho Lee, Arthur Fut Tak Mak
JOURNAL OF BIOMECHANICS
(2017)
Article
Oncology
Roberta Milani, Eleonora Brognara, Enrica Fabbri, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giovanni Marzaro, Adriana Chilin, Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Chung-Hin Chui, Roberto Gambari
Article
Toxicology
Ping Zhang, Guang Wang, Zhuangling Lin, Yushi Wu, Jing Zhang, Meng Liu, Kenneth Ka Ho Lee, Manli Chuai, Xuesong Yang
TOXICOLOGY LETTERS
(2017)
Article
Chemistry, Multidisciplinary
David W. Green, Stephen T. Kelly, Kenneth Ka-Ho Lee, Gregory S. Watson, Jolanta A. Watson, Han Sung Jung
ADVANCED MATERIALS INTERFACES
(2018)
Article
Cell Biology
Xiao-tan Zhang, Guang Wang, Yan Li, Manli Chuai, Kenneth Ka Ho Lee, Xuesong Yang
Article
Oncology
Charmaine Cheuk-Man Pun, Kenneth Ka-Ho Lee, Yiu-Loon Chui
LEUKEMIA & LYMPHOMA
(2019)
Article
Multidisciplinary Sciences
Angelo S. Mao, Berna Ozkale, Nisarg J. Shah, Kyle H. Vining, Tiphaine Descombes, Liyuan Zhang, Christina M. Tringides, Sing-Wan Wong, Jae-Won Shin, David T. Scadden, David A. Weitz, David J. Mooney
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Jingyi Gan, Florence Mei Kuen Tang, Xianwei Su, Gang Lu, Jing Xu, Henry Siu Sum Lee, Kenneth Ka Ho Lee
ANNALS OF TRANSLATIONAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Sing Wan Wong, Stephen Lenzini, Madeline H. Cooper, David J. Mooney, Jae-Won Shin
Article
Chemistry, Multidisciplinary
Sing Wan Wong, Stephen Lenzini, Raymond Bargi, Zhe Feng, Celine Macaraniag, James C. Lee, Zhangli Peng, Jae-Won Shin
Article
Engineering, Biomedical
Sing Wan Wong, Chandramohan R. Tamatam, Ik Sung Cho, Peter T. Toth, Raymond Bargi, Patrick Belvitch, James C. Lee, Jalees Rehman, Sekhar P. Reddy, Jae-Won Shin
Summary: Coating mesenchymal stromal cells with a soft conformal gel incorporating specific chemomechanical cues can inhibit aberrant tissue remodelling in mice with fibrotic lung injury. Understanding and controlling microenvironmental cues could optimize the efficacy of cell therapeutics, promoting matrix remodelling.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Daniel Devine, Vishwaarth Vijayakumar, Sing Wan Wong, Stephen Lenzini, Peter Newman, Jae-Won Shin
ADVANCED BIOSYSTEMS
(2020)
Article
Materials Science, Biomaterials
Lok Man Lo, Michael Raghunath, Kenneth K. H. Lee
ADVANCED BIOSYSTEMS
(2019)
Article
Engineering, Biomedical
Sing Wan Wong, Stephen Lenzini, Jae-Won Shin
APL BIOENGINEERING
(2018)
Review
Microbiology
P. L. Lam, K. K. H. Lee, R. S. M. Wong, G. Y. M. Cheng, Z. X. Bian, C. H. Chui, R. Gambari
CRITICAL REVIEWS IN MICROBIOLOGY
(2018)