The MAPK Pathway Signals Telomerase Modulation in Response to Isothiocyanate-Induced DNA Damage of Human Liver Cancer Cells

Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage

(2012) Fulvia Zanichelli et al.   APOPTOSIS

Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate

(2012) Na Young Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Protein Kinase C (PKC) and Telomerase by Phenethyl Isothiocyanate (PEITC) Sensitizes PC-3 Cells Towards Chemotherapeutic Drug-Induced Apoptosis

(2012) Sutapa Mukherjee et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

(2011) Fulvia Zanichelli et al.   AGE

Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement

(2011) John D. Clarke et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway

(2010) Dong-Oh Moon et al.   CANCER LETTERS

N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells

(2010) I-Lun Hsin et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Are isothiocyanates potential anti-cancer drugs?

(2009) Xiang Wu et al.   ACTA PHARMACOLOGICA SINICA

MTBITC mediates cell cycle arrest and apoptosis induction in human HepG2 cells despite its rapid degradation kinetics in the in vitro model

(2009) Evelyn Lamy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Three structurally homologous isothiocyanates exert “Janus” characteristics in human HepG2 cells

(2009) Evelyn Lamy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

4-Hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity

(2009) Stefania Pizzimenti et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells

(2009) Sutapa Mukherjee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of Reactive Oxygen Intermediates in Cellular Responses to Dietary Cancer Chemopreventive Agents

(2008) Jedrzej Antosiewicz et al.   PLANTA MEDICA

Transforming growth factor-β inhibits telomerase through SMAD3 and E2F transcription factors

(2007) Annie Lacerte et al.   CELLULAR SIGNALLING