Article
Geriatrics & Gerontology
Xiaoqi Chu, Peng Wu, Hongting Yan, Xuejing Chen, Liting Fan, Zheng Wu, Chunmei Tao, Yue Ma, Yu Fu, Yunchu Guo, Yang Dong, Chao Yang, Yusong Ge
Summary: This study used diffusion kurtosis imaging to analyze the differences in brain microstructure between patients with Alzheimer's disease, patients with mild cognitive impairment, and cognitively normal individuals. The findings suggest that hippocampal mean kurtosis is the most sensitive parameter for differentiating between these groups. This study contributes to the search for potential non-invasive biomarkers of Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Qili Hu, Qianqian Wang, Yunfei Li, Zhou Xie, Xiaomei Lin, Guofeng Huang, LinLin Zhan, Xize Jia, Xiaohu Zhao
Summary: A study found significant differences in brain activity between MCI reverters and healthy controls, which may be related to the cognitive reversion of MCI patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Uk-Su Choi, Jun Young Park, Jang Jae Lee, Kyu Yeong Choi, Sungho Won, Kun Ho Lee
Summary: We developed a novel brain age prediction model using brain volume and cortical thickness features. Acceleration of brain age (ABA) was strongly associated with the diagnostic groups of cognitively normal, mild cognitive impairment, and Alzheimer's disease. Our classification models for CN to MCI conversion and MCI to AD conversion exhibited acceptable and robust performances.
Article
Neurosciences
Boshra Khajehpiri, Hamid Abrishami Moghaddam, Mohamad Forouzanfar, Reza Lashgari, Jaime Ramos-Cejudo, Ricardo S. Osorio, Babak A. Ardekani
Summary: This study developed a PH model using an Xgboost regressor to estimate the risk of AD in MCI patients and the risk of MCI in CN subjects. By capturing complex interactions between predictors and non-linear predictor-risk associations, the Xgboost model achieved higher accuracy in predicting risk compared to the Cox PH model. Using non-invasive and widely available predictors, reasonable risk stratification can be achieved in a cost-effective manner.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Christopher Gonzalez, Nicole S. Tommasi, Danielle Briggs, Michael J. Properzi, Rebecca E. Amariglio, Gad A. Marshall
Summary: This study found an association between financial capacity impairment and regional tau burden in early-stage AD patients, suggesting the potential utility of such assessments in detecting meaningful decline that may aid clinical trials of early-stage AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Yu-Qian Wu, Yi-Ning Wang, Li-Juan Zhang, Li-Qi Liu, Yi-Cong Pan, Ting Su, Xu-Lin Liao, Hui-Ye Shu, Min Kang, Ping Ying, San-Hua Xu, Yi Shao
Summary: The study aimed to analyze potential changes in brain neural networks in patients with mild cognitive impairment (MCI) using the regional homogeneity (ReHo) method in resting state functional magnetic resonance imaging (rs-fMRI) scans. The results showed significant differences in signal intensity in specific brain regions between MCI patients and healthy controls, and these differences were correlated with clinical features. These findings may have implications for clinical diagnosis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Feng Sha, Ziyi Zhao, Chang Wei, Bingyu Li
Summary: This study identified several modifiable dietary/lifestyle factors associated with the reversion of mild cognitive impairment (MCI) to cognitive normal (CN) status, which may have important implications for large-scale dementia prevention practices.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Wen Luo, Hao Wen, Shuqi Ge, Chunzhi Tang, Xiufeng Liu, Liming Lu
Summary: This study developed a sex-specific risk scoring system, SRSS-CNMCI, to predict the conversion of cognitively normal individuals to mild cognitive impairment and provide a reliable tool for MCI prevention. The system was validated in two independent databases and demonstrated good predictive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sabrina Esposito, Francesca Trojsi, Giovanni Cirillo, Manuela de Stefano, Federica Di Nardo, Mattia Siciliano, Giuseppina Caiazzo, Domenico Ippolito, Dario Ricciardi, Daniela Buonanno, Danilo Atripaldi, Roberta Pepe, Giulia D'Alvano, Antonella Mangione, Simona Bonavita, Gabriella Santangelo, Alessandro Iavarone, Mario Cirillo, Fabrizio Esposito, Sandro Sorbi, Gioacchino Tedeschi
Summary: This preliminary study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on patients with mild cognitive impairment (MCI). The results showed significant improvements in executive performance and changes in brain functional connectivity (FC) in MCI patients who received rTMS treatment.
Article
Clinical Neurology
Yilan Xing, Shishun Fu, Meng Li, Xiaofen Ma, Mengchen Liu, Xintong Liu, Yan Huang, Guang Xu, Yonggang Jiao, Hong Wu, Guihua Jiang, Junzhang Tian
Summary: This study aimed to compare regional homogeneity (ReHo) changes between PD-MCI patients, PD-CN patients, and NC subjects, as well as investigate the relationship between ReHo changes and neuropsychological variation. The results revealed significant ReHo value differences in various brain regions among the three groups, suggesting potential early biomarkers for cognitive impairment in PD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Neurosciences
Sydney Y. Schaefer, Michael Malek-Ahmadi, Andrew Hooyman, Jace B. King, Kevin Duff
Summary: Hippocampal atrophy is a common biomarker for Alzheimer's disease, but its use is limited by the cost and contraindications of magnetic resonance imaging (MRI). Recent research has found that a low-cost upper extremity motor task has the potential to identify Alzheimer's disease risk. The study shows that measures of motor task performance can predict hippocampal volume, offering a cost-effective and non-invasive screening method for Alzheimer's disease risk and progression.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zahinoor Ismail, Alexander McGirr, Sascha Gill, Sophie Hu, Nils D. Forkert, Eric E. Smith
Summary: The study showed that individuals with both MBI and SCD had the highest risk of cognitive and functional decline, suggesting that these two conditions combined can serve as a simple and scalable method to identify high-risk patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Leonie C. P. Banning, Inez H. G. B. Ramakers, Paul B. Rosenberg, Constantine G. Lyketsos, Jeannie-Marie S. Leoutsakos
Summary: This study examined the trajectories of depression and apathy in (prodromal) Alzheimer's disease patients and found that they were associated with AD biomarkers. Lower A beta(42) and higher tau levels were related to increased probability of depression and apathy over time.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Lucio Marinelli, Carlo Trompetto, Luca Puce, Fiammetta Monacelli, Laura Mori, Carlo Serrati, Francesco Fattapposta, Maria Felice Ghilardi, Antonio Curra
Summary: Paratonia increases with normal aging and cognitive decline progression. Facilitatory paratonia is due to involuntary contraction of the shortening muscle, while oppositional paratonia is primarily due to involuntary contraction of the lengthening muscle. EMG activity during passive movements correlates with paratonia clinical scores and is velocity-dependent.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Ju An Park, Yejin Youm, Hwa-Rim Lee, Yongwoo Lee, Sarah L. Barron, Taejeong Kwak, Gyu Tae Park, Young-Cheol Song, Roisin M. Owens, Jae Ho Kim, Sungjune Jung
Summary: A cell sheet transfer method from a culture surface to a target tissue is introduced in this study. UV-treated parylene, a commercially available flexible material, is used as the culture surface to provide adequate cell adhesiveness for both cell attachment during culture and efficient transfer. Various cell types are successfully transferred using this versatile cell-transfer process. The mechanism of interfacial cell migration between surfaces with different adhesion preferences is observed, and the re-establishment and reversal of cell polarity after transfer are identified. The unique capabilities of 3D multilayer stacking, freeform design, and curved surface application are demonstrated. The therapeutic potential of the cell-sheet delivery system is demonstrated through experiments on cutaneous wound healing and skin-tissue regeneration in mice models.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Ju Won Jung, So Young Park, Eun Jin Seo, Il Ho Jang, Yeji Park, Dasun Lee, Dohyun Kim, Jin Man Kim
Summary: Dental pulp-derived stromal cells (DPSCs) are important for maintaining the tissue integrity of the pulp-dentin complex. In this study, we demonstrate the biological functions and significance of the oxytocin receptor (OXTR) in DPSCs. Blocking OXTR activity promotes DPSC differentiation and is involved in extracellular matrix (ECM) remodeling. The genetic changes mediated by OXTR are regulated by the transcriptional activity of Yes-associated protein (YAP). These findings provide new insights into the regenerative process of the pulp-dentin complex.
Article
Cardiac & Cardiovascular Systems
Joo Myung Lee, Hyun Kuk Kim, Keun Ho Park, Eun Ho Choo, Chan Joon Kim, Seung Hun Lee, Min Chul Kim, Young Joon Hong, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don Park, Hyun-Jong Lee, Min Gyu Kang, Jin-Sin Koh, Yun-Kyeong Cho, Chang-Wook Nam, Bon-Kwon Koo, Bong-Ki Lee, Kyeong Ho Yun, David Hong, Hyun Sung Joh, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, FRAME AMI Invest
Summary: For patients with acute myocardial infarction and multivessel coronary artery disease, FFR-guided PCI is superior to angiography-guided PCI in reducing the risk of death or myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Coen K. M. Boerhout, Guus A. de Waard, Joo Myung Lee, Hernan Mejia-Renteria, Seung Hun Lee, Ji-Hyun Jung, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Javier Escaned, Tsunekazu Kakuta, Bon Kwon Koo, Jan J. Piek, Tim P. van de Hoef
Summary: The study aimed to evaluate the diagnostic and prognostic value of non-hyperemic Pd/Pa and its additional value when combined with hyperemic pressure ratio (FFR) to guide revascularization. A total of 2141 patients with physiological data in 2726 vessels were included in a retrospective registry. Abnormal pressure ratios in both non-hyperemic and hyperemic conditions were found to have important prognostic value. The combined use of FFR and non-hyperemic Pd/Pa efficiently identified vessels with concordant normal pressure ratios and excellent long-term clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David Hong, Seung Hun Lee, Doosup Shin, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Hyun Sung Joh, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: This study evaluated the association between cardiac diastolic dysfunction and coronary microvascular dysfunction (CMD) in patients without significant left ventricular systolic dysfunction and epicardial coronary stenosis. The study found that CMD was independently associated with cardiac diastolic dysfunction and both were associated with an increased risk of cardiovascular death or admission for heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jae Hyun Kim, Jeong Hee Yoon, Ijin Joo, Jeong Min Lee
Summary: This study compared two different two-dimensional shear wave elastography techniques, PWI and MB imaging, for evaluating liver fibrosis. The results showed that the MB technique is more reliable for long-term follow-up, suggesting its preference in assessing liver fibrosis in chronic liver disease patients.
Article
Biochemistry & Molecular Biology
Kyung-Taek Kang, Min-Joo Shin, Hye-Ji Moon, Kyung-Un Choi, Dong-Soo Suh, Jae-Ho Kim
Summary: This study found that TRRAP overexpression increases NANOG protein stability and enhances the tumorigenic potential of colon cancer stem cells. TRRAP inhibits the ubiquitination degradation of NANOG by binding to it. TRRAP knockdown decreases the expression of CD44, a cancer stem cell marker, and increases the expression of P53, a tumor suppressor gene, in colon cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sang Won Kwak, Jina Koo, Minju Song, Il Ho Jang, Gianluca Gambarini, Hyeon-Cheol Kim
Summary: The aim of this study was to compare the physicochemical properties and biocompatibility between various calcium silicate-based bioceramic sealers (CSBSs) and the epoxy resin-based sealer AH Plus (AHP). The physical properties of CSBSs, including flow, setting time, radiopacity, dimensional stability, and pH, were evaluated according to the ISO 6876 standards. The biocompatibility of CSBSs was found to be higher than that of AHP, as assessed through cytotoxicity and cell attachment assays.
JOURNAL OF ENDODONTICS
(2023)
Article
Oncology
Jeongin Yoo, Jeong Min Lee, Ijin Joo, Dong Ho Lee, Jeong Hee Yoon, Mi Hye Yu, Jin-Young Jang, Sang Hyub Lee
Summary: This study aimed to determine if the addition of PET/MRI and CA 19-9 to CECT can improve the accuracy of predicting resectability and prognosis in PDAC patients. The results showed that the combination of CECT, PET, and CA 19-9 increased the AUC and sensitivity for determining resectability without compromising specificity. Additionally, FDG avidity on post-NAT PET and pathologically confirmed vascular invasion predicted recurrence-free survival in PDAC patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiane Kuhl, Tibor Csoszi, Wojciech Piskorski, Tomasz Miszalski, Jeong-Min Lee, Pamela M. Otto
Summary: This study compared the effectiveness of Gadopiclenol and Gadobutrol for lesion visualization in body MRI. The results showed that Gadopiclenol at a dose of 0.05 mmol/kg was comparable to Gadobutrol at a dose of 0.1 mmol/kg in terms of lesion evaluation, and both had a similar safety profile.
Review
Radiology, Nuclear Medicine & Medical Imaging
Hyo-Jin Kang, Jeong Min Lee, Se Woo Kim
Summary: Contrast-enhanced ultrasonography (CEUS) is a noninvasive imaging modality used for diagnosing hepatocellular carcinoma (HCC) without the need for pathological confirmation. Different contrast agents, such as SonoVue and Sonazoid, are available for CEUS imaging. Major guidelines recognize CEUS as a reliable method for HCC diagnosis, but the choice of contrast agent varies. This review provides a comparative overview of the pharmacokinetic features, examination protocols, diagnostic criteria, and potential applications of these contrast agents in the HCC diagnostic algorithm.
Meeting Abstract
Cardiac & Cardiovascular Systems
Marina Piccinelli, Joo Myung Lee, C. David Cooke, Jonathon Nye, Sang-Geon Cho, Bon Kwon Koo, Hee-Seung Bom, Ernest V. Garcia
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junghoan Park, Jae Seok Bae, Jong-Min Kim, Joseph Nathanael Witanto, Sang Joon Park, Jeong Min Lee
Summary: This study aimed to develop a deep-learning model for classifying LI-RADS major features using subtraction MRI images. The model showed satisfactory performance in both HCC segmentation and LI-RADS major feature classification.
ABDOMINAL RADIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bon-Kwon Koo, Doyeon Hwang, Jaewook Chung, Joo Myung Lee, Hyunjong Lee, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Akiko Matsuo, Hitoshi Matsuo, Shao-Liang Chen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sonali Kumar, David Molony, Sameer Khawaja, Kaylyn Crawford, Elizabeth W. Thompson, Olivia Hung, Imran Shah, Jessica Navas-Simbana, Arlen Ho, Arnav Kumar, Yi-An Ko, Hossein Hosseini, Adrien Lefieux, Joo Myung Lee, Joo-Yong Hahn, Shao-Liang Chen, Hiromasa Otake, Takashi Akasaka, Eun-Seok Shin, Bon-Kwon Koo, Goran Stankovic, Dejan Milasinovic, Chang-Wook Nam, Ki-Bum Won, Javier Escaned, Andrejs Erglis, Yoshinobu Murasato, Alessandro Veneziani, Habib Samady
Summary: Coronary stent underexpansion is associated with restenosis and stent thrombosis. High wall shear stress (WSS) has been linked to prothrombotic pathways activation, matrix metalloproteinases upregulation, and future myocardial infarction in atherosclerosis studies. This study aimed to investigate the relationship between stent underexpansion and WSS. The results showed that frames with stent underexpansion were more likely to exhibit high WSS, while no significant association was found between underexpansion and low WSS or between underexpansion and stent platform.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)