Article
Microbiology
Danicke Willemse, Chivonne Moodley, Smriti Mehra, Deepak Kaushal
Summary: Smoking is a known added risk factor for tuberculosis, increasing the risk of active TB and reducing cure and treatment completion rates. Cigarette smoke contains harmful compounds that may potentially enhance the virulence of the tubercle bacilli. Further research is needed to explore the impact of cigarette smoke on Mycobacterium tuberculosis and its potential implications for TB treatment efficacy.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Wei Fu, Pei-Chuan Ho, Chia-Lun Liu, Kai-Teh Tzeng, Nawar Nayeem, Jonni S. Moore, Li-San Wang, Shin-Yi Chou
Summary: Research suggests that the BCG vaccine may offer some protection against COVID-19, especially in the early stages of the pandemic, but the effectiveness seems to diminish as the pandemic progresses. The protective effect of BCG vaccination may also vary depending on the age structure of the vaccinated population.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jerald R. Chavez, Wangyuan Yao, Harrison Dulin, Jasmine Castellanos, Duo Xu, Rong Hai
Summary: Due to the lack of pandemic potential, research on the pathology and immunological responses of IBV lags behind that of IAV. The impact of lifestyle and environmental factors, such as cigarette smoking, on IBV infections is still unclear. By pre-treating mice with cigarette smoke extract for two weeks, infecting them with IBV, and monitoring the effects, we developed an animal model system. The results showed that cigarette smoke extract treatment decreased IBV specific IgG levels but did not change viral replication and weight recovery post infection in the upper airway/lung. However, higher concentrations of cigarette smoke extract did lead to higher mortality post infection, suggesting that inflammation induced by smoking coupled with IBV infection resulted in exacerbated disease outcome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Toxicology
Arnab Maiti, Nabanita Saha, Aditya Shukla, Srimonti Sarkar, Alok Kumar Sil
Summary: Cigarette smoke extract impairs ESCRT pathway function in yeast, leading to compromised vacuolar degradation and increased accumulation of misfolded proteins, while leucine has the potential to attenuate the accumulation of misfolded proteins induced by cigarette smoke.
TOXICOLOGY LETTERS
(2021)
Review
Chemistry, Medicinal
Sahar Fanoudi, Mohaddeseh Sadat Alavi, Soghra Mehri, Hossein Hosseinzadeh
Summary: Cigarette smoking is a significant risk factor for developing various diseases and cancers, and curcumin has the potential to attenuate the toxic effects of smoking and provide protection.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carmen A. Ochoa, Claire G. Nissen, Deanna D. Mosley, Christopher D. Bauer, Destiny L. Jordan, Kristina L. Bailey, Todd A. Wyatt
Summary: Most individuals with alcohol use disorders also smoke cigarettes. Exposure to cigarette smoke and alcohol can cause lung injury, but aldehyde-trapping compounds like ADX-102 may offer protection against this damage.
Article
Medicine, General & Internal
Neus Altet, Irene Latorre, Maria Angeles Jimenez-Fuentes, Antoni Soriano-Arandes, Raquel Villar-Hernandez, Celia Mila, Pablo Rodriguez-Fernandez, Beatriz Muriel-Moreno, Patricia Comella-del-Barrio, Pere Godoy, Joan-Pau Millet, Maria Luiza de Souza-Galvao, Carlos A. Jimenez-Ruiz, Jose Dominguez
Summary: This study found that exposure to second-hand smoke (SHS) is associated with an increased risk of tuberculosis (TB) and latent TB infection (LTBI) in children. Furthermore, smoking also affects the accuracy of Interferon-Gamma Release Assays (IGRAs) and cytokine immune responses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhou, Fang Fang, Jinying Qi, Tengteng Li, Lin Zhang, Hui Liu, Jingzhu Lv, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian
Summary: Tuberculosis is a global threat to public health, and Nrf2 plays a key role in regulating protective immunity against mycobacterial infection. The expression of Nrf2 protein increases after M. tuberculosis infection, while the expression of Keap1 protein remains low. The activation of Nrf2 by SFN reduces inflammation, increases ROS levels, promotes autophagy, and enhances bacterial killing by macrophages.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Quan-Zhen Lv, De-Dong Li, Hua Han, Yi-Heng Yang, Jie-Lin Duan, Hui-Hui Ma, Yao Yu, Jiang-Ye Chen, Yuan-Ying Jiang, Xin-Ming Jia
Summary: Preconditioning with the FLO8-deficient mutant of C. albicans provides protection against subsequent lethal infections by inducing Dectin-2/CARD9-mediated IL-10 production. This protection is achieved by preventing C. albicans-induced apoptosis of thymic T cells, leading to enhanced Th1-biased immune responses against fungal infections.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Food Science & Technology
Wataru Otsu, Naoki Chinen, Emi Sugisawa, Haru Kitano, Shinsuke Nakamura, Naofumi Umigai, Hideshi Tsusaki, Masamitsu Shimazawa
Summary: In this study, the researchers investigated the effect of crocetin on muscular injury induced by cigarette smoke extract (CSE) and acrolein. They found that crocetin could restore the damaged muscle cell morphology and function, suggesting that daily intake of crocetin may help protect muscles from environmental oxidants such as cigarette smoke.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Mithun Rudrapal, Siddhartha Maji, Shiv Kumar Prajapati, Payal Kesharwani, Prashanta Kumar Deb, Johra Khan, Randa Mohamed Ismail, Rani S. Kankate, Ranjan Kumar Sahoo, Shubham J. Khairnar, Atul R. Bendale
Summary: Cigarette smoking can cause life-threatening diseases such as lung cancer and pulmonary and cardiovascular diseases. One of the major health implications of smoking is the oxidative damage to cellular constituents, and dietary polyphenols have shown potential benefits in protecting against various chronic conditions.
Article
Biochemistry & Molecular Biology
Fatma Saaoud, Ying Shao, William Cornwell, Hong Wang, Thomas J. Rogers, Xiaofeng Yang
Summary: Cigarette smoke plays a significant role in causing various diseases and poses a serious challenge to the global healthcare system. This review aims to synthesize recent advances and provide a comprehensive understanding of the immunomodulatory action of cigarette smoke, particularly in relation to cardiovascular diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Nutrition & Dietetics
Ji-Soo Jeong, Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Je-Won Ko, Tae-Won Kim
Summary: The study found that Chestnut inner shell extract (CIE) has pharmacological effects against various diseases. It effectively inhibited the development of respiratory infectious diseases caused by cigarette smoke condensate (CSC) and treated emphysema. CIE suppressed the PI3K/Akt/NF-κB signal pathway, downregulated matrix metalloprotease-9 expression, and inhibited CSC-induced emphysema progression.
Article
Biochemistry & Molecular Biology
Marit Zuurveld, Veronica Ayechu-Muruzabal, Gert Folkerts, Johan Garssen, Belinda Van't Land, Linette E. M. Willemsen
Summary: Proper early-life immune development is crucial for a healthy immune system. Human milk oligosaccharides (HMOS) have immunomodulatory properties that are essential for neonatal immune maturation. In this study, five HMOS present in human milk were studied for their effects on the immune system. The results showed that 2'FL and 3FL had the most pronounced immunomodulatory effects, enhancing the secretion of key immune mediators.
Review
Immunology
Jin Kyung Kim, Eun-Jin Park, Eun-Kyeong Jo
Summary: Immune metabolic regulation plays a crucial role in the host-pathogen interaction during tuberculosis infection. Metabolites such as itaconate, L-arginine, and L-citrulline are involved in innate immune protection against Mycobacterium tuberculosis, by restricting bacterial growth and enhancing host defense mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pamela Shen, Mathieu C. Morissette, Gilles Vanderstocken, Yang Gao, Muhammad Hassan, Abraham Roos, Danya Thayaparan, Maria Merlano, Michael G. Dorrington, Jake K. Nikota, Carla M. T. Bauer, Jacek M. Kwiecien, Renee Labiris, Dawn M. E. Bowdish, Christopher S. Stevenson, Martin R. Stampfli
INFECTION AND IMMUNITY
(2016)
Article
Microbiology
Varun C. Anipindi, Puja Bagri, Kristy Roth, Sara E. Dizzell, Philip V. Nguyen, Christopher R. Shaler, Derek K. Chu, Rodrigo Jimenez-Saiz, Hong Liang, Stephanie Swift, Aisha Nazli, Jessica K. Kafka, Jonathan Bramson, Zhou Xing, Manel Jordana, Yonghong Wan, Denis P. Snider, Martin R. Stampfli, Charu Kaushic
Article
Immunology
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M. Mansour Haeryfar
JOURNAL OF IMMUNOLOGY
(2017)
Article
Virology
Puja Bagri, Varun C. Anipindi, Philip V. Nguyen, Danielle Vitali, Martin R. Stampfli, Charu Kaushic
JOURNAL OF VIROLOGY
(2017)
Review
Pharmacology & Pharmacy
Abraham B. Roos, Martin R. Stampfli
PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Biochemistry & Molecular Biology
Christopher R. Shaler, Joshua Choi, Patrick T. Rudak, Arash Memarnejadian, Peter A. Szabo, Mauro E. Tun-Abraham, Jamie Rossjohn, Alexandra J. Corbett, James McCluskey, John K. McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S. M. Mansour Haeryfar
Article
Biochemistry & Molecular Biology
Gilles Vanderstocken, Anna Dvorkin-Gheva, Pamela Shen, Corry-Anke Brandsma, Ma'en Obeidat, Yohan Bosse, John A. Hassell, Martin R. Stampfli
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Editorial Material
Biochemistry & Molecular Biology
Martin R. Stampfli, Andrew M. Churg
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Christopher R. Shaler, Wael Elhenawy, Brian K. Coombes
JOURNAL OF MOLECULAR BIOLOGY
(2019)
Article
Endocrinology & Metabolism
Trevor C. Lau, Aline A. Fiebig-Comyn, Christopher R. Shaler, Joseph B. McPhee, Brian K. Coombes, Jonathan D. Schertzer
Summary: This study shows that lower dietary fiber is a key factor in promoting the expansion of gut pathobionts associated with Crohn's disease in mice, independent of obesity status. Reduction in dietary fiber was found to be sufficient to promote the intestinal expansion of pathogenic Escherichia coli, even without affecting body mass.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes
Summary: Psychological stress impairs gut microbiome and immune system, allowing invasive bacteria to colonize; Immune modulation and administration of certain cytokines can counteract the negative impact of stress on gut health.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Christopher R. Shaler, Mauro E. Tun-Abraham, Anton I. Skaro, Khashayarsha Khazaie, Alexandra J. Corbett, Tina Mele, Roberto Hernandez-Alejandro, S. M. Mansour Haeryfar
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)
Article
Immunology
Pamela Shen, Fiona J. Whelan, L. Patrick Schenck, Joshua J. C. McGrath, Gilles Vanderstocken, Dawn M. E. Bowdish, Michael G. Surette, Martin R. Satmpfli
INFECTION AND IMMUNITY
(2017)
Letter
Respiratory System
Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Juergen Hoffmann, Jonas S. Erjefaelt, Martin R. Stampfli
RESPIRATORY RESEARCH
(2017)
Article
Medicine, General & Internal
Ram Venkatesh Anantha, Christopher Ryan Shaler, Courtney Erin Meilleur, Jeremy Parfitt, S. M. Mansour Haeryfar, Roberto Hernandez-Alejandro
FRONTIERS IN MEDICINE
(2016)